WO2007030266A3 - Polymeres a liberation d'acide nitrique derives de polyimines modifiees - Google Patents

Polymeres a liberation d'acide nitrique derives de polyimines modifiees Download PDF

Info

Publication number
WO2007030266A3
WO2007030266A3 PCT/US2006/031425 US2006031425W WO2007030266A3 WO 2007030266 A3 WO2007030266 A3 WO 2007030266A3 US 2006031425 W US2006031425 W US 2006031425W WO 2007030266 A3 WO2007030266 A3 WO 2007030266A3
Authority
WO
WIPO (PCT)
Prior art keywords
nitric oxide
polymers derived
polyimines
modified
coatings
Prior art date
Application number
PCT/US2006/031425
Other languages
English (en)
Other versions
WO2007030266A2 (fr
Inventor
Mingfei Cheng
Peiwen Chen
Kishore Udipi
Original Assignee
Medtronic Vascular Inc
Mingfei Cheng
Peiwen Chen
Kishore Udipi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Vascular Inc, Mingfei Cheng, Peiwen Chen, Kishore Udipi filed Critical Medtronic Vascular Inc
Priority to JP2008530056A priority Critical patent/JP2009506869A/ja
Priority to EP06801283A priority patent/EP1928515A2/fr
Publication of WO2007030266A2 publication Critical patent/WO2007030266A2/fr
Publication of WO2007030266A3 publication Critical patent/WO2007030266A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Materials For Medical Uses (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

L'invention concerne des polyimines modifiées et des dérivés de celles-ci utilisés comme dispositifs médicaux implantables et comme revêtements. Les dispositifs médicaux implantables et/ou revêtements comprennent plus spécifiquement des polymères amphiphiles dérives de polyimines modifiées. Les dispositifs médicaux et les revêtements de l'invention peuvent également être utilisés pour distribuer in situ des médicaments à libération d'oxyde nitrique/libération contrôlée et pour traiter ou prévenir des troubles médicaux, tels que la resténose, les anévrismes et les plaques vulnérables.
PCT/US2006/031425 2005-09-07 2006-08-14 Polymeres a liberation d'acide nitrique derives de polyimines modifiees WO2007030266A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2008530056A JP2009506869A (ja) 2005-09-07 2006-08-14 修飾ポリイミン由来一酸化窒素放出ポリマー
EP06801283A EP1928515A2 (fr) 2005-09-07 2006-08-14 Polymeres a liberation d'acide nitrique derives de polyimines modifiees

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/222,142 US20070053952A1 (en) 2005-09-07 2005-09-07 Nitric oxide-releasing polymers derived from modified polymers
US11/222,142 2005-09-07

Publications (2)

Publication Number Publication Date
WO2007030266A2 WO2007030266A2 (fr) 2007-03-15
WO2007030266A3 true WO2007030266A3 (fr) 2008-01-24

Family

ID=37830268

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/031425 WO2007030266A2 (fr) 2005-09-07 2006-08-14 Polymeres a liberation d'acide nitrique derives de polyimines modifiees

Country Status (4)

Country Link
US (1) US20070053952A1 (fr)
EP (1) EP1928515A2 (fr)
JP (1) JP2009506869A (fr)
WO (1) WO2007030266A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8282967B2 (en) 2005-05-27 2012-10-09 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
US8981139B2 (en) 2011-02-28 2015-03-17 The University Of North Carolina At Chapel Hill Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same
US9526738B2 (en) 2009-08-21 2016-12-27 Novan, Inc. Topical gels and methods of using the same

