WO2007043901A1 - Systeme de regulation de temperature - Google Patents

Systeme de regulation de temperature Download PDF

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Publication number
WO2007043901A1
WO2007043901A1 PCT/NZ2006/000266 NZ2006000266W WO2007043901A1 WO 2007043901 A1 WO2007043901 A1 WO 2007043901A1 NZ 2006000266 W NZ2006000266 W NZ 2006000266W WO 2007043901 A1 WO2007043901 A1 WO 2007043901A1
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WO
WIPO (PCT)
Prior art keywords
panel
source
temperature regulation
network
fluid
Prior art date
Application number
PCT/NZ2006/000266
Other languages
English (en)
Inventor
Samuel Kwun Hei Wong
Original Assignee
Auximedic Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auximedic Limited filed Critical Auximedic Limited
Publication of WO2007043901A1 publication Critical patent/WO2007043901A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F7/03—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F7/03—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction
    • A61F7/032—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction using oxygen from the air, e.g. pocket-stoves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24—HEATING; RANGES; VENTILATING
    • F24V—COLLECTION, PRODUCTION OR USE OF HEAT NOT OTHERWISE PROVIDED FOR
    • F24V30/00—Apparatus or devices using heat produced by exothermal chemical reactions other than combustion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0001—Body part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F2007/0268—Compresses or poultices for effecting heating or cooling having a plurality of compartments being filled with a heat carrier
    • A61F2007/0276—Compresses or poultices for effecting heating or cooling having a plurality of compartments being filled with a heat carrier with separate compartments connectable by rupturing a wall or membrane
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F3/00—Plate-like or laminated elements; Assemblies of plate-like or laminated elements
    • F28F3/12—Elements constructed in the shape of a hollow panel, e.g. with channels

Definitions

  • This invention relates to a temperature regulation system which may be useful for warming or cooling articles including mammals particularly human beings.
  • a typical, portable temperature stabilising method for a body or article is the use of insulation such as padding or a blanket.
  • insulation such as padding or a blanket.
  • An alternative standard for humans in danger of hypothermia is the use of a thermal blanket. This has no insulation properties, but is highly radiative for body heat. Such simple methods however may be insufficient to save the life of a patient.
  • US 6,800,087 discloses a blanket system for controlling a patient's body temperature which comprises a blanket under which are an air inlet and outlet. Warmed or cooled air can be supplied depending upon need. A pump is used to supply the air and a vacuum system to remove it.
  • US 6,969,399 discloses an enclosure for a patient's body. This enclosure allows heat transfer liquid to be contained and to pass over the patient's body. The enclosure has a liquid inlet and outlet, and allows for the heat transfer liquid to be in direct contact with the patient.
  • US 7,101,386, US 6,991,645 and related patents disclose more intervention based method and apparatus. A patient's body temperature is regulated by altering directly the temperature of blood flowing in a large vein feeding the heart. The temperature of this vein can be regulated by local heating, with an external heat applicator or by using a heating blanket for the whole body, such as those which use forced warm or cool air blowers.
  • a temperature regulation system for a body or article comprising: >
  • a body temperature regulation fluid source (“the source”) containing a precursor to a temperature regulation fluid, said precursor capable of being activated to form said temperature regulation fluid, and said source capable of releasing said temperature regulation fluid following activation of said precursor,
  • the network a fluid circulation network
  • said system is used for transferring heat to or from a human or animal body.
  • said fluid circulation network has at least one outlet.
  • said fluid circulation network has a plurality of outlets.
  • said source contains two or more substances partitioned or separated from one another, wherein said activation comprises mixing said two or more substances to either release energy as heat via an exothermic process or absorb energy via an endothermic process.
  • the product of said activation of said precursor results in a liquid phase product.
  • said two or more substances react according to a chemical exothermic pathway or chemical endothermic pathway.
  • said two or more substances are selected from one of the following list: calcium chloride and water, anhydrous magnesium sulphate and water, calcium chloride, water and glycerol, ammonium nitrate and water.
  • said two or more substances react according to a biochemical exothermic pathway or biochemical endothermic pathway.
  • said biochemical pathway is an enzyme catalysed pathway.
