WO2007057724A1 - Hollow pin for the creation of frozen zones - Google Patents
Hollow pin for the creation of frozen zones Download PDFInfo
- Publication number
- WO2007057724A1 WO2007057724A1 PCT/IB2005/003526 IB2005003526W WO2007057724A1 WO 2007057724 A1 WO2007057724 A1 WO 2007057724A1 IB 2005003526 W IB2005003526 W IB 2005003526W WO 2007057724 A1 WO2007057724 A1 WO 2007057724A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hollow pin
- tissue
- freezing
- gas
- cryogenic gas
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0262—Characteristics of handpieces or probes using a circulating cryogenic fluid
Definitions
- cryogenic gas there are a variety of dosing devices that apply cryogenic gas to tissue in the medical field. This has the consequence that due to the cryogenic gases cryogenic distribution zones are generated in the tissue in that heat is removed from the surrounding tissue, thus this iced.
- the icing causes when temperatures of more than -40 0 C tissue is present that cells are killed. This is desirable, for example, when cancer cells in the derma are to be eliminated.
- cryogenic gas for example, to heal skin lesions favorably.
- the technique used can vary between so-called spray freezing, contact freezing or liquid freezing.
- the tissue zone is acted upon from the outside with cryogenic gas.
- the efficient technology is certainly the liquid freezing, since the refrigerant consumption is directly close to the theoretically required refrigerant demand.
- the specific evaporation temperature is constantly available during the therapy. This is necessary in order to achieve reproducible healing results.
- the externally applied effective freezing zone with -40 0 C in the tissue with the application of N 2 O to max. 3mm depth is enough.
- N 2 is used , the freezing temperature of -1 96 ° C results in a freezing depth of max. 5mm at -40 0 C. This limits for certain lesions that are far deeper in the tissue, which then did not get the necessary destruction temperature.
- the object of the invention is therefore to provide a device which can produce destructions on the one hand with liquid cryogenic gas in deep-lying tissue zones, but on the other hand tissue damage is reliably excluded by the expanding gas.
- the object is achieved in that in the region of the indication zone a one-side open hollow pin (or more) is introduced into the tissue, while the open side is used for filling liquid cryogenic gas.
- the liquid gas relaxation takes place in the interior of the hollow pin, thereby removing the heat from the adjacent tissue.
- the hollow pin is provided on the closed side with a patient-compatible tip.
- the hollow pin consists of good conductive material and should have a gold coating for reasons of biocompatibility.
- the hollow pin is sterilizable and reusable.
- the hollow pin shape is selected according to the requirements made. In nest-like lesions in tissue a hollow pin is connected BEZW with a heat-insulated exhaust pipe. Exhaust hose used to effectively prevent a freezing zone at the Gewebeinstechkanal and sure the relaxed gas is discharged. The loading of the hollow pin via a hand-guided supply line.
- This may be, for example, a stainless steel capillary which places the cryogenic gas within the hollow pin and then immediately withdrawn.
- the gas release takes place via the insulated exhaust pipe BEZW. via the insulated hose line into the atmosphere.
- the position of the hollow pin is shown so that its open side is in contact with the surrounding atmosphere and protrudes slightly out of the tissue.
- the liquid cryogenic gas is introduced through the opening of the valve 4 through the microcapillary into the hollow pin. After reaching the desired freezing result, the valve is closed and the microcapillary pulled out.
- the gas relaxation and this takes place in the atmosphere, between the free space of the hollow pin and the microcapillary derived.
- the hollow pin can be connected with an insulating tube or tube to an endoscopy and temperature control device to be brought to the lesion.
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- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Abstract
The invention relates to a hollow pin which is optionally connected to a thermally insulated exhaust gas pipe or tube and is impinged upon by cryogenic gas in order to create frozen zones in tissue. The aim of the invention is to be able to obtain frozen zones of less than -40 °C which are located deep down in the tissue. Said aim is achieved by introducing a hollow pin that is closed on one side and comprises an insulated exhaust gas pipe/tube into the tissue and impinging said hollow pin with liquid cryogenic gas, e.g. N<SUB>2</SUB>O, with the aid of a separate mobile feed line. Impinging the hollow pin with liquid N<SUB>2</SUB>O having a latent heat of -89 <SUP>°</SUP>C creates frozen zones of less than -40 °C in the tissue.
