GB873526A - Fluid compositions comprising (acetyl-salicylic acid)-anhydride - Google Patents
Fluid compositions comprising (acetyl-salicylic acid)-anhydrideInfo
- Publication number
- GB873526A GB873526A GB23544/58A GB2354458A GB873526A GB 873526 A GB873526 A GB 873526A GB 23544/58 A GB23544/58 A GB 23544/58A GB 2354458 A GB2354458 A GB 2354458A GB 873526 A GB873526 A GB 873526A
- Authority
- GB
- United Kingdom
- Prior art keywords
- glycerine
- ingredients
- anhydride
- propylene glycol
- acetyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
- A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
Abstract
A stable, fluid composition for oral use comprises (acetylsalicylic acid)-anhydride and a liquid carrier which may be glycerine, propylene glycol, a liquid polyalkylene glycol, a vegetable oil, e.g. coconut, cottonseed or sesame oils, 2,2-dimethyl-4-oxymethyl-1,3-dioxolane, N,N-dimethyl acetamide (preferred for solutions) or mixtures thereof which are miscible with each other and compatible with other ingredients. Anhydrous ethanol may also be present when compatible, e.g. with glycerine or propylene glycol. The water content of the vehicle should not exceed 5% by weight and preferably should not be more than 1%. Additional active ingredients, for example, acetophenetidin, caffeine, codeine, salicylamide, N - acetyl - p - aminophenol, cortisone, hydrocortisone or its derivatives, tranquilizers, sedatives, antihistaminics, anti-ussive agents, antibiotics and vitamins, especially ascorbic, pantothenic and p-aminobenzoic acids, may also be present. Other ingredients, for example, sweetening, suspending, demulcent, flavouring and surface-active agents, may also be added. The anhydride and other ingredients may be in particles of reduced size produced, for example, by milling to give particles of about 10 to 100 microns in size or by jet-pulverizing e.g. air-micronizing to give particles of under 10 microns. For suspensions, for which glycerine is the preferred vehicle, uniformity of the product may be assured, e.g. by passage through a colloid mill or homogenizing equipment. Examples given are suspensions in glycerine, glycerine and ethanol, polyethylene glycol, propylene glycol, coconut oil and cottonseed oil comprising also acetophenetidin, caffeine, codeine, hydrocortisone, phenobarbitol, benactyzine, tetracycline and b -ortho-methoxyphenylisopropyl methylamine and of a solution in N,N-dimethylacetamide.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US873526XA | 1957-08-14 | 1957-08-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB873526A true GB873526A (en) | 1961-07-26 |
Family
ID=22204677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB23544/58A Expired GB873526A (en) | 1957-08-14 | 1958-07-22 | Fluid compositions comprising (acetyl-salicylic acid)-anhydride |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB873526A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0856310A2 (en) * | 1997-02-04 | 1998-08-05 | Senju Pharmaceutical Co., Ltd. | Method for stabilizing acriylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized acrylcarboxylic acid |
GB2533669A (en) * | 2014-12-23 | 2016-06-29 | Innovate Pharmaceuticals Ltd | Salicylate compound composition |
US10010612B2 (en) | 2007-05-25 | 2018-07-03 | Indivior Uk Limited | Sustained delivery formulations of risperidone compounds |
US10022367B2 (en) | 2014-03-10 | 2018-07-17 | Indivior Uk Limited | Sustained-release buprenorphine solutions |
US10058554B2 (en) | 2005-09-30 | 2018-08-28 | Indivior Uk Limited | Sustained release small molecule drug formulation |
US10172849B2 (en) | 2010-06-08 | 2019-01-08 | Indivior Uk Limited | Compositions comprising buprenorphine |
US10198218B2 (en) | 2010-06-08 | 2019-02-05 | Indivior Uk Limited | Injectable flowable composition comprising buprenorphine |
-
1958
- 1958-07-22 GB GB23544/58A patent/GB873526A/en not_active Expired
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0856310A3 (en) * | 1997-02-04 | 2000-01-19 | Senju Pharmaceutical Co., Ltd. | Method for stabilizing acriylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized acrylcarboxylic acid |
US6274592B1 (en) | 1997-02-04 | 2001-08-14 | Senju Pharmaceutical Co., Ltd. | Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid |
EP1389469A1 (en) * | 1997-02-04 | 2004-02-18 | Senju Pharmaceutical Co., Ltd. | Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid |
US7320985B2 (en) | 1997-02-04 | 2008-01-22 | Senju Pharmaceutical Co., Ltd. | Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid |
EP0856310A2 (en) * | 1997-02-04 | 1998-08-05 | Senju Pharmaceutical Co., Ltd. | Method for stabilizing acriylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized acrylcarboxylic acid |
US11110093B2 (en) | 2005-09-30 | 2021-09-07 | Indivior Uk Limited | Sustained release small molecule drug formulation |
US10058554B2 (en) | 2005-09-30 | 2018-08-28 | Indivior Uk Limited | Sustained release small molecule drug formulation |
US10376590B2 (en) | 2007-05-25 | 2019-08-13 | Indivior Uk Limited | Sustained delivery formulations of risperidone compound |
US11712475B2 (en) | 2007-05-25 | 2023-08-01 | Indivior Uk Limited | Sustained delivery formulations of risperidone compound |
US11013809B2 (en) | 2007-05-25 | 2021-05-25 | Indivior Uk Limited | Sustained delivery formulations of risperidone compound |
US10010612B2 (en) | 2007-05-25 | 2018-07-03 | Indivior Uk Limited | Sustained delivery formulations of risperidone compounds |
US10558394B2 (en) | 2010-06-08 | 2020-02-11 | Indivior Uk Limited | Injectable flowable composition comprising buprenorphine |
US10198218B2 (en) | 2010-06-08 | 2019-02-05 | Indivior Uk Limited | Injectable flowable composition comprising buprenorphine |
US10172849B2 (en) | 2010-06-08 | 2019-01-08 | Indivior Uk Limited | Compositions comprising buprenorphine |
US10592168B1 (en) | 2010-06-08 | 2020-03-17 | Indivior Uk Limited | Injectable flowable composition comprising buprenorphine |
US10517864B2 (en) | 2014-03-10 | 2019-12-31 | Indivior Uk Limited | Sustained-release buprenorphine solutions |
US10022367B2 (en) | 2014-03-10 | 2018-07-17 | Indivior Uk Limited | Sustained-release buprenorphine solutions |
GB2533669B (en) * | 2014-12-23 | 2016-12-14 | Innovate Pharmaceuticals Ltd | Salicylate compound composition |
AU2015370673B2 (en) * | 2014-12-23 | 2021-06-03 | Innovate Pharmaceuticals Limited | Salicylate compound composition |
WO2016102959A1 (en) * | 2014-12-23 | 2016-06-30 | Innovate Pharmaceuticals Limited | Salicylate compound composition |
US11129837B2 (en) | 2014-12-23 | 2021-09-28 | Innovate Pharmaceuticals Limited | Salicylate compound composition |
GB2533669A (en) * | 2014-12-23 | 2016-06-29 | Innovate Pharmaceuticals Ltd | Salicylate compound composition |
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