WO2007068240A3 - Peptides interacting with alpha-helical coiled-coil structures and/or coiled-coil sequences, substances derived therefrom, and use thereof - Google Patents

Peptides interacting with alpha-helical coiled-coil structures and/or coiled-coil sequences, substances derived therefrom, and use thereof Download PDF

Info

Publication number
WO2007068240A3
WO2007068240A3 PCT/DE2006/002295 DE2006002295W WO2007068240A3 WO 2007068240 A3 WO2007068240 A3 WO 2007068240A3 DE 2006002295 W DE2006002295 W DE 2006002295W WO 2007068240 A3 WO2007068240 A3 WO 2007068240A3
Authority
WO
WIPO (PCT)
Prior art keywords
coiled
coil
peptides
sequences
derived therefrom
Prior art date
Application number
PCT/DE2006/002295
Other languages
German (de)
French (fr)
Other versions
WO2007068240A2 (en
Inventor
Carsten Mahrenholz
Michael Portwich
Original Assignee
Charite Universitaetsmedizin
Carsten Mahrenholz
Michael Portwich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charite Universitaetsmedizin, Carsten Mahrenholz, Michael Portwich filed Critical Charite Universitaetsmedizin
Priority to DE112006003448T priority Critical patent/DE112006003448A5/en
Publication of WO2007068240A2 publication Critical patent/WO2007068240A2/en
Publication of WO2007068240A3 publication Critical patent/WO2007068240A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to novel peptides for neutralizing and/or attaching to coiled-coil structures and associating with coiled-coil sequences, substances that are derived therefrom, and the use thereof, preferably for detecting, marking, and influencing coiled-coil structures and sequences in a biological or biotechnological system, particularly peptides of general formula (abcdefg)n, wherein a to g represent amino acid radicals, among which a and/or d are hydrophobic while e and/or g are loaded, and n represents a number between 1 and 3, or fractions thereof that are composed of a minimum of 2 and a maximum of 15 amino acid radicals. The invention further relates to pharmaceutical compositions containing novel peptides and the use of such peptides for producing medicaments used for the treatment of HIV, influenza virus, or Mycobacterium tuberculosis infections.
PCT/DE2006/002295 2005-12-18 2006-12-18 Peptides interacting with alpha-helical coiled-coil structures and/or coiled-coil sequences, substances derived therefrom, and use thereof WO2007068240A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE112006003448T DE112006003448A5 (en) 2005-12-18 2006-12-18 Peptides for interaction with alpha-helical coiled-coil structures and / or coiled-coil sequences, means derived therefrom and their use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005060920.1 2005-12-18
DE102005060920A DE102005060920A1 (en) 2005-12-18 2005-12-18 Peptides for interaction with alpha-helical coiled-coil structures and / or coiled-coil sequences, means derived therefrom and their use

Publications (2)

Publication Number Publication Date
WO2007068240A2 WO2007068240A2 (en) 2007-06-21
WO2007068240A3 true WO2007068240A3 (en) 2008-04-10

Family

ID=38089507

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2006/002295 WO2007068240A2 (en) 2005-12-18 2006-12-18 Peptides interacting with alpha-helical coiled-coil structures and/or coiled-coil sequences, substances derived therefrom, and use thereof

Country Status (2)

Country Link
DE (2) DE102005060920A1 (en)
WO (1) WO2007068240A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2691358C (en) * 2007-06-25 2017-08-22 The Administrators Of The Tulane Educational Fund Influenza inhibiting compositions comprising hemagglutinin 2-derived peptides and use thereof
CN102305855A (en) * 2011-05-19 2012-01-04 中山大学 Reagent and method for detecting Mycobacterium tuberculosis infection in vitro
BR112014020153A2 (en) 2012-02-14 2017-07-04 Council Scient Ind Res synthetic peptides capable of binding to influenza hemagglutinin protein
JP6463678B2 (en) * 2012-08-29 2019-02-06 アリゾナ ボード オブ リージェンツ ア ボディ コーポレート オブ ザ ステイト オブ アリゾナ アクティング フォー アンド オン ビハーフ オブ アリゾナ ステイト ユニバーシティーＡｒｉｚｏｎａ Ｂｏａｒｄ Ｏｆ Ｒｅｇｅｎｔｓ， Ａ Ｂｏｄｙ Ｃｏｒｐｏｒａｔｅ Ｏｆ Ｔｈｅ Ｓｔａｔｅ Ｏｆ Ａｒｉｚｏｎａ Ａｃｔｉｎｇ Ｆｏｒ Ａｎｄ Ｏｎ Ｂｅｈａｌｆ Ｏｆ Ａｒｉｚｏｎａ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Immune signature: methods for early diagnosis and health monitoring
AU2017281039A1 (en) 2016-06-20 2019-01-24 Healthtell Inc. Methods for differential diagnosis of autoimmune diseases
CN109790203A (en) 2016-06-20 2019-05-21 健康之语公司 The diagnostic and therapeutic method of autoimmune disease
JP2018070571A (en) * 2016-11-04 2018-05-10 国立研究開発法人理化学研究所 Immunity inducing agent
CN110168370A (en) 2016-11-11 2019-08-23 健康之语公司 Method for identifying candidate biomarker
WO2019055618A1 (en) 2017-09-15 2019-03-21 Arizona Board Of Regents On Behalf Of Arizona State University Methods of classifying response to immunotherapy for cancer
WO2021067550A1 (en) 2019-10-02 2021-04-08 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for identifying neoantigens for use in treating and preventing cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000267A1 (en) * 1995-06-16 1997-01-03 Pence Conformationally-restricted combinatorial library composition and method
WO1998032848A1 (en) * 1997-01-28 1998-07-30 The Regents Of The University Of California Peptide probes to coil proteins and methods for making the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000267A1 (en) * 1995-06-16 1997-01-03 Pence Conformationally-restricted combinatorial library composition and method
WO1998032848A1 (en) * 1997-01-28 1998-07-30 The Regents Of The University Of California Peptide probes to coil proteins and methods for making the same

