WO2007095069A3 - Nf-ya activates multiple hematopoietic stem cell (hsc) regulatory genes and promotes hsc self-renewal - Google Patents

Nf-ya activates multiple hematopoietic stem cell (hsc) regulatory genes and promotes hsc self-renewal Download PDF

Info

Publication number
WO2007095069A3
WO2007095069A3 PCT/US2007/003434 US2007003434W WO2007095069A3 WO 2007095069 A3 WO2007095069 A3 WO 2007095069A3 US 2007003434 W US2007003434 W US 2007003434W WO 2007095069 A3 WO2007095069 A3 WO 2007095069A3
Authority
WO
WIPO (PCT)
Prior art keywords
hsc
renewal
stem cell
hematopoietic stem
self
Prior art date
Application number
PCT/US2007/003434
Other languages
French (fr)
Other versions
WO2007095069A2 (en
Inventor
Stephen G Emerson
Jiang Zhu
Alevtina Domashenko
Original Assignee
Univ Pennsylvania
Stephen G Emerson
Jiang Zhu
Alevtina Domashenko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania, Stephen G Emerson, Jiang Zhu, Alevtina Domashenko filed Critical Univ Pennsylvania
Publication of WO2007095069A2 publication Critical patent/WO2007095069A2/en
Publication of WO2007095069A3 publication Critical patent/WO2007095069A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors

Abstract

Provide are methods for enhancing hematopoietic stem cell (HSC) self-renewal and/or proliferation resulting from increasing the intracellular concentration of NF-Ya in the cell, as well as, the resulting enhanced HSC resulting from the use of the provided methods, therapeutic use of such enhanced HSC and kits relating thereto.
PCT/US2007/003434 2006-02-10 2007-02-08 Nf-ya activates multiple hematopoietic stem cell (hsc) regulatory genes and promotes hsc self-renewal WO2007095069A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77250706P 2006-02-10 2006-02-10
US60/772,507 2006-02-10

Publications (2)

Publication Number Publication Date
WO2007095069A2 WO2007095069A2 (en) 2007-08-23
WO2007095069A3 true WO2007095069A3 (en) 2008-03-27

Family

ID=38372010

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/003434 WO2007095069A2 (en) 2006-02-10 2007-02-08 Nf-ya activates multiple hematopoietic stem cell (hsc) regulatory genes and promotes hsc self-renewal

Country Status (1)

Country Link
WO (1) WO2007095069A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014120714A1 (en) * 2013-01-30 2014-08-07 Cornell University Compositions and methods for the expansion of stem cells
CN110938597A (en) * 2018-09-25 2020-03-31 北京大学 Method for amplifying hematopoietic stem cells and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050221487A1 (en) * 2002-09-26 2005-10-06 Zon Leonard I Method of enhancing proliferation and/or hematopoietic differentiation of stem cells
US20050272152A1 (en) * 2004-05-14 2005-12-08 Becton, Dickinson And Company Stem cell populations and methods of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050221487A1 (en) * 2002-09-26 2005-10-06 Zon Leonard I Method of enhancing proliferation and/or hematopoietic differentiation of stem cells
US20050272152A1 (en) * 2004-05-14 2005-12-08 Becton, Dickinson And Company Stem cell populations and methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZHU ET AL.: "NF-Ya activates multiple hematopoietic stem cell regulatory genes and promotes HSC self-renewal", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, no. 33, 16 August 2005 (2005-08-16), pages 11728 - 11733 *

Also Published As

Publication number Publication date
WO2007095069A2 (en) 2007-08-23

Similar Documents

Publication Publication Date Title
SG164368A1 (en) Treatment of cancer
IL189555A0 (en) Compositions of cells enriched for combinations of various stem and progenitor cell populations, methods of use thereof and methods of private banking thereof
WO2007098150A3 (en) Photobioreactor and uses therefor
EP1988159A4 (en) Additive for culture medium for use in serum-free culture of animal cell, kit, and use of the additive or kit
WO2007028079A3 (en) Methods of stimulating expansion of hematopoietic stem cells
WO2008089397A3 (en) Adrb2 cancer markers
MY159230A (en) P38 map kinase inhibitors
WO2007136790A3 (en) Intracellular kinase inhibitors
WO2005117557A3 (en) Expression system
WO2008118392A3 (en) Synthetic cell platforms and methods of use thereof
JO3134B1 (en) Inhibitors of akt activity
MX2010001821A (en) Purin derivatives for use in the treatment of fab-related diseases.
WO2009126310A3 (en) Methods for identification and use of agents targeting cancer stem cells
SG158133A1 (en) Method for reversing multiple resistance in animal cells
UA101944C2 (en) Compositions and methods of use for dickopf-1 antibodies
WO2007014169A3 (en) Anti-cd26 antibodies and methods of use thereof
WO2010115118A3 (en) Methods for preparing and using multichaperone-antigen complexes
WO2008131150A3 (en) New urethane (meth)acrylates and their use in curable coating compositions
MX2009010066A (en) Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer.
MX359639B (en) METHODS and COMPOSITIONS FOR USE IN CELLULAR THERAPIES.
WO2006107670A3 (en) In vitro association studies
WO2009050267A3 (en) Il24 for inducing hyperproliferative or autoimmune cell death
WO2007076320A3 (en) Compounds
WO2009134962A3 (en) Claudin-4 binding peptides, compositions and methods of use
AU316238S (en) Lawning applicator for microbiological cultures

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07750283

Country of ref document: EP

Kind code of ref document: A2