Description
HOHLSTIFT ZUR ERZEUGUNG VON GEFRIERZONEN HOLLOW PENCIL FOR THE PRODUCTION OF FREEZING ZONES
Beschreibungdescription
Bekαnnterweise gibt es eine Vielzahl von Dosierungsapparaten, mit denen cryogenes Gas im medizinischen Bereich auf Gewebe appliziert wird. Das hat zur Folge, daß aufgrund der Tiefsttemperaturen der cryogenen Gase Distributionszonen im Gewebe erzeugt werden dadurch, daß Wärme dem umliegenden Gewebe entzogen wird, somit dieses dann vereist. Die Vereisung bewirkt, wenn Temperaturen von mehr als -400C am Gewebe vorliegt, dass Zellen abgetötet werden. Das ist zum Beispiel erwünscht, wenn Krebszellen in der Derma eliminiert werden sollen. Es gibt bereits ein großes Erfahrungspotenzial mit cryogenem Gas, zum Beispiel Hautläsionen vorteilhaft zu heilen.Conventionally, there are a variety of dosing devices that apply cryogenic gas to tissue in the medical field. This has the consequence that due to the cryogenic gases cryogenic distribution zones are generated in the tissue in that heat is removed from the surrounding tissue, thus this iced. The icing causes when temperatures of more than -40 0 C tissue is present that cells are killed. This is desirable, for example, when cancer cells in the derma are to be eliminated. There is already a great deal of experience with cryogenic gas, for example, to heal skin lesions favorably.
Die dabei angewandte Technik kann je nach vorliegenden bestimmten Kriterien variieren zwischen dem sogenannten Spray-freezing, Kontakt- freezing oder Liquid-freezing.Depending on the given criteria, the technique used can vary between so-called spray freezing, contact freezing or liquid freezing.
Bei diesen genannten Prinzipien wird die Gewebszone von außen mit cryogenem Gas beaufschlagt. Die effiziente Technik ist sicher das Liquid- freezing, da hier der Kältemittelverbrauch unmittelbar dicht bei dem theoretisch erforderlichen Kältemittelbedarf liegt. Weiterhin hat man durch das Applizieren der reinen Flüssig-Phase die spezifische Verdampfungstemperatur ständig bei der Therapie zur Verfügung. Das ist wiederum vonnöten, um reproduzierbare Heilerfolge zu erzielen. Die Praxis hat nun gezeigt, daß die von außen applizierte wirksame Gefrierzone mit -400C im Gewebe bei der Anwendung von N2O bis max. 3mm Tiefe reicht. Bei Verwendung von N2 erreicht man aufgrund der niedrigeren Verdampfungstemperatur von -1 96° eine Gefriertiefe von max. 5mm bei -400C. Damit sind Grenzen gesetzt für bestimmte Läsionen, die weit tiefer im Gewebe liegen, die dann nicht die notwendige Destruktionstemperatur bekommen. Um auch brauchbare Destruktionen in tieferliegenden Gewebezonen zu erreichen, wird bei einer bekannten
Ausführung mithilfe ähnlich einer Injektionskanüle tiefer im Gewebe an der entsprechenden Läsion das flüssige cryogene Gas plaziert. Bei der anschließenden Gasentspannung kann es zu vagabundierenden Gasausbrüchen kommen, die bei bestimmten Indikationen nicht erwünscht sind und auch Gewebeschäden verursachen können. Die Aufgabe der Erfindung besteht nun darin, eine Vorrichtung zu schaffen, die einerseits mit flüssigem cryogenen Gas in tiefliegenden Gewebezonen Destruktionen erzeugen kann, andererseits aber Gewebeschäden durch das expandierende Gas sicher ausgeschlossen ist.In these principles, the tissue zone is acted upon from the outside with cryogenic gas. The efficient technology is certainly the liquid freezing, since the refrigerant consumption is directly close to the theoretically required refrigerant demand. Furthermore, by applying the pure liquid phase, the specific evaporation temperature is constantly available during the therapy. This is necessary in order to achieve reproducible healing results. Practice has now shown that the externally applied effective freezing zone with -40 0 C in the tissue with the application of N 2 O to max. 3mm depth