WO2007041410A2 - Sustained release small molecule drug formulation - Google Patents
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- WO2007041410A2 WO2007041410A2 PCT/US2006/038268 US2006038268W WO2007041410A2 WO 2007041410 A2 WO2007041410 A2 WO 2007041410A2 US 2006038268 W US2006038268 W US 2006038268W WO 2007041410 A2 WO2007041410 A2 WO 2007041410A2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1213—Semi-solid forms, gels, hydrogels, ointments, fats and waxes that are solid at room temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Definitions
- the invention relates generally to delivery of small molecule drugs.
- small molecule drug refers to beneficial agents having low molecular weight.
- the beneficial agents are usually synthesized by organic chemistry, but may also be isolated from natural sources such as plants, fungi, and microbes.
- the common routes for delivering small molecule drugs are oral, injection, pulmonary, and transdermal.
- Many psychotherapeutic drugs are small molecule drugs and are usually provided as oral pills or bolus injections that can be administered one or more times daily.
- oral pills and bolus injections may not be optimal routes for administering small molecule psychotherapeutic drugs because of the peaks and troughs observed in plasma concentration after dosing. Adverse effects and loss of therapeutic effect have been associated with plasma concentration peaks and troughs, respectively.
- the invention relates to an injectable depot formulation which comprises a biocompatible polymer, an organic solvent combined with the biocompatible polymer to form a viscous gel, and a small molecule drug incorporated in the viscous gel such that the formulation exhibits an in vivo release profile having C max to C m i n ratio less than 200 and lag time less than 0.2.
- the invention in another aspect, relates to a method of administering a small molecule drug to a subject in a controlled manner which comprises implanting in the subject an effective amount of an injectable depot formulation comprising a biocompatible polymer, an organic solvent combined with the biocompatible polymer to form a viscous gel, and a small molecule drug incorporated in the viscous gel such that the formulation exhibits an in vivo release profile having C max to C m i n ratio less than 200 and lag time less than 0.2.
- FIG. 1 shows influence of drug salt form on in vivo release profile of formulations according to embodiments of the invention.
- FIG. 2 shows influence of solvent type on in vivo release profile of formulations according to embodiments of the invention.
- FIG. 3 shows influence of polymer type on in vivo release profile of formulations according to embodiments of the invention.
- FIG. 4 shows formulations having near zero-order release profiles according to embodiments of the invention.
- the release profile shows minimal lag time and burst.
- this release profile is surprising because the prevailing thought in the art is that a low burst, near zero-order release is virtually impossible to attain unless special steps are taken, such as coatings for drugs and microencapsulation.
- Several small drug formulations have been identified in this invention with in vivo release profiles having a C max to C m i n ratio less than 200 and lag time, Ti ag , less than 0.2.
- C m i n is the minimum drug concentration in plasma or serum.
- the variable "C max " is the maximum drug concentration in plasma or serum.
- the variable "Tiag” is the ratio of T va iiey to T tota i, where T va iiey is less than T to tai.
- the variable "T va ii e y” is the time to reach C va iiey
- the variable "C va uey is the first trough of drug concentration in plasma or serum during release.
- the variable "T tota i" is the total release duration.
- Small molecule drug formulations can be prepared as depot injections.
- the environment of use is a fluid environment and may include a subcutaneous, intramuscular, intramyocardial, adventitial, intratumoral, or intracerebral portion, a wound site, or tight joint spaces or body cavity of a human or animal. Multiple or repeated injections may be administered to the subject, for example, when the therapeutic effect of the drug has subsided or the period of time for the drug to have a therapeutic effect has lapsed or when the subject requires further administration of the drug for any reason.
- the formulation serves as an implanted sustained release drug delivery system after injection into the subject.
- Such controlled release can be over a period of one week, more than one week, one month, or more than one month.
- the controlled release is over at least a period of one week, more preferably over a period of at least one month.
- a small molecule drug formulation according to an embodiment of the invention includes a depot gel vehicle.
- the depot gel vehicle includes a biocompatible polymer, i.e., a polymer that would not cause irritation or necrosis in the environment of use.
- Biocompatible polymers that may be useful in the invention may be bioerodible, i.e., gradually decompose, dissolve, hydrolyze and/or erode in situ.
- bioerodible polymers include, but are not limited to, polylactides, polyglycolides, polycaprolactones, polyanhydrides, polyamines, polyurethanes, polyesteramides, polyorthoesters, polydioxanones, polyacetals, polyketals, polycarbonates, polyorthocarbonates, polyphosphazenes, succinates, poly(malic acid), poly(amino acids), polyvinylpyrrolidone, polyethylene glycol, polyhydroxycellulose, polysaccharides, chitin, chitosan, and copolymers, terpolymers and mixtures thereof.