  • said two or more substances are glucose oxidase/catakse and a sugar molecule.
  • said two or more substances are glucose oxidase/catalase and ⁇ — D-glucose.
  • the source takes the form of a capsule or cartridge.
  • said activation can be conducted manually.
  • the connection of the source to the network can be conducted manually.
  • connection of the source to the network is conducted following said activation of the precursor.
  • said panel includes one or more layers of insulative material.
  • said panel includes one or more layers of material having water resistive properties.
  • said network is arranged in a tortuous pattern within the panel.
  • said network is arranged in a substantially regular serpentine pattern within the panel.
  • said network is regularly arranged within the panel.
  • said system includes one or more valves capable of adjusting the pressure within the network.
  • said panel includes one or more fittings allowing the panel to be interlocked or attached to at least a second panel.
  • said one or more inlets and/ or one or more outlets are capable of interlocking or engagement -with said second (or further) panel.
  • said panel may contain one or more temperature sensors to record and/or transmit and/ or display a temperature.
  • a source of temperature regulation fluid suitable for use with the temperature regulation system including two or more substances partitioned or separated from one another, which upon mixing, will either release energy as heat via an exothermic process or absorb energy via a endothermic process.
  • the product of the exothermic or endothermic process is a liquid.
  • said source comprises a cartridge or capsule adapted to interlock or engage with an inlet of the fluid circulation network of the system.
  • said mixing can be instigated manually.
  • said manual instigation is by hand pressure causing rupture of the partitioning between the substances.
  • the two or more substances when mixed will react according to a chemical exothermic pathway or chemical endothermic pathway.
  • the two or more substances are selected from one of the following list: calcium chloride and water, anhydrous magnesium sulphate and water. - calcium chloride, water and glycerol. ammonium nitrate and water.
  • the two or more substances when mixed will react according to a biochemical exothermic pathway or biochemical endothermic pathway.
  • biochemical pathway is an enzyme catalysed pathway.
  • said two or more substances are glucose oxidase/catalase and a sugar molecule.
  • said two or more substances are glucose oxidase/catalase and ⁇ — D-glucose.
  • a panel including a fluid circulation network suitable for use in the body regulation system above.
  • said panel includes one or more layers of insulative material.
  • said panel includes one or more layers of material having water resistive properties.
  • said network is arranged in a tortuous pattern within the panel.
  • said network is arranged in a substantially regular serpentine pattern within the panel.
  • said network is regularly arranged within the panel.
  • said panel includes one or more fittings allowing the panel to be interlocked or attached to a second (or further) panel.
  • said one or more inlets and/ or one or more outlets are capable of interlocking or engagement with said second (or further) panel.
  • said panel contains one or more temperature sensors to record and/ or transmit and/ or display the temperature of said panel or the body or article i ⁇ contact with said panel.
  • a temperature regulation covering comprising one or more of the panels above interlocked together and one or more sources of temperature regulation fluid.
  • kitset for temperature regulation of a body or article including one or more panels above and one or more sources of temperature regulation fluid above.
  • a method of temperature regulation of a body or an article comprising the steps of engaging a said source of temperature regulation fluid with an inlet of a said panel, and activating the source either before, substantially simultaneous with, or after the step of engaging the source with the inlet.
  • the method includes the step of interlocking one or more of said panels together.
  • the method includes engaging one or more of said sources with said network either simultaneously or sequentially.
  • the method includes draining the network of the temperature regulation fluid by gravity or suction.
  • draining the network of the temperature regulation fluid by gravity or suction.
  • swipetine as used in this specification, means a winding path or line.
  • glucose regulation as used in this specification includes temperature adjustment whether it be by heating or cooling.
  • glucose oxidase/catalase refers to the glucose oxidase system which is an enzyme highly specific for D-glucose producing hydrogen peroxide which can be followed by treatment with catalase to convert hydrogen peroxide to water. In many applications these two enzymatic activities are not separated. Glucose oxidase and catalase may be used together when hydrogen peroxide is to be avoided. This is generally the case in the present invention. However use of this term does not preclude use of the glucose oxidase enzyme only.
