WO2007052001A3 - Production process of ortho-substituted benzoic acid derivatives usin 4-(2-carboxybenzyloxy or thio)-phenylacetic acid as key intermediate - Google Patents

Production process of ortho-substituted benzoic acid derivatives usin 4-(2-carboxybenzyloxy or thio)-phenylacetic acid as key intermediate Download PDF

Info

Publication number
WO2007052001A3
WO2007052001A3 PCT/GB2006/004044 GB2006004044W WO2007052001A3 WO 2007052001 A3 WO2007052001 A3 WO 2007052001A3 GB 2006004044 W GB2006004044 W GB 2006004044W WO 2007052001 A3 WO2007052001 A3 WO 2007052001A3
Authority
WO
WIPO (PCT)
Prior art keywords
carboxybenzyloxy
usin
thio
ortho
production process
Prior art date
Application number
PCT/GB2006/004044
Other languages
French (fr)
Other versions
WO2007052001A2 (en
Inventor
Julian Gordon Knight Chaffey
John Peter Gilday
David Hoile
Philip Hopes
Simon Nicholas George Tyler
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Julian Gordon Knight Chaffey
John Peter Gilday
David Hoile
Philip Hopes
Simon Nicholas George Tyler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd, Julian Gordon Knight Chaffey, John Peter Gilday, David Hoile, Philip Hopes, Simon Nicholas George Tyler filed Critical Astrazeneca Ab
Publication of WO2007052001A2 publication Critical patent/WO2007052001A2/en
Publication of WO2007052001A3 publication Critical patent/WO2007052001A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for the preparation of a compound of formula (I) in which Y is absent or represents methylene, and X is O or S which comprises reacting a compound of formula (II) with a compound of formula (III) in which Y is absent or represents methylene, and X is O or S or a salt thereof optionally in the presence of a base and optionally in the presence of an inert solvent, at a temperature in the range of 0 to 150°C and reaction of the compound of formula (I) with a compound of formula (IV) to give a compound of formula (V) or a salt thereof.
PCT/GB2006/004044 2005-11-03 2006-10-31 Production process of ortho-substituted benzoic acid derivatives usin 4-(2-carboxybenzyloxy or thio)-phenylacetic acid as key intermediate WO2007052001A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0522431A GB0522431D0 (en) 2005-11-03 2005-11-03 Chemical process
GB0522431.6 2005-11-03

Publications (2)

Publication Number Publication Date
WO2007052001A2 WO2007052001A2 (en) 2007-05-10
WO2007052001A3 true WO2007052001A3 (en) 2007-07-12

Family

ID=35516262

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/004044 WO2007052001A2 (en) 2005-11-03 2006-10-31 Production process of ortho-substituted benzoic acid derivatives usin 4-(2-carboxybenzyloxy or thio)-phenylacetic acid as key intermediate

Country Status (3)

Country Link
GB (1) GB0522431D0 (en)
TW (1) TW200800859A (en)
WO (1) WO2007052001A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2247225A1 (en) * 1973-09-13 1975-05-09 Sandoz Sa
EP0119540A2 (en) * 1983-03-10 1984-09-26 Hoechst-Roussel Pharmaceuticals Incorporated Substituted alkylamine derivatives of 6,11-dihydro-11-oxodibenz (b,e)-oxepins, a process for the preparation and intermediates thereof and their use as medicaments
JPH072733A (en) * 1993-06-16 1995-01-06 Kyowa Hakko Kogyo Co Ltd Production of benzoic acid and nicotinic acid derivative
WO2004000790A1 (en) * 2002-06-20 2003-12-31 Astrazeneca Ab Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2247225A1 (en) * 1973-09-13 1975-05-09 Sandoz Sa
EP0119540A2 (en) * 1983-03-10 1984-09-26 Hoechst-Roussel Pharmaceuticals Incorporated Substituted alkylamine derivatives of 6,11-dihydro-11-oxodibenz (b,e)-oxepins, a process for the preparation and intermediates thereof and their use as medicaments
JPH072733A (en) * 1993-06-16 1995-01-06 Kyowa Hakko Kogyo Co Ltd Production of benzoic acid and nicotinic acid derivative
WO2004000790A1 (en) * 2002-06-20 2003-12-31 Astrazeneca Ab Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance

Also Published As

Publication number Publication date
TW200800859A (en) 2008-01-01
GB0522431D0 (en) 2005-12-14
WO2007052001A2 (en) 2007-05-10

Similar Documents

Publication Publication Date Title
NO20074055L (en) Processes for preparing 4- (phenoxy-5-methylpyrimidin-4-yloxy) piperidine-1-carboxylic acid derivatives and related compounds
WO2005108349A3 (en) Process for preparing atazanavir bisulfate and novel forms
WO2009102155A3 (en) Process for preparation of 2-methyl-2´-phenylpropionic acid derivatives and novel intermediate compounds
NZ593214A (en) Compounds and Processes for preparing serine protease inhibitors
AU2015221439B2 (en) Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same
WO2007020527A3 (en) Process for the preparation of strontium ranelate
WO2006121648A3 (en) Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids
WO2006059103A3 (en) Pyridine based compounds useful as intermediates for pharmaceutical or agricultural end-products
NZ614088A (en) Process for preparing pyridinamines and novel polymorphs thereof
PT1601653E (en) Process for the production of substituted nicotinic acid esters
WO2009066735A1 (en) Method for producing 2-azaadamantane
CN104557800A (en) 2-phenoxyl tetrahydrofuran (tetrahydropyrane) derivatives and application thereof in synthesis of penoxsulam
WO2007018807A3 (en) Methods and intermediates for the synthesis of porphyrins
TW200640830A (en) Process for the preparation of intermediates
NO20080788L (en) Aripiprazolsalter
WO2006034092A8 (en) Process for production of piperidine derivatives
WO2008103367A3 (en) Method for assembling high-purity chemical libraries, proapoptotic compounds discovered by same
WO2007105021A3 (en) Duloxetine salts
NO20082005L (en) Synthesis of renin inhibitors comprising a cyclot addition reaction
WO2007039117A3 (en) A process for the preparation of sartan derivatives and intermediates useful in such process
IL200323A0 (en) Synthesis of glyt-1 inhibitors
WO2007052001A3 (en) Production process of ortho-substituted benzoic acid derivatives usin 4-(2-carboxybenzyloxy or thio)-phenylacetic acid as key intermediate
TW200740763A (en) A method for preparing 5-hydroxy-1-alkyl pyrazole derivatives
WO2003066653A3 (en) Process for the production of fluticasone propionate, in particular of polymorphic form 1
WO2007074391A3 (en) Preparation of a key intermediate in the synthesis of rosuvastatin

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06794945

Country of ref document: EP

Kind code of ref document: A2