WO2007088897A1

WO2007088897A1 - Iontophoresis system of cartridge type

Info

Publication number: WO2007088897A1
Application number: PCT/JP2007/051614
Authority: WO
Inventors: Takehiko Matsumura; Mizuo Nakayama; Tsutomu Shibata
Original assignee: Tti Ellebeau, Inc.
Priority date: 2006-01-31
Filing date: 2007-01-31
Publication date: 2007-08-09

Abstract

An iontophoresis system wherein an electrode construct in the non-working side to be used for administering a drug ion by iontophoresis is composed of a first power collector electrically connected to a power system and a first cartridge having a drug ion, and the first cartridge is structurally and electrically connected in a separable manner to the first power collector with the use of a mechanical fastener mechanism.

Description

Specification

Cartridge type iontophoresis device

Technical field

[0001] The present invention relates to an iontophoresis device for administering drug ions to a living body, and more particularly to an iontophoresis device capable of exchanging a drug solution holding unit for holding drug ions as a cartridge.

Background art

[0002] Iontophoresis is one of the methods for allowing a drug to penetrate into a living body through skin or mucous membranes. In iontophoresis, a drug ion is electrically driven by applying a voltage of the same conductivity type as that of the drug ion in the drug solution while the drug solution is in contact with the skin or mucous membrane, via the skin or mucous membrane. It is transferred to the living body.

[0003] Also, an ion exchange membrane having a function of selectively passing the same type of conductive ion as the charged ion of the drug ion or a function of selectively passing an ion of the opposite conductivity type to the charged ion of the drug ion. In addition to the site where drug ions are retained, an electrolyte site containing a substance that is more easily electrolyzed than water as a solvent is provided to efficiently administer drug ions. An iontophoresis device is known (for example, see JP-A-2004-188188).

[0004] Further, as described in Japanese Patent Application Laid-Open No. 2004-202057, the inclusion in which drug ions are enclosed in an ion exchange membrane is replaced with a cartridge, so that the entire apparatus is not replaced. Devices are also known that administer different drug ions by simply replacing them.

[0005] However, in an iontophoresis device as described in Japanese Patent Application Laid-Open No. 2004-188188, since drug ions are arranged at an integral part of the device as a whole, it is desired to administer different drug ions. Had to replace the entire device.

[0006] On the other hand, in the case of the iontophoresis device described in Japanese Patent Application Laid-Open No. 2004-202057, it is true that only the inclusion containing the drug ion to be administered is replaced without replacing the entire device. Various drugs can be administered. But simply ion In the state where drug ions are simply sealed in the exchange membrane and sealed, there is a possibility of damage when the inclusion is subjected to an impact due to the strength of the ion exchange membrane itself. In addition, if only the part containing the drug ions (chemical solution holding part) is made into a cartridge as a loose inclusion and replaced as necessary, the other electrolyte layer etc. can be replaced with paste or gel in a tube. It is also suggested in Patent Document 2 that it is necessary to carry it further as it is not convenient to carry and re-inject, and the one that comes into contact with the external environment such as the patient's skin will be reused. For safety reasons, hygiene problems are likely to occur.

[0007] Further, in Japanese Patent Application Laid-Open No. 2004-202057, the coupling mode between the enclosure and the apparatus itself is not necessarily clear, but the upper force of the enclosure is simply brought into contact with the apparatus. If it is to be used, it is necessary to always press the device itself against the enclosure during use, which is also inconvenient.

[0008] Furthermore, when the contact state (electrical connection state) between the device itself and the inclusion is not always kept good, the original mechanism for administering drug ions into the living body by electrical drive. In some cases, the ability cannot be demonstrated.

Disclosure of the invention

[0009] The present invention has been made to solve these problems, and various drug ions can be used as a cartridge while maintaining a good connection state between the cartridge portion containing the drug ions and the apparatus main body. The problem is to provide an iontophoresis device that can be replaced as needed.