- the polymer is typically present in the depot gel vehicle in an amount ranging from about 5 to 80% by weight, preferably from about 20 to 70%, often from about 40 to 60% by weight.
- the polymer is a polylactide.
- a polylactide polymer is a polymer based on lactic acid or a copolymer based on lactic acid and glycolic acid.
- the polylactide polymer can include small amounts of other comonomers that do not substantially affect the advantageous results that can be achieved in accordance with the invention.
- the term "lactic acid” includes the isomers L-lactic acid, D-lactic acid, DL-lactic acid, and lactide.
- the term "glycolic acid” includes glycolide.
- the polymer may have a lactic-acid to glycolic-acid monomer ratio of from about 100:0 to 15:85, preferably from about 60:40 to 75:25, often about 50:50.
- the polylactide polymer has a number average molecular weight ranging from about 1,000 to about 120,000, preferably from about 5,000 to about 30,000, as determined by gel permeation chromatography. Suitable polylactide polymers are available commercially.
- the depot gel vehicle further includes a biocompatible solvent which when combined with the polymer forms a viscous gel, typically exhibiting viscosity in a range from 500 poise to 200,000 poise, preferably from about 1,000 poise to 50,000 poise.
- the solvent used in the depot gel vehicle is typically an organic solvent and may be a single solvent or a mixture of solvents.
- the solvent, or at least one of the components of the solvent in the case of a multi-component solvent preferably has limited miscibility with water, e.g., less than 7% by weight, preferably less than 5% by weight, more preferably less than 3% by weight miscibility with water.
- Suitable solvents include, but are not limited to, benzyl benzoate (BB), benzyl alcohol (BA), ethyl benzoate (EB), triacetin, and N-methyl-2-pyrrolidone (NMP).
- the solvent is typically present in the depot gel vehicle in an amount ranging from about 20 to 95% by weight, preferably in an amount ranging from about 30 to 80% by weight, often in an amount ranging from about 40 to 60 % by weight.
- a formulation according to an embodiment of the invention includes a small molecule drug dispersed or dissolved in a depot gel vehicle as described above.
- the term "dispersed or dissolved” is intended to encompass all means of establishing the presence of the small molecule drug in the viscous gel and includes dissolution, dispersion, suspension, and the like.
- Small molecule drugs used in formulations of the invention are sparingly soluble in water. In a preferred embodiment, small molecule drugs used in formulations of the invention have less than 1 mg/ml solubility in water. In one embodiment, small molecule drugs used in formulations of the invention have a molecular weight in a range from 200 to 2,000 Daltons. Small molecule drugs used in formulations of the invention may have a narrow or wide therapeutic window.
- the invention generally delivers salubrious results in terms of C ma ⁇ and toxicity control for small molecule drugs having a narrow therapeutic window.
- the small molecule drug is typically present in the formulation in an amount ranging from about 1 to 50% by weight, more preferably in an amount ranging from about 5 to 40% by weight, often in an amount ranging from about 10 to 30% by weight.
- a small molecule drug formulation includes a small molecule psychotherapeutic drug, such as a small molecule antipsychotic, dopamine receptor agonist, dopamine receptor antagonist, serotonin receptor agonist, serotonin receptor antagonist, and serotonin uptake inhibitor drug.
- Table 1 shows physiochemical properties of some small molecule psychotherapeutic drugs.
- R209130-base has the molecular formula C 19 H 20 FNO.
- R209130-mandelic acid salt (R209130) has the molecular formula C 19 H 20 FNO-C 8 H 8 O 3 .
- R209130-tartaric acid salt R167154
- R209130 and its analogs possess putative atypical antipsychotic properties and have demonstrated antianxiety, antidepressive, and socializing effects in animal models. These characteristics may be attributed to R209130 dual antagonism of central dopamine D 2 receptors, serotonin 5-HT 2A and 5-HT 2 c receptors, and the inhibition norepinephrine uptake.
- Risperidone-base has the molecular formula C 23 H 27 FN 4 O 2 .
- Risperidone-pamoate has the molecular formula C 23 H 27 FN 4 O 2 -C 23 H 16 O 6 . Risperidone is a combined serotonin (5-HT 2 ) and dopamine (D2) receptor antagonist.
