WO2007067770A3 - Pharmaceutical compositions and methods for improved bacterial eradication - Google Patents

Pharmaceutical compositions and methods for improved bacterial eradication Download PDF

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Publication number
WO2007067770A3
WO2007067770A3 PCT/US2006/047040 US2006047040W WO2007067770A3 WO 2007067770 A3 WO2007067770 A3 WO 2007067770A3 US 2006047040 W US2006047040 W US 2006047040W WO 2007067770 A3 WO2007067770 A3 WO 2007067770A3
Authority
WO
WIPO (PCT)
Prior art keywords
penicillin
methods
pharmaceutical compositions
mic90
day
Prior art date
Application number
PCT/US2006/047040
Other languages
French (fr)
Other versions
WO2007067770A2 (en
Inventor
Henry H Flanner
Robert J Guttendorf
Susan P Clausen
Donald Treacy
Beth A Burnside
Original Assignee
Advancis Pharmaceutical Corp
Henry H Flanner
Robert J Guttendorf
Susan P Clausen
Donald Treacy
Beth A Burnside
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advancis Pharmaceutical Corp, Henry H Flanner, Robert J Guttendorf, Susan P Clausen, Donald Treacy, Beth A Burnside filed Critical Advancis Pharmaceutical Corp
Priority to AU2006321782A priority Critical patent/AU2006321782B2/en
Priority to CA2635378A priority patent/CA2635378C/en
Priority to EP06845116A priority patent/EP1968586A4/en
Publication of WO2007067770A2 publication Critical patent/WO2007067770A2/en
Publication of WO2007067770A3 publication Critical patent/WO2007067770A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed are once-a-day penicillin-type antibiotic products, comprising at least one modified release dosage form comprising penicillin-type antibiotics and pharmaceutically acceptable carriers, that are administered once-a-day in a dosage and for a number of days that provide a Total T>MIC that is sufficient to achieve at least the minimum amount of bacterial eradication for treatment of a bacterial infection. In one embodiment the products provide a T>MIC90 in the serum for at least 5 hours (preferably for at least five consecutive hours), within a 24-hour dosing interval, for a given bacterial pathogen's MIC90, while providing a total dosage of the penicillin-type antibiotic for a 24-hour dosing interval.
PCT/US2006/047040 2005-12-08 2006-12-08 Pharmaceutical compositions and methods for improved bacterial eradication WO2007067770A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2006321782A AU2006321782B2 (en) 2005-12-08 2006-12-08 Pharmaceutical compositions and methods for improved bacterial eradication
CA2635378A CA2635378C (en) 2005-12-08 2006-12-08 Pharmaceutical compositions and methods for improved bacterial eradication
EP06845116A EP1968586A4 (en) 2005-12-08 2006-12-08 Pharmaceutical compositions and methods for improved bacterial eradication

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74866005P 2005-12-08 2005-12-08
US60/748,660 2005-12-08
US79810906P 2006-05-05 2006-05-05
US60/798,109 2006-05-05

Publications (2)

Publication Number Publication Date
WO2007067770A2 WO2007067770A2 (en) 2007-06-14
WO2007067770A3 true WO2007067770A3 (en) 2008-02-21

Family

ID=38123546

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/047040 WO2007067770A2 (en) 2005-12-08 2006-12-08 Pharmaceutical compositions and methods for improved bacterial eradication

Country Status (4)

Country Link
EP (1) EP1968586A4 (en)
AU (1) AU2006321782B2 (en)
CA (1) CA2635378C (en)
WO (1) WO2007067770A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544555B2 (en) * 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
WO2005030178A1 (en) * 2003-09-30 2005-04-07 Lupin Ltd. Extended release formulation of beta-lactam antibiotics

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7966694A (en) * 1993-07-21 1996-05-02 University Of Kentucky Research Foundation, The A multicompartment hard capsule with control release properties
US6610328B2 (en) * 2000-02-24 2003-08-26 Advancis Pharmaceutical Corp. Amoxicillin-clarithromycin antibiotic composition
US6730320B2 (en) * 2000-02-24 2004-05-04 Advancis Pharmaceutical Corp. Tetracycline antibiotic product, use and formulation thereof
EA011215B1 (en) * 2003-02-21 2009-02-27 Лек Фармасьютиклз Д.Д. Therapeutic system comprising amoxicillin and clavulanic acid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544555B2 (en) * 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
WO2005030178A1 (en) * 2003-09-30 2005-04-07 Lupin Ltd. Extended release formulation of beta-lactam antibiotics

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CRAIG: "Pharmacokinetic/Pharmcodynamic Parameters: Rationale for Antibacterial Dosing of Mice and Men", CLINICAL INFECTIOUS DISEASES, vol. 2, January 1998 (1998-01-01), pages 1 - 12, XP009043536 *

Also Published As

Publication number Publication date
EP1968586A4 (en) 2011-12-21
CA2635378C (en) 2015-06-16
WO2007067770A2 (en) 2007-06-14
CA2635378A1 (en) 2007-06-14
AU2006321782B2 (en) 2012-11-29
AU2006321782A1 (en) 2007-06-14
EP1968586A2 (en) 2008-09-17

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