WO2007072592A1 - Procédé de mesure du sang dans la cavité pulpaire, appareil pour ce faire et adaptateur servant à mesurer le sang dans la cavité pulpaire - Google Patents

Procédé de mesure du sang dans la cavité pulpaire, appareil pour ce faire et adaptateur servant à mesurer le sang dans la cavité pulpaire Download PDF

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Publication number
WO2007072592A1
WO2007072592A1 PCT/JP2006/312423 JP2006312423W WO2007072592A1 WO 2007072592 A1 WO2007072592 A1 WO 2007072592A1 JP 2006312423 W JP2006312423 W JP 2006312423W WO 2007072592 A1 WO2007072592 A1 WO 2007072592A1
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WO
WIPO (PCT)
Prior art keywords
light
blood
pulp cavity
hemoglobin
oxygen saturation
Prior art date
Application number
PCT/JP2006/312423
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English (en)
Japanese (ja)
Inventor
Zenzo Miwa
Satoko Kakino
Motohide Ikawa
Setsuo Takatani
Katsuhiro Ohuchi
Hideo Hoshi
Yuzo Takagi
Akiko Kirimoto
Original Assignee
National University Corporation Tokyo Medical And Dental University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation Tokyo Medical And Dental University filed Critical National University Corporation Tokyo Medical And Dental University
Priority to JP2007550990A priority Critical patent/JP4909904B2/ja
Publication of WO2007072592A1 publication Critical patent/WO2007072592A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552—Details of sensors specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/417—Evaluating particular organs or parts of the immune or lymphatic systems the bone marrow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4538—Evaluating a particular part of the muscoloskeletal system or a particular medical condition
    • A61B5/4542—Evaluating the mouth, e.g. the jaw
    • A61B5/4547—Evaluating teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0238—Optical sensor arrangements for performing transmission measurements on body tissue