[0010] As in the embodiments described below, the working electrode structure and the non-working electrode structure used for administering an ionic drug by iontophoresis, and the working electrode structure A power supply device connected by a first conductivity type and connected to the non-working side electrode structure by a second conductivity type, wherein at least the working side electrode structure is The first current collector electrically connected to the power supply device and the first cartridge cover provided with the ionizing agent, and the first cartridge and the first current collector are: The above-mentioned problems are solved by configuring the mechanical and mechanical fastener mechanisms so that they can be connected and separated structurally and electrically.

[0011] This makes it necessary to use various drug ions as a cartridge without replacing the entire device. It can be replaced as needed. In addition, the mechanical fastener mechanism makes the cartridge and current collector (device main body) structurally stable, and it is not necessary to press the cartridge part so that it does not always come off during use. Connected to. In addition, even for the same type of drug ions, a large amount of drug ions can be introduced by replacing the cartridge without increasing the size of the apparatus itself. In addition, there is no problem even if a liner or the like for protecting the connecting surface (hook part and loop part) is not arranged before the cartridge and the current collector are connected.

[0012] The mechanical fastener mechanism includes a loop portion provided on one side of the current collector or the first cartridge, and a hook portion provided on the other side. Both the loop part and the hook part may be configured to have conductivity by forming at least a part of the carbon force.

[0013] Thereby, the mechanical fastener mechanism itself can be energized, and there is no need to provide a separate structure for electrical connection.

[0014] Further, the mechanical fastener mechanism includes a loop portion provided on one side of the current collector or the first cartridge, and a hook portion provided on the other side, Both the loop part and the hook part may be configured to have conductivity by being subjected to at least a part of the surface coating treatment.

[0015] With this, the mechanical-fastener mechanism can be configured at low cost using the mechanical fastener that is distributed in the factory.

[0016] The mechanical fastener mechanism includes a loop portion provided on one side of the current collector or the first cartridge, and a hook portion provided on the other side. Either one of the loop part and the hook part has conductivity by forming at least a part of the carbon force, and the other part is subjected to at least a part of the surface coating treatment. It may be configured to have conductivity by.

[0017] Thereby, for example, on the loop portion side of the mechanical fastener mechanism, a loop can be formed using carbon fiber, while on the hook portion side, the material circulated in the yard is subjected to a mating treatment. By applying, it is possible to ensure the electrical conductivity.

[0018] Further, the non-working side electrode structure is electrically connected to the power supply device. And a second cartridge force comprising the current collector and the drug ions, and the second force cartridge is structurally and electrically connected to the second current collector by a mechanical fastener mechanism. It can be configured to be separable!

[0019] This makes it possible to simultaneously administer drug ions having a polarity different from that of the working electrode structure to the living body even in the non-working electrode structure.

[0020] In the present specification and claims, the "front surface" means a side closer to the administration target of a drug ion such as a living body when the apparatus is used, and the "rear surface" , Means the side farther away from the target for administration of drug ions, such as living organisms, when using the device

[0021] Here, the "first conductivity type" and the "second conductivity type" mean the polarity of electricity. For example, if the “first conductivity type” is positive, the “second conductivity type” is negative.

If “first conductivity type” is positive, “first conductivity type electrode” is an anode, and “first conductivity type ion” is a cation. On the other hand, the “second conductivity type electrode” is a force sword, and the “second conductivity type electrode” is an ani sword.

[0023] This makes it possible to replace various drug ions as necessary as cartridges while maintaining a good structural and electrical connection between the cartridge unit containing the drug ions and the device. A tophoresis device can be provided.

Brief Description of Drawings

[0024] FIG. 1 is an overall schematic diagram of an iontophoresis device according to the present invention.

[Fig. 2] Sectional view of working electrode structure in Fig. 1

[Fig. 3] Diagram showing the engaged state of the mechanical fastener

[Figure 4] Diagram showing an example of the mechanical fastener configuration

BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, an example of an embodiment according to the present invention will be described in detail with reference to the accompanying drawings.

FIG. 1 is a schematic configuration diagram of an iontophoresis device 110 that is an example of an embodiment of the present invention.