  • Figure 1 shows a cross section of one embodiment of a panel of the invention
  • Figure 2 shows a cross section of an alternative embodiment of a panel of the invention with the tubular channel in a collapsed configuration
  • Figure 3 shows a cross section of the panel of Figure 2, but with the tubular channel filled
  • Figure 4 shows a plan view of one possible arrangement of the tubular network within a panel of the invention
  • Figure 5 shows a plan view of multiple panels in accordance with the invention, interlocked together
  • Figure 6 shows a schematic side cross sectional view of one source of temperature regulation fluid in accordance with the invention
  • Figure 7 Shows a schematic experimental set, up testing a biochemical reaction pathway.
  • the present invention provides a novel approach to temperature regulation of an article or body.
  • the following description relates predominantly to regulating the temperature of a human (whether by heating or cooling) it will be understood by one skilled in the art that the invention and the method of its use can be employed for a wider range of purposes. This will include the temperature modification or maintenance of food stuffs and beverages for example, and also to the temperature regulation of animals.
  • One preferred embodiment of the invention comprises a panel having therein a network capable of containing a temperature regulation fluid, and a temperature regulation fluid capable of acting as a heating source or temperature drain.
  • the panel of invention may be of varying sizes.
  • the panel may be large enough to cover or even wrap a human.
  • the panel may be sized to cover only a single body part.
  • panels of the invention may also be capable of interlocking with one another to provide a much larger blanket of modular interlocked panels.
  • the network for containing the temperature regulation fluid may also interconnect if desired, to allow the fluid to pass through a plurality of interlocked panels.
  • Each panel may be merely a simple fabric, membrane or support structure for the fluid network system.
  • the panel may be a more complex structure of layers including insulation and/ or waterproof layers for example.
  • One preferred form of the invention involves three principle lightweight layers, with insulated, tubular and laminated water-proof layers.
  • the device may also include an elastic fabric layer and sealed collapsible channel network.
  • Specific materials which could be incorporated include: neoprene insulation, AerogelTM insulation, synthetic foam, bubblewrap, elastomers, natural and synthetic fibres e.g. polypropylene - waterproofing such as hospital grade PVC, latex, synthetic film, nylon, GortexTM
  • any form of tubing or sealed channel which can contain water is possible.
  • the nature of the tubing may depend upon the temperature regulation fluid which is employed. It should be invert to the fluid.
  • tubing may comprise plastic piping such as PVC oxygen line, laminated public channels or alternatively metal foil lubing or other materials as known in the art.
  • the tubular network may comprise a single pathway arranged throughout a panel. It may or may not have an outlet capable of draining the fluid, depending upon whether or not the system is intended to be reused. In a preferred embodiment one or more outlets are included to allow efficient fluid drainage once used.
  • the network system may also include partitioned regions that is, regions which may be closed off to the fluid or opened up should it be desired.
  • the fluid network system may also be capable of being interlocked with the analogous system of another panel.
  • the interlocking can be of many different forms as known by one skilled in the art. Screw fittings, modular click-fit fittings, for example are included.
  • Figure 1, 2 and 3 show cross-section views of a panel of the invention.
  • Figure 1 is cross section of one embodiment of a panel.
  • This panel has an inner side 1, closest to the body of a patient with a temperature to be regulated and an outer side 2, farthest away from the body.
  • both the inner 1 and outer 3 layers have a waterproof layer 3. It may be strictly waterproof or may be a breathable membrane material as is known in the art.
  • insulative layer 4 In this embodiment, closer to the outer side 2, there is an insulative layer 4. In this Figure one layer of insulative material is illustrated. However as would be envisaged by one skilled in the art, a plurality of layers of such material could be used. Varying degrees of thickness could also be employed. As would be appreciated, the less the number of layers of insulative or other materials, the more portable and packable the panel wiJl be. Thus all
  • Figure 2 also illustrates a tubular network or channel 5 within which the temperature regulation fluid is contained within the panel.
  • Figure 2 is a cross section of an alternative embodiment of a panel of the invention. Again the inner layer 1 and outer layer 2 are illustrated and shown to have outer waterproof layers 3. This embodiment however has an elastic fabric layer 21 which can be for example a LycraTM based material or similar where the material has significant elastic properties in ideally both directions.
