WO2007096906A3 - Novel buccoadhesive compositions and process of preparation thereof - Google Patents

Novel buccoadhesive compositions and process of preparation thereof Download PDF

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Publication number
WO2007096906A3
WO2007096906A3 PCT/IN2007/000074 IN2007000074W WO2007096906A3 WO 2007096906 A3 WO2007096906 A3 WO 2007096906A3 IN 2007000074 W IN2007000074 W IN 2007000074W WO 2007096906 A3 WO2007096906 A3 WO 2007096906A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
novel
buccoadhesive
bioactive agent
preparation
Prior art date
Application number
PCT/IN2007/000074
Other languages
French (fr)
Other versions
WO2007096906A2 (en
Inventor
Rajesh Jain
Kour Chand Jindal
Sampath Kumar Devarajan
Original Assignee
Panacea Biotec Ltd
Rajesh Jain
Kour Chand Jindal
Sampath Kumar Devarajan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panacea Biotec Ltd, Rajesh Jain, Kour Chand Jindal, Sampath Kumar Devarajan filed Critical Panacea Biotec Ltd
Publication of WO2007096906A2 publication Critical patent/WO2007096906A2/en
Publication of WO2007096906A3 publication Critical patent/WO2007096906A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Nutrition Science (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

Novel buccoadhesive compositions comprising at least one bioactive agent(s), at least one bioadhesive polymer(s), at least one water soluble sugar component(s) and at least one binder(s), optionally with other excipients are provided, wherein the said composition has improved cohesiveness, enhanced intactness and improved adhesion at the desired site of the mucosa for substantially longer duration and releases the bioactive agent(s) in a sustained manner in the oral cavity for extended time period. The bioactive agent(s) is a pharmaceutically active agent(s) or a nutritional supplement(s) or a food product(s), or combinations thereof. Also provided is a process of preparation of such novel compositions and method of using them.
PCT/IN2007/000074 2006-02-27 2007-02-23 Novel buccoadhesive compositions and process of preparation thereof WO2007096906A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN512DE2006 2006-02-27
IN512/DEL/2006 2006-02-27

Publications (2)

Publication Number Publication Date
WO2007096906A2 WO2007096906A2 (en) 2007-08-30
WO2007096906A3 true WO2007096906A3 (en) 2007-10-18

Family

ID=38293932

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000074 WO2007096906A2 (en) 2006-02-27 2007-02-23 Novel buccoadhesive compositions and process of preparation thereof

Country Status (1)

Country Link
WO (1) WO2007096906A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8865692B2 (en) 2007-11-13 2014-10-21 Meritage Pharma, Inc Compositions for the treatment of gastrointestinal inflammation
US8975243B2 (en) 2005-11-12 2015-03-10 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US9119863B2 (en) 2005-11-12 2015-09-01 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
JP7125791B2 (en) 2018-05-23 2022-08-25 シャンハイ ダブリュディー ファーマシューティカル カンパニー，リミティド Controlled release system for active drug ingredient and method for manufacturing same

