WO2007088531A3 - Pem-3-like polypeptides, complexes, and related methods - Google Patents

Pem-3-like polypeptides, complexes, and related methods Download PDF

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Publication number
WO2007088531A3
WO2007088531A3 PCT/IL2006/001506 IL2006001506W WO2007088531A3 WO 2007088531 A3 WO2007088531 A3 WO 2007088531A3 IL 2006001506 W IL2006001506 W IL 2006001506W WO 2007088531 A3 WO2007088531 A3 WO 2007088531A3
Authority
WO
WIPO (PCT)
Prior art keywords
pem
polypeptides
complexes
discovery
related methods
Prior art date
Application number
PCT/IL2006/001506
Other languages
French (fr)
Other versions
WO2007088531A2 (en
WO2007088531A8 (en
Inventor
Daniel N Taglicht
Omri Erez
Original Assignee
Protelogiecs Ltd
Daniel N Taglicht
Omri Erez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protelogiecs Ltd, Daniel N Taglicht, Omri Erez filed Critical Protelogiecs Ltd
Publication of WO2007088531A2 publication Critical patent/WO2007088531A2/en
Publication of WO2007088531A3 publication Critical patent/WO2007088531A3/en
Publication of WO2007088531A8 publication Critical patent/WO2007088531A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Abstract

The present disclosure relates to the discovery that PEM-3-LIKE (also known as RKHD2) interacts with three polypeptides: p32, FNBP3 and PCBP1 . Given that PEM-3-LIKE participates in viral replication, the polypeptide complexes and methods disclosed herein may, for example, be used in the identification of antiviral agents. The present disclosure also relates to novel compositions and methods for treating HIV infection. The disclosure relates to the discovery that reduced expression of p32 or PEM-3-LIKE results in decreased expression of the HIV-1 structural protein GAG.
PCT/IL2006/001506 2006-02-02 2006-12-28 Pem-3-like polypeptides, complexes, and related methods WO2007088531A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76473206P 2006-02-02 2006-02-02
US60/764,732 2006-02-02
US83915806P 2006-08-21 2006-08-21
US60/839,158 2006-08-21

Publications (3)

Publication Number Publication Date
WO2007088531A2 WO2007088531A2 (en) 2007-08-09
WO2007088531A3 true WO2007088531A3 (en) 2008-02-07
WO2007088531A8 WO2007088531A8 (en) 2008-06-12

Family

ID=38327770

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2006/001506 WO2007088531A2 (en) 2006-02-02 2006-12-28 Pem-3-like polypeptides, complexes, and related methods

Country Status (1)

Country Link
WO (1) WO2007088531A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2504700A4 (en) * 2009-11-23 2013-07-17 Univ Wake Forest Health Sciences Mex3c regulation and target to control obesity and diabetes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005001485A2 (en) * 2003-05-30 2005-01-06 Proteologics, Inc. Pem-3-like compositions and related methods thereof
WO2005007141A2 (en) * 2003-07-11 2005-01-27 Proteologics, Inc. Ubiquitin ligase inhibitors and methods related thereto

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005001485A2 (en) * 2003-05-30 2005-01-06 Proteologics, Inc. Pem-3-like compositions and related methods thereof
WO2005007141A2 (en) * 2003-07-11 2005-01-27 Proteologics, Inc. Ubiquitin ligase inhibitors and methods related thereto

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
COVINGTON LINDA W: "Update on antiviral agents for HIV and AIDS.", THE NURSING CLINICS OF NORTH AMERICA MAR 2005, vol. 40, no. 1, March 2005 (2005-03-01), pages 149 - 165, XP009089537, ISSN: 0029-6465 *
FARBER C M ET AL: "Detection of anti-p32 mycobacterial IgG antibodies in patients with AIDS.", THE JOURNAL OF INFECTIOUS DISEASES JUL 1990, vol. 162, no. 1, July 1990 (1990-07-01), pages 279 - 280, XP009089538, ISSN: 0022-1899 *

Also Published As

Publication number Publication date
WO2007088531A2 (en) 2007-08-09
WO2007088531A8 (en) 2008-06-12

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