WO2007056905A1 - Systeme d'ablation de tumeur hifu - Google Patents

Systeme d'ablation de tumeur hifu Download PDF

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Publication number
WO2007056905A1
WO2007056905A1 PCT/CN2006/000322 CN2006000322W WO2007056905A1 WO 2007056905 A1 WO2007056905 A1 WO 2007056905A1 CN 2006000322 W CN2006000322 W CN 2006000322W WO 2007056905 A1 WO2007056905 A1 WO 2007056905A1
Authority
WO
WIPO (PCT)
Prior art keywords
hifu
treatment device
tumor ablation
hifu treatment
magnetic materials
Prior art date
Application number
PCT/CN2006/000322
Other languages
English (en)
Chinese (zh)
Inventor
Jiwei Jiang
Jiaxian Dong
Haijin Ma
Yisheng Chen
Yong Zhou
Original Assignee
Shanghai A & S Science Technology Development Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai A & S Science Technology Development Co., Ltd. filed Critical Shanghai A & S Science Technology Development Co., Ltd.
Publication of WO2007056905A1 publication Critical patent/WO2007056905A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2256—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves with means for locating or checking the concrement, e.g. X-ray apparatus, imaging means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
    • G01R33/3806—Open magnet assemblies for improved access to the sample, e.g. C-type or U-type magnets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4808—Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
    • G01R33/4814—MR combined with ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2256—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves with means for locating or checking the concrement, e.g. X-ray apparatus, imaging means
    • A61B17/2258—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves with means for locating or checking the concrement, e.g. X-ray apparatus, imaging means integrated in a central portion of the shock wave apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/374—NMR or MRI

