WO2007053455A3 - Ligands polypeptidiques pour recepteur de type toll 4 (tlr4) - Google Patents

Ligands polypeptidiques pour recepteur de type toll 4 (tlr4) Download PDF

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Publication number
WO2007053455A3
WO2007053455A3 PCT/US2006/042051 US2006042051W WO2007053455A3 WO 2007053455 A3 WO2007053455 A3 WO 2007053455A3 US 2006042051 W US2006042051 W US 2006042051W WO 2007053455 A3 WO2007053455 A3 WO 2007053455A3
Authority
WO
WIPO (PCT)
Prior art keywords
tlr4
polypeptide
ligands
toll
receptor
Prior art date
Application number
PCT/US2006/042051
Other languages
English (en)
Other versions
WO2007053455A2 (fr
Inventor
Valerie Odegard
Thomas J Powell
Original Assignee
Vaxinnate Corp
Valerie Odegard
Thomas J Powell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaxinnate Corp, Valerie Odegard, Thomas J Powell filed Critical Vaxinnate Corp
Publication of WO2007053455A2 publication Critical patent/WO2007053455A2/fr
Publication of WO2007053455A3 publication Critical patent/WO2007053455A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne de nouveaux ligands polypeptidiques pour récepteur de type Toll 4 (TLR4). Ces nouveaux ligands polypeptidiques modulent la signalisation de TLR4, régulant ainsi la réponse immunitaire innée. L'invention concerne des procédés permettant de moduler la signalisation de TLR4 à l'aide desdits ligands de TLR4 polypeptidiques. L'invention concerne également des vaccins comprenant les nouveaux ligands de TLR4 polypeptidiques et un antigène. Elle concerne enfin des procédés permettant de stimuler une réponse immunitaire au moyen de ces ligands de TLR4 polypeptidiques et de ces vaccins.
PCT/US2006/042051 2005-10-28 2006-10-27 Ligands polypeptidiques pour recepteur de type toll 4 (tlr4) WO2007053455A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73159505P 2005-10-28 2005-10-28
US60/731,595 2005-10-28

Publications (2)

Publication Number Publication Date
WO2007053455A2 WO2007053455A2 (fr) 2007-05-10
WO2007053455A3 true WO2007053455A3 (fr) 2007-06-14

Family

ID=38006399

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/042051 WO2007053455A2 (fr) 2005-10-28 2006-10-27 Ligands polypeptidiques pour recepteur de type toll 4 (tlr4)

Country Status (2)

Country Link
AR (1) AR056591A1 (fr)
WO (1) WO2007053455A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200745158A (en) 2006-03-07 2007-12-16 Vaxinnate Corp Compositions that include hemagglutinin, methods of making and methods of use thereof
US7629135B2 (en) 2006-12-22 2009-12-08 The Board Of Trustees Of The University Of Illinois Toll-like receptor agonists and antagonists and methods of use thereof
WO2013132041A2 (fr) 2012-03-08 2013-09-12 Novartis Ag Formulations à adjuvant de vaccins de rappel
JP2015509963A (ja) 2012-03-08 2015-04-02 ノバルティス アーゲー Ｔｌｒ４アゴニストを含む混合ワクチン
JP6081574B2 (ja) 2012-03-28 2017-02-15 ユニヴァーシティー オブ メリーランド バルチモア オルトミクソウイルス感染を処置するためのエリトラン又は薬学的に許容されるその塩の投与
AU2013311702A1 (en) 2012-09-06 2015-02-19 Novartis Ag Combination vaccines with serogroup B meningococcus and D/T/P
EP3620172A1 (fr) 2012-10-12 2020-03-11 GlaxoSmithKline Biologicals SA Antigènes de pertussis acellulaires non réticulés pour leur utilisation dans des vaccins combinés
CA2899787A1 (fr) 2013-02-01 2014-08-07 Glaxosmithkline Biologicals Sa Administration intradermique de compositions immunologiques comprenant des agonistes des recepteurs de type toll
WO2014184683A2 (fr) * 2013-04-26 2014-11-20 Oslo Universitetssykehus Hf Compositions et procédés de ciblage de cellules présentatrices d'antigène
EP3701964B1 (fr) * 2016-02-17 2023-11-08 Pepticom Ltd Agonistes et antagonistes peptidiques de l'activation de tlr4
CN112203681B (zh) * 2018-02-07 2024-05-24 免疫基因有限公司 疫苗组合物及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040214272A1 (en) * 1999-05-06 2004-10-28 La Rosa Thomas J Nucleic acid molecules and other molecules associated with plants

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040214272A1 (en) * 1999-05-06 2004-10-28 La Rosa Thomas J Nucleic acid molecules and other molecules associated with plants

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BALDRIDGE J.R. ET AL.: "Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents", EXPERT OPINION ON. BIO. THER., vol. 4, no. 7, July 2004 (2004-07-01), pages 1129 - 1138, XP008082206 *
DATABASE GEMBANK 3 August 2000 (2000-08-03), HEIDELBERG J.F.: "DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae", XP003014127 *
NATURE, vol. 406, no. 6795, pages 477 - 483 *
RYAN E.T. ET AL.: "Cholera vaccines", CLINICAL INFECTIOUS DISEASES, vol. 31, 2000, pages 561 - 565, XP002343357 *

Also Published As

Publication number Publication date
AR056591A1 (es) 2007-10-10
WO2007053455A2 (fr) 2007-05-10

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