Definitions

  • the present invention relates to a method for measuring blood in a dental pulp cavity, an apparatus, and an adapter for measuring blood in a dental pulp cavity.
  • a method, apparatus, and device for measuring blood in the pulp cavity capable of quantitatively measuring the blood concentration, blood flow volume and oxygen saturation in the pulp cavity non-invasively and objectively without causing pain to the subject
  • the present invention relates to an adapter for measuring blood in a dental pulp cavity.
  • the structure of the tooth 10 as shown in Fig. 1 is that the external force is enamel 12, dentin 14, and the pulp cavity 16 is located in the center, and the blood flow to the tooth is in the pulp cavity 16. It is made up of blood vessels distributed inside. Therefore, it is important to measure the blood flow rate, blood concentration, and oxygen saturation in the pulp cavity 16 in order to understand the health condition of the teeth, and it has the potential to be widely applied in dentistry. .
  • the electrical dental pulp diagnostic method is used for diagnosis, and this method is used to give pain to the subject.
  • some subjects have a lack of objectivity in their responses, and also point out that they have high sensory thresholds such as immature permanent teeth and traumatic teeth, and do not respond to teeth. Desirable, not a diagnostic method.
  • the latter transmitted light photoelectric pulse wave method is used to inspect a change in the amount of transmitted light on the lip side by irradiating a certain amount of light from the side of the dental palate to be examined. From finger veins It has been reported that the pulpal pulse wave synchronized with the wave can be observed.
  • the conventional method needs to perform measurement in the dark place by blocking the external light. However, even if a qualitative change is obtained, it lacks quantitativeness and accurate diagnosis is possible. I helped.
  • the photoelectric pulse wave method has a problem that it cannot be measured by pulsing the pulse.
  • the present invention has been made to solve the above-mentioned conventional problems.
  • the blood concentration in the dental pulp cavity is objectively non-invasively and objectively in a light place without causing pain to the subject.
  • the objective is to make it possible to quantitatively measure hemoglobin concentration), blood flow, and oxygen saturation.
  • the present invention irradiates a tooth with light having a plurality of equal absorption wavelengths that is not affected by the oxygen saturation of hemoglobin, receives light transmitted through the tooth, and scatters light from the tooth.
  • the above-mentioned problem is solved by obtaining the blood pulp concentration and blood flow volume in the pulp cavity excluding the influence of absorption.
  • the plurality of isosbestic wavelengths may be a combination of 522 ⁇ 10 nm or 506 ⁇ 10 nm and 810 ⁇ 10 nm.
  • the isoabsorption wavelength may be 522 ⁇ 10 nm or 506 ⁇ 10 nm, and the non-isosorption wavelength may be 467 nm.
  • the light of the plurality of wavelengths is sequentially irradiated with a time difference, and in synchronization with this, light of each wavelength can be received, for example, during ON-OFF.
  • the light can be irradiated from the palate side.
  • the present invention also includes a light source for irradiating the teeth with light having a plurality of equal absorption wavelengths that is not affected by the oxygen saturation of hemoglobin, and means for receiving light transmitted through the teeth.
  • a device for calculating blood concentration and blood flow in a dental pulp cavity characterized in that it comprises a computing means for determining the blood concentration and blood flow in the pulp cavity, excluding the effect of light scattering and absorption by the tooth substance. Is provided.
  • the light source irradiates the teeth with light of an unequal absorption wavelength that is affected by the oxygen saturation of hemoglobin, and the calculation means moves the total amount of globin into the pulp cavity determined by the device.
  • the oxygen saturation of the pulp cavity blood can be obtained.
  • the light source may be a light emitting diode.
  • the present invention also provides an approximately C-shaped projecting light guide for guiding light from the light source to the tooth palate side, and light receiving for extracting light transmitted to the lip side of the tooth.
  • An adapter for measuring blood in the pulp cavity characterized by comprising a light guide.
  • blood concentration hemoglobin concentration
  • blood flow rate hemoglobin concentration
  • oxygen saturation in the dental pulp cavity are quantified noninvasively and objectively without causing pain to the subject even in a bright place. Can be measured automatically. Furthermore, it can be measured even if the pulse is not beaten.
