WO2007052173A3 - Activity of thap-family chemokine-binding domains - Google Patents

Activity of thap-family chemokine-binding domains Download PDF

Info

Publication number
WO2007052173A3
WO2007052173A3 PCT/IB2006/003973 IB2006003973W WO2007052173A3 WO 2007052173 A3 WO2007052173 A3 WO 2007052173A3 IB 2006003973 W IB2006003973 W IB 2006003973W WO 2007052173 A3 WO2007052173 A3 WO 2007052173A3
Authority
WO
WIPO (PCT)
Prior art keywords
thap
chemokine
activity
binding domains
polypeptide
Prior art date
Application number
PCT/IB2006/003973
Other languages
French (fr)
Other versions
WO2007052173A2 (en
Inventor
Luc Aguilar
Denis Jullien
Jean-Philippe Girard
Original Assignee
Endocube S A S
Luc Aguilar
Denis Jullien
Jean-Philippe Girard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endocube S A S, Luc Aguilar, Denis Jullien, Jean-Philippe Girard filed Critical Endocube S A S
Publication of WO2007052173A2 publication Critical patent/WO2007052173A2/en
Publication of WO2007052173A3 publication Critical patent/WO2007052173A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Described herein are chemokine-binding domains of THAP-family polypeptides and pharmaceutical compositions which include a polypeptide comprising a chemokine-binding domain of a THAP-family polypeptide. Also disclosed are methods of binding chemokines, inhibiting the activity of chemokines, detecting chemokines, and reducing the symptoms associated with a chemokine mediated or influenced condition by contacting the chemokine with an agent that includes a polypeptide comprising a chemokine binding domain of a THAP-family polypeptide.
PCT/IB2006/003973 2005-02-23 2006-02-22 Activity of thap-family chemokine-binding domains WO2007052173A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65615205P 2005-02-23 2005-02-23
US60/656,152 2005-02-23

Publications (2)

Publication Number Publication Date
WO2007052173A2 WO2007052173A2 (en) 2007-05-10
WO2007052173A3 true WO2007052173A3 (en) 2008-02-14

Family

ID=38006265

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/003973 WO2007052173A2 (en) 2005-02-23 2006-02-22 Activity of thap-family chemokine-binding domains

Country Status (1)

Country Link
WO (1) WO2007052173A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2765188A1 (en) * 2009-06-15 2010-12-23 Biokine Therapeutics Ltd. Novel chemokine binding polypeptides capable of inhibiting the course of autoimmunity, inflammation and cancer
MX2020011500A (en) 2015-12-17 2020-12-07 Alonbio Ltd Small molecules for inhibiting chemokine activity, a kinase activity and/or cancer cells growth.
EP3390378B1 (en) 2015-12-17 2022-03-30 AlonBio Ltd. Small molecules against cancer
BR112021022775A2 (en) 2019-05-15 2022-02-01 Alonbio Ltd Small molecules for cancer treatment, inhibition of chemokine activity and/or induction of cell death

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224408A1 (en) * 2002-12-10 2004-11-11 Jean-Philippe Girard THAP proteins as nuclear receptors for chemokines and roles in transcriptional regulation, cell proliferation and cell differentiation
WO2004111087A2 (en) * 2003-06-19 2004-12-23 Endocube Sas Chemokin-binding protein thap1, methods and use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224408A1 (en) * 2002-12-10 2004-11-11 Jean-Philippe Girard THAP proteins as nuclear receptors for chemokines and roles in transcriptional regulation, cell proliferation and cell differentiation
WO2004111087A2 (en) * 2003-06-19 2004-12-23 Endocube Sas Chemokin-binding protein thap1, methods and use thereof

Also Published As

Publication number Publication date
WO2007052173A2 (en) 2007-05-10

Similar Documents

Publication Publication Date Title
WO2006105338A3 (en) Fc VARIANTS WITH OPTIMIZED PROPERTIES
BRPI0618969A2 (en) Functional sweetener composition, functional sweetener composition, and functional beverage.
BRPI0618929A2 (en) Functional sweetener composition, functional sweetener composition, and functional beverage.
WO2007041635A3 (en) Fc variants with optimized fc receptor binding properties
WO2007136893A3 (en) Anti-fgf19 antibodies and methods using same
WO2004111087A3 (en) Chemokin-binding protein thap1, methods and use thereof
WO2007008276A3 (en) Turnover probes and use thereof for nucleic acid detection
WO2007010034A3 (en) Ampholytic copolymer, production thereof, and use of the same
WO2008121767A3 (en) Stitched polypeptides
WO2010053518A3 (en) Methods and compositions for inactivating glutamine synthetase gene expression
WO2006079076A3 (en) Yersinia spp. polypeptides and methods of use
WO2005113592A3 (en) Interferon-alpha polypeptides and conjugates
WO2007115837A3 (en) Combination of an anti-edb fibronectin domain antibody/ il2 fusion protein and a further small molecule
WO2007022385A3 (en) Use of cxcr4 binding molecules for the treatment of whim syndrome
WO2005087793A3 (en) Immunostimulatory compositions and uses thereof
WO2007071692A3 (en) Immunogenic composition
WO2007009018A3 (en) Il-6 binding proteins
WO2006047535A3 (en) Melanocortin receptor binding mimetibodies, compositions, methods and uses
WO2008086035A3 (en) Split mutant hydrolase fusion reporter and uses thereof
WO2008157697A3 (en) Copolymer assay
WO2010014830A3 (en) Peptide therapeutics that bind vegf and methods of use thereof
WO2006135793A3 (en) Protein engineering with analogous contact environments
IL223077A0 (en) Novel as160-like protein, test systems, methods and uses involving it for the identification of diabetes type 2 therapeutics
WO2007076174A3 (en) Methods, systems, and apparatus for multi-domain markers
WO2008089073A3 (en) Combinatorial libraries of conformationally constrained polypeptide sequences

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 06842389

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 06842389

Country of ref document: EP

Kind code of ref document: A2

WWW Wipo information: withdrawn in national office

Ref document number: 6842389

Country of ref document: EP