[0027] The iontophoresis device 110 includes a working electrode structure 120A and a non-working electrode structure. The body 120B is connected to the power supply device 112, respectively. In addition, the working electrode structure 12 OA is provided with drug ions for administration into the living body S.

FIG. 2 is a cross-sectional view showing in detail the working electrode structure 120A in FIG. For convenience of explanation, an iontophoresis device for administering a drug whose medicinal component dissociates into a cation (for example, an anesthetic such as Lido hydrochloride or morphine hydrochloride) will be described as an example. In the case of an iontophoresis device for administering a drug whose medicinal component is dissociated into an anion (for example, ascorbic acid which is a vitamin), the voltage applied to the electrode in the following embodiments, and the ion exchange membrane or It can be constituted by changing the polarity of the exchange group introduced into the ion exchange resin. Further, for convenience of explanation, only the working electrode structure is taken out for explanation, but it is needless to say that the same structure can be adopted even when the non-working side electrode structure is used.

[0029] As the power supply device 112, various devices such as a primary battery, a storage battery (including a secondary battery and a capacitor), and a fuel battery can be used.

[0030] The working-side electrode structure 120A is connected to the anode (first conductivity type) of the power supply device 112, and includes a first current collector 114A having conductivity and a first cartridge 160A.

[0031] The first current collector 114A can be made of any conductive material. For example, not only metals, but also the surface of a resin with a surface treatment having conductivity, or even a single-boner can be used. Further, a loop portion 115A that can be coupled to a hook portion 142A described later is provided integrally on the front side of the first current collector 114A.

[0032] The loop portion 115A and the hook portion 142A constitute a mechanical fastener (one Velcro fastener) mechanism 150A. As shown in FIG. 3, in the mechanical fastener mechanism 150A, the loop portion 115A and the hook portion 142A are engaged and structurally integrated by bringing them into close contact with each other with a certain pressure or more. In addition, even after being integrated, it can be peeled off by applying a certain level of force (tensile force).

[0033] The loop portion 115A is a constituent element of the mechanical fastener mechanism 150A, and is formed of a conductive member. In the present embodiment, the loop portion 115A is configured by twisting a resin fiber P such as polyamide resin and a carbon fiber C (FIG. 4). (Refer to (A)). Of course, the present invention is not limited to this configuration, and the entire loop portion can be made of carbon fiber to further increase the conductivity. Further, as shown in FIG. 4B, a part of the plurality of loops may be a loop Lc made of carbon fiber, and the rest may be a loop Lp made of resin fiber fiber. Also, as shown in FIG. 4 (C), a part (or all) of the loop made of polyamide resin may be a conductive loop Ld that has been subjected to a conductive plating treatment. In this way, mechanical fasteners distributed in the factory can be processed and used, and manufacturing costs can be reduced.

[0034] The "metal treatment" herein includes all metal treatments as long as they have electrical conductivity. For example, gold plating, silver plating, rhodium plating, platinum plating, no << radium plating, ruthenium plating. Copper plating, tin plating, tin-lead alloy plating, 10 plating, indium plating, etc. are applicable, and gold plating and platinum plating are particularly preferable in consideration of minimizing the influence on the human body. The same applies to the plating process described below.

[0035] The first cartridge 160A includes a plurality of hook portions 142A, a working electrode 122A disposed on the front surface of the hook portions 142A and electrically connected to the hook portions 142A, and the working electrodes 122A. Electrolyte holding part 126A arranged on the front surface and holding the electrolytic solution, key-on exchange membrane (second ion selective membrane) 128A arranged on the front surface of the electrolyte holding part 126A, and the key ion A chemical solution holding part 130A that is disposed in front of the exchange membrane 128A and holds drug ions, and a cation exchange membrane (first ion selective membrane) 132A that is arranged in front of the chemical liquid holding part 130A are containers 124A. Is housed inside. In addition, an adhesive portion 134A for attaching the first cartridge 160A to the living body S is provided around the outermost peripheral portion of the front surface side of the container 124A to protect the adhesive portion 134A and the cation exchange membrane 132A. The first liner 136 A is provided so as to be peelable.

