WO2007100568A3 - T cell receptors and related materials and methods of use - Google Patents

T cell receptors and related materials and methods of use Download PDF

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Publication number
WO2007100568A3
WO2007100568A3 PCT/US2007/004454 US2007004454W WO2007100568A3 WO 2007100568 A3 WO2007100568 A3 WO 2007100568A3 US 2007004454 W US2007004454 W US 2007004454W WO 2007100568 A3 WO2007100568 A3 WO 2007100568A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
antigen
host
related materials
isolated
Prior art date
Application number
PCT/US2007/004454
Other languages
French (fr)
Other versions
WO2007100568A2 (en
Inventor
Qiong J Wang
Kenichi Hanada
James C Yang
Original Assignee
Us Gov Health & Human Serv
Qiong J Wang
Kenichi Hanada
James C Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Qiong J Wang, Kenichi Hanada, James C Yang filed Critical Us Gov Health & Human Serv
Publication of WO2007100568A2 publication Critical patent/WO2007100568A2/en
Publication of WO2007100568A3 publication Critical patent/WO2007100568A3/en
Priority to US12/196,833 priority Critical patent/US7820174B2/en
Priority to US12/870,941 priority patent/US8431690B2/en
Priority to US13/851,473 priority patent/US9567387B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e.g., a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.
PCT/US2007/004454 2006-02-24 2007-02-22 T cell receptors and related materials and methods of use WO2007100568A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/196,833 US7820174B2 (en) 2006-02-24 2008-08-22 T cell receptors and related materials and methods of use
US12/870,941 US8431690B2 (en) 2006-02-24 2010-08-30 T cell receptors and related materials and methods of use
US13/851,473 US9567387B2 (en) 2006-02-24 2013-03-27 T cell receptors and related materials and methods of use

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77619406P 2006-02-24 2006-02-24
US60/776,194 2006-02-24
US81142206P 2006-06-07 2006-06-07
US60/811,422 2006-06-07

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/196,833 Continuation-In-Part US7820174B2 (en) 2006-02-24 2008-08-22 T cell receptors and related materials and methods of use

Publications (2)

Publication Number Publication Date
WO2007100568A2 WO2007100568A2 (en) 2007-09-07
WO2007100568A3 true WO2007100568A3 (en) 2008-03-13

Family

ID=38459523

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/004454 WO2007100568A2 (en) 2006-02-24 2007-02-22 T cell receptors and related materials and methods of use

Country Status (1)

Country Link
WO (1) WO2007100568A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820174B2 (en) * 2006-02-24 2010-10-26 The United States Of America As Represented By The Department Of Health And Human Services T cell receptors and related materials and methods of use
AU2010210083C1 (en) * 2009-02-09 2015-11-26 Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) Repertoire of allo-restricted peptide-specific T cell receptor sequences and use thereof
JPWO2010114129A1 (en) * 2009-04-03 2012-10-11 国立大学法人愛媛大学 T cell receptor and nucleic acid encoding the receptor
US11186624B2 (en) * 2016-09-23 2021-11-30 Lion Tcr Pte. Ltd. HBV antigen specific binding molecules and fragments thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001073032A2 (en) * 2000-03-27 2001-10-04 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
WO2003000928A2 (en) * 2001-06-25 2003-01-03 Buadbo Aps Methods for identification of cancer cell surface molecules and cancer specific promoters, and therapeutic uses thereof
EP1275400A1 (en) * 2001-07-05 2003-01-15 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Therapeutic composition of non MHC-restricted T-cells/NK-cells and MHC-restricted cells for the treatment of tumors
WO2005056595A2 (en) * 2003-12-06 2005-06-23 Imperial Innovations Limited T cell receptor specific for wilms tumor antigen

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001073032A2 (en) * 2000-03-27 2001-10-04 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
WO2003000928A2 (en) * 2001-06-25 2003-01-03 Buadbo Aps Methods for identification of cancer cell surface molecules and cancer specific promoters, and therapeutic uses thereof
EP1275400A1 (en) * 2001-07-05 2003-01-15 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Therapeutic composition of non MHC-restricted T-cells/NK-cells and MHC-restricted cells for the treatment of tumors
WO2005056595A2 (en) * 2003-12-06 2005-06-23 Imperial Innovations Limited T cell receptor specific for wilms tumor antigen

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EPO Proteins 21 March 2003 (2003-03-21), "Sequence 217 from Patent WO03000928", XP002460994, retrieved from EBI Database accession no. AX658301 *
DATABASE Geneseq 30 January 2002 (2002-01-30), "Human T cell receptor Va chain of clone 4E5", XP002460993, retrieved from EBI Database accession no. AAU69943 *
ENGELS BORIS ET AL: "Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes.", HUMAN GENE THERAPY JUL 2005, vol. 16, no. 7, July 2005 (2005-07-01), pages 799 - 810, XP002460992, ISSN: 1043-0342 *
JANTZER P ET AL: "Human renal cell carcinoma antigen-specific CTLs: antigen-driven selection and long-term persistence in vivo.", CANCER RESEARCH 15 JUL 1998, vol. 58, no. 14, 15 July 1998 (1998-07-15), pages 3078 - 3086, XP002460991, ISSN: 0008-5472 *
SCHENDEL D J ET AL: "Cellular and molecular analyses of major histocompatibility complex (MHC) restricted and non-MHC-restricted effector cells recognizing renal cell carcinomas: Problems and perspectives for immunotherapy", JOURNAL OF MOLECULAR MEDICINE, SPRINGER VERLAG, DE, vol. 75, no. 6, 1997, pages 400 - 413, XP002217506, ISSN: 0946-2716 *
WANG QIONG J ET AL: "Generating renal cancer-reactive T cells using dendritic cells (DCs) to present autologous tumor.", JOURNAL OF IMMUNOTHERAPY (HAGERSTOWN, MD. : 1997) 2005 NOV-DEC, vol. 28, no. 6, November 2005 (2005-11-01), pages 551 - 559, XP009093116, ISSN: 1524-9557 *

Also Published As

Publication number Publication date
WO2007100568A2 (en) 2007-09-07

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