WO2007051071A3 - Procede en deux etapes de fonctionnalisation d'allotropes de carbone et allotropes de carbone pegyles obtenus par ces procedes - Google Patents

Procede en deux etapes de fonctionnalisation d'allotropes de carbone et allotropes de carbone pegyles obtenus par ces procedes Download PDF

Info

Publication number
WO2007051071A3
WO2007051071A3 PCT/US2006/042589 US2006042589W WO2007051071A3 WO 2007051071 A3 WO2007051071 A3 WO 2007051071A3 US 2006042589 W US2006042589 W US 2006042589W WO 2007051071 A3 WO2007051071 A3 WO 2007051071A3
Authority
WO
WIPO (PCT)
Prior art keywords
carbon allotropes
conjugate
methods
functionalizing
peg
Prior art date
Application number
PCT/US2006/042589
Other languages
English (en)
Other versions
WO2007051071A2 (fr
Inventor
W Edward Billups
Anil Sadana
Jayanta Chattopadhyay
Original Assignee
Univ Rice William M
W Edward Billups
Anil Sadana
Jayanta Chattopadhyay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rice William M, W Edward Billups, Anil Sadana, Jayanta Chattopadhyay filed Critical Univ Rice William M
Publication of WO2007051071A2 publication Critical patent/WO2007051071A2/fr
Publication of WO2007051071A3 publication Critical patent/WO2007051071A3/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B32/00—Carbon; Compounds thereof
    • C01B32/15—Nano-sized carbon materials
    • C01B32/158—Carbon nanotubes
    • C01B32/168—After-treatment
    • C01B32/174—Derivatisation; Solubilisation; Dispersion in solvents
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B32/00—Carbon; Compounds thereof
    • C01B32/20—Graphite
    • C01B32/21—After-treatment
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B2202/00—Structure or properties of carbon nanotubes
    • C01B2202/02—Single-walled nanotubes
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B2202/00—Structure or properties of carbon nanotubes
    • C01B2202/04—Nanotubes with a specific amount of walls
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B2202/00—Structure or properties of carbon nanotubes
    • C01B2202/06—Multi-walled nanotubes
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B2202/00—Structure or properties of carbon nanotubes
    • C01B2202/20—Nanotubes characterized by their properties
    • C01B2202/28—Solid content in solvents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Geology (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Composite Materials (AREA)
  • Epidemiology (AREA)
  • Manufacturing & Machinery (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyethers (AREA)
  • Carbon And Carbon Compounds (AREA)

Abstract

Cette invention concerne un procédé de fonctionnalisation d'un allotrope de carbone consistant à faire réagir un allotrope de carbone avec un métal alcalin et une espèce organohalogénure pour produire un premier produit de réaction. Le premier produit de réaction réagit avec une espèce réactive pour produire un conjugué polyéthylène glycol-allotrope de carbone. Des nanotubes de carbone hydrosolubles et du graphite sont obtenus par ces procédés. Un conjugué utilisé dans l'administration de médicaments comprend un médicament et/ou un anticorps et/ou un indicateur fluorescent. Le conjugué comprend également un conjugué polyéthylène glycol-nanotube de carbone et/ou un conjugué polyéthylène glycol-graphite.
PCT/US2006/042589 2005-10-28 2006-10-30 Procede en deux etapes de fonctionnalisation d'allotropes de carbone et allotropes de carbone pegyles obtenus par ces procedes WO2007051071A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73118805P 2005-10-28 2005-10-28
US60/731,188 2005-10-28

Publications (2)

Publication Number Publication Date
WO2007051071A2 WO2007051071A2 (fr) 2007-05-03
WO2007051071A3 true WO2007051071A3 (fr) 2007-06-14

Family

ID=37872182

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/042589 WO2007051071A2 (fr) 2005-10-28 2006-10-30 Procede en deux etapes de fonctionnalisation d'allotropes de carbone et allotropes de carbone pegyles obtenus par ces procedes

Country Status (1)

