WO2007092909A3 - Molecular interaction sensors - Google Patents
Molecular interaction sensors Download PDFInfo
- Publication number
- WO2007092909A3 WO2007092909A3 PCT/US2007/061808 US2007061808W WO2007092909A3 WO 2007092909 A3 WO2007092909 A3 WO 2007092909A3 US 2007061808 W US2007061808 W US 2007061808W WO 2007092909 A3 WO2007092909 A3 WO 2007092909A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- molecular interaction
- linker
- coupled
- preferred embodiments
- detectable label
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/12—Apparatus specially adapted for use in combinatorial chemistry or with libraries for screening libraries
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54346—Nanoparticles
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Composite Materials (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
In preferred embodiments, the present invention provides a specific molecular interaction sensor and methods of use thereof, comprising at least one molecular interaction complex comprising a disruptable linker having first and second end, the first end being coupled to a detectable label and the second end being coupled to a surface of a support, wherein the linker is disrupted by a specific predetermined target molecule; a detector adapted to detect the label; and at least one readout device. In preferred embodiments, the detectable label is a superparamagnetic nanoparticle and the detector is a magnetoresistive device.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77110706P | 2006-02-07 | 2006-02-07 | |
US60/771,107 | 2006-02-07 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2007092909A2 WO2007092909A2 (en) | 2007-08-16 |
WO2007092909A3 true WO2007092909A3 (en) | 2008-11-13 |
WO2007092909A8 WO2007092909A8 (en) | 2009-07-16 |
Family
ID=38345949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/061808 WO2007092909A2 (en) | 2006-02-07 | 2007-02-07 | Molecular interaction sensors |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007092909A2 (en) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003063693A2 (en) | 2002-01-31 | 2003-08-07 | Expressive Constructs, Inc. | Method for detecting microorganisms |
GB0618524D0 (en) * | 2006-09-20 | 2006-11-01 | Isis Innovation | Multimeric particles |
WO2009102349A2 (en) * | 2007-10-28 | 2009-08-20 | Eci Biotech Inc. | Sensors for measuring contaminants |
DE102007057667A1 (en) | 2007-11-30 | 2009-09-03 | Siemens Ag | Device for detecting particles in a fluid |
US9958442B2 (en) | 2009-02-11 | 2018-05-01 | Duke University | Sensors incorporating antibodies and methods of making and using the same |
US9599591B2 (en) * | 2009-03-06 | 2017-03-21 | California Institute Of Technology | Low cost, portable sensor for molecular assays |
WO2010121223A2 (en) * | 2009-04-17 | 2010-10-21 | California Institute Of Technology | Electromagnetic molecular sensors and methods of using same |
FR2963106A1 (en) * | 2010-07-21 | 2012-01-27 | Ecole Polytechnique Dgar | METHOD AND DEVICE FOR ANALYZING MOLECULAR INTERACTIONS, AND USES THEREOF |
US8815610B2 (en) * | 2010-10-15 | 2014-08-26 | International Business Machines Corporation | Magnetic nanoparticle detection across a membrane |
US9303063B2 (en) | 2011-03-18 | 2016-04-05 | Duke University | Peptide compounds for suppressing inflammation |
CN106905427A (en) | 2011-03-18 | 2017-06-30 | 艺杰斯有限责任公司 | Peptide for suppressing inflammation |
AU2013204332B2 (en) | 2012-04-16 | 2015-07-16 | Commonwealth Scientific And Industrial Research Organisation | Methods and systems for detecting an analyte or classifying a sample |
WO2015187227A2 (en) | 2014-03-13 | 2015-12-10 | Duke University | Electronic platform for sensing and control of electrochemical reactions |
EP2930497A1 (en) * | 2014-04-07 | 2015-10-14 | Institut Pasteur | Enzyme-independent photon emission |
US20160011182A1 (en) * | 2014-07-09 | 2016-01-14 | Zepto Life Technology, LLC | Method and system for substance detection with a magnetic sensor |
EP2977347A1 (en) * | 2014-07-22 | 2016-01-27 | Niklas Anttu | Optical molecular nanowire sensor |
CN106248944A (en) * | 2016-06-30 | 2016-12-21 | 深圳市亚辉龙生物科技股份有限公司 | A kind of CPn IgG chemiluminescence immune detection reagent kit and preparation method thereof |
WO2018085895A1 (en) * | 2016-11-14 | 2018-05-17 | Commonwealth Scientific And Industrial Research Organisation | Protease sensor molecules |
US20200131558A1 (en) * | 2017-04-21 | 2020-04-30 | Colorado State University Research Foundation | Paper-based assay for antimicrobial resistance |
CA3071994A1 (en) | 2017-08-08 | 2019-02-14 | Commonwealth Scientific And Industrial Research Organisation | Carbohydrate sensors |
JP6982099B2 (en) | 2018-07-27 | 2021-12-17 | ゼプト ライフ テクノロジー, エルエルシーZepto Life Technology, Llc | Systems and methods for detecting test substances in the detection of biomarkers by GMR |
US11291997B2 (en) | 2018-08-02 | 2022-04-05 | Colorado State University Research Foundation | Rotary manifold for paper-based immunoassays |
WO2021145889A1 (en) * | 2020-01-17 | 2021-07-22 | Zepto Life Technology, LLC | Systems and methods for sensing analytes in gmr-based detection of biomarkers |
WO2022263523A1 (en) * | 2021-06-17 | 2022-12-22 | F. Hoffmann-La Roche Ag | Method for immunosensing on a lipid layer |
CN117501121A (en) * | 2021-06-17 | 2024-02-02 | 豪夫迈·罗氏有限公司 | Method for immunosensory of lipid layers using magnetic tunnel junction II |
US20220404347A1 (en) * | 2021-06-17 | 2022-12-22 | Roche Diagnostics Operations, Inc. | Methods for detecting an analyte using structure switching binding agents |
CN117501122A (en) * | 2021-06-17 | 2024-02-02 | 豪夫迈·罗氏有限公司 | Method for immunosensing lipid layers using magnetic tunnel junctions |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010007022A1 (en) * | 1999-12-22 | 2001-07-05 | Dade Behring Marburg Gmbh. | Anti-procalcitonin antibodies and the preparation and use thereof |
US20040219590A1 (en) * | 2000-02-10 | 2004-11-04 | Todd Dickinson | Methods of detecting targets on an arrary |
US20050100930A1 (en) * | 2003-11-12 | 2005-05-12 | Wang Shan X. | Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules |
-
2007
- 2007-02-07 WO PCT/US2007/061808 patent/WO2007092909A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010007022A1 (en) * | 1999-12-22 | 2001-07-05 | Dade Behring Marburg Gmbh. | Anti-procalcitonin antibodies and the preparation and use thereof |
US20040219590A1 (en) * | 2000-02-10 | 2004-11-04 | Todd Dickinson | Methods of detecting targets on an arrary |
US20050100930A1 (en) * | 2003-11-12 | 2005-05-12 | Wang Shan X. | Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules |
Also Published As
Publication number | Publication date |
---|---|
WO2007092909A2 (en) | 2007-08-16 |
WO2007092909A8 (en) | 2009-07-16 |
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