- a depot gel vehicle was prepared as follows: A HDPE container was tared on a Mettler PJ3000 top loader balance. Poly D,L-lactide-co-glycolide (PLGA), (L/G ratio of 50/50), available as RESOMER® RG 502 (PLGA-502), was weighed into the container. The container containing PLGA-502 was tared, and the corresponding solvent was added to the PLGA-502. Amounts expressed as percentages for various combinations of PLGA-502 and solvent are set forth below in Table 2. A hybrid mixer was used to mix the PLGA-502 and solvent mixture, resulting in a clear gel-like solution of the polymer in the solvent.
- Additional depot gel vehicles were prepared with solvents, selected from benzyl benzoate (BB), benzyl alcohol (BA), ethyl benzoate (EB), ethyl hydroxide (EtOH), triacetin, and N-methyl-2-pyrrolidone (NMP), and mixtures thereof, and polymers, selected from Poly D,L-lactide, available as RESOMER® L 104, RESOMER® R 104, RESOMER® 202, RESOMER® 203, RESOMER® 206, RESOMER® 207, RESOMER® 208; PLGA, L/G ratio of 50/50, available as RESOMER® RG 502H; PLGA, L/G ratio of 50/50, available as RESOMER® RG 503; PLGA, L/G ratio of 50/50, available as RESOMER® RG 755; Poly L-lactide, molecular weight of 2000, available as RESOMER® L 206, RESOMER® L 207
- PCL-GA-LA Polycaprolactone-glycolic acid-lactic acid copolymer
- PVP polyvinylpyrrolidone
- Drug particles were prepared as follows: R209130, R167154, risperidone base, or risperidone pamoate drug was passed through sieves of different sizes to obtain drug particles having a certain range of particle size distribution. Particles in the range of 20 to 63 ⁇ m, 63 to 125 ⁇ m, 75 to 125 ⁇ m, or less than 38 ⁇ m were obtained. Micronized particles received were also used as drug particles.
- Depot formulations were prepared as follows: sieved drug particles prepared as described in Example 2 were added into the depot gel vehicles prepared as described in Example 1 in an amount of 0 to 50% by weight and blended manually until the drug particles were wetted completely. Then, the mixture of drug particles and depot gel was thoroughly blended by conventional mixing using a Caframo mechanical stirrer with an attached square- tip metal spatula. Final homogeneous gel formulations were transferred to 3, 10, or 30 cc disposable syringes for storage or dispensing.
- a representative number of implantable gels were prepared in accordance with the foregoing procedures and tested in vivo in rats to determine release of the drug as determined by blood serum or plasma concentration of drug as a function of time.
- Formulation 7 (R209130) has C max to C min ratio of 19.2 and Ti ag of 0.61, while formulation 3 (R167154) has C max to C m i n ratio of 25.7 and Ti ag of 0.33.
- This example shows that in vivo release is influenced by salt form of the formulation. Even though Ti ag for formulation 7 (R209130) is higher than Ti ag for formulation 3 (Rl 67154), formulation 7 appears to have better release rate profile and duration of release in comparison to formulation 3.
- Example 3 BA, BB, EB, EtOH, NMP, and triacetin, and combinations thereof, as per procedure in Example 1.
- the depot gel vehicles were loaded with drug substance, in appropriate range, as per procedure in Example 3.
- Resulting formulations are illustrated in Table 3 below.
- Final homogeneous depot formulations were transferred to 3, 10 or 30 cc disposable syringes for storage or dispensing.
- In vivo release profiles of the formulations in Table 3 are shown in FIG. 2.
- Ctnax to C m in ratio and T] ag of the formulations are shown in Table 3.
- formulation 63 (risperidone base/PLGA/triacetin depot) has a C max to C ⁇ i m ratio of 1364.64.
- formulation 73 (risperidone base/PLGA/EB depot) has a C max to C m i n ratio of 5.20, which is significantly lower than the C max to C m i n ratio for formulation 63.
- Formulation 2 (R167154/PLGA/BB depot) has a C max to C min ratio of 59.68.
- formulation 3 (R167154/PLGA/BA/BB) has a C max to C m i n ratio of 25.68, which is less than half the C max to C m i n ratio for formulation 2. This indicates that solvent type can influence in vivo release profile of the formulation.
- Depot gel vehicles were prepared with polymers with different molecular weights and loaded with drug substance, in appropriate size range, as per procedure in Example 3. Resulting formulations are illustrated in Table 5 below. Final homogeneous depot formulations were transferred to 3, 10 or 30 cc disposable syringes for storage or dispensing. Table 5 shows C m3x to C m i n ratio and T lag for in vivo release profiles of the formulations.