is enough. When N 2 is used , the freezing temperature of -1 96 ° C results in a freezing depth of max. 5mm at -40 0 C. This limits for certain lesions that are far deeper in the tissue, which then did not get the necessary destruction temperature. In order to achieve useful destructions in deeper tissue zones, is in a known Performing similar to an injection cannula deeper into the tissue at the corresponding lesion, the liquid cryogenic gas placed. In the subsequent gas relaxation can lead to straying gas outbreaks, which are not desirable in certain indications and can also cause tissue damage. The object of the invention is therefore to provide a device which can produce destructions on the one hand with liquid cryogenic gas in deep-lying tissue zones, but on the other hand tissue damage is reliably excluded by the expanding gas.
Erfindungsgemäß wird die Aufgabe dadurch gelöst, daß im Bereich der Indikationszone ein einserseits offener Hohlstift (oder mehrere) in das Gewebe eingebracht wird, dabei die offene Seite zum Einfüllen von flüssigem cryogenen Gas benutzt wird. Die Flüssig-Gasentspannung findet dabei im Inneren des Hohlstift statt und entzieht dabei dem anliegenden Gewebe die Wärme.According to the invention the object is achieved in that in the region of the indication zone a one-side open hollow pin (or more) is introduced into the tissue, while the open side is used for filling liquid cryogenic gas. The liquid gas relaxation takes place in the interior of the hollow pin, thereby removing the heat from the adjacent tissue.
Damit tritt der Destruktionsprozeß ein. Nachdem die Gefrierung beendet ist, kann der Hohlstift aus dem Gewebe mühelos entfernt werden. Damit hat der typische Anfriereffekt seine Wirkung versagt. Der Hohlstift ist an der geschlossenen Seite mit einer patientenverträglichen Spitze versehen. Der Hohlstift besteht aus gutleitendem Material und sollte einen Goldüberzug aus Bikompatibilitätsgründen haben. Der Hohlstift ist sterilisierbar und mehrfach verwendbar. Die Hohlstiftform ist den entsprechenden Anforderungen gefertigt ausgewählt. Bei nestartigen Läsionen im Gewebe wird ein Hohlstift verbunden mit einem wärmeisolierten Abgasrohr bezw. Abgasschlauch verwendet, damit an dem Gewebeeinstechkanal wirksam eine Angefrierzone verhindert wird und sicher das entspannte Gas abgeführt wird. Die Beaufschlagung des Hohlstiftes erfolgt über eine mit Hand geführte Versorgungsleitung. Diese kann zum Beispiel eine Edelstahlkapillare sein, die innerhalb des Hohlstifts das cryogene Gas plaziert und danach sofort wieder herausgezogen wird. Die Gasentspannung erfolgt über das isolierte Abgasrohr
bezw. über die isolierte Schlauchleitung in die Atmosphäre. In der Zeichnung Nr. 1 ist die Position des Hohlstifts so dargestellt, daß seine offene Seite mit der umliegenden Atmosphäre Kontakt hat und etwas aus dem Gewebe herausragt. Über die Gasquelle 3 wird durch die Öffnung des Ventils 4 das flüssige cryogene Gas durch die Mikrokapillare in den Hohlstift eingeleitet. Nach dem Erreichen des gewünschten Gefrierergebnisses wird das Ventil geschlossen und die Mikrokapillare herausgezogen. Während der Beaufschlagung mit flüssigem cryogenen Gas erfolgt die Gasentspannung und dieses in die Atmosphäre, zwischen dem Freiraum des Hohlstiftes und der Mikrokapillare abgeleitet. Die Zeichnung Nr. 2 zeigt die Möglichkeit Gefriernester in tiefliegendem Gewebe zu erzeugen. Hier wird mit Hilfe des wärmeisolierenden Abgasrohres- oder Abgasschlauches Pos. 8 ein möglicher Anfriereffekt am Gewebe durch die abgeleitete entspannte Gasmenge verhindert und dieses kontrolliert in die Atmosphäre abgeleitet. Um diesen Destruktionsverlauf überwachen zu können, kann der Hohlstift mit Isolierrohr oder Schlauch mit einem Endoskopie- und Temperaturkontrollgerät verbunden, an die Läsion herangeführt werden.