Definitions

  • the invention relates to the field of tumor treatment, in particular to a HIFU tumor ablation system.
  • the MRI (Magnetic Resonance Imaging) system is an imaging technique that reconstructs an image by collecting signals generated by magnetic resonance phenomena.
  • the nucleus in the human tissue including the base proton or neutron, generally referred to as the proton of hydrogen
  • the RF pulse excites the hydrogen proton at a specific precession frequency, and the hydrogen proton that receives the excitation is in motion.
  • the energy released during the process of helium is the magnetic resonance signal.
  • the magnetic resonance signals are collected by a computer and converted into black and white gray scales according to the intensity of the signal.
  • the two-dimensional or three-dimensional form is formed by position, and the magnetic resonance image (MRI) is finally formed.
  • non-invasive real-time temperature measurement for patients can be achieved by using temperature-dependent parameter changes such as changes in hydrogen proton resonance frequency and spin lattice relaxation time in MRI.
  • the basic components of the MRI system are magnets, spectrometers, patient carriers, computer analysis software, and more.
  • the magnet has two basic structures, one is an open structure, and one magnetic material is placed on the upper and lower sides, and the main constant magnetic field generated is perpendicular to the ground, which is called an open MRI system;
  • the MRI system is a ring-shaped structure that produces a main constant magnetic field in a closed annulus, in which the patient is placed in the annulus.
  • HIFU High Intensity Focused Ultrasound
  • HIFU treatment devices also known as ultrasound transducers, transducer groups, wave sources, treatment heads, etc.
  • patient carriers for carrying patients computer control software, power generators, etc.
  • the basic treatment principle is that a single or multiple ultrasonic transducers emit an ultrasound beam, and the patient's external body is focused by the medium to the target region of the body, so that the ultrasonic intensity at the focus of the target region reaches several thousand or even tens of thousands of W/cm 2 .
  • the biological tissue at the focus of the target area produces intense mechanical vibration (relaxation) under the action of energy superposition, and continuously converts the ordered molecular vibration energy into disordered molecular thermal motion energy, that is, the mechanical energy is converted into thermal energy in the medium.
  • the temperature of the biological tissue at the focus of the target region rises to above 65 °C in an instant (0.1-ls), and the irreversible coagulative necrosis of the protein is rapidly caused.
  • HIFU tumor ablation therapy is a non-invasive, non-toxic and side-effect tumor treatment method.
  • HIFU treatment technology has been promoted by certain clinical applications. It has been confirmed that China is the earliest and largest number of clinically applied HIFU treatment technologies in the world, and is also the country with the largest number of products manufacturing systems.
  • the HIFU treatment system on the market adopts B-mode image guidance to implement positioning, and the system has fatal defects such as unclear imaging effect, inaccurate tumor positioning accuracy, and relatively poor safety and reliability.
  • the inability to perform non-invasive temperature measurement and real-time evaluation of imaging has become a problem for its clinical application.
  • the EXABLTE 2000 ultrasound treatment system produced by Israel INSIGHTEC company uses US 1.5 GE magnetic resonance imaging system to guide the positioning, and the imaging effect is clear and the tumor positioning is accurate.
  • the magnets are made of superconducting materials, and a circulating cooling device using liquid nitrogen is required, which makes the entire system too bulky, relatively cumbersome to operate, and expensive to manufacture.
  • the MRI system part of the HIFU system they use uses a traditional ring structure.
  • a HIFU tumor ablation system comprising at least one HIFU treatment device, further comprising an open MRI system, the magnetic material of the open MRI system being disposed perpendicular to the ground, the HIFU treatment device being disposed between the magnetic materials.
  • the direction of the main constant magnetic field of the MRI system is parallel to the ground.
  • the HIFU treatment device is an upper HIFU treatment device disposed between the magnetic materials of the open MRI system.
  • the HIFU treatment device can be an underlying HIFU treatment device disposed between the magnetic materials of the open M I system.
  • the HIFU tumor ablation system includes an upper HIFU treatment device disposed between the magnetic materials of the open MRI system and an underlying HIFU treatment device disposed between the magnetic materials of the open MRI system.
  • the upper HIFU treatment device is disposed on the upper portion between the magnetic materials by suspension or support.
  • the underlying HIFU treatment device is carried on the base of the HIFU tumor ablation system.
  • system further includes a patient carrying device coupled to the base by a lifting device, and The sealing device is connected to the underlying HIFU treatment device.
  • the patient carrying device is provided with an opening corresponding to the underlying HIFU treatment device.
  • the positive progress of the invention is as follows:
  • the invention combines the MRI technology and the HIFU technology into one body, and creatively changes the magnetic material of the MRI system from the traditional horizontal up and down to the vertical plane setting, so that the magnetic material is more convenient to install HIFU.
  • the treatment device solves the fundamental problems of precise positioning, non-invasive temperature measurement and therapeutic evaluation in the development and application of the B-type HIFU system by utilizing the MRI system precise positioning technology, real-time temperature change detection technology, and high-definition real-time image technology. It breaks through the development bottleneck of HIFU tumor ablation technology, makes HIFU treatment technology more secure, reliable, practical and credible, and it also has the advantages of low manufacturing cost and convenient use.
  • Figure 1 is a front elevational view showing a first embodiment of the present invention.
  • Fig. 2 is a side view showing the first embodiment of the present invention. detailed description
  • a HIFU tumor ablation system includes an open MRI system in which the magnetic materials 5, 6 are placed perpendicular to the ground, and the direction of the main constant magnetic field of the MRI system is parallel to the ground. Further comprising an upper HIFU treatment device 1 disposed between the magnetic materials of the open MRI system and an underlying HIFU treatment device 2 disposed between the magnetic materials of the open MRI system, further comprising a A patient carrying device 3 for carrying a patient.
  • the magnetic material 5, 6 is placed vertically on a horizontally placed base 4, and the MRI magnetic resonance imaging system has an open structure with an upward opening and a HIFU high intensity focused ultrasound system placed at the opening of the MRI magnetic resonance imaging system.
  • the upper HIFU treatment device 1 is suspended or supported in an upper portion between the magnetic materials 5, 6 above the patient carrying device 3, that is, above the patient.
  • the upper HIFU treatment device 1 is connected to the two magnetic materials 5, 6 via a bracket 8 and suspended above the patient carrying device 3.
  • the upper HIFU treatment device 1 is controlled to perform a positioning sway of ⁇ 90° along the axial and radial directions of the patient carrier 3.
  • the underlying HIFU treatment device 2 is located below the patient carrier device 3 and is disposed on the base 4 and connected to the patient carrier device 3 by a sealing material (not shown).
  • the patient carrier 3 is carried on a lifting device 9 connected to the base 4 of the HIFU tumor ablation system.
  • the lifting device 9 is disposed on the base 4, and the patient carrying device 3 is provided with an opening corresponding to the underlying HIFU treatment device 2 for use in the treatment of the lower HIFU treatment device 2.
  • the patient 7 is placed in the center of the magnetic field formed by the magnetic materials 5 and 6 of the MRI magnetic resonance imaging system to form an integrated MRI-guided HIFU tumor.
  • Ablation system to achieve the purpose of treating tumors.
  • Embodiment 2 differs from Embodiment 1 in that: the HIFU treatment device is an upper-mounted HIFU treatment device located above the patient carrier device, not shown, and the other structures of Embodiment 2 are the same as Embodiment 1, and Make a statement.
  • Embodiment 3 differs from Embodiment 1 in that: the HIFU treatment device is an underlying HIFU treatment device located below the patient carrier device, and is not shown.
  • the other structures of Embodiment 3 are the same as in Embodiment 1, and Make a statement.