  • Figure 2 also illustrates the tubular network or channel 22 in a collapsed configuration. In some preferred embodiments of the invention, this channel 22 prior to use is collapsed, thereby reducing the volume of the panel. This can be performed by applying manual pressure to the panel to evacuate the network of any gas or fluid.
  • the panel of the invention is reusable. Thus it may be that it is initially sold or presented vacuum packed and after its first use the network is cleared manually, vacuum pumped or drained by gravity, as would be envisaged by one skilled in the art.
  • FIG 3 illustrates the panel of Figure 2 differing only in that the tubular channel or network 5 is not filled with the temperature regulation fluid 31 and the elastic fabric layer 21 is now stretched.
  • Figure 4 illustrates a plan view of one panel 41 of the invention.
  • the tubular fluid network 42 is shown along with a fluid inlet 43 and three fluid outlets 44.
  • no fluid outlet 44 is necessary although even then it is preferred (to facilitate fluid flow into the network).
  • the fluid network 42 is regularly arranged within the panel 41 in a regular serpentine arrangement.
  • FIG. 3 outlets 44 are shown. These outlets or connection points 44 can be used to connect with other panels, or to connect to a pumping or other circulation device as might be expected in the art (discussed below).
  • the use of multiple panels such as that of Figure 4, interlocked together, is illustrated in Figure 5.
  • two panels 41 are illustrated each with a tubular fluid network 42. They are interlocked together with one inlet 43 and one outlet 44.
  • a separate modular pump 51 capable of fitting with the standard inlets 43 and outlets 44 of the panels 41.
  • the pump 51 assists with the circulation of the heat regulation fluid within the fluid network 42.
  • Such a pump 51 may be used in the case of multiple panels or equally it may be used when there is only one panel employed.
  • each inlet and outlet is valve controlled. This can be by manual valve control or in conjunction with a pressurising device that enables unidirectional or bidirectional flow depending on requirements or modular connections.
  • Each valve can be connected to each other by in some fashion, preferably by twist lock mechanisms.
  • the valves have specialised adaptors which only permit the head of the injecting tubes to fit and unlock the valve, allowing one possible flow pathway (illustrated for example with the arrows indicating the direction of temperature regulating fluid circulation through the tubular network in Figures 4 and 5).
  • the temperature regulation fluid has the general characteristic of being a source or drain of heat, in other words the fluid is hotter than or cooler than the body 'or article which is to have its temperature altered. In the simplest sense, this may mean hot or cold water may act as a temperature regulation fluid for example.
  • our preferred temperature regulation fluid is one which can be provided in a precursor form and activated to give rise to a heating or cooling effect.
  • One embodiment uses a chemical pathway to achieve the effect.
  • An alternative embodiment uses a biochemical pathway.
  • a number of constituents may be used to form the temperature regulation fluid. Our preference is to use those (for heating and for cooling) which will remain as a liquid once activated.
  • the chemicals are non- toxic, biodegradable and easily handled. This allows easy flushing/removal afterwards. Thus we ensure we remain below the saturation point of the fluid.
  • those that do crystallise or form a solid upon activation are also within the scope of the invention. It may or may not be possible to regenerate the crystallised fluid and re-use the network and panel(s) but this is also within the scope of the invention.
  • Solid reactions includes calcium chloride, water and glycerol.
  • -Cooling endo thermic: - ammonium nitrate and water.
  • Enthalpy of heat + 23 kj mol "1
  • Antifreeze may also be included to allow operation at sub-zero temperatures.
  • Propylene glycol and other non-toxic varieties e.g. Noburst, RV antifreeze, may be added to provide sub-zero reactions.
  • biochemical and bioactive constituents may be used to form the temperature regulation fluid. Our preference is to use those (for heating or for cooling) which will remain liquid once activated.
  • bioactive reagents are non- toxic, biodegradable and easily handled. This allows easy flushing/removal afterwards. Thus we ensure we remain below the saturation point of the fluid. It may or may not be possible to regenerate the bioreactive fluid and re-use the network and panel(s) but this is also within the scope of the invention.
