WO2007096931A3 - Use of piperacillin in topical intravaginal preparations for the treatment of vaginal bacterial infections - Google Patents

Use of piperacillin in topical intravaginal preparations for the treatment of vaginal bacterial infections Download PDF

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Publication number
WO2007096931A3
WO2007096931A3 PCT/IT2007/000131 IT2007000131W WO2007096931A3 WO 2007096931 A3 WO2007096931 A3 WO 2007096931A3 IT 2007000131 W IT2007000131 W IT 2007000131W WO 2007096931 A3 WO2007096931 A3 WO 2007096931A3
Authority
WO
WIPO (PCT)
Prior art keywords
gram
organisms
piperacillin
micro
topical
Prior art date
Application number
PCT/IT2007/000131
Other languages
French (fr)
Other versions
WO2007096931A2 (en
Inventor
Enrico Boldrini
Giulia Falcone
Original Assignee
Opocrin Spa
Enrico Boldrini
Giulia Falcone
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opocrin Spa, Enrico Boldrini, Giulia Falcone filed Critical Opocrin Spa
Priority to EP07713470A priority Critical patent/EP1991224A2/en
Publication of WO2007096931A2 publication Critical patent/WO2007096931A2/en
Publication of WO2007096931A3 publication Critical patent/WO2007096931A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Piperacillin, a broad-range semi-synthetic β-lactamic antibiotic currently used for parenteral administrations, is used for the production of topical preparations of bactericide activity that are effective on the pathogens responsible for vaginal ecosystem alterations, and that also lend themselves to the treatment and prevention of gynaecological and obstetric bacterial infections by means of topical vaginal application. The piperacillin-based topical preparation has bactericide activity against Gram-positive aerobic micro-organisms, Gram-negative aerobic micro-organisms, Gram-positive anaerobic micro-organisms and Gram-negative anaerobic micro-organisms in the vaginal tract of pregnant and non-pregnant women, and is particularly active in Gram-positive aerobic vaginitis such as from group B streptococci or Streptococcus agalactiae.
PCT/IT2007/000131 2006-02-24 2007-02-23 Use of piperacillin in topical intravaginal preparations for the treatment of vaginal bacterial infections WO2007096931A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07713470A EP1991224A2 (en) 2006-02-24 2007-02-23 Use of piperacillin in topical intravaginal preparations for the treatment of vaginal bacterial infections

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM2006A000094 2006-02-24
IT000094A ITRM20060094A1 (en) 2006-02-24 2006-02-24 USE OF PIPERACILLIN IN INTRAVAGINAL TOPICS PREPARATIONS FOR THE TREATMENT OF VAGINAL BACTERIAL AND GYNECOLOGICAL INFECTIONS

Publications (2)

Publication Number Publication Date
WO2007096931A2 WO2007096931A2 (en) 2007-08-30
WO2007096931A3 true WO2007096931A3 (en) 2007-11-08

Family

ID=38229923

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2007/000131 WO2007096931A2 (en) 2006-02-24 2007-02-23 Use of piperacillin in topical intravaginal preparations for the treatment of vaginal bacterial infections

Country Status (3)

Country Link
EP (1) EP1991224A2 (en)
IT (1) ITRM20060094A1 (en)
WO (1) WO2007096931A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11682487B2 (en) 2021-01-22 2023-06-20 Cilag Gmbh International Active recognition and pairing sensing systems
US11694533B2 (en) 2021-01-22 2023-07-04 Cilag Gmbh International Predictive based system adjustments based on biomarker trending
US20220240869A1 (en) * 2021-01-22 2022-08-04 Ethicon Llc Hysterectomy surgery post-surgical monitoring
US12011163B2 (en) 2021-01-22 2024-06-18 Cilag Gmbh International Prediction of tissue irregularities based on biomarker monitoring

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581028A (en) * 1984-04-30 1986-04-08 The Trustees Of Columbia University In The City Of New York Infection-resistant materials and method of making same through use of sulfonamides
EP0215697A2 (en) * 1985-08-16 1987-03-25 Merck & Co. Inc. Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal compartments
EP0763359A1 (en) * 1995-07-14 1997-03-19 R.R.A. S.r.l. Pharmaceutical composition for topical use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581028A (en) * 1984-04-30 1986-04-08 The Trustees Of Columbia University In The City Of New York Infection-resistant materials and method of making same through use of sulfonamides
EP0215697A2 (en) * 1985-08-16 1987-03-25 Merck & Co. Inc. Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal compartments
EP0763359A1 (en) * 1995-07-14 1997-03-19 R.R.A. S.r.l. Pharmaceutical composition for topical use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LOCKWOOD C J ET AL: "Double-blind; placebo-controlled trial of piperacillin prophylaxis in preterm membrane rupture.", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY OCT 1993, vol. 169, no. 4, October 1993 (1993-10-01), pages 970 - 976, XP009086747, ISSN: 0002-9378 *
PETRUCCA ANDREA ET AL: "Burkholderia cenocepacia vaginal infection in patient with smoldering myeloma and chronic hepatitis C.", EMERGING INFECTIOUS DISEASES NOV 2004, vol. 10, no. 11, November 2004 (2004-11-01), pages 1957 - 1959, XP002442773, ISSN: 1080-6040 *
SHANKER S ET AL: "In vitro activity of seventeen antimicrobial agents against Gardnerella vaginalis.", EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY OCT 1982, vol. 1, no. 5, October 1982 (1982-10-01), pages 298 - 300, XP009086822, ISSN: 0722-2211 *
TRIMBOS J B ET AL: "Piperacillin for prophylaxis in gynecological surgery.", EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY FEB 1989, vol. 30, no. 2, February 1989 (1989-02-01), pages 141 - 149, XP009086776, ISSN: 0301-2115 *

Also Published As

Publication number Publication date
WO2007096931A2 (en) 2007-08-30
ITRM20060094A1 (en) 2007-08-25
EP1991224A2 (en) 2008-11-19

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