  • FIG. 1 is a cross-sectional view showing a tooth configuration.
  • FIG. 2 The structure and optical model of the teeth used in the present invention (A) Cross-sectional view from above and (B) Cross-sectional view from lateral force
  • FIG. 3 is a diagram showing an absorption spectrum of hemoglobin for explaining the measurement principle of the present invention.
  • FIG.4 A diagram showing an example of measurement of the change in transmitted light attenuation depending on the LED center wavelength.
  • FIG. 5A is a perspective view of an adapter suitable for use in an embodiment of the present invention
  • FIG. 5B is a sectional view
  • FIG. 5A is a perspective view of an adapter suitable for use in an embodiment of the present invention
  • FIG. 5B is a sectional view
  • FIG. 5A is a perspective view of an adapter suitable for use in an embodiment of the present invention
  • FIG. 5B is a sectional view
  • FIG. 5A is a perspective view of an adapter suitable for use in an embodiment of the present invention
  • FIG. 5B is a sectional view
  • FIG. 9 is a diagram showing the pulse wave amplitude and transmitted light attenuation of a human maxillary central incisor for explaining the principle of the second embodiment of the present invention.
  • FIG. 2 An optical model of tooth 10 is shown in Fig. 2 (A) (cross-sectional view from above) and (B) (cross-sectional view from side), enamel 12, dentin 14 and pulp.
  • the palatal force is also incident on the light source (e.g., light-emitting diode LED) via optical fiber 20, and light is received from lip-side optical fiber 22 (e.g., photodiode PD).
  • the light source e.g., light-emitting diode LED
  • lip-side optical fiber 22 e.g., photodiode PD
  • ⁇ is the light attenuation (scattering) coefficient of the tooth
  • d is the thickness of the tooth
  • ⁇ is the sb light coefficient of hemoglobin
  • d is the optical path length in the pulp cavity
  • H is the hemoglobin concentration in the pulp cavity It is.
  • the total transmitted light attenuation OD can be expressed by the following equation as the sum of the light attenuation by the tooth and the light attenuation by the blood in the pulp cavity.
  • the absorption coefficient of hemoglobin is approximately equal to oxygenation and deoxygenation, and the isosbestic wavelengths ⁇ (for example, 522 nm) and ⁇ (for example, 810 nm) of hemoglobin are: The following formula is also obtained for MBLL force.
  • A is a constant.
  • Figure 4 shows the results of measuring the average of three examples of changes in transmitted light attenuation depending on the LED center wavelength using four center wavelengths of 396 nm, 467 nm, 506 nm, and 522 nm.
  • the shorter wavelengths of 396 nm and 467 nm are longer than the wavelengths of 506 nm and 522 nm.
  • the difference in the amount of transmitted light between the ischemic tooth model filled with saline and the healthy tooth model filled with blood is large, but the transmitted light attenuation at 506 nm and 522 nm is approximated. Can be ignored.
  • the present invention is not limited to those using 506 nm and 522 nm, and 810 nm can also be used.
  • the wavelength of 810 nm is suitable for use as the reference wavelength because the wavelength is far from the wavelengths of 506 nm and 522 nm, and the light easily passes through and changes little.
  • the combination of a wavelength of 522 nm and a wavelength of 8 lOnm with little individual difference is optimal, and a combination of wavelengths of 506 nm and 810 nm is also excellent.
  • 420nm, 445nm, 549nm, 569nm, and 586nm also have isosbestic wavelengths and may be used.
  • the number of wavelengths is not limited to two.
  • the outer side is made of, for example, acrylic as shown in Fig. 5 (A) (perspective view), (B) (side view) and (C) (perspective view showing the mounted state).
  • a light guide 32 for light projection which is coated with light-shielding paint to prevent light from leaking, and guides the light from the light source (LED) to the tooth palate side, and the lip side of the tooth
  • the adapter 30 including the light receiving light guide 34 for taking out the light transmitted through the light and guiding it to the light receiving element (PD) it can be easily attached to the subject's teeth.
  • the two LEDs blink sequentially with a time difference as shown in FIG. 7, and the light receiving side detects the difference between this and ON-OFF as shown in FIG. Can be detected in bright places.
  • 40 is a pulse generation circuit
  • 42 is a light emission switching circuit for turning on two LEDs sequentially with a time difference when the pulse generated by the pulse generation circuit 40 is turned on and off
  • 44 Is an amplifier that amplifies the output of the PD
  • 46 is a light receiving switching circuit for switching the output of the amplifier 44 in synchronism with the output of the pulse generating circuit 40