[0036] The hook portion 142A is a component of the mechanical fastener mechanism 150A, and is formed of a member having electrical conductivity. In the present embodiment, the hook portion 142A is configured by mixing a synthetic resin and carbon, and achieves both conductivity and strength. Needless to say, the entire hook portion is not limited to this configuration, and can be made of a carbon material to further increase the conductivity. As shown in FIG. 4 (B), a part of the plurality of hooks may be made of a hook He made of a carbon material cover, and the rest may be made of a synthetic resin hook Hs. In addition, as shown in Fig. 4 (C), conductive hooks Hd are applied to some (or all) hooks Hs made of synthetic resin, etc. It is good. In this way, mechanical fasteners distributed in the factory can be processed and used, and manufacturing costs can be reduced. In the drawings, a force describing a “fishhook” -shaped hook, for example, a mushroom-shaped hook portion may be used. In the present embodiment, the force may be reversed such that the loop portion 115A is formed on the first current collector 114A side and the hook portion 142A is formed on the first cartridge 160A side.

[0037] The working electrode 122A can be made of any conductive material. However, when the electrolyte solution holding portion 126A described later is present as in this embodiment, a carbon electrode (carbon electrode) is used. Is preferably used.

[0038] The electrolytic solution holding unit 126A holds an electrolytic solution for ensuring the conductivity of the iontophoresis device for a long time. Examples of the electrolytic solution include phosphate buffered saline and organic acids. It is possible to use an aqueous solution. More preferably, electrolytes that are more easily oxidized or reduced than water electrolysis (oxidation reaction at the anode electrode and reduction reaction at the force sword electrode), such as ferrous phosphate, ferric phosphate, etc. By using inorganic compounds, substances such as ascorbic acid (vitamin C) sodium ascorbate, organic acids of lactic acid, oxalic acid, malic acid, succinic acid, fumaric acid and Z or salts thereof, or mixtures thereof It is also possible to prevent the generation of gas by electrolysis of water and the increase of the conductive resistance or the fluctuation of pH value due to this. Of course, it is not intended to be limited to the substances described here.

[0039] The char-on exchange membrane 128A is an ion-exchange membrane having a function of selectively passing the char-on, for example, NEOSEPTA AM-1, AM-3, AMX manufactured by Tokuma Corporation. Key-on exchange membranes such as AHA, AMH, and ACS can be used without particular limitation. In addition, the ion exchange resin is polymerized in a part or all of the pores of the porous film made of polyolefin resin, salt resin resin, fluorine resin, polyamide resin, polyimide resin. The type of anion exchange membrane can be used particularly preferably. In this case, the anion exchange resin is filled with a solution obtained by mixing a polymerization initiator with a crosslinkable monomer such as styrene / dibutylbenzene or chloromethylstyrene / divinylbenzene. The polymer is impregnated after being impregnated in the pores of the polymer, and this polymer is polymerized in primary to tertiary quaternary groups, quaternary ammonium groups, pyridyl groups, imidazole groups, quaternary pyridinium groups, quaternary imidazolium groups, etc. This can be carried out by introducing a cation exchange group.

[0040] The drug solution holding unit 130A contains drug ions for administration purposes. When the working electrode structure 120A is connected to the anode of the power supply device 112 as in this embodiment, the medicinal component dissociates into cations in the drug holding unit 130A. For example, a local anesthetic (hydrochloric acid) Pro-power-in, lidocaine hydrochloride, etc.) Gastrointestinal treatments (salt carnitine, etc.), skeletal muscle relaxants (eg, bromide mouth-um), antibiotics (tetracycline, kanamycin, gentamicin, etc.) ) Is held. On the other hand, when the force acting side electrode structure not shown in the present embodiment is connected to the force sword of the power supply device 112, the medicinal component is dissociated into anions in the drug holding part, for example, vitamin ( Riboflavin phosphate, nicotinic acid, ascorbic acid, folic acid, etc.), corticosteroids (hydrocortisone water-soluble preparations, prednisolone sodium phosphate, dexamethasone sodium phosphate, prednisolone water-soluble preparations, etc.), antibacterial agents (Quinolone preparation) is retained.