- a formulation is described as near zero-order if the ratio of C ma ⁇ to C m i n is less than 200, preferably less than 50, more preferably less than 30. Ti ag in release of formulation is preferably less than 0.2. Formulations that do not show C va ii e y do not exhibit lag. Table 9 shows a number of formulations that exhibited the characteristic near zero-order release. FIG. 4 shows in vivo release profiles of selected formulations in Table 9.
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Abstract
Description
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Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2006299657A AU2006299657B2 (en) | 2005-09-30 | 2006-09-28 | Sustained release small molecule drug formulation |
CN2006800412698A CN101365423B (en) | 2005-09-30 | 2006-09-28 | Sustained release small molecule drug formulation |
DK06825283.2T DK1940351T3 (en) | 2005-09-30 | 2006-09-28 | Formulation of small-molecule drugs with long-term release |
EP06825283A EP1940351B1 (en) | 2005-09-30 | 2006-09-28 | Sustained release small molecule drug formulation |
JP2008533726A JP2009510116A (en) | 2005-09-30 | 2006-09-28 | Sustained release formulation of small molecule drugs |
ES06825283T ES2385384T3 (en) | 2005-09-30 | 2006-09-28 | Small-molecule extended-release drug formulation |
AT06825283T ATE551989T1 (en) | 2005-09-30 | 2006-09-28 | SUSTAINED RELEASE SMALL MOLECULE MEDICINE FORMULATION |
CA2624088A CA2624088C (en) | 2005-09-30 | 2006-09-28 | Sustained release small molecule drug formulation |
IL190499A IL190499A (en) | 2005-09-30 | 2008-03-27 | Injectable sustained release risperidone formulation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US72284505P | 2005-09-30 | 2005-09-30 | |
US60/722,845 | 2005-09-30 |
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WO2007041410A2 true WO2007041410A2 (en) | 2007-04-12 |
WO2007041410A3 WO2007041410A3 (en) | 2007-07-12 |
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PCT/US2006/038268 WO2007041410A2 (en) | 2005-09-30 | 2006-09-28 | Sustained release small molecule drug formulation |
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US (6) | US8852638B2 (en) |
EP (2) | EP2361609B1 (en) |
JP (3) | JP2009510116A (en) |
CN (1) | CN101365423B (en) |
AR (1) | AR056554A1 (en) |
AT (1) | ATE551989T1 (en) |
AU (1) | AU2006299657B2 (en) |
CA (1) | CA2624088C (en) |
DK (2) | DK2361609T3 (en) |
ES (2) | ES2422681T3 (en) |
IL (1) | IL190499A (en) |
PL (1) | PL2361609T3 (en) |
TW (1) | TW200803920A (en) |
WO (1) | WO2007041410A2 (en) |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008054772A2 (en) * | 2006-10-30 | 2008-05-08 | Alza Corporation | Implantable elastomeric caprolactone depot compositions and uses thereof |
WO2008153611A2 (en) | 2007-05-25 | 2008-12-18 | Qlt Usa, Inc. | Sustained delivery formulations of risperidone compounds |
JP2010527926A (en) * | 2007-05-18 | 2010-08-19 | デュレクト コーポレーション | Improved depot formulation |
EP1909689A4 (en) * | 2005-07-18 | 2011-11-16 | Univ Pennsylvania | Drug-containing implants and methods of use thereof |
WO2011151355A1 (en) * | 2010-05-31 | 2011-12-08 | Laboratorios Farmacéuticos Rovi, S.A. | Antipsychotic injectable depot composition |
US8470360B2 (en) | 2008-04-18 | 2013-06-25 | Warsaw Orthopedic, Inc. | Drug depots having different release profiles for reducing, preventing or treating pain and inflammation |
US20130177603A1 (en) * | 2010-05-31 | 2013-07-11 | Laboratorios Farmaceuticos Rovi, S.A. | Methods for the Preparation of Injectable Depot Compositions |
US9498432B2 (en) | 2010-06-08 | 2016-11-22 | Indivior Uk Limited | Injectable flowable composition comprising buprenorphine |
WO2017053346A1 (en) | 2015-09-21 | 2017-03-30 | Teva Pharmaceuticals International Gmbh | Sustained release olanzapine formulations |
US9717799B2 (en) | 2004-01-12 | 2017-08-01 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
US10022367B2 (en) | 2014-03-10 | 2018-07-17 | Indivior Uk Limited | Sustained-release buprenorphine solutions |
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