Country Link
WO (1) WO2007051071A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008097343A2 (fr) * 2006-08-08 2008-08-14 William Marsh Rice University Matériaux de graphène fonctionnalisé et leur procédé de production
CN100590070C (zh) * 2008-04-23 2010-02-17 郑州大学 一种利用聚乙二醇修饰碳纳米管的方法
US8921600B2 (en) 2011-05-18 2014-12-30 Basf Se Process for producing carbon fillers having covalently bonded amino groups
BR112013029652A2 (pt) * 2011-05-18 2019-09-24 Basf Se "processo para a produção de materiais de enchimento de carbono"
CN106913886A (zh) * 2015-12-28 2017-07-04 上海交通大学医学院附属新华医院 一种肿瘤靶向的碳纳米管光声造影剂及其制备方法
CN110980693A (zh) * 2019-12-09 2020-04-10 宁波中乌新材料产业技术研究院有限公司 碳复合材料及其制造方法
CN114518453B (zh) * 2022-01-26 2023-05-16 东北农业大学 一种多壁碳纳米管复合物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005090233A2 (fr) * 2004-03-12 2005-09-29 William Marsh Rice University Functionalisation reductrice de nanotubes de carbone
US20060191842A1 (en) * 2005-02-25 2006-08-31 Fred Wudl Hydrogen cyano fullerene containing proton conducting membranes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005090233A2 (fr) * 2004-03-12 2005-09-29 William Marsh Rice University Functionalisation reductrice de nanotubes de carbone
US20060191842A1 (en) * 2005-02-25 2006-08-31 Fred Wudl Hydrogen cyano fullerene containing proton conducting membranes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIN ZHAO, HUI HU, AIPING YU,: "Synthesis and characterization of water soluble single-walled carbon nanotube graft copolymers", J. AM. CHEM. SOC., vol. 127, 5 December 2005 (2005-12-05), pages 8197 - 8203, XP002426704 *
BORONDICS F ET AL: "Reductive functionalization of carbon nanotubes", FULLERENES, NANOTUBES, AND CARBON NANOSTRUCTURES MARCEL DEKKER USA, vol. 13, 2005, pages 375 - 382, XP002426703, ISSN: 1536-383X *
DAE-HWAN JUNG, YOUNG KOAN KO, HEE-TAE JUNG: "Aggregation behavior of chemically attached poly(ethylene glycol) to single-walled carbon nanotubes (SWNTs) ropes", MATERIALS SCIENCE AND ENGINEERING, vol. 24, 2004, pages 117 - 121, XP002426702 *
E-MRS SPRING MEETING, SYMPOSIUM I "ADVANCED MULTIFUNCTIONAL NANOCARBON MATERIALS AND NANOSYSTEMS" 24-28 MAY 2004 STRASBOURG, FRANCE, 2004, ISSN: 1536-383X *
TABATA Y ET AL: "ANTITUMOR EFFECT OP POLY(ETHYLENE GLYCOL)- MODIFIED FULLERENE", FULLERENCE SCIENCE AND TECHNOLOGY, MARCEL DEKKER INC., NEW YORK, NY, US, vol. 5, no. 5, 1997, pages 989 - 1007, XP001007193, ISSN: 1064-122X *

Also Published As

Publication number Publication date
WO2007051071A2 (fr) 2007-05-03

Similar Documents

Publication Publication Date Title
WO2007051071A3 (fr) Procede en deux etapes de fonctionnalisation d'allotropes de carbone et allotropes de carbone pegyles obtenus par ces procedes
WO2008030439A3 (fr) Procédé de déshydrofluoration pour fabriquer des hydrofluorooléfines
WO2005037320A3 (fr) Procede de preparation de vaccins conjugues polyssacharide-proteine
MY148295A (en) ?process for preparing a chlorohydrin by converting polyhydroxylated aliphatic hydrocarbons
WO2008115753A3 (fr) Procédé de préparation de nanotube en carbone contenant des électrodes
WO2005090233A3 (fr) Functionalisation reductrice de nanotubes de carbone
WO2006076611A3 (fr) Production de nanoparticules metalliques
WO2007109129A8 (fr) procede de preparation de conjugues immunogeniques multivalents complexes
TW200744945A (en) Functionalized carbon nanotubes
WO2008054349A3 (fr) Structures de nanotubes de carbone formées sur de grands substrats flottant librement
TW200642963A (en) Surface modified nanoparticle and method of preparing same
IL196894A0 (en) Process for preparing 3-dihalomethylpyrazole-4-carboxylic acid derivatives
EP2647711A3 (fr) Voies d'export alternatives pour l'interférence d'ARN exprimée par vecteur
WO2006102722A8 (fr) Procede de production de $g(g)-glutamylcysteine
GB2446088B (en) Production of conjugates
WO2006127017A3 (fr) Procedes permettant de realiser la synthese en masse de nanotubes de carbone a paroi unique
WO2008032103A3 (fr) PROCÉDÉ DE PRÉPARATION D'UN cAMPS (Rp)-8-SUBSTITUÉ
MY146360A (en) Process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof
TW200704752A (en) Synthesis process
WO2006058858A3 (fr) Procede pour synthetiser des derives d'acide phosphonique a chaine longue et des derives de thiol
WO2010059027A3 (fr) Procédé de fabrication de nanotubes de carbone
UA90530C2 (uk) СПОСІБ ОДЕРЖАННЯ 4β-АМІНО-4'-ДЕМЕТИЛ-4-ДЕЗОКСИПОДОФІЛОТОКСИНУ (ВАРІАНТИ)
TW200738650A (en) Process for synthesis of aryloxy diaminopyrimidines
TW200640895A (en) Improved process for the kumada coupling reaction
WO2008077035A3 (fr) Procédés de préparation de lévétiracétam

Legal Events

Date Code Title Description
DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06836743

Country of ref document: EP

Kind code of ref document: A2