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

Un système d'ablation de tumeur HIFU comprend au moins des moyens de traitement HIFU et un système MRI de type ouvert. La substance magnétique du système MRI de type ouvert est placée verticale par rapport au sol et les moyens de traitement HIFU sont disposés entre les substances magnétiques. La technique MRI est combinée à la technologie HIFU. L'agencement parallèle au sens commun des substances magnétiques est modifié et disposé de manière verticale.
PCT/CN2006/000322 2005-11-16 2006-03-03 Systeme d'ablation de tumeur hifu WO2007056905A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200510110387.7 2005-11-16
CNA2005101103877A CN1966108A (zh) 2005-11-16 2005-11-16 Hifu肿瘤消融系统

Publications (1)

Publication Number Publication Date
WO2007056905A1 true WO2007056905A1 (fr) 2007-05-24

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Application Number Title Priority Date Filing Date
PCT/CN2006/000322 WO2007056905A1 (fr) 2005-11-16 2006-03-03 Systeme d'ablation de tumeur hifu

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CN (1) CN1966108A (fr)
WO (1) WO2007056905A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2268361B8 (fr) 2008-04-09 2019-05-22 Julian Itzcovitz Sonde transcutanée
EP2223719A1 (fr) * 2009-02-27 2010-09-01 Koninklijke Philips Electronics N.V. Appareil thérapeutique pour traiter un sujet utilisant des nanoparticules magnétiques
CN101947129B (zh) * 2010-10-12 2012-03-21 上海交通大学 相控高强度聚焦超声换能器和磁共振乳腺线圈融合的装置
US11103731B2 (en) * 2017-01-12 2021-08-31 Insightec, Ltd. Overcoming acoustic field and skull non-uniformities
CN108969909A (zh) * 2018-07-25 2018-12-11 宋世鹏 可跟随治疗目标的放射治疗系统

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5247935A (en) * 1992-03-19 1993-09-28 General Electric Company Magnetic resonance guided focussed ultrasound surgery
US5275165A (en) * 1992-11-06 1994-01-04 General Electric Company Magnetic resonance guided ultrasound therapy system with inclined track to move transducers in a small vertical space
US5443068A (en) * 1994-09-26 1995-08-22 General Electric Company Mechanical positioner for magnetic resonance guided ultrasound therapy
EP0938913A2 (fr) * 1993-03-10 1999-09-01 Kabushiki Kaisha Toshiba Appareil de traitement médical par sondes ultrasonores apte à l utilisation de guidage d imagerie par résonance magnétique
CN1257414A (zh) * 1997-05-23 2000-06-21 外科器械股份有限公司 由mri引导的治疗装置和方法
CN1466476A (zh) * 2000-07-31 2004-01-07 �۲켼��-�ؿ�˹�����˹���޹�˾ 磁共振成像引导的超声波治疗系统的机械定位装置
WO2005030330A1 (fr) * 2003-09-30 2005-04-07 Koninklijke Philips Electronics, N.V. Procede et appareil de suivi de cible pour la planification et l'administration d'une radiotherapie

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5247935A (en) * 1992-03-19 1993-09-28 General Electric Company Magnetic resonance guided focussed ultrasound surgery
US5275165A (en) * 1992-11-06 1994-01-04 General Electric Company Magnetic resonance guided ultrasound therapy system with inclined track to move transducers in a small vertical space
EP0938913A2 (fr) * 1993-03-10 1999-09-01 Kabushiki Kaisha Toshiba Appareil de traitement médical par sondes ultrasonores apte à l utilisation de guidage d imagerie par résonance magnétique
US5443068A (en) * 1994-09-26 1995-08-22 General Electric Company Mechanical positioner for magnetic resonance guided ultrasound therapy
CN1257414A (zh) * 1997-05-23 2000-06-21 外科器械股份有限公司 由mri引导的治疗装置和方法
CN1466476A (zh) * 2000-07-31 2004-01-07 �۲켼��-�ؿ�˹�����˹���޹�˾ 磁共振成像引导的超声波治疗系统的机械定位装置
WO2005030330A1 (fr) * 2003-09-30 2005-04-07 Koninklijke Philips Electronics, N.V. Procede et appareil de suivi de cible pour la planification et l'administration d'une radiotherapie

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Publication number Publication date
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