[0041] The cation exchange membrane 132A is an ion exchange membrane having a function of selectively allowing cations to pass through, such as NEOSEPTA CM-l, CM-2, CMX, CMS, CMB, etc. manufactured by Tokuma Corporation. A cation exchange membrane can be used without any particular limitation. A type in which a part or all of the pores of a porous film made of polyolefin resin, salt resin resin, fluorine resin, polyamide resin, polyimide resin, etc. is filled with a cation exchange resin. The cation exchange membrane can be used particularly preferably. In this case, the cation exchange resin is filled with, for example, a solution in which a polymerization initiator is blended with a crosslinkable monomer such as styrene-dibutylbenzene or chloromethylstyrene-dibulabenzene in the pores of the porous film. Polymerization can be performed after impregnation, and a cation exchange group such as a sulfonic acid group, a carboxylic acid group, or a phosphonic acid group is introduced into the polymer.

[0042] The adhesive part 134A is composed of an adhesive hydrogel and the like, and the working electrode structure 120A (and the iontophoresis device 110 itself) can be affixed to a drug ion administration target such as the living body S. Furthermore, re-sticking after peeling is allowed as necessary. [0043] The first liner 136A is provided to prevent adhesion of oil and fat, dust and the like to the adhesive portion 134A and the cation exchange membrane 132A, thereby reducing the adhesive force and reducing the administration efficiency of drug ions. It is composed of a single-layer or multi-layer film.

[0044] Next, the operation of the iontophoresis device 110 will be described.

[0045] When using the device 110, first, the first cartridge 160A needs to be attached to the first current collector 114A.

In the embodiment shown in FIG. 1, the loop portion 115A of the first current collector 114A and the hook portion 142A of the first cartridge 160A are brought into close contact with each other. Thus, the first current collector 114A and the first force cartridge 160A are structurally and electrically connected. The mechanical fastener mechanism 150A can be freely removed (peeled) even after it is once connected. In this way, desorption can be realized with a simple configuration, and at the same time, structural and electrical connection and separation can be reliably performed. In addition, when the same configuration is adopted for the non-working side electrode structure, the same operation is required for the non-working side electrode structure.

[0047] After that, after applying the working electrode structure 120A (and the non-working electrode structure 120B) to the living body S, application of drug ions is started by applying electricity from the power supply device 112. Is done.

[0048] When a current is transmitted from the power source 112 to the working electrode 122A, the electrolytic solution provided in the electrolytic solution holding unit 126A is oxidized. For example, in the case of ferrous phosphate, it changes to ferric phosphate. As a result, the balance of cations and ions in the electrolyte solution holding part 126A is lost (the number of cations increases). In order to compensate for this balance, the cation of the electrolyte solution holding unit 126A tends to move toward the chemical solution holding unit 130A. On the other hand, the key provided in the chemical solution holding unit 130A also moves in the direction of the electrolyte solution holding unit 126A and tries to maintain the balance. However, due to the presence of the ion-exchange membrane 128A located between the electrolyte solution holding unit 126A and the chemical solution holding unit 130A, only the ion can permeate selectively without passing cations. It will be. That is, the movement of the cation from the electrolyte solution holding unit 126A to the chemical solution holding unit 130A is not recognized, and only the movement of the ions from the chemical solution holding unit 130A to the electrolyte solution holding unit 126A is allowed. In this case, the balance between the cation and the ion of the chemical solution holding unit 130A is broken. Furthermore, in order to compensate for this balance loss, The cation passes through the cation exchange membrane 132A and moves to the outside of the working electrode structure 120A (the living body S side) to maintain the balance. On the other hand, from the living body S side (inside the living body S) with which the cation exchange membrane 132A comes into contact, in order to compensate for this loss of balance, the ions in the living body S move to the chemical solution holding section 130A to maintain the balance. To do. However, due to the presence of the cation exchange membrane 132A located between the chemical solution holding part 130A and the living body S, the cation cannot pass through, and only cations are selectively passed. That is, the movement of the ion from the living body S to the drug solution holding unit 130A is not recognized, and only the movement of the cation from the drug solution holding unit 130A to the living body S side is allowed. The cations (drug ions) at this time are selectively permeated through the cation exchange membrane 132A, and thus can move to the living body S side.