Thus the destruction process begins. After the freezing is completed, the hollow pin can be easily removed from the tissue. Thus, the typical freezing effect has failed its effect. The hollow pin is provided on the closed side with a patient-compatible tip. The hollow pin consists of good conductive material and should have a gold coating for reasons of biocompatibility. The hollow pin is sterilizable and reusable. The hollow pin shape is selected according to the requirements made. In nest-like lesions in tissue a hollow pin is connected BEZW with a heat-insulated exhaust pipe. Exhaust hose used to effectively prevent a freezing zone at the Gewebeinstechkanal and sure the relaxed gas is discharged. The loading of the hollow pin via a hand-guided supply line. This may be, for example, a stainless steel capillary which places the cryogenic gas within the hollow pin and then immediately withdrawn. The gas release takes place via the insulated exhaust pipe BEZW. via the insulated hose line into the atmosphere. In the drawing No. 1, the position of the hollow pin is shown so that its open side is in contact with the surrounding atmosphere and protrudes slightly out of the tissue. Via the gas source 3, the liquid cryogenic gas is introduced through the opening of the valve 4 through the microcapillary into the hollow pin. After reaching the desired freezing result, the valve is closed and the microcapillary pulled out. During the application of liquid cryogenic gas, the gas relaxation and this takes place in the atmosphere, between the free space of the hollow pin and the microcapillary derived. The drawing no. 2 shows the possibility to produce freezer in low-lying tissue. Here, with the help of the heat-insulating Abgasrohres- or exhaust hose Pos. 8 prevents a possible freezing effect on the fabric by the derived expanded gas and this controlled in the atmosphere derived. In order to be able to monitor this destruction process, the hollow pin can be connected with an insulating tube or tube to an endoscopy and temperature control device to be brought to the lesion.
Claims
1 . Betrifft den Patentanspruch eines Hohlstiftes für das Gefrieren von Gewebe im medizinischen Bereich, der in das Gewebe kurzzeitig während der Gefrierphase implantiert wird, dadurch gekennzeichnet, daß er einseitig eine geschlossene Spitze hat und von seiner offenen Seite her mit flüssigem cryogenen Gas beaufschlagt werden kann.1 . Concerns the claim of a hollow pin for the freezing of tissue in the medical field, which is implanted in the tissue for a short time during the freezing phase, characterized in that it unilaterally has a closed tip and can be acted upon from its open side with liquid cryogenic gas.
2. Anspruch nach 1 dadurch gekennzeichnet, daß der Hohlstift aus einem gutwärmeleitenden Material besteht, vorzugsweise aus Kupfer und einer sehr dünnen Mantelflächenstärke nicht mehr als 0, 1 mm hat.2. Claim 1 characterized in that the hollow pin consists of a good heat conducting material, preferably of copper and a very thin lateral surface thickness not more than 0, 1 mm.
3. Anspruch nach 1 und 2 dadurch gekennzeichnet, daß der Hohlstift mit einem isolierten Abgasrohr- oder Abgasschlauch verbunden ist, um auch tief im Gewebe Gefriernester zu erzeugen, durch diesen ein Anfriereffekt desselben am Gewebe verhindert wird, aber wirksam kontrolliert die Gasentspannung zurück in die Atmosphäre sichert.3. claim according to 1 and 2, characterized in that the hollow pin is connected to an insulated Abgasrohr- or exhaust hose to produce low in tissue Gefriernester, by this a freezing effect of the same on the tissue is prevented, but effectively controls the gas relaxation back into the Atmosphere secures.
