WO2007084464A3 - Water channel blockers and methods of use thereof - Google Patents

Water channel blockers and methods of use thereof Download PDF

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Publication number
WO2007084464A3
WO2007084464A3 PCT/US2007/001044 US2007001044W WO2007084464A3 WO 2007084464 A3 WO2007084464 A3 WO 2007084464A3 US 2007001044 W US2007001044 W US 2007001044W WO 2007084464 A3 WO2007084464 A3 WO 2007084464A3
Authority
WO
WIPO (PCT)
Prior art keywords
subject
methods
water channel
channel blockers
water channels
Prior art date
Application number
PCT/US2007/001044
Other languages
French (fr)
Other versions
WO2007084464A2 (en
Inventor
Richard C Boucher
Robert Tarran
Original Assignee
Univ North Carolina
Richard C Boucher
Robert Tarran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina, Richard C Boucher, Robert Tarran filed Critical Univ North Carolina
Publication of WO2007084464A2 publication Critical patent/WO2007084464A2/en
Publication of WO2007084464A3 publication Critical patent/WO2007084464A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The present invention provides a method of blocking water channels (such as aquaporins) in a subject in need thereof, comprising administering to said subject an active compound to block water channels in said subject, as well as the use of an active compound for the preparation of a medicament for blocking water channels in a subject in need thereof. Active compounds include pyrazinoylguanidine compounds (e.g. amiloride, benzamil, phenamil) and pharmaceutically acceptable salts or prodrugs thereof.
PCT/US2007/001044 2006-01-17 2007-01-16 Water channel blockers and methods of use thereof WO2007084464A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75936006P 2006-01-17 2006-01-17
US60/759,360 2006-01-17

Publications (2)

Publication Number Publication Date
WO2007084464A2 WO2007084464A2 (en) 2007-07-26
WO2007084464A3 true WO2007084464A3 (en) 2008-01-24

Family

ID=38288167

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/001044 WO2007084464A2 (en) 2006-01-17 2007-01-16 Water channel blockers and methods of use thereof

Country Status (1)

Country Link
WO (1) WO2007084464A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109512805B (en) 2012-05-08 2021-12-31 埃罗米克斯公司 Compounds for the treatment of aquaporin mediated diseases
JP6535338B2 (en) 2013-11-06 2019-06-26 エアロミクス・インコーポレイテッドＡｅｒｏｍｉｃｓ，Ｉｎｃ． New formulation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952582A (en) * 1982-01-04 1990-08-28 Beyer Jr Karl H Pyrazinoylguanidine and derivatives thereof having few polar substituents and being useful as hyperuretic agents
US5618557A (en) * 1994-11-22 1997-04-08 E.R. Squibb & Sons, Inc. Prophylactic treatment of allergic contact dermatitis
US6369110B1 (en) * 1998-05-26 2002-04-09 Sumitomo Pharmaceuticals Company Substituted guanidine derivatives and process for producing the same
US20040110241A1 (en) * 2002-12-06 2004-06-10 Segal Mark S. Materials and methods for monitoring vascular endothelial function
US20050095225A1 (en) * 2003-03-31 2005-05-05 Engelhardt John F. Compounds and methods for pharmico-gene therapy of epithelial sodium channel associated disorders
US6962909B2 (en) * 1995-06-07 2005-11-08 Genaera Corporation Treatment of neovascularization disorders with squalimine

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952582A (en) * 1982-01-04 1990-08-28 Beyer Jr Karl H Pyrazinoylguanidine and derivatives thereof having few polar substituents and being useful as hyperuretic agents
US5618557A (en) * 1994-11-22 1997-04-08 E.R. Squibb & Sons, Inc. Prophylactic treatment of allergic contact dermatitis
US6962909B2 (en) * 1995-06-07 2005-11-08 Genaera Corporation Treatment of neovascularization disorders with squalimine
US6369110B1 (en) * 1998-05-26 2002-04-09 Sumitomo Pharmaceuticals Company Substituted guanidine derivatives and process for producing the same
US20040110241A1 (en) * 2002-12-06 2004-06-10 Segal Mark S. Materials and methods for monitoring vascular endothelial function
US20050095225A1 (en) * 2003-03-31 2005-05-05 Engelhardt John F. Compounds and methods for pharmico-gene therapy of epithelial sodium channel associated disorders

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
COULOIGNER ET AL.: "Effect of Locally Applied Drug on the Endolympathic Sac Potential. Independent Papers", LARYNGOSCOPE, vol. 108, no. 4, April 1998 (1998-04-01), pages 592 - 598 *
FIDZINSKI ET AL.: "Inhibition of NHE-1 NA+/N+ exchanger by natriuretic peptides in ocular non-pigmented ciliary epitheium", AM. J. PHYSIOL. CELL PHYSIOL., vol. 287, May 2004 (2004-05-01), pages 655 - 663 *
HOLM ET AL.: "Effect of Crystalloid Resuscitation and Inhalation Injury of Extravascular Lung Water", CHEST, vol. 121, no. 6, June 2002 (2002-06-01), pages 1956 - 1962 *
JOINER ET AL.: "Deoxygenation of sickle red blood cels stimulates KCI cotransport without affecting Na+/H+ exchange", AM. J. PHYSIOL. CELL PHYSIOL., vol. 274, 1998, pages 1466 - 1475 *
JOURNAL OF TRAUMA-INJURY INFECTION & CRITICAL CARE, vol. 42, no. 5S, SUPPL., May 1997 (1997-05-01), pages 38S - 40S *
KUNZELMANN ET AL.: "Influenza virus inhibits amiloride-sensitive Na+ channels in respiratory epithelia", PNAS, vol. 97, no. 18, 29 August 2000 (2000-08-29), pages 10282 - 10287 *
O'BRIEN ET AL.: "Treatment of edema", AMERICAN FAMILY PHYSICIAN, vol. 71, no. 11, 1 June 2005 (2005-06-01), pages 2111 - 2117 *
SALIBA ET AL.: "pH regulation in the intracellular malaria parasite, Plasmodium Falciparum", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 47, 19 November 1999 (1999-11-19), pages 33213 - 33219 *
SIMOES ET AL.: "Type 1 glycogen storage disease and recurrent calcium nephrolithiasis", NEPHROL. DIAL TRANSPLANT, vol. 16, 2001, pages 1277 - 1279 *

Also Published As

Publication number Publication date
WO2007084464A2 (en) 2007-07-26

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