  • Typical biochemical and bioreactive combinations include all of the above. Our preferred combinations include (but are not restricted to) Heating (exothermic):
  • the temperature regulation device for use on surfaces allows relatively rapid warming or cooling of the inner surface, and then maintains a temporary but constant temperature throughout the device for the duration of the aqueous chemical or biochemical reagent reactions.
  • the preferred system of the invention relies upon external injection of the temperature regulation fluid (or its precursors) into the fluid network.
  • This input of fluid can come from many difference sources.
  • Figure 6 illustrates a capsule 60 capable of interlocking with the fluid system. This is preferably via connection or interlocking of the nozzle of the capsule that can attach and lock onto a valve similar to inlet 43 of Figures 4 and 5, allowing for fluid in capsule to transfer the contents without leakage or spillage.
  • the capsule 60 contains a small sealed sachet or reservoir 61 of preferably aqueous solution surrounded by a flexible tubular container 62 enclosing solid or liquid chemical or biochemical reagents.
  • the operating mechanism of the device requites the rupture of the sachet (typically by hand) and mixing of the reagents within the tube before pressure induced squeeze injection through the specialised nozzle into the valve.
  • the cartridge or other container holding these reagents is connected before activation or even could be provided in place in the network prior to use.
  • the chemicals can be permitted to flow through the miniature tubular network such as the flow direction as shown in Figures 4 or 5 to distribute heat evenly throughout the device. Once the chemicals reach the ends of the valves, pressure is necessary to close the valve of that outlet point and prevent die fluid leaking. Pressure release can be achieved by a manual lock on each valve.
  • the invention is designed for immediate and temporary generation of heat as required in the situation and not exceeds safe exposure levels where adverse temperatures can inflict injury.
  • the insulation layer should provide enough thermal resistance that allows the thermal conduction to be minimised externally and heat distribution only towards the inner layer.
  • the invention can have a number of different embodiments which are included within the scope of the claimed invention. These include (but are not limited to): a single panel with single inlet and outlet; a panel with single or multiple inlet(s) and outlet(s) - panels which may be flat or shaped (such as tents, gloves, hoods, chilly bins.
  • hospitals e.g. cooling for stroke patients — in the form of a collar or a hood, full body blanket for example, or to heat intravenous infusion liquid bags
  • Ammonium Nitrate and Water reaction performed with 11.5g of granulised NH 4 Cl and 60ml of H 2 O reacted under atmospheric temperatures of 18.9 0 C and liquid temperature of 18.1 0 C.
  • the reaction produced a heat decrease to a minimum of 6.2°C within three minutes before increasing to 9.6°C at 15 minutes under a mildly insulated environment
  • Ammonium Nitrate and Water reaction performed with 3Og of granulised NH 4 Cl and 60ml of H 2 O reacted under atmospheric temperatures of 18.5°C and liquid temperature of 17.9°C.
  • the reaction produced a heat decrease to a minimum of -4.1 0 C within three minutes before receding to 0.4 0 C at 15 minutes under a mildly insulated environment.
  • Figure 7 shows our experimental set up for investigation of the ⁇ -D-glucose-glucose oxidase system.
  • a 300ml plastic cylinder 71 is employed as the reaction vessel. Air is pumped in from an air pump 72 to a diffuser 73 below the level of the reaction solution 74. pH, temperature, pressure and dissolved oxygen, probes are housed with the housing 75.
  • the solution is stirred by a magnetic stirring rod 76, powered by a magnetic stirrer 77.
  • a phosphate buffer system was employed to alter the pH of the system.
  • potassium hydrogen phosphate, potassium dihydrogen phosphate and glucose powder are weighted and mixed in about 300 ml of cold tap water. Then, the solution is transferred to a 300ml plastic measuring cylinder.
  • the air pump and magnetic stirrer are turned on for 5-10 minutes to allow thorough mixing and aeration.
  • the enzyme is added, logging of the multi-parameter In-Situ Inc Troll 9500 probe (to measure pH, redox potential, dissolved oxygen, temperature and pressure) and the picologger PC-08 to measure temperature are started.
  • the experiment was finished when there was no significant increase of temperature of the solution.
