WO2007068240A3 - Peptides destines a interagir avec des structures bispiralees alpha-helicoidales et/ou des sequences bispiralees, agents derives de ceux-ci, et leur utilisation - Google Patents

Peptides destines a interagir avec des structures bispiralees alpha-helicoidales et/ou des sequences bispiralees, agents derives de ceux-ci, et leur utilisation Download PDF

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Publication number
WO2007068240A3
WO2007068240A3 PCT/DE2006/002295 DE2006002295W WO2007068240A3 WO 2007068240 A3 WO2007068240 A3 WO 2007068240A3 DE 2006002295 W DE2006002295 W DE 2006002295W WO 2007068240 A3 WO2007068240 A3 WO 2007068240A3
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WO
WIPO (PCT)
Prior art keywords
coiled
coil
peptides
sequences
derived therefrom
Prior art date
Application number
PCT/DE2006/002295
Other languages
German (de)
English (en)
Other versions
WO2007068240A2 (fr
Inventor
Carsten Mahrenholz
Michael Portwich
Original Assignee
Charite Universitaetsmedizin
Carsten Mahrenholz
Michael Portwich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charite Universitaetsmedizin, Carsten Mahrenholz, Michael Portwich filed Critical Charite Universitaetsmedizin
Priority to DE112006003448T priority Critical patent/DE112006003448A5/de
Publication of WO2007068240A2 publication Critical patent/WO2007068240A2/fr
Publication of WO2007068240A3 publication Critical patent/WO2007068240A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne de nouveaux peptides qui servent à supprimer des structures bispiralées et/ou réalisent une réaction d'addition avec celles-ci, et s'associent à des séquences bispiralées, des agents dérivés de ces peptides, et leur utilisation, de préférence pour reconnaître, marquer et agir sur des structures bispiralées et des séquences bispiralées dans un système biologique ou biotechnologique, en particulier des peptides de formule générale (abcdefg)n, dans laquelle a-g sont des radicaux acides aminés dont a et/ou d sont hydrophobes, et e et/ou g sont chargés, et n est un nombre de 1 à 3, ou des parties de ces peptides comprenant au minimum 2 et au maximum 15 radicaux acides aminés. L'invention a également pour objet des compositions pharmaceutiques contenant ces peptides et l'utilisation de tels peptides pour préparer des médicaments destinés à traiter une infection par le VIH, le virus de la grippe ou Mycobacterium tuberculosis.
PCT/DE2006/002295 2005-12-18 2006-12-18 Peptides destines a interagir avec des structures bispiralees alpha-helicoidales et/ou des sequences bispiralees, agents derives de ceux-ci, et leur utilisation WO2007068240A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE112006003448T DE112006003448A5 (de) 2005-12-18 2006-12-18 Peptide für die Wechselwirkung mit alpha-helikalen Coiled-Coil-Strukturen und/oder Coiled-Coil-Sequenzen, davon abgeleitete Mittel und ihre Verwendung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005060920A DE102005060920A1 (de) 2005-12-18 2005-12-18 Peptide für die Wechselwirkung mit alpha-helikalen Coiled-Coil-Strukturen und/oder Coiled-Coil-Sequenzen, davon abgeleitete Mittel und ihre Verwendung
DE102005060920.1 2005-12-18

Publications (2)

Publication Number Publication Date
WO2007068240A2 WO2007068240A2 (fr) 2007-06-21
WO2007068240A3 true WO2007068240A3 (fr) 2008-04-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2006/002295 WO2007068240A2 (fr) 2005-12-18 2006-12-18 Peptides destines a interagir avec des structures bispiralees alpha-helicoidales et/ou des sequences bispiralees, agents derives de ceux-ci, et leur utilisation

Country Status (2)

Country Link
DE (2) DE102005060920A1 (fr)
WO (1) WO2007068240A2 (fr)

