WO2007089946A3 - Animal model for hiv induced disease - Google Patents

Animal model for hiv induced disease Download PDF

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Publication number
WO2007089946A3
WO2007089946A3 PCT/US2007/003184 US2007003184W WO2007089946A3 WO 2007089946 A3 WO2007089946 A3 WO 2007089946A3 US 2007003184 W US2007003184 W US 2007003184W WO 2007089946 A3 WO2007089946 A3 WO 2007089946A3
Authority
WO
WIPO (PCT)
Prior art keywords
hiv
animal
animal model
present
induced disease
Prior art date
Application number
PCT/US2007/003184
Other languages
French (fr)
Other versions
WO2007089946A2 (en
Inventor
Nelson M Karp
Original Assignee
Nelson M Karp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nelson M Karp filed Critical Nelson M Karp
Priority to AU2007211230A priority Critical patent/AU2007211230A1/en
Priority to JP2008553412A priority patent/JP2009525054A/en
Priority to EP07762942A priority patent/EP1981333A4/en
Priority to CA002635722A priority patent/CA2635722A1/en
Priority to MX2008009902A priority patent/MX2008009902A/en
Priority to PCT/US2007/003184 priority patent/WO2007089946A2/en
Publication of WO2007089946A2 publication Critical patent/WO2007089946A2/en
Priority to IL192715A priority patent/IL192715A0/en
Publication of WO2007089946A3 publication Critical patent/WO2007089946A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/05—Animals modified by non-integrating nucleic acids, e.g. antisense, RNAi, morpholino, episomal vector, for non-therapeutic purpose
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/10—Animals modified by protein administration, for non-therapeutic purpose
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/20—Animals treated with compounds which are neither proteins nor nucleic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Abstract

HIV does not cause disease in any non-human species. Thus, there is no animal model system to evaluate the efficacy of strategies aimed at preventing, treating or curing disease caused by this virus. The present invention provides compositions and a method for producing an animal model for HIV induced disease. The present invention is an animal adapted to simulate a human-like immune response to HIV, which is accomplished by activation and inactivation of complement of proteins within the animal. Accordingly, the present invention stages certain human proteins within an animal by way of its gut associated lymphoid tissue followed by infection of live HIV.
PCT/US2007/003184 2006-02-03 2007-02-05 Animal model for hiv induced disease WO2007089946A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2007211230A AU2007211230A1 (en) 2007-02-05 2007-02-05 Animal model for HIV induced disease
JP2008553412A JP2009525054A (en) 2006-02-03 2007-02-05 Animal model of HIV-induced disease
EP07762942A EP1981333A4 (en) 2006-02-03 2007-02-05 Animal model for hiv induced disease
CA002635722A CA2635722A1 (en) 2006-02-03 2007-02-05 Animal model for hiv induced disease
MX2008009902A MX2008009902A (en) 2006-02-03 2007-02-05 Animal model for hiv induced disease.
PCT/US2007/003184 WO2007089946A2 (en) 2006-02-03 2007-02-05 Animal model for hiv induced disease
IL192715A IL192715A0 (en) 2006-02-03 2008-07-09 Animal model for hiv induced disease

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76531506P 2006-02-03 2006-02-03
US60/765,315 2006-02-03
PCT/US2007/003184 WO2007089946A2 (en) 2006-02-03 2007-02-05 Animal model for hiv induced disease

Publications (2)

Publication Number Publication Date
WO2007089946A2 WO2007089946A2 (en) 2007-08-09
WO2007089946A3 true WO2007089946A3 (en) 2008-11-27

Family

ID=39731807

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/003184 WO2007089946A2 (en) 2006-02-03 2007-02-05 Animal model for hiv induced disease

Country Status (6)

Country Link
EP (1) EP1981333A4 (en)
JP (1) JP2009525054A (en)
CA (1) CA2635722A1 (en)
IL (1) IL192715A0 (en)
MX (1) MX2008009902A (en)
WO (1) WO2007089946A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104530241B (en) * 2014-12-15 2018-05-18 武汉市畜牧兽医科学研究所 A kind of genetic engineering bacterium for expressing cell-penetrating peptide fusion protein and application
CN106967739B (en) * 2017-01-25 2020-05-05 河南科技大学 Fusion gene beta TrCP-CypA with HIV-1 inhibiting effect and construction method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030143191A1 (en) * 2001-05-25 2003-07-31 Adam Bell Chemokine beta-1 fusion proteins
US20040126793A1 (en) * 2002-08-20 2004-07-01 Genitrix, Llc Lectin compositions and methods for modulating an immune response to an antigen
US20050118677A1 (en) * 1996-05-28 2005-06-02 The Gov. Of The U.S.A, As Represented By The Secretary Of The Dept. Of Health & Human Services CC chemokine receptor 5 DNA, new animal models and therapeutic agents for HIV infection
US20050214751A1 (en) * 2004-03-02 2005-09-29 Proteologics, Inc. Inhibition of viral maturation, methods and compositions related thereto

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000039316A1 (en) * 1998-12-31 2000-07-06 The J. David Gladstone Institutes Transgenic rodents and rodent cell lines expressing hiv co-receptors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050118677A1 (en) * 1996-05-28 2005-06-02 The Gov. Of The U.S.A, As Represented By The Secretary Of The Dept. Of Health & Human Services CC chemokine receptor 5 DNA, new animal models and therapeutic agents for HIV infection
US20030143191A1 (en) * 2001-05-25 2003-07-31 Adam Bell Chemokine beta-1 fusion proteins
US20040126793A1 (en) * 2002-08-20 2004-07-01 Genitrix, Llc Lectin compositions and methods for modulating an immune response to an antigen
US20050214751A1 (en) * 2004-03-02 2005-09-29 Proteologics, Inc. Inhibition of viral maturation, methods and compositions related thereto

Also Published As

Publication number Publication date
JP2009525054A (en) 2009-07-09
EP1981333A2 (en) 2008-10-22
IL192715A0 (en) 2011-08-01
MX2008009902A (en) 2008-10-17
CA2635722A1 (en) 2007-08-09
WO2007089946A2 (en) 2007-08-09
EP1981333A4 (en) 2010-11-17

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