WO2007069033A3 - Pharmaceutical compositions comprising dexibuprofen, an opiate analgesic and paracetamol - Google Patents
Pharmaceutical compositions comprising dexibuprofen, an opiate analgesic and paracetamol Download PDFInfo
- Publication number
- WO2007069033A3 WO2007069033A3 PCT/IB2006/003567 IB2006003567W WO2007069033A3 WO 2007069033 A3 WO2007069033 A3 WO 2007069033A3 IB 2006003567 W IB2006003567 W IB 2006003567W WO 2007069033 A3 WO2007069033 A3 WO 2007069033A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dexibuprofen
- paracetamol
- pharmaceutically acceptable
- opiate
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A pharmaceutical composition including a combination of a sub-therapeutic amount of the S isomer of ibuprofen, also referred to as dexibuprofen, or a pharmaceutically acceptable salt or derivative thereof, an opiate or a pharmaceutically acceptable salt or derivative thereof, and a centrally-acting cyclo-oxygenase inhibitor, as active ingredients, and a pharmaceutically acceptable carrier. A typical combination includes paracetamol, dexibuprofen and codeine, with the dexibuprofen being provided in an amount to give a daily dose of 100 mg or less. A method of treatment using a combination of a sub-therapeutic amount of dexibuprofen, an opiate and a centrally-acting cyclo-oxygenase inhibitor is also described.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ZA2005/10091 | 2005-12-12 | ||
ZA200510091 | 2005-12-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007069033A2 WO2007069033A2 (en) | 2007-06-21 |
WO2007069033A3 true WO2007069033A3 (en) | 2007-10-04 |
Family
ID=38055508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2006/003567 WO2007069033A2 (en) | 2005-12-12 | 2006-12-12 | Pharmaceutical compositions comprising dexibuprofen, an opiate analgesic and paracetamol |
Country Status (2)
Country | Link |
---|---|
WO (1) | WO2007069033A2 (en) |
ZA (1) | ZA200803566B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2711211A1 (en) * | 2008-01-03 | 2009-07-09 | Aft Pharmaceuticals Ltd. | Oral pharmaceutical suspension comprising paracetamol and ibuprofen |
GB201811858D0 (en) * | 2018-07-20 | 2018-09-05 | Wockhardt Uk Ltd | Liquid pharmaceutical composition for oral administration comprising paracetamol and codeine |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU605538B2 (en) * | 1988-01-19 | 1991-01-17 | Adcock Ingram Limited | Pharmaceutical unit |
US5164398A (en) * | 1991-04-01 | 1992-11-17 | Merck & Co., Inc. | Ibuprofen-antitussive combinations |
WO1996005834A1 (en) * | 1994-08-23 | 1996-02-29 | Smithkline Beecham Plc | Improved pharmaceutical formulations containing ibuprofen and codeine |
WO2006004449A2 (en) * | 2004-07-07 | 2006-01-12 | Aft Pharmaceuticals Limited | A combination composition |
-
2006
- 2006-12-12 WO PCT/IB2006/003567 patent/WO2007069033A2/en active Application Filing
- 2006-12-12 ZA ZA200803566A patent/ZA200803566B/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU605538B2 (en) * | 1988-01-19 | 1991-01-17 | Adcock Ingram Limited | Pharmaceutical unit |
US5164398A (en) * | 1991-04-01 | 1992-11-17 | Merck & Co., Inc. | Ibuprofen-antitussive combinations |
WO1996005834A1 (en) * | 1994-08-23 | 1996-02-29 | Smithkline Beecham Plc | Improved pharmaceutical formulations containing ibuprofen and codeine |
WO2006004449A2 (en) * | 2004-07-07 | 2006-01-12 | Aft Pharmaceuticals Limited | A combination composition |
Non-Patent Citations (6)
Title |
---|
BEUBLER E: "Clinical pharmacology of analgesics: outlook and risks", DER INTERNIST ; ORGAN DES BERUFSVERBANDES DEUTSCHER INTERNISTEN ORGAN DER DEUTSCHEN GESELLSCHAFT FÜR INNERE MEDIZIN, SPRINGER-VERLAG, BE, vol. 46, no. 10, 1 October 2005 (2005-10-01), pages 1076 - 1086, XP019320006, ISSN: 1432-1289 * |
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 17 October 1987 (1987-10-17), VLOK G J ET AL: "Comparison of a standard ibuprofen treatment regimen with a new ibuprofen/paracetamol/codeine combination in chronic osteo-arthritis.", XP002440673, Database accession no. NLM3313757 * |
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; September 1992 (1992-09-01), LOWNIE J F ET AL: "Comparison of the safety and efficacy of a combination analgesic Myprodol and Ponstan in the treatment of dental pain.", XP002440674, Database accession no. NLM9511622 * |
SOUTH AFRICAN MEDICAL JOURNAL = SUID-AFRIKAANSE TYDSKRIF VIR GENEESKUNDE 17 OCT 1987, vol. Suppl, 17 October 1987 (1987-10-17), pages 1 , 4 - 6, ISSN: 0256-9574 * |
THE JOURNAL OF THE DENTAL ASSOCIATION OF SOUTH AFRICA = DIE TYDSKRIF VAN DIE TANDHEELKUNDIGE VERENIGING VAN SUID-AFRIKA SEP 1992, vol. 47, no. 9, September 1992 (1992-09-01), pages 403 - 406, ISSN: 0011-8516 * |
WARD ET AL: "Paracetamol revisited: A review of the pharmacokinetics and pharmacodynamics", ACUTE PAIN, ELSEVIER, vol. 2, no. 3, September 1999 (1999-09-01), pages 139 - 149, XP005162523, ISSN: 1366-0071 * |
Also Published As
Publication number | Publication date |
---|---|
ZA200803566B (en) | 2009-10-28 |
WO2007069033A2 (en) | 2007-06-21 |
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