WO2007102812A3 - Natively glycosylated mammalian biological molecules produced by eletromagnetically stimulating living mammalian cells - Google Patents

Natively glycosylated mammalian biological molecules produced by eletromagnetically stimulating living mammalian cells Download PDF

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Publication number
WO2007102812A3
WO2007102812A3 PCT/US2006/008071 US2006008071W WO2007102812A3 WO 2007102812 A3 WO2007102812 A3 WO 2007102812A3 US 2006008071 W US2006008071 W US 2006008071W WO 2007102812 A3 WO2007102812 A3 WO 2007102812A3
Authority
WO
WIPO (PCT)
Prior art keywords
biological molecules
eletromagnetically
mammalian cells
mammalian
molecules produced
Prior art date
Application number
PCT/US2006/008071
Other languages
French (fr)
Other versions
WO2007102812A9 (en
WO2007102812A2 (en
Inventor
Donnie Rudd
Thomas J Goodwin
Original Assignee
Regenetech Inc
Donnie Rudd
Thomas J Goodwin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regenetech Inc, Donnie Rudd, Thomas J Goodwin filed Critical Regenetech Inc
Priority to CNA2006800240719A priority Critical patent/CN101213206A/en
Priority to MX2008000232A priority patent/MX2008000232A/en
Priority to CA002613600A priority patent/CA2613600A1/en
Priority to EP06748309A priority patent/EP1991569A4/en
Priority to PCT/US2006/008071 priority patent/WO2007102812A2/en
Priority to BRPI0612893A priority patent/BRPI0612893A2/en
Publication of WO2007102812A2 publication Critical patent/WO2007102812A2/en
Publication of WO2007102812A3 publication Critical patent/WO2007102812A3/en
Priority to IL188396A priority patent/IL188396A0/en
Publication of WO2007102812A9 publication Critical patent/WO2007102812A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/204—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2053—IL-8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0004—Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person

Abstract

The disclosure describes a method for producing natively glycosylated mammalian biological molecules by electromagnetically stimulating mammalian cells using an electromagnetic field. The mammalian cells can be grown in a cell culture chamber, and preferably in a bioreactor that is exposed to a time varying electromagnetic force. The biological molecules can be isolated from the cells and used for therapeutic, research, or other purposes.
PCT/US2006/008071 2005-06-29 2006-03-07 Natively glycosylated mammalian biological molecules produced by eletromagnetically stimulating living mammalian cells WO2007102812A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CNA2006800240719A CN101213206A (en) 2006-03-07 2006-03-07 Natively glycosylated mammalian biological molecules produced by electromagnetically stimulating living mammalian cells
MX2008000232A MX2008000232A (en) 2005-06-29 2006-03-07 Natively glycosylated mammalian biological molecules produced by eletromagnetically stimulating living mammalian cells.
CA002613600A CA2613600A1 (en) 2005-06-29 2006-03-07 Natively glycosylated mammalian biological molecules produced by eletromagnetically stimulating living mammalian cells
EP06748309A EP1991569A4 (en) 2006-03-07 2006-03-07 Natively glycosylated mammalian biological molecules produced by eletromagnetically stimulating living mammalian cells
PCT/US2006/008071 WO2007102812A2 (en) 2006-03-07 2006-03-07 Natively glycosylated mammalian biological molecules produced by eletromagnetically stimulating living mammalian cells
BRPI0612893A BRPI0612893A2 (en) 2005-06-29 2006-03-07 composition, natively mammalian glycosylated biological mixture, and, method for producing natively mammalian glycosylated biological molecules
IL188396A IL188396A0 (en) 2006-03-07 2007-12-25 Natively glycosylated mammalian biological molecules prouced by eletromagnetically stimulating living mammalian cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2006/008071 WO2007102812A2 (en) 2006-03-07 2006-03-07 Natively glycosylated mammalian biological molecules produced by eletromagnetically stimulating living mammalian cells

Publications (3)

Publication Number Publication Date
WO2007102812A2 WO2007102812A2 (en) 2007-09-13
WO2007102812A3 true WO2007102812A3 (en) 2007-12-21
WO2007102812A9 WO2007102812A9 (en) 2008-02-21

Family

ID=38475285

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/008071 WO2007102812A2 (en) 2005-06-29 2006-03-07 Natively glycosylated mammalian biological molecules produced by eletromagnetically stimulating living mammalian cells

Country Status (4)

Country Link
EP (1) EP1991569A4 (en)
CN (1) CN101213206A (en)
IL (1) IL188396A0 (en)
WO (1) WO2007102812A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2944019B1 (en) * 2009-04-03 2011-04-22 Biomerieux Sa METHOD FOR DETERMINING PRODEFENSIN-A6 FOR IN VITRO DIAGNOSIS OF COLORECTAL CANCER
WO2013148147A1 (en) 2012-03-26 2013-10-03 The U.S.A., As Represented By The Secretary Dept. Of Health And Human Services Dna methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms
KR20180081821A (en) 2015-12-03 2018-07-17 더 브리검 앤드 우먼즈 하스피털, 인크. How to generate functional hematopoietic stem cells
CN107541790B (en) * 2016-06-24 2021-07-06 上海交通大学 Human agglutinin/human-like agglutinin chip for glycosylation detection and preparation method thereof
CN113252616B (en) * 2021-01-29 2022-05-03 厦门大学 Glycosylation research method of exosome

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6348191B1 (en) * 1986-07-08 2002-02-19 Genetics Institute, Inc. Production and use of IL-6
US20070048253A1 (en) * 2004-06-30 2007-03-01 Goodwin Thomas J Natively glycosylated mammalian biological molecules produced by electromagnetically stimulating living mammalian cells

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL77081A (en) * 1984-12-04 1999-10-28 Genetics Inst Dna sequence encoding human erythropoietin process for the preparation thereof and a pharmaceutical composition of human erythropoietin
GB2169312A (en) * 1985-01-02 1986-07-09 Beaconsfield Tina A method for producing proteins
US20050009161A1 (en) * 2002-11-01 2005-01-13 Jackson Streeter Enhancement of in vitro culture or vaccine production using electromagnetic energy treatment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6348191B1 (en) * 1986-07-08 2002-02-19 Genetics Institute, Inc. Production and use of IL-6
US20070048253A1 (en) * 2004-06-30 2007-03-01 Goodwin Thomas J Natively glycosylated mammalian biological molecules produced by electromagnetically stimulating living mammalian cells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
TAO ET AL.: "EMF Induces Differentiation in HL-60 Cells", J. CELL BOCHEM., vol. 73, 1999, pages 212 - 217, XP008092816 *
WOODWARD ET AL.: "Further Studies on Growth Factor Production by the TC-1 Stromal Cell Line: Pre-B Stimulating Activity", BLOOD, vol. 75, no. 11, 1 June 1990 (1990-06-01), pages 2130 - 2136, XP008126069 *

Also Published As

Publication number Publication date
WO2007102812A9 (en) 2008-02-21
IL188396A0 (en) 2008-08-07
EP1991569A2 (en) 2008-11-19
EP1991569A4 (en) 2009-12-23
CN101213206A (en) 2008-07-02
WO2007102812A2 (en) 2007-09-13

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