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BURKHARD P ET AL: "Design of a minimal protein oligomerization domain by a structural approach.", PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY DEC 2000, vol. 9, no. 12, December 2000 (2000-12-01), pages 2294 - 2301, XP009092318, ISSN: 0961-8368 *
BURKHARD P ET AL: "Improving Coiled-coil Stability by Optimizing Ionic Interactions", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 318, no. 3, 3 May 2002 (2002-05-03), pages 901 - 910, XP004449573, ISSN: 0022-2836 *
COLE JAMES L ET AL: "Thermodynamics of peptide inhibitor binding to HIV-1 gp41", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 40, no. 19, 15 May 2001 (2001-05-15), pages 5633 - 5641, XP002170633, ISSN: 0006-2960 *
MANT C T ET AL: "Effect of mobile phase on the oligomerization state of alpha-helical coiled-coil peptides during high-performance size-exclusion chromatography", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, vol. 791, no. 1-2, 12 December 1997 (1997-12-12), pages 85 - 98, XP004107599, ISSN: 0021-9673 *
PECHAR ET AL., MACROMOL. BIOSCI., vol. 2, no. 5, 2002, pages 199 - 206, XP009092285 *
SIA SAMUEL K ET AL: "Short constrained peptides that inhibit HIV-1 entry.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 12 NOV 2002, vol. 99, no. 23, 12 November 2002 (2002-11-12), pages 14664 - 14669, XP009092286, ISSN: 0027-8424 *
SU J Y ET AL: "Effect of chain length on the formation and stability of synthetic alpha-helical coiled coils.", BIOCHEMISTRY 27 DEC 1994, vol. 33, no. 51, 27 December 1994 (1994-12-27), pages 15501 - 15510, XP002458954, ISSN: 0006-2960 *
VANDERMEULEN & KLOK, POLYMER PREPRINTS, vol. 42, no. 2, 2001, pages 84 - 85, XP009092282 *

Also Published As

Publication number Publication date
DE102005060920A1 (en) 2007-06-21
DE112006003448A8 (en) 2010-09-09
DE112006003448A5 (en) 2008-09-25
WO2007068240A2 (en) 2007-06-21

Similar Documents

Publication Publication Date Title
WO2007068240A3 (en) Peptides interacting with alpha-helical coiled-coil structures and/or coiled-coil sequences, substances derived therefrom, and use thereof
IL180727A (en) Anti-fungal peptides comprising an arginine- and/or lysine-containing motif
EP2426141A3 (en) Method for preventing or treating M tuberculosis infection
WO2008052173A8 (en) Novel h5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use
WO2007062160A8 (en) Methods and compositions for sequencing a nucleic acid
EP2583976A3 (en) Peptide vaccines with SEQ ID NO: 210, 196, 202, 213, 214, 214 or 223 for cancers expressing tumor-associated antigens
WO2004096842A3 (en) Sars virus nucleotide and amino acid sequences and uses thereof
WO2008128775A3 (en) Stabilised pharmaceutical composition containing pregabaline
WO2007010080A3 (en) Novel carbosilane dendrimers, preparation method thereof and use of same
UA100127C2 (en) Peptide cdh3 and drug containing it
EP2481748A3 (en) Foxp3 peptide vaccine
WO2006138745A3 (en) Therapeutic peptides and vaccines
WO2006000213A3 (en) Peptides for inhibiting the interaction of protein kinase a and protein kinase a anchor proteins
WO2005059131A3 (en) Protein binding miniature proteins and uses thereof
WO2010057275A8 (en) Cyclic peptides and uses thereof
MX2010005816A (en) Stat3 epitope peptides.
WO2007066018A3 (en) Novel peptides and the biological use thereof
WO2009101604A3 (en) Recombinant lumpy skin disease virus for preventing aids
WO2007110772A8 (en) Immunomodulating oligopeptides
WO2009130256A3 (en) Tat protein for preventing or treating aids
WO2008076370A3 (en) P21 compositions and methods for the treatment of hiv
WO2007111628A3 (en) Mxa as an antiviral drug and as a target for identification of antiviral drugs for dna virus infections
ATE368117T1 (en) COMPLETE GENE SEQUENCE OF THE DONKEY LEUKOCYTE VACCINE STRAIN OF THE EQUINE INFECTIOUS ANEMIA VIRUS AND ITS APPLICATION
JP2006525223A5 (en)
WO2004032869A3 (en) Identification of anti-hiv compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1120060034480

Country of ref document: DE

REF Corresponds to

Ref document number: 112006003448

Country of ref document: DE

Date of ref document: 20080925

Kind code of ref document: P

122 Ep: pct application non-entry in european phase

Ref document number: 06828721

Country of ref document: EP

Kind code of ref document: A2