[0049] Drug ions are administered through such an action.

[0050] At this time, the first current collector 114A and the working electrode 122A are electrically connected via the loop portion 115A and the hook portion 142A. In addition, since it is structurally connected, there is no need to hold (push down) the device by hand when using the device.

[0051] In addition, this mechanical fastener mechanism 150A can be easily removed from the attached cartridge, so it can be used for various diseases by replacing the cartridge containing different drug ions as needed. it can. It is also possible to administer a large amount of drug ions without changing the size of the apparatus by exchanging the same type of cartridge. Also, since only the cartridge part is replaced, the amount of waste after use can be reduced. In addition to the drug ions, the cartridge also includes an electrolyte holding part that holds the required electrolyte, so there is no need to carry a separate electrolyte paste or gel.

[0052] Also, although not shown, the non-working side electrode structure has the same configuration (but the polarity is different) as that of the above working side electrode structure. In parallel with the administration of the first conductivity type drug ion, the second conductivity type drug ion can be administered.

[0053] It should be noted that in the above-described embodiment, only the uppermost structural portion of the working electrode structure (or Z and the non-working electrode structure) is used as the current collector portion, and the others. This portion is described as a cartridge portion. However, the present invention is not intended to be limited to such a configuration. That is, the portion that is electrically connected to the power supply device without the mechanical fastener mechanism and does not include the ionic drug as its structure is the portion that can be the first current collector, The portion that contains the ionic drug as its structure and can be electrically connected to the power supply device only through the mechanical fastener mechanism is the portion that can be the first cartridge.

Industrial applicability

By applying the present invention, it is possible to reduce medical waste.

Claims

The scope of the claims

[1] A working-side electrode structure and a non-working-side electrode structure used for administering an ionic drug by iontophoresis, connected to the working-side electrode structure by a first conductivity type, and A power supply device connected to the non-working side electrode structure with a second conductivity type, and an iontophoresis device comprising:

At least the working electrode structure is composed of a first current collector that is electrically connected to the power supply device, and a first cartridge that includes the ionic drug, and

The first cartridge and the first current collector can be structurally and electrically connected and separated by a mechanical fastener mechanism.

An iontophoresis device characterized by that.

[2] In claim 1,

The mechanical fastener mechanism includes a loop portion provided on one side of the current collector or the first cartridge, and a hook portion provided on the other side. The loop portion and the hook portion include: Both have electrical conductivity due to at least a part of it being composed of carbon.

An iontophoresis device characterized by that.

[3] In claim 1,

The mechanical fastener mechanism includes a loop portion provided on one side of the current collector or the first cartridge, and a hook portion provided on the other side. The loop portion and the hook portion include: Both have at least a part of the surface force S-plated to have conductivity

An iontophoresis device characterized by that.

[4] In claim 1,

The mechanical fastener mechanism includes a loop portion provided on one side of the current collector or the first cartridge and a hook portion provided on the other side, and the loop portion and the hook portion ! /, One of them has conductivity by at least part of it being composed of carbon,

The other has conductivity by being surface-coated at least in part. Have

An iontophoresis device characterized by that.

In a hurry

Further, the non-working side electrode structure includes a second current collector electrically connected to the power supply device, and a second cartridge force including the drug ions, and

The second cartridge can be structurally and electrically connected and disconnected from the second current collector by a mechanical fastener mechanism.

An iontophoresis device characterized by that.