WO2007103273A3 - Thioredoxin and thioredoxin reductase inhibitors - Google Patents

Thioredoxin and thioredoxin reductase inhibitors Download PDF

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Publication number
WO2007103273A3
WO2007103273A3 PCT/US2007/005530 US2007005530W WO2007103273A3 WO 2007103273 A3 WO2007103273 A3 WO 2007103273A3 US 2007005530 W US2007005530 W US 2007005530W WO 2007103273 A3 WO2007103273 A3 WO 2007103273A3
Authority
WO
WIPO (PCT)
Prior art keywords
thioredoxin
reductase inhibitors
thioredoxin reductase
sulfones
alzheimer
Prior art date
Application number
PCT/US2007/005530
Other languages
French (fr)
Other versions
WO2007103273A2 (en
Inventor
Scott E Schaus
Erin L Eastwood
Original Assignee
Univ Boston
Scott E Schaus
Erin L Eastwood
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Boston, Scott E Schaus, Erin L Eastwood filed Critical Univ Boston
Publication of WO2007103273A2 publication Critical patent/WO2007103273A2/en
Publication of WO2007103273A3 publication Critical patent/WO2007103273A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
    • C07C317/10—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/76—Sulfur atoms attached to a second hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to sulfone derivatives and to their use as modulators of the thioredoxin/thioredoxin reductase redox system, including for the treatment and/or prevention of pathophysiological conditions mediated by thioredoxin/thioredoxin reductase, such as cancer, HIV/ AIDS, Alzheimer's disease, rheumatoid arthritis, and skin disorders. Also provided are pharmaceutical compositions comprising the inventive sulfones.
PCT/US2007/005530 2006-03-03 2007-03-02 Thioredoxin and thioredoxin reductase inhibitors WO2007103273A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77887606P 2006-03-03 2006-03-03
US60/778,876 2006-03-03

Publications (2)

Publication Number Publication Date
WO2007103273A2 WO2007103273A2 (en) 2007-09-13
WO2007103273A3 true WO2007103273A3 (en) 2007-11-22

Family

ID=38475450

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/005530 WO2007103273A2 (en) 2006-03-03 2007-03-02 Thioredoxin and thioredoxin reductase inhibitors

Country Status (1)

Country Link
WO (1) WO2007103273A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8173688B2 (en) 2008-06-13 2012-05-08 Nexmed Holdings, Inc. Thiazole compounds, and compositions and methods using same
CA2727595A1 (en) * 2008-06-13 2009-12-17 Bioquant, Inc. Thiazole compounds, and compositions and methods using same
US20130324603A1 (en) * 2012-06-05 2013-12-05 Olatec Industries Llc Pharmaceutical composition for treating inflammation and pain
US9481644B2 (en) 2012-06-05 2016-11-01 Olatec Therapeutics Llc Pharmaceutical composition comprising omega-(arylsulfonyl)alkylnitrile
WO2013184708A1 (en) * 2012-06-05 2013-12-12 Olatec Industries Llc Pharmaceutical composition for treating inflammation and pain
US9999610B2 (en) 2013-10-01 2018-06-19 Olatec Therapeutics Llc Pharmaceutical use of 3-benzylsulfonylpropionitrile
WO2018171619A1 (en) * 2017-03-21 2018-09-27 南京凯熙医学科技有限公司 Method for detecting activity of thioredoxin reductase, detection device and operation method therefor
CN115124485B (en) * 2021-03-26 2023-12-15 中国医学科学院药物研究所 Sulfoxide-containing benzoxazole derivative, and preparation method and application thereof
CN113106077B (en) * 2021-04-01 2023-05-23 芜湖英特菲尔生物制品产业研究院有限公司 Preparation method of saccharomyces cerevisiae expressed recombinant porcine thioredoxin and application of saccharomyces cerevisiae expressed recombinant porcine thioredoxin in breeding industry

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1011340A (en) * 1972-07-10 1977-05-31 Merck And Co. 1-aryl-5-substituted tetrazoles
US5468903A (en) * 1992-03-03 1995-11-21 Zeneca Limited Regioselective sulfonylation reaction of substituted aromatic compounds
US5594145A (en) * 1993-04-28 1997-01-14 Hoechst Ag Process for the preparation of 2(3H)-benzothiazolones
US20030191179A1 (en) * 1999-10-25 2003-10-09 Supergen, Inc. Methods for administration of paclitaxel

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1011340A (en) * 1972-07-10 1977-05-31 Merck And Co. 1-aryl-5-substituted tetrazoles
US5468903A (en) * 1992-03-03 1995-11-21 Zeneca Limited Regioselective sulfonylation reaction of substituted aromatic compounds
US5594145A (en) * 1993-04-28 1997-01-14 Hoechst Ag Process for the preparation of 2(3H)-benzothiazolones
US20030191179A1 (en) * 1999-10-25 2003-10-09 Supergen, Inc. Methods for administration of paclitaxel

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DI BERNADO ET AL.: "Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks", NATURE BIOTECHNOLOGY, vol. 23, no. 3, March 2005 (2005-03-01), pages 377 - 383, XP008090921 *

Also Published As

Publication number Publication date
WO2007103273A2 (en) 2007-09-13

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