WO2007044937A3 - Compositions and methods to modulate memory - Google Patents

Compositions and methods to modulate memory Download PDF

Info

Publication number
WO2007044937A3
WO2007044937A3 PCT/US2006/040274 US2006040274W WO2007044937A3 WO 2007044937 A3 WO2007044937 A3 WO 2007044937A3 US 2006040274 W US2006040274 W US 2006040274W WO 2007044937 A3 WO2007044937 A3 WO 2007044937A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
memory
modulate memory
modulating
Prior art date
Application number
PCT/US2006/040274
Other languages
French (fr)
Other versions
WO2007044937A2 (en
Inventor
Shovon I Ashraf
Samuel Kunes
Original Assignee
Harvard College
Shovon I Ashraf
Samuel Kunes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Shovon I Ashraf, Samuel Kunes filed Critical Harvard College
Publication of WO2007044937A2 publication Critical patent/WO2007044937A2/en
Publication of WO2007044937A3 publication Critical patent/WO2007044937A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Disclosed herein are compositions and methods for modulating memory. In one aspect, the regulation of protein expression of certain proteins related to both long-term and short-term memory is described. In one aspect, modulating the RISC pathway and associated targets is described.
PCT/US2006/040274 2005-10-13 2006-10-13 Compositions and methods to modulate memory WO2007044937A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72631805P 2005-10-13 2005-10-13
US60/726,318 2005-10-13

Publications (2)

Publication Number Publication Date
WO2007044937A2 WO2007044937A2 (en) 2007-04-19
WO2007044937A3 true WO2007044937A3 (en) 2007-08-02

Family

ID=37943570

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/040274 WO2007044937A2 (en) 2005-10-13 2006-10-13 Compositions and methods to modulate memory

Country Status (1)

Country Link
WO (1) WO2007044937A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101235256B1 (en) * 2010-09-13 2013-02-21 서울대학교산학협력단 Treatment of Neurodegenerative Diseases by Targeting a miRNA
WO2012038956A1 (en) * 2010-09-20 2012-03-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of treating neurodegenerative diseases
WO2012164398A2 (en) * 2011-06-01 2012-12-06 Netherlands Cancer Institute Modulation of the ubiquitin-proteasome system (ups)
KR102082016B1 (en) * 2011-06-27 2020-02-26 에자이 알앤드디 매니지먼트 가부시키가이샤 Microrna biomarkers indicative of alzheimer's disease
EP2731422B1 (en) * 2011-07-12 2017-08-09 Mart Saarma miRNA antagonists for use in treating neurodegenerative disorders by increasing expression of GDNF
EP2761002B1 (en) 2011-09-28 2021-11-17 Royal College of Surgeons in Ireland Inhibition of microrna-134 for the treatment of seizure-related disorders and neurologic injuries
DK177327B1 (en) * 2011-12-23 2013-01-14 Entomopharm Aps OPTIMIZED INSECT BASED EX VIVO MODEL FOR EXAMINATION OF BLOOD BRAIN BARRIER penetration and method of exposing the insect brain to chemical compounds
RS60524B1 (en) 2014-04-23 2020-08-31 Takeda Pharmaceuticals Co Isoindoline-1-one derivatives as cholinergic muscarinic m1 receptor positive alloesteric modulator activity for the treatment of alzheimers disease
UA121503C2 (en) 2015-06-26 2020-06-10 Такеда Фармасьютікал Компані Лімітед 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor
US10548899B2 (en) 2015-10-20 2020-02-04 Takeda Pharmaceutical Company Limited Quinazolinone and benzotriazinone compounds with cholinergic muscarinin M1 receptor positive allosteric modulator activity
US11890278B2 (en) 2018-01-17 2024-02-06 University Of Florida Research Foundation, Incorporated Betel quid cessation therapy with nicotine and pilocarpine
CN110791560B (en) * 2019-11-06 2021-09-14 中国医学科学院医药生物技术研究所 miRNA marker for diagnosing and/or treating Alzheimer disease

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221600B1 (en) * 1999-10-08 2001-04-24 Board Of Regents, The University Of Texas System Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis
US6767705B2 (en) * 2000-05-26 2004-07-27 The Board Of Trustees Of The University Of Illinois Reagents and methods for identifying and modulating expression of genes regulated by retinoids
US6864261B2 (en) * 2002-05-02 2005-03-08 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221600B1 (en) * 1999-10-08 2001-04-24 Board Of Regents, The University Of Texas System Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis
US6767705B2 (en) * 2000-05-26 2004-07-27 The Board Of Trustees Of The University Of Illinois Reagents and methods for identifying and modulating expression of genes regulated by retinoids
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US6864261B2 (en) * 2002-05-02 2005-03-08 Euro-Celtique S.A. Therapeutic agents useful for treating pain

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SMITH C.L. ET AL.: "Coregulator Function: A Key to Understanding Tissue Specificity of Selective Receptor Modulators", ENDOCRINE REVIEWS, vol. 25, no. 1, February 2004 (2004-02-01), pages 45 - 71, XP003016131 *

Also Published As

Publication number Publication date
WO2007044937A2 (en) 2007-04-19

Similar Documents

Publication Publication Date Title
WO2007044937A3 (en) Compositions and methods to modulate memory
WO2009111159A3 (en) Biocompatible materials containing stable complexes of tsg-6 and hyaluronan and method of using same
WO2008133722A3 (en) Anti human sclerostin antibodies
WO2011072266A3 (en) Aminoacyl trna synthetases for modulating hematopoiesis
WO2008147867A3 (en) Cross-linked collagen and uses thereof
WO2007103490A3 (en) System for the expression of orthogonal translation components in eubacterial host cells
WO2006017538A3 (en) Hk1-binding proteins
WO2009099641A3 (en) Stabilized protein compositions
WO2008106644A3 (en) Treatment of diseases characterized by inflammation
WO2007021694A3 (en) Protein kinase modulation by hops and acacia products
WO2001052620A3 (en) Methods and compositions to modulate expression in plants
WO2007136685A3 (en) Methods and compositions for inactivation of dihydrofolate reductase
WO2009101503A3 (en) Use of natural active substances in cosmetic or therapeutic compositions
WO2008066583A3 (en) Cell-free synthesis of proteins containing unnatural amino acids
WO2007067812A3 (en) Protein kinase modulation by hops and acacia products
WO2009036460A3 (en) Modified human apolipoprotein a-i polypeptides and their uses
WO2007033221A3 (en) Methods and compositions for inhibition of immune responses
WO2009102367A3 (en) Tight junction protein modulators and uses thereof
WO2007059513A3 (en) Compositions and methods for modulating hemostasis
WO2007075438A3 (en) Polypeptides comprising unnatural amino acids, methods for their production and uses therefor
WO2007081878A3 (en) Indoleamine 2,3-dioxygenase pathways in the generation of regulatory t cells
WO2010034015A3 (en) Modulating the alternative complement pathway
WO2008021250A3 (en) Compositions and methods for modulating apoptosis in cells over-expressing bcl-2 family member proteins
WO2009111586A3 (en) Autonomous in vitro evolution
WO2006113475A3 (en) Methods and compositions to modulate adhesion and stress tolerance in bacteria

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06836319

Country of ref document: EP

Kind code of ref document: A2