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MX363240B (es) * 2007-06-25 2019-03-15 The Administrators Of The Tulane Educational Fund Composiciones que inhiben la influenza y métodos.
CN102305855A (zh) * 2011-05-19 2012-01-04 中山大学 体外检测结核分枝杆菌感染的试剂和方法
IN2012DE00411A (fr) * 2012-02-14 2015-06-05 Council Scient Ind Res
CN104781668B (zh) * 2012-08-29 2018-07-24 亚利桑那州评议委员会,亚利桑那州法人团体,代理和代表亚利桑那州立大学 免疫特征分析：通向早期诊断和健康监测的途径
WO2017223116A2 (fr) 2016-06-20 2017-12-28 Healthtell Inc. Procédés pour le diagnostic différentiel de maladies auto-immunes
WO2017223117A1 (fr) 2016-06-20 2017-12-28 Healthtell Inc. Méthodes pour le diagnostic et le traitement de maladies auto-immunes
JP2018070571A (ja) * 2016-11-04 2018-05-10 国立研究開発法人理化学研究所 免疫誘導剤
EP3538893A4 (fr) 2016-11-11 2020-09-23 Healthtell Inc. Procédés pour l'identification de biomarqueurs candidats
US12025615B2 (en) 2017-09-15 2024-07-02 Arizona Board Of Regents On Behalf Of Arizona State University Methods of classifying response to immunotherapy for cancer
WO2021067550A1 (fr) 2019-10-02 2021-04-08 Arizona Board Of Regents On Behalf Of Arizona State University Procédés et compositions pour identifier des néo-antigènes destinés à être utilisés dans le traitement et la prévention du cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000267A1 (fr) * 1995-06-16 1997-01-03 Pence Composition de banques combinatoires a limitation conformationnelle et procedes d'utilisation
WO1998032848A1 (fr) * 1997-01-28 1998-07-30 The Regents Of The University Of California Sondes peptidiques pour proteines superenroulees et methodes pour les preparer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000267A1 (fr) * 1995-06-16 1997-01-03 Pence Composition de banques combinatoires a limitation conformationnelle et procedes d'utilisation
WO1998032848A1 (fr) * 1997-01-28 1998-07-30 The Regents Of The University Of California Sondes peptidiques pour proteines superenroulees et methodes pour les preparer

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BURKHARD P ET AL: "Design of a minimal protein oligomerization domain by a structural approach.", PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY DEC 2000, vol. 9, no. 12, December 2000 (2000-12-01), pages 2294 - 2301, XP009092318, ISSN: 0961-8368 *
BURKHARD P ET AL: "Improving Coiled-coil Stability by Optimizing Ionic Interactions", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 318, no. 3, 3 May 2002 (2002-05-03), pages 901 - 910, XP004449573, ISSN: 0022-2836 *
COLE JAMES L ET AL: "Thermodynamics of peptide inhibitor binding to HIV-1 gp41", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 40, no. 19, 15 May 2001 (2001-05-15), pages 5633 - 5641, XP002170633, ISSN: 0006-2960 *
MANT C T ET AL: "Effect of mobile phase on the oligomerization state of alpha-helical coiled-coil peptides during high-performance size-exclusion chromatography", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, vol. 791, no. 1-2, 12 December 1997 (1997-12-12), pages 85 - 98, XP004107599, ISSN: 0021-9673 *
PECHAR ET AL., MACROMOL. BIOSCI., vol. 2, no. 5, 2002, pages 199 - 206, XP009092285 *
SIA SAMUEL K ET AL: "Short constrained peptides that inhibit HIV-1 entry.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 12 NOV 2002, vol. 99, no. 23, 12 November 2002 (2002-11-12), pages 14664 - 14669, XP009092286, ISSN: 0027-8424 *
SU J Y ET AL: "Effect of chain length on the formation and stability of synthetic alpha-helical coiled coils.", BIOCHEMISTRY 27 DEC 1994, vol. 33, no. 51, 27 December 1994 (1994-12-27), pages 15501 - 15510, XP002458954, ISSN: 0006-2960 *
VANDERMEULEN & KLOK, POLYMER PREPRINTS, vol. 42, no. 2, 2001, pages 84 - 85, XP009092282 *

Also Published As

Publication number Publication date
DE112006003448A5 (de) 2008-09-25
DE102005060920A1 (de) 2007-06-21
WO2007068240A2 (fr) 2007-06-21
DE112006003448A8 (de) 2010-09-09

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