WO2008146569A1 - Biosensor - Google Patents

Biosensor Download PDF

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Publication number
WO2008146569A1
WO2008146569A1 PCT/JP2008/058330 JP2008058330W WO2008146569A1 WO 2008146569 A1 WO2008146569 A1 WO 2008146569A1 JP 2008058330 W JP2008058330 W JP 2008058330W WO 2008146569 A1 WO2008146569 A1 WO 2008146569A1
Authority
WO
WIPO (PCT)
Prior art keywords
biosensor
molecule
analyte
stimulation
produced
Prior art date
Application number
PCT/JP2008/058330
Other languages
French (fr)
Japanese (ja)
Inventor
Tatsuro Endo
Original Assignee
Tanaka Kikinzoku Kogyo K.K.
Tokyo Institute Of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanaka Kikinzoku Kogyo K.K., Tokyo Institute Of Technology filed Critical Tanaka Kikinzoku Kogyo K.K.
Publication of WO2008146569A1 publication Critical patent/WO2008146569A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/44—Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Abstract

Disclosed is a biosensor which can be measured and produced in simple manners, can be used in home care medicine or the like, and is inexpensive. Specifically disclosed is a biosensor which comprises: a molecule-recognizing component which can react specifically with an analyte; a stimulation-responsive polymer which can vary in volume by the reaction between the analyte and the molecule-recognizing component; and a metal particle which can vary in the intensity of the localized surface plasmon resonance by the change in the volume of the stimulation-responsive polymer and has an average particle diameter of 0.2 to 200 nm, wherein the metal particle and the molecule-recognizing component are immobilized on the stimulation-responsive polymer. The biosensor can be produced and measured in simple manners, and can detect the analyte with high sensitivity. Further, the biosensor can be produced at a lower cost compared to a conventional one, because it is not needed to use any special material such as a labeling molecule.
PCT/JP2008/058330 2007-05-28 2008-05-01 Biosensor WO2008146569A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007140511A JP2010197046A (en) 2007-05-28 2007-05-28 Biosensor
JP2007-140511 2007-05-28

Publications (1)

Publication Number Publication Date
WO2008146569A1 true WO2008146569A1 (en) 2008-12-04

Family

ID=40074838

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/058330 WO2008146569A1 (en) 2007-05-28 2008-05-01 Biosensor

Country Status (2)

Country Link
JP (1) JP2010197046A (en)
WO (1) WO2008146569A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010123073A1 (en) * 2009-04-24 2010-10-28 コニカミノルタホールディングス株式会社 Assay method using plasmon excitation sensor comprising stimulus-responsive polymer
JP2011080848A (en) * 2009-10-07 2011-04-21 Daikin Industries Ltd Biosensor
JPWO2011129220A1 (en) * 2010-04-14 2013-07-18 日東紡績株式会社 Test instrument for measuring an analyte in a sample and method for measuring an analyte using the same
WO2014196169A1 (en) * 2013-06-04 2014-12-11 パナソニック株式会社 Sensor chip, detection method and detection device

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104755932B (en) 2012-09-04 2017-03-08 捷恩智株式会社 substance-measuring sensor
KR101494776B1 (en) 2013-06-25 2015-02-23 국방과학연구소 Stimuli-responsive Surface Enhanced Raman Scattering Substrates with High Sensitivity for Trace Analysis and the Method Thereof
KR101511036B1 (en) 2014-01-20 2015-04-10 한국과학기술원 Nano Plasmonic bio-sensor
KR101726033B1 (en) 2015-01-13 2017-04-26 한양대학교 산학협력단 Plasmonic metal-polymer film hybrid nanostructure which can reversibly modulate Surface Enhanced Raman Scattering (SERS) signals of organic molecules according to external temperature
CN108351305B (en) 2015-11-18 2021-11-09 浜松光子学株式会社 Concentration measuring method
JP6818521B2 (en) * 2016-11-17 2021-01-20 キヤノン株式会社 Method for producing polymer
KR101910378B1 (en) 2017-03-31 2018-10-22 한양대학교 산학협력단 Two dimensional hybrid nanopatternd structures through spontaneous self-assembly of plasmonic nanoparticles on a hydrogel colloidal crystal monolayer
JP7394383B2 (en) 2020-01-29 2023-12-08 三菱マテリアル株式会社 biosensor

