WO2007074391A3 - Preparation of a key intermediate in the synthesis of rosuvastatin - Google Patents

Preparation of a key intermediate in the synthesis of rosuvastatin Download PDF

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Publication number
WO2007074391A3
WO2007074391A3 PCT/IB2006/003791 IB2006003791W WO2007074391A3 WO 2007074391 A3 WO2007074391 A3 WO 2007074391A3 IB 2006003791 W IB2006003791 W IB 2006003791W WO 2007074391 A3 WO2007074391 A3 WO 2007074391A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
compound
iia
rosuvastatin
synthesis
Prior art date
Application number
PCT/IB2006/003791
Other languages
French (fr)
Other versions
WO2007074391A2 (en
Inventor
Bakulesh Mafatlal Khamar
Indravadan Ambalal Modi
Jayaraman Venkatraman
Ponnaiah Ravi
Sanjay Jagadish Desai
Amarsingh L Rajput
Original Assignee
Bakulesh Mafatlal Khamar
Indravadan Ambalal Modi
Jayaraman Venkatraman
Ponnaiah Ravi
Sanjay Jagadish Desai
Amarsingh L Rajput
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bakulesh Mafatlal Khamar, Indravadan Ambalal Modi, Jayaraman Venkatraman, Ponnaiah Ravi, Sanjay Jagadish Desai, Amarsingh L Rajput filed Critical Bakulesh Mafatlal Khamar
Publication of WO2007074391A2 publication Critical patent/WO2007074391A2/en
Publication of WO2007074391A3 publication Critical patent/WO2007074391A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Abstract

The present invention discloses a novel process to prepare a compound of formula (IIA) by reacting a compound of formula-[D], wherein R1 is C1 to C6 alkyl and R2 is C1 to C8 n-alkyl or branched alkyl, cycloalkyl, phenyl, benzyl or substituted phenyl group; with N-methyl methanesulfonamide and a base, optionally with a salt of N-methyl methanesulfonamide, in suitable solvent(s), to give a compound of formula (IIA), followed by converting compound of formula (IIA) to a compound for formula -[B], by a known process and finally converting a compound of formula (B) to a compound of formula (II), by a novel process using calcium hypochlorite / TEMPO as an oxidant.
PCT/IB2006/003791 2005-12-28 2006-12-28 Preparation of a key intermediate in the synthesis of rosuvastatin WO2007074391A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1632/MUM/2005 2005-12-28
IN1632MU2005 2005-12-28

Publications (2)

Publication Number Publication Date
WO2007074391A2 WO2007074391A2 (en) 2007-07-05
WO2007074391A3 true WO2007074391A3 (en) 2008-06-26

Family

ID=38218355

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/003791 WO2007074391A2 (en) 2005-12-28 2006-12-28 Preparation of a key intermediate in the synthesis of rosuvastatin

Country Status (1)

Country Link
WO (1) WO2007074391A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8212034B2 (en) 2006-12-13 2012-07-03 Aurobindo Pharma Ltd. Process for preparing rosuvastatin calcium
SI2752407T1 (en) 2009-01-14 2016-07-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Crystalline rosuvastatin calcium trihydrate
CN103467349B (en) * 2013-08-19 2015-04-15 浙江大洋生物科技集团股份有限公司 Method utilizing methyl sodium sulfate offscum to synthesize S-methyl-iso-thiourea sulfate
CN109796414B (en) * 2019-02-26 2022-05-20 中国药科大学 Method for continuously preparing rosuvastatin intermediate by adopting micro-channel modular reaction device

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003097614A2 (en) * 2002-05-21 2003-11-27 Ranbaxy Laboratories Limited Process for the preparation of rosuvastatin
US20050059648A1 (en) * 2003-06-17 2005-03-17 Schering Corporation Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof
US20060004200A1 (en) * 2004-06-21 2006-01-05 Srinivasulu Gudipati Processes to produce intermediates for rosuvastatin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003097614A2 (en) * 2002-05-21 2003-11-27 Ranbaxy Laboratories Limited Process for the preparation of rosuvastatin
US20050059648A1 (en) * 2003-06-17 2005-03-17 Schering Corporation Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof
US20060004200A1 (en) * 2004-06-21 2006-01-05 Srinivasulu Gudipati Processes to produce intermediates for rosuvastatin

Also Published As

Publication number Publication date
WO2007074391A2 (en) 2007-07-05

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