4. Anspruch nach 1 , 2 und 3 dadurch gekennzeichnet, daß der Hohlstift entsprechend des Einsatzgebietes bestimmter Läsionen in zweckentsprechender Form gestaltet ist und ungehindert über den isolierten Abgasrohr- oder isolierter Abgasschlauch von einer Quelle über eine z.B. flexible Edelstahlmikrokapillare mit flüssigem cryogenem Gas beaufschlagt werden kann.4. Claim according to 1, 2 and 3, characterized in that the hollow pin is designed according to the application of certain lesions in appropriate form and unhindered over the isolated exhaust pipe or insulated exhaust hose from a source via a e.g. Flexible stainless steel micro capillary can be acted upon with liquid cryogenic gas.
5. Anspruch nach 1 , 2 , 3 und 4 dadurch gekennzeichnet, daß der Hohlstift vorzugsweise aus Kupfer besteht, einen Goldüberzug hat, um die Bikompatibilität zu erfüllen.5. Claim 1, 2, 3 and 4, characterized in that the hollow pin is preferably made of copper, has a gold coating in order to meet the Bikompatibilität.
6. Anspruch nach 1 dadurch gekennzeichnet, daß der Hohlstift zusammen mit einem Endoskopiegerät und einer Temperaturmeßeinheit verbunden ist, um den Destruktionsverlauf in der zu behandelnden Zone überwachen zu können. 6. Claim according to 1, characterized in that the hollow pin is connected together with an endoscopy device and a Temperaturmeßeinheit to monitor the destruction process in the zone to be treated can.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/IB2005/003526 WO2007057724A1 (en) | 2005-11-17 | 2005-11-17 | Hollow pin for the creation of frozen zones |
Applications Claiming Priority (1)
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PCT/IB2005/003526 WO2007057724A1 (en) | 2005-11-17 | 2005-11-17 | Hollow pin for the creation of frozen zones |
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PCT/IB2005/003526 WO2007057724A1 (en) | 2005-11-17 | 2005-11-17 | Hollow pin for the creation of frozen zones |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1402632A (en) * | 1972-02-02 | 1975-08-13 | Wilkinson Sword Ltd | Medical equipment |
WO1983003961A1 (en) * | 1982-05-17 | 1983-11-24 | Andrzej Kamil Drukier | Cryoprobes, especially for the cryosurgery of deeply lying lesions |
US6503246B1 (en) * | 2000-07-05 | 2003-01-07 | Mor Research Applications Ltd. | Cryoprobe and method of treating scars |
US6575969B1 (en) * | 1995-05-04 | 2003-06-10 | Sherwood Services Ag | Cool-tip radiofrequency thermosurgery electrode system for tumor ablation |
US6786902B1 (en) * | 1996-06-24 | 2004-09-07 | Allegheny-Singer Research Institute | Method and apparatus for cryosurgery |
-
2005
- 2005-11-17 WO PCT/IB2005/003526 patent/WO2007057724A1/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1402632A (en) * | 1972-02-02 | 1975-08-13 | Wilkinson Sword Ltd | Medical equipment |
WO1983003961A1 (en) * | 1982-05-17 | 1983-11-24 | Andrzej Kamil Drukier | Cryoprobes, especially for the cryosurgery of deeply lying lesions |
US6575969B1 (en) * | 1995-05-04 | 2003-06-10 | Sherwood Services Ag | Cool-tip radiofrequency thermosurgery electrode system for tumor ablation |
US6786902B1 (en) * | 1996-06-24 | 2004-09-07 | Allegheny-Singer Research Institute | Method and apparatus for cryosurgery |
US6503246B1 (en) * | 2000-07-05 | 2003-01-07 | Mor Research Applications Ltd. | Cryoprobe and method of treating scars |
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