  • 48 is connected in advance by the output of the light receiving switching circuit 46.
  • 50 is an arithmetic circuit that calculates the blood flow.
  • LEDs having emission wavelengths of 467 nm, 506 nm, 522 nm, and 810 nm are used as the light emitting elements, two wavelengths are selected from them, and high-precision measurement is performed with a simple configuration. Can do. Note that the type of light-emitting element and the emission wavelength are not limited thereto.
  • the configuration is simple.
  • the kind of light receiving element is not limited to this.
  • the light from the optical fibers 20, 22 is further transferred to the teeth via the adapter 30. Since irradiation and light reception are performed, application to the subject is easy.
  • Adapter 30 Since irradiation and light reception are performed, application to the subject is easy.
  • the shape and type of 30 are not limited to this, and can be omitted.
  • the type of optical fiber is not limited to plastic, and can be omitted.
  • the incident direction of light is not limited to this, and conversely, the labial force can also be incident.
  • the present invention has been applied to the measurement of blood volume in the dental pulp.
  • the application target of the present invention is not limited to this.
  • the blood concentration in the bone marrow and the tissue small It may also be possible to measure blood concentration and Z or blood flow in blood vessels.
  • OD is the average of the 13-tooth data
  • each line other than OD is the measured 13-tooth pulse wave amplitude data. From the hemoglobin absorption spectrum shown in Fig. 3, the magnitude relationship of the amplitude of the pulp pulse wave in Fig. 9 is consistent with the hemoglobin absorption spectrum. That is, as is apparent from Fig.
  • the pulse wave amplitude is larger at 522nm for all subjects at the isosbestic wavelengths of 506nm and 522nm.
  • 467 nm which is an unequal absorption wavelength, it may increase or decrease with respect to 506 nm. This is thought to be due to the influence of oxygen saturation in the pulp cavity blood.
  • the second embodiment has been made paying attention to this point.
  • Intramedullary blood oxygen saturation SO can be calculated as follows.
  • ⁇ is the light attenuation coefficient of the tooth of wavelength ⁇
  • ⁇ is the light attenuation coefficient of the tooth of wavelength ⁇
  • C is a constant.
  • the oxygen saturation SO in the dental pulp cavity can be obtained by the following equation.
  • [Hb] is calculated from two equal absorption wavelengths (e, ⁇ ) to MB total 1 2
  • two isosbestic wavelengths for example, a wavelength of 522 ⁇
  • the pathological condition of the dental pulp can be understood, and the treatment method for the dental pulp can be accurately determined.
  • the wavelength for hemoglobin concentration, ⁇ , and the wave for oxygen saturation are used.
  • non-isoabsorption wavelength and iso-absorption wavelength is 467nm and 522nm or 506nm. It is not limited to nm, and any combination of 467 nm and 810 nm, 420 nm, 445 nm, 549 nm, 569 nm or 586 nm may be used. It is also possible to measure at 4 wavelengths, using different wavelengths for hemoglobin concentration and oxygen saturation.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Dentistry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Selon l’invention, une dent (10) est irradiée avec des lumières isobestiques ayant de multiples longueurs d'onde et qui ne sont pas affectées par le degré de saturation de l'hémoglobine par l'oxygène. Ensuite, la lumière transmise à travers la dent (10) est détectée et la concentration du sang et la quantité du flux sanguin dans la cavité pulpaire sont déterminées tout en éliminant les effets de la diffusion et de l'absorption de la lumière dus aux substances de la dent (l'émail (12) et la dentine (14)). En outre, le degré de saturation par l'oxygène du sang présent dans la cavité pulpaire est déterminé en utilisant : l'atténuation de la lumière transmise observée en irradiant la dent avec les lumières isobestiques non affectées par le degré de saturation de l'hémoglobine par l'oxygène et avec des lumières non isobestiques affectées par le degré de saturation de l'hémoglobine par l'oxygène ; et le niveau total d'hémoglobine dans la cavité pulpaire, lequel a été déterminé par le procédé tel que décrit ci-dessus. Ainsi, on peut mesurer de façon non invasive, objective et quantitative la concentration du sang (la concentration de l'hémoglobine), la quantité de flux sanguin et le degré de saturation par l'oxygène du sang présent dans la cavité pulpaire, même en pleine lumière sans faire souffrir un patient.
PCT/JP2006/312423 2005-12-21 2006-06-21 Procédé de mesure du sang dans la cavité pulpaire, appareil pour ce faire et adaptateur servant à mesurer le sang dans la cavité pulpaire WO2007072592A1 (fr)