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
FI20080351A0 (en) * 2008-05-09 2008-05-09 Atacama Labs Oy Process for preparing a tablet with low drug content
US8951562B2 (en) 2006-11-10 2015-02-10 Atacama Labs Oy Method and apparatus or dry granulation
FI20070521L (en) 2006-11-10 2008-05-11 Atacama Labs Oy Grains, tablets and granulation process
SI3354276T1 (en) 2007-11-13 2020-09-30 Meritage Pharma, Inc. Compositions for the treatment of gastrointestinal inflammation
WO2009114192A2 (en) * 2008-03-14 2009-09-17 Cephalon, Inc. Enhanced transmucosal composition and dosage form
EP2291233B1 (en) 2008-05-09 2019-09-04 Atacama Labs Oy Method for dry granulation
EP2165706A1 (en) * 2008-09-18 2010-03-24 BioAlliance Pharma Treating Inflammatory Pain in Mucosa of the Oral Cavity Using Mucosal Prolonged Release Bioadhesive Therapeutic Carriers.
DE102008047910A1 (en) 2008-09-19 2010-03-25 Molkerei Meggle Wasserburg Gmbh & Co. Kg Tabletting excipient based on lactose and cellulose
US20120093738A1 (en) * 2009-06-11 2012-04-19 Rubicon Research Private Limited Taste-masked oral formulations of influenza antivirals
EP2525783A1 (en) * 2010-01-18 2012-11-28 Cephalon France Improved oral lysophilisates containing pvp/va
ES2487271T3 (en) * 2011-10-06 2014-08-20 Sanovel Ilac Sanayi Ve Ticaret A.S. DPP-IV inhibitor solid dosage formulations
EP2606747A1 (en) * 2011-12-22 2013-06-26 Nutrinova Nutrition Specialties & Food Ingredients GmbH Sweetness enhancer, sweetener compositions, and consumables containing the same
JP2016204260A (en) * 2013-10-04 2016-12-08 日本曹達株式会社 Production method of tablet
US20160256392A1 (en) * 2013-10-31 2016-09-08 Cima Labs Inc. Abuse-deterrent dosage forms
US9132096B1 (en) 2014-09-12 2015-09-15 Alkermes Pharma Ireland Limited Abuse resistant pharmaceutical compositions
US11911513B2 (en) 2018-05-23 2024-02-27 Shanghai Wd Pharmaceutical Co., Ltd Controlled-release system of active pharmaceutical ingredient and preparation method therefor
CN109223798A (en) * 2018-09-13 2019-01-18 集美大学 Purposes of the caffeine as aldose reductase inhibitor
DE102019135432A1 (en) * 2019-12-20 2021-06-24 Lts Lohmann Therapie-Systeme Ag Soluble backing for OTF
CA3178769A1 (en) 2020-05-18 2021-11-25 Jonas Savmarker New pharmaceutical composition for drug delivery
CA3238850A1 (en) 2021-11-25 2023-06-01 Jonas Savmarker Pharmaceutical composition comprising adrenaline
CN115624530B (en) * 2022-09-22 2024-04-12 九华华源药业(桂林)有限公司 Desloratadine citrate oral cavity adhesive tablet and preparation method thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073931A (en) * 1974-03-27 1978-02-14 Teijin Limited Nitroglycerine inclusion compounds with cyclodextrin and composition containing same
WO1991006289A1 (en) * 1989-10-31 1991-05-16 Watson Laboratories, Inc. Mucoadhesive carrier for delivery of therapeutical agent
WO1999032081A1 (en) * 1997-12-19 1999-07-01 Orion Corporation Transmucosal formulations of levosimendan
WO2000010536A1 (en) * 1998-08-25 2000-03-02 Columbia Laboratories (Bermuda) Limited Extended release buccal bioadhesive tablet
WO2001039749A2 (en) * 1999-11-30 2001-06-07 Panacea Biotec Limited Fast dissolving composition with prolonged sweet taste
US20040202693A1 (en) * 2003-04-14 2004-10-14 Rong-Kun Chang Pharmaceutical compositions releasing their active agents from a buccal or sublingual location to overcome an absorption window problem
WO2005065640A1 (en) * 2004-01-06 2005-07-21 Panacea Biotec Ltd. Compositions of buccal dosage forms for extended drug release and the process of preparing such compositions

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073931A (en) * 1974-03-27 1978-02-14 Teijin Limited Nitroglycerine inclusion compounds with cyclodextrin and composition containing same
WO1991006289A1 (en) * 1989-10-31 1991-05-16 Watson Laboratories, Inc. Mucoadhesive carrier for delivery of therapeutical agent
WO1999032081A1 (en) * 1997-12-19 1999-07-01 Orion Corporation Transmucosal formulations of levosimendan
WO2000010536A1 (en) * 1998-08-25 2000-03-02 Columbia Laboratories (Bermuda) Limited Extended release buccal bioadhesive tablet
WO2001039749A2 (en) * 1999-11-30 2001-06-07 Panacea Biotec Limited Fast dissolving composition with prolonged sweet taste
US20040202693A1 (en) * 2003-04-14 2004-10-14 Rong-Kun Chang Pharmaceutical compositions releasing their active agents from a buccal or sublingual location to overcome an absorption window problem
WO2005065640A1 (en) * 2004-01-06 2005-07-21 Panacea Biotec Ltd. Compositions of buccal dosage forms for extended drug release and the process of preparing such compositions

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8975243B2 (en) 2005-11-12 2015-03-10 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US9119863B2 (en) 2005-11-12 2015-09-01 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8865692B2 (en) 2007-11-13 2014-10-21 Meritage Pharma, Inc Compositions for the treatment of gastrointestinal inflammation
JP7125791B2 (en) 2018-05-23 2022-08-25 シャンハイ ダブリュディー ファーマシューティカル カンパニー，リミティド Controlled release system for active drug ingredient and method for manufacturing same

Also Published As

Publication number Publication date
WO2007096906A2 (en) 2007-08-30

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