  • OxyGO enzyme at 35°C pH 5.1 is rated at >1500 Titrimetric Unit per ml 1 Titrimetric unit will oxidize 3.0 mg glucose to gluconic acid in 15 minutes, i.e. 0.2 mg glucose oxidized per minute for each titrimetric unit Therefore, 0.2 mg min '1 ⁇ 18Og mol "1 — 1.1 x 10 "6 mol glucose oxidised per itninute per titrimetric unit
  • Heat capacity for IL of water is 4186 J 0 C "1
  • oxygen consumption from air consisting of 20% oxygen is included with the reaction.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Combustion & Propulsion (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Abstract

Système de régulation de température comprenant un panneau doté d'un réseau pour fluide agencé à l'intérieur de celui-ci. Un fluide de régulation de température est préparé par activation de précurseurs et est ensuite admis dans le réseau pour fluide. L'invention comprend le système, les panneaux individuels qui peuvent être imbriqués ensemble et les précurseurs de fluide qui peuvent prendre la forme de capsules adaptées pour interagir avec le réseau. Le fluide peut donner lieu à un effet de chauffage ou de refroidissement.
PCT/NZ2006/000266 2005-10-13 2006-10-13 Systeme de regulation de temperature WO2007043901A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NZ542979 2005-10-13
NZ54297905 2005-10-13
NZ545976 2006-03-16
NZ54597606 2006-03-16

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WO2007043901A1 true WO2007043901A1 (fr) 2007-04-19

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014194304A2 (fr) * 2013-05-31 2014-12-04 Hirokane Laurie Enveloppements thérapeutiques chauffants et refroidissants comprenant des éléments décoratifs
CN109452702A (zh) * 2017-07-25 2019-03-12 福建锐翔体育科技股份有限公司 一种智能温控保暖运动服
EP3689302A1 (fr) * 2019-02-01 2020-08-05 Centre de Formacio I Docencia Formes S.L. Matelas thermique pour support corporel
CN111568640A (zh) * 2020-05-28 2020-08-25 刘子琛 一种新型自发热眼罩及制备工艺
WO2020198029A1 (fr) * 2019-03-25 2020-10-01 Ahh, LLC Serviette auto-chauffante ou auto-rafraîchissante

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Publication number Priority date Publication date Assignee Title
US3670716A (en) * 1970-12-21 1972-06-20 Us Navy Self-heated protective garment
US4334519A (en) * 1979-06-18 1982-06-15 Stanley Cieslak Portable heater for generating and circulating heat in wearing apparel
US5901698A (en) * 1996-12-11 1999-05-11 Welles; Clifford G. Mechanically compliant and portable catalytic heating device
US6062210A (en) * 1998-02-04 2000-05-16 Clifford G. Welles Portable heat generating device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3670716A (en) * 1970-12-21 1972-06-20 Us Navy Self-heated protective garment
US4334519A (en) * 1979-06-18 1982-06-15 Stanley Cieslak Portable heater for generating and circulating heat in wearing apparel
US5901698A (en) * 1996-12-11 1999-05-11 Welles; Clifford G. Mechanically compliant and portable catalytic heating device
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Cited By (7)

* Cited by examiner, † Cited by third party
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WO2014194304A2 (fr) * 2013-05-31 2014-12-04 Hirokane Laurie Enveloppements thérapeutiques chauffants et refroidissants comprenant des éléments décoratifs
WO2014194304A3 (fr) * 2013-05-31 2015-01-22 Hirokane Laurie Enveloppements thérapeutiques chauffants et refroidissants comprenant des éléments décoratifs
CN109452702A (zh) * 2017-07-25 2019-03-12 福建锐翔体育科技股份有限公司 一种智能温控保暖运动服
CN109452702B (zh) * 2017-07-25 2021-10-15 福建锐翔体育科技股份有限公司 一种智能温控保暖运动服
EP3689302A1 (fr) * 2019-02-01 2020-08-05 Centre de Formacio I Docencia Formes S.L. Matelas thermique pour support corporel
WO2020198029A1 (fr) * 2019-03-25 2020-10-01 Ahh, LLC Serviette auto-chauffante ou auto-rafraîchissante
CN111568640A (zh) * 2020-05-28 2020-08-25 刘子琛 一种新型自发热眼罩及制备工艺

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