WO2007052173A3 - Activity of thap-family chemokine-binding domains - Google Patents

Activity of thap-family chemokine-binding domains Download PDF

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Publication number
WO2007052173A3
WO2007052173A3 PCT/IB2006/003973 IB2006003973W WO2007052173A3 WO 2007052173 A3 WO2007052173 A3 WO 2007052173A3 IB 2006003973 W IB2006003973 W IB 2006003973W WO 2007052173 A3 WO2007052173 A3 WO 2007052173A3
Authority
WO
WIPO (PCT)
Prior art keywords
thap
chemokine
activity
binding domains
polypeptide
Prior art date
Application number
PCT/IB2006/003973
Other languages
French (fr)
Other versions
WO2007052173A2 (en
Inventor
Luc Aguilar
Denis Jullien
Jean-Philippe Girard
Original Assignee
Endocube S A S
Luc Aguilar
Denis Jullien
Jean-Philippe Girard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endocube S A S, Luc Aguilar, Denis Jullien, Jean-Philippe Girard filed Critical Endocube S A S
Publication of WO2007052173A2 publication Critical patent/WO2007052173A2/en
Publication of WO2007052173A3 publication Critical patent/WO2007052173A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Described herein are chemokine-binding domains of THAP-family polypeptides and pharmaceutical compositions which include a polypeptide comprising a chemokine-binding domain of a THAP-family polypeptide. Also disclosed are methods of binding chemokines, inhibiting the activity of chemokines, detecting chemokines, and reducing the symptoms associated with a chemokine mediated or influenced condition by contacting the chemokine with an agent that includes a polypeptide comprising a chemokine binding domain of a THAP-family polypeptide.
PCT/IB2006/003973 2005-02-23 2006-02-22 Activity of thap-family chemokine-binding domains WO2007052173A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65615205P 2005-02-23 2005-02-23
US60/656,152 2005-02-23

Publications (2)

Publication Number Publication Date
WO2007052173A2 WO2007052173A2 (en) 2007-05-10
WO2007052173A3 true WO2007052173A3 (en) 2008-02-14

Family

ID=38006265

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/003973 WO2007052173A2 (en) 2005-02-23 2006-02-22 Activity of thap-family chemokine-binding domains

Country Status (1)

Country Link
WO (1) WO2007052173A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8685398B2 (en) 2009-06-15 2014-04-01 Biokine Therapeutics Ltd. Chemokine binding polypeptides capable of inhibiting the course of autoimmunity, inflammation and cancer
MX2020011500A (en) 2015-12-17 2020-12-07 Alonbio Ltd Small molecules for inhibiting chemokine activity, a kinase activity and/or cancer cells growth.
WO2017103931A1 (en) 2015-12-17 2017-06-22 Biokine Therapeutics Ltd. Small molecules against cancer
CA3090315C (en) 2019-05-15 2023-09-19 Biokine Therapeutics Ltd. 8-phenoxy-quinolinone derivatives for treating cancer, inhibiting chemokine activity and/or inducing cell death

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224408A1 (en) * 2002-12-10 2004-11-11 Jean-Philippe Girard THAP proteins as nuclear receptors for chemokines and roles in transcriptional regulation, cell proliferation and cell differentiation
WO2004111087A2 (en) * 2003-06-19 2004-12-23 Endocube Sas Chemokin-binding protein thap1, methods and use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224408A1 (en) * 2002-12-10 2004-11-11 Jean-Philippe Girard THAP proteins as nuclear receptors for chemokines and roles in transcriptional regulation, cell proliferation and cell differentiation
WO2004111087A2 (en) * 2003-06-19 2004-12-23 Endocube Sas Chemokin-binding protein thap1, methods and use thereof

Also Published As

Publication number Publication date
WO2007052173A2 (en) 2007-05-10

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