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JP2007550990A JP4909904B2 (ja) 2005-12-21 2006-06-21 歯髄腔内血液測定方法、装置及び歯髄腔内血液測定用アダプタ

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JP2005368811A JP2007167339A (ja) 2005-12-21 2005-12-21 歯髄内血液濃度・血流量測定方法及び装置
JP2005-368811 2005-12-21

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012130504A (ja) * 2010-12-21 2012-07-12 Fujifilm Corp 内視鏡システム、内視鏡システムのプロセッサ装置、及び画像生成方法
JP2015514960A (ja) * 2011-12-28 2015-05-21 ポリマー テクノロジー システムズ インコーポレーテッド 検体モニタ
JP2016535654A (ja) * 2013-11-06 2016-11-17 ケアストリーム ヘルス インク 歯周病検出システムおよび方法
JP2018115946A (ja) * 2017-01-18 2018-07-26 パイオニア株式会社 計測装置、計測方法、コンピュータプログラム及び記録媒体
RU2758963C1 (ru) * 2021-01-28 2021-11-03 Сергей Дарчоевич Арутюнов Устройство для мониторинга гемодинамики тканей пародонта
RU2783057C1 (ru) * 2017-12-12 2022-11-08 Конинклейке Филипс Н.В. Способ и система для улучшенной устойчивости к перемещению во время измерения локализованного воспаления ротовой полости
US11666223B2 (en) * 2017-02-22 2023-06-06 University Of Maryland, Baltimore Apparatus and method for tooth pulp vitality detection

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
JP5510796B2 (ja) * 2010-01-12 2014-06-04 独立行政法人産業技術総合研究所 低侵襲血管新生計測装置
JP5619050B2 (ja) * 2012-02-29 2014-11-05 日本電信電話株式会社 生体情報検出装置
KR101897778B1 (ko) * 2016-12-21 2018-09-12 서울대학교산학협력단 치수 검사 장치
WO2024034839A1 (fr) * 2022-08-09 2024-02-15 삼성전자 주식회사 Dispositif électronique de mesure de saturation en oxygène et procédé de commande associé

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US4836206A (en) * 1987-02-25 1989-06-06 The United States Of America As Represented By The Department Of Health And Human Services Method and device for determining viability of intact teeth
JPH07246191A (ja) * 1994-03-11 1995-09-26 Nippon Koden Corp 生理量検出装置
JP2003070752A (ja) * 2001-06-12 2003-03-11 Yoshida Dental Mfg Co Ltd 歯科用築造体を利用した生体情報計測・記録及び通信装置とこの装置の情報入出力を制御する情報制御方法

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US5040539A (en) * 1989-05-12 1991-08-20 The United States Of America Pulse oximeter for diagnosis of dental pulp pathology

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US4836206A (en) * 1987-02-25 1989-06-06 The United States Of America As Represented By The Department Of Health And Human Services Method and device for determining viability of intact teeth
JPH07246191A (ja) * 1994-03-11 1995-09-26 Nippon Koden Corp 生理量検出装置
JP2003070752A (ja) * 2001-06-12 2003-03-11 Yoshida Dental Mfg Co Ltd 歯科用築造体を利用した生体情報計測・記録及び通信装置とこの装置の情報入出力を制御する情報制御方法

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012130504A (ja) * 2010-12-21 2012-07-12 Fujifilm Corp 内視鏡システム、内視鏡システムのプロセッサ装置、及び画像生成方法
JP2015514960A (ja) * 2011-12-28 2015-05-21 ポリマー テクノロジー システムズ インコーポレーテッド 検体モニタ
JP2016535654A (ja) * 2013-11-06 2016-11-17 ケアストリーム ヘルス インク 歯周病検出システムおよび方法
JP2018115946A (ja) * 2017-01-18 2018-07-26 パイオニア株式会社 計測装置、計測方法、コンピュータプログラム及び記録媒体
US11666223B2 (en) * 2017-02-22 2023-06-06 University Of Maryland, Baltimore Apparatus and method for tooth pulp vitality detection
RU2783057C1 (ru) * 2017-12-12 2022-11-08 Конинклейке Филипс Н.В. Способ и система для улучшенной устойчивости к перемещению во время измерения локализованного воспаления ротовой полости
RU2758963C1 (ru) * 2021-01-28 2021-11-03 Сергей Дарчоевич Арутюнов Устройство для мониторинга гемодинамики тканей пародонта

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