WO2007092574A3 - Crystalline forms of ciclesonide - Google Patents

Crystalline forms of ciclesonide Download PDF

Info

Publication number
WO2007092574A3
WO2007092574A3 PCT/US2007/003405 US2007003405W WO2007092574A3 WO 2007092574 A3 WO2007092574 A3 WO 2007092574A3 US 2007003405 W US2007003405 W US 2007003405W WO 2007092574 A3 WO2007092574 A3 WO 2007092574A3
Authority
WO
WIPO (PCT)
Prior art keywords
ciclesonide
crystalline forms
theta
degrees
peaks
Prior art date
Application number
PCT/US2007/003405
Other languages
French (fr)
Other versions
WO2007092574A2 (en
Inventor
Rossetto Pierluigi
Peter Lindsay Macdonald
Sigalit Levi
Judith Aronhime
Original Assignee
Sicor Inc
Rossetto Pierluigi
Peter Lindsay Macdonald
Sigalit Levi
Judith Aronhime
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc, Rossetto Pierluigi, Peter Lindsay Macdonald, Sigalit Levi, Judith Aronhime filed Critical Sicor Inc
Priority to JP2008554347A priority Critical patent/JP2009526068A/en
Priority to EP07763367A priority patent/EP1904514A2/en
Priority to CA002637815A priority patent/CA2637815A1/en
Publication of WO2007092574A2 publication Critical patent/WO2007092574A2/en
Publication of WO2007092574A3 publication Critical patent/WO2007092574A3/en
Priority to IL193025A priority patent/IL193025A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention encompasses a crystalline form of ciclesonide characterized by an XRD pattern having peaks at about 1 1.0, 14.8, 15.7, 16.5, and 22.8 degrees two-theta ± 0.2 degrees two-theta, methods of its preparation and pharmaceutical compositions thereof. Formula (I).
PCT/US2007/003405 2006-02-08 2007-02-07 Crystalline forms of ciclesonide WO2007092574A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2008554347A JP2009526068A (en) 2006-02-08 2007-02-07 Ciclesonide crystal form
EP07763367A EP1904514A2 (en) 2006-02-08 2007-02-07 Crystalline forms of ciclesonide
CA002637815A CA2637815A1 (en) 2006-02-08 2007-02-07 Crystalline forms of ciclesonide
IL193025A IL193025A0 (en) 2006-02-08 2008-07-24 Crystalline forms of ciclesonide

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77165406P 2006-02-08 2006-02-08
US60/771,654 2006-02-08
US77384106P 2006-02-15 2006-02-15
US60/773,841 2006-02-15

Publications (2)

Publication Number Publication Date
WO2007092574A2 WO2007092574A2 (en) 2007-08-16
WO2007092574A3 true WO2007092574A3 (en) 2007-10-18

Family

ID=38330141

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/003405 WO2007092574A2 (en) 2006-02-08 2007-02-07 Crystalline forms of ciclesonide

Country Status (5)

Country Link
EP (1) EP1904514A2 (en)
JP (1) JP2009526068A (en)
CA (1) CA2637815A1 (en)
IL (1) IL193025A0 (en)
WO (1) WO2007092574A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008062450A2 (en) * 2006-09-18 2008-05-29 Cadila Healthcare Limited Crystalline polymorphs of ciclesonide
CN106883283B (en) * 2015-12-15 2021-02-02 天津金耀集团有限公司 Ciclesonide monohydrate, crystal form and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5482934A (en) * 1990-09-07 1996-01-09 Especialidades Latinas Medicamentos Universales, S.A. (Elmu, S.A.) Pregna-1,4-diene3,20-dione-16-17-acetal-21 esters, process for their preparation, composition, and methods for the treatment of inflammatory conditions
EP0929566A1 (en) * 1996-09-03 1999-07-21 Byk Gulden Lomberg Chemische Fabrik GmbH Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione derivatives
WO2004085460A1 (en) * 2003-03-27 2004-10-07 Altana Pharma Ag Process for preparing crystalline ciclesonide with defined particle size
WO2007056181A2 (en) * 2005-11-02 2007-05-18 Sicor, Inc. Process for the preparation of ciclesonide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0745512B2 (en) * 1986-10-21 1995-05-17 タマ生化学株式会社 Method for concentrating and purifying oryzanol constituents
JPH07146125A (en) * 1993-11-26 1995-06-06 Hitachi Zosen Corp Straightness measuring apparatus
EP1670482B2 (en) * 2003-09-16 2022-06-29 Covis Pharma B.V. Use of ciclesonide for the treatment of respiratory diseases
JP2005251505A (en) * 2004-03-03 2005-09-15 Teijirou Azuma Proton conductor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5482934A (en) * 1990-09-07 1996-01-09 Especialidades Latinas Medicamentos Universales, S.A. (Elmu, S.A.) Pregna-1,4-diene3,20-dione-16-17-acetal-21 esters, process for their preparation, composition, and methods for the treatment of inflammatory conditions
EP0929566A1 (en) * 1996-09-03 1999-07-21 Byk Gulden Lomberg Chemische Fabrik GmbH Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione derivatives
WO2004085460A1 (en) * 2003-03-27 2004-10-07 Altana Pharma Ag Process for preparing crystalline ciclesonide with defined particle size
WO2007056181A2 (en) * 2005-11-02 2007-05-18 Sicor, Inc. Process for the preparation of ciclesonide

Also Published As

Publication number Publication date
CA2637815A1 (en) 2007-08-16
JP2009526068A (en) 2009-07-16
WO2007092574A2 (en) 2007-08-16
EP1904514A2 (en) 2008-04-02
IL193025A0 (en) 2009-02-11

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