WO2007091039A3 - Production of cabergoline and novel polymorphic form thereof - Google Patents

Production of cabergoline and novel polymorphic form thereof Download PDF

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Publication number
WO2007091039A3
WO2007091039A3 PCT/GB2007/000397 GB2007000397W WO2007091039A3 WO 2007091039 A3 WO2007091039 A3 WO 2007091039A3 GB 2007000397 W GB2007000397 W GB 2007000397W WO 2007091039 A3 WO2007091039 A3 WO 2007091039A3
Authority
WO
WIPO (PCT)
Prior art keywords
cabergoline
polymorphic form
production
novel polymorphic
novel
Prior art date
Application number
PCT/GB2007/000397
Other languages
French (fr)
Other versions
WO2007091039A2 (en
WO2007091039A8 (en
Inventor
Alan Kenneth Greenwood
Parveen Bhatarah
Mahmood Raza
Original Assignee
Resolution Chemicals Ltd
Mchattie Derek
Alan Kenneth Greenwood
Parveen Bhatarah
Mahmood Raza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resolution Chemicals Ltd, Mchattie Derek, Alan Kenneth Greenwood, Parveen Bhatarah, Mahmood Raza filed Critical Resolution Chemicals Ltd
Priority to BRPI0707161-2A priority Critical patent/BRPI0707161A2/en
Priority to EP07705129A priority patent/EP2007761A2/en
Priority to AU2007213571A priority patent/AU2007213571A1/en
Priority to JP2008553820A priority patent/JP2009526030A/en
Priority to CA002640081A priority patent/CA2640081A1/en
Publication of WO2007091039A2 publication Critical patent/WO2007091039A2/en
Publication of WO2007091039A3 publication Critical patent/WO2007091039A3/en
Priority to IL192870A priority patent/IL192870A0/en
Publication of WO2007091039A8 publication Critical patent/WO2007091039A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present application relates to a novel polymorphic form of cabergoline comprising cabergoline and t-amyl methyl ether, designated Form TAME cabergoline, together with a novel method of producing cabergoline.
PCT/GB2007/000397 2006-02-08 2007-02-06 Production of cabergoline and novel polymorphic form thereof WO2007091039A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BRPI0707161-2A BRPI0707161A2 (en) 2006-02-08 2007-02-06 cabergoline production and its new polymorphic forms
EP07705129A EP2007761A2 (en) 2006-02-08 2007-02-06 Production of cabergoline and novel polymorphic form thereof
AU2007213571A AU2007213571A1 (en) 2006-02-08 2007-02-06 Production of cabergoline and novel polymorphic form thereof
JP2008553820A JP2009526030A (en) 2006-02-08 2007-02-06 CABERGOLINE AND METHOD FOR PRODUCING NOVEL POLYMORPHIM FORM
CA002640081A CA2640081A1 (en) 2006-02-08 2007-02-06 Production of cabergoline and novel polymorphic form thereof
IL192870A IL192870A0 (en) 2006-02-08 2008-07-17 A polymorphic form of cabergoline and methods for the production thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0602557.1A GB0602557D0 (en) 2006-02-08 2006-02-08 Production of cabergoline and novel polymorphic form thereof
GB0602557.1 2006-02-08

Publications (3)

Publication Number Publication Date
WO2007091039A2 WO2007091039A2 (en) 2007-08-16
WO2007091039A3 true WO2007091039A3 (en) 2007-10-18
WO2007091039A8 WO2007091039A8 (en) 2008-11-13

Family

ID=36119736

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/000397 WO2007091039A2 (en) 2006-02-08 2007-02-06 Production of cabergoline and novel polymorphic form thereof

Country Status (9)

Country Link
EP (1) EP2007761A2 (en)
JP (1) JP2009526030A (en)
CN (1) CN101384589A (en)
AU (1) AU2007213571A1 (en)
BR (1) BRPI0707161A2 (en)
CA (1) CA2640081A1 (en)
GB (1) GB0602557D0 (en)
IL (1) IL192870A0 (en)
WO (1) WO2007091039A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2525104A1 (en) 2003-05-08 2004-11-25 Ivax Pharmaceuticals S.R.O. Polymorphs of cabergoline
US7939665B2 (en) * 2007-05-04 2011-05-10 Apotex Pharmachem Inc. Efficient process for the preparation of cabergoline and its intermediates

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526892A (en) * 1981-03-03 1985-07-02 Farmitalia Carlo Erba, S.P.A. Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
WO2002085902A1 (en) * 2001-04-16 2002-10-31 Finetech Laboratories Ltd. Process and intermediates for production of cabergoline and related compounds
WO2004094368A2 (en) * 2003-04-21 2004-11-04 Finetech Laboratories, Ltd. New forms of cabergoline
WO2004101510A2 (en) * 2003-05-08 2004-11-25 Ivax Corporation Polymorphs of cabergoline

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526892A (en) * 1981-03-03 1985-07-02 Farmitalia Carlo Erba, S.P.A. Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
WO2002085902A1 (en) * 2001-04-16 2002-10-31 Finetech Laboratories Ltd. Process and intermediates for production of cabergoline and related compounds
WO2004094368A2 (en) * 2003-04-21 2004-11-04 Finetech Laboratories, Ltd. New forms of cabergoline
WO2004101510A2 (en) * 2003-05-08 2004-11-25 Ivax Corporation Polymorphs of cabergoline

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BRAMBILLA E ET AL: "SYNTHESIS AND NIDATION INHIBITORY ACTIVITY OF A NEW CLASS OF ERGOLINE DERIVATIVES SYNTHESE ET ACTIVITE INHIBITRICE SUR LA NIDATION D'UNE NOUVELLE CLASSE DE DERIVES DE L'ERGOLINE", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 24, 1989, pages 421 - 426, XP001005360, ISSN: 0223-5234 *

Also Published As

Publication number Publication date
IL192870A0 (en) 2009-02-11
AU2007213571A1 (en) 2007-08-16
CA2640081A1 (en) 2007-08-16
CN101384589A (en) 2009-03-11
WO2007091039A2 (en) 2007-08-16
WO2007091039A8 (en) 2008-11-13
GB0602557D0 (en) 2006-03-22
EP2007761A2 (en) 2008-12-31
BRPI0707161A2 (en) 2011-04-26
JP2009526030A (en) 2009-07-16

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