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10505910A (en) * 1994-09-23 1998-06-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング A method for studying biomolecular interactions using surface plasmon resonance
JPH11502922A (en) * 1995-03-20 1999-03-09 インスティテュート ファー ヒェモ ウント ビオゼンゾリック ミュンスター エー． ファー． Sensitive substances and devices for detecting organic components and solvent vapors in air
JP2001505236A (en) * 1996-11-06 2001-04-17 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウエルス システム オブ ハイアー エデュケイション Novel polymerized crystalline colloid array sensor
JP3157952B2 (en) * 1993-06-02 2001-04-23 アヴェンティス・リサーチ・ウント・テクノロジーズ・ゲーエムベーハー・ウント・コー・カーゲー Optical sensor for chemical substance detection
JP2004506893A (en) * 2000-08-14 2004-03-04 ファーフィールド・センサーズ・リミテッド Sensor device
JP2004531703A (en) * 2001-02-16 2004-10-14 ビール アクティーゼルスカブ Method for producing optical (bio) chemical sensor device
JP2004346177A (en) * 2003-05-22 2004-12-09 Fuji Photo Film Co Ltd Imprinted polymer with immobilized gold nanoparticle
JP2005283140A (en) * 2004-03-26 2005-10-13 Fuji Photo Film Co Ltd Biosensor
JP2006008969A (en) * 2004-05-25 2006-01-12 Ube Ind Ltd Metal fine particle/polymer composite
JP2006250668A (en) * 2005-03-10 2006-09-21 Tatsuro Endo Non-labelled biochip

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3157952B2 (en) * 1993-06-02 2001-04-23 アヴェンティス・リサーチ・ウント・テクノロジーズ・ゲーエムベーハー・ウント・コー・カーゲー Optical sensor for chemical substance detection
JPH10505910A (en) * 1994-09-23 1998-06-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング A method for studying biomolecular interactions using surface plasmon resonance
JPH11502922A (en) * 1995-03-20 1999-03-09 インスティテュート ファー ヒェモ ウント ビオゼンゾリック ミュンスター エー． ファー． Sensitive substances and devices for detecting organic components and solvent vapors in air
JP2001505236A (en) * 1996-11-06 2001-04-17 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウエルス システム オブ ハイアー エデュケイション Novel polymerized crystalline colloid array sensor
JP2004506893A (en) * 2000-08-14 2004-03-04 ファーフィールド・センサーズ・リミテッド Sensor device
JP2004531703A (en) * 2001-02-16 2004-10-14 ビール アクティーゼルスカブ Method for producing optical (bio) chemical sensor device
JP2004346177A (en) * 2003-05-22 2004-12-09 Fuji Photo Film Co Ltd Imprinted polymer with immobilized gold nanoparticle
JP2005283140A (en) * 2004-03-26 2005-10-13 Fuji Photo Film Co Ltd Biosensor
JP2006008969A (en) * 2004-05-25 2006-01-12 Ube Ind Ltd Metal fine particle/polymer composite
JP2006250668A (en) * 2005-03-10 2006-09-21 Tatsuro Endo Non-labelled biochip

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ENDO T. ET AL.: "Kyokuzai Plasmon Kyomei Cell Assay Biochip no Kaihatsu", DENKI KAGAKU DAI 73 KAI TAIKAI KOEN YOSHISHU, 1 April 2006 (2006-04-01), pages 225 + ABSTR. NO. 2J07 *
ENDO T., YANAGIDA Y., HATSUZAWA T.: "Kikinzoku Nano Ryushi - Shigeki Otosei Kobunshi Fukugogata Biosensor no Kaihatsu", THE ELECTROCHEMICAL SOCIETY OF JAPAN DAI 75 KAI TAIKAI KOEN YOSHISHU, 29 March 2008 (2008-03-29), pages 177 + ABSTR. NO. 2H09 *
TATSURO ENDO ET AL.: "Multiple Label-Free Detection of Antigen-Antibody Reaction Using Localized Surface Plasmon Resonacne-Based Core-Shell Structured Nanoparticle Layer Nanochip", ANALYTICAL CHEMISTRY, vol. 78, no. 18, 15 September 2006 (2006-09-15), pages 6465 - 6475, XP002559106, DOI: doi:10.1021/ac0608321 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010123073A1 (en) * 2009-04-24 2010-10-28 コニカミノルタホールディングス株式会社 Assay method using plasmon excitation sensor comprising stimulus-responsive polymer
JP2011080848A (en) * 2009-10-07 2011-04-21 Daikin Industries Ltd Biosensor
JPWO2011129220A1 (en) * 2010-04-14 2013-07-18 日東紡績株式会社 Test instrument for measuring an analyte in a sample and method for measuring an analyte using the same
JP5831448B2 (en) * 2010-04-14 2015-12-09 日東紡績株式会社 Test instrument for measuring an analyte in a sample and method for measuring an analyte using the same
US10670586B2 (en) 2010-04-14 2020-06-02 Nitto Boseki Co., Ltd. Test instrument for measuring analyte in sample by an aggregation assay using a metal colloid and using a reagent attached in a dry state in a reaction chamber, and method for measuring analyte using same
WO2014196169A1 (en) * 2013-06-04 2014-12-11 パナソニック株式会社 Sensor chip, detection method and detection device
JP5889487B2 (en) * 2013-06-04 2016-03-22 パナソニック株式会社 Sensor chip, detection method and detection apparatus
US9610033B2 (en) 2013-06-04 2017-04-04 Panasonic Corporation Sensor chip, detection method, and detection apparatus

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