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US7763063B2 (en) 2003-09-03 2010-07-27 Bolton Medical, Inc. Self-aligning stent graft delivery system, kit, and method
US9198786B2 (en) 2003-09-03 2015-12-01 Bolton Medical, Inc. Lumen repair device with capture structure
US11259945B2 (en) 2003-09-03 2022-03-01 Bolton Medical, Inc. Dual capture device for stent graft delivery system and method for capturing a stent graft
US8292943B2 (en) 2003-09-03 2012-10-23 Bolton Medical, Inc. Stent graft with longitudinal support member
US20080264102A1 (en) 2004-02-23 2008-10-30 Bolton Medical, Inc. Sheath Capture Device for Stent Graft Delivery System and Method for Operating Same
US8500792B2 (en) 2003-09-03 2013-08-06 Bolton Medical, Inc. Dual capture device for stent graft delivery system and method for capturing a stent graft
US11596537B2 (en) 2003-09-03 2023-03-07 Bolton Medical, Inc. Delivery system and method for self-centering a proximal end of a stent graft
US20070198078A1 (en) 2003-09-03 2007-08-23 Bolton Medical, Inc. Delivery system and method for self-centering a Proximal end of a stent graft
WO2006078320A2 (fr) 2004-08-04 2006-07-27 Brookwood Pharmaceuticals, Inc. Procede de production de systemes d'administration, et systemes d'administration
JP2009505727A (ja) 2005-08-25 2009-02-12 メドトロニック ヴァスキュラー インコーポレイテッド 医療機器及びそのコーティングとして有益な一酸化窒素放出生分解性ポリマー
US8241619B2 (en) 2006-05-15 2012-08-14 Medtronic Vascular, Inc. Hindered amine nitric oxide donating polymers for coating medical devices
US7811600B2 (en) * 2007-03-08 2010-10-12 Medtronic Vascular, Inc. Nitric oxide donating medical devices and methods of making same
US8273828B2 (en) * 2007-07-24 2012-09-25 Medtronic Vascular, Inc. Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation
US8124601B2 (en) * 2007-11-21 2012-02-28 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
US8728528B2 (en) 2007-12-20 2014-05-20 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
US20090196900A1 (en) * 2008-02-01 2009-08-06 Medtronic Vascular, Inc. Use of Phosphodiesterase Inhibitor as a Component of Implantable Medical Devices
US20090222088A1 (en) * 2008-02-29 2009-09-03 Medtronic Vascular, Inc. Secondary Amine Containing Nitric Oxide Releasing Polymer Composition
US20090232863A1 (en) * 2008-03-17 2009-09-17 Medtronic Vascular, Inc. Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers
US20090232868A1 (en) * 2008-03-17 2009-09-17 Medtronic Vascular, Inc. Nitric Oxide Releasing Polymer Composition
EP2328513B1 (fr) 2008-06-30 2017-05-31 Bolton Medical Inc. Systèmes de traitement des anévrismes aortiques abdominaux
US8852640B2 (en) * 2008-07-03 2014-10-07 Ecole Polytechnique Federale De Lausanne (Epfl) Micelles for delivery of nitric oxide
US8580912B2 (en) * 2008-09-19 2013-11-12 Northwestern University Biodegradable nitric oxide generating polymers and related biomedical devices
EP2334279A4 (fr) * 2008-10-16 2013-03-20 Novan Inc Particules libérant du monoxyde d'azote utilisables en hygiène bucco-dentaire
US8158187B2 (en) * 2008-12-19 2012-04-17 Medtronic Vascular, Inc. Dry diazeniumdiolation methods for producing nitric oxide releasing medical devices
EP2405868B1 (fr) 2009-03-13 2017-06-28 Bolton Medical Inc. Système d'une prothèse endoluminale au niveau d'un site chirurgical
US8709465B2 (en) * 2009-04-13 2014-04-29 Medtronic Vascular, Inc. Diazeniumdiolated phosphorylcholine polymers for nitric oxide release
CN102695528B (zh) 2009-08-21 2016-07-13 诺万公司 创伤敷料、其使用方法及其形成方法
EP2846743B1 (fr) 2012-04-12 2016-12-14 Bolton Medical Inc. Dispositif de mise en place d'une prothèse vasculaire
US9439751B2 (en) 2013-03-15 2016-09-13 Bolton Medical, Inc. Hemostasis valve and delivery systems
EP3551140A4 (fr) 2016-12-09 2020-07-08 Zenflow, Inc. Systèmes, dispositifs et méthodes pour le déploiement précis d'un implant dans l'urètre prostatique
AU2020387396A1 (en) 2019-11-19 2022-04-21 Zenflow, Inc. Systems, devices, and methods for the accurate deployment and imaging of an implant in the prostatic urethra

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5155137A (en) * 1990-09-20 1992-10-13 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Complexes of nitric oxide with polyamines
WO2005039664A2 (fr) * 2003-10-14 2005-05-06 Cube Medical A/S Dispositif medical
WO2005081752A2 (fr) * 2004-02-09 2005-09-09 Amulet Pharmaceuticals, Inc. Polymeres liberant du monoxyde d'azote
WO2006037105A2 (fr) * 2004-09-27 2006-04-06 Government Of The United States Of America, Represented By The Secretary Department Of Health And Human Services Polymeres diazeniumdiolates a base d'acrylonitrile liberant du monoxyde d'azote et compositions, dispositifs medicaux et utilisations correspondantes
WO2007024501A2 (fr) * 2005-08-25 2007-03-01 Medtronic Vascular, Inc. Polymeres biodegradables liberant de l'oxyde nitrique utiles comme dispositifs medicaux et revetements associes

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954526A (en) * 1989-02-28 1990-09-04 The United States Of America As Represented By The Department Of Health And Human Services Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
US5039705A (en) * 1989-09-15 1991-08-13 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5212204A (en) * 1989-10-18 1993-05-18 The United States Of America As Represented By The Department Of Health And Human Services Antihypertensive compositions and use thereof
US5268465A (en) * 1991-01-18 1993-12-07 The Johns Hopkins University Purification and molecular cloning of nitric oxide synthase
US5380758A (en) * 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
JP3190340B2 (ja) * 1991-09-24 2001-07-23 アメリカ合衆国 酸化窒素供与体プロドラッグとしての求核試薬−酸化窒素付加物の酸素置換誘導体
US5525357A (en) * 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US5650447A (en) * 1992-08-24 1997-07-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitric oxide-releasing polymers to treat restenosis and related disorders
US5658565A (en) * 1994-06-24 1997-08-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Inducible nitric oxide synthase gene for treatment of disease
WO1994012645A2 (fr) * 1992-11-25 1994-06-09 University Of Pittsburgh Of The Commonwealth System Of Higher Education CLONE D'ADNc DE SYNTHASE D'OXYDE NITRIQUE INDUCTIBLE CHEZ L'HOMME ET PROCEDE DE PREPARATION
US5891459A (en) * 1993-06-11 1999-04-06 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of vascular function by modulation of endogenous nitric oxide production or activity
US5945452A (en) * 1993-06-11 1999-08-31 The Board Of Trustees Of The Leland Stanford Junior University Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production or activity
US5428070A (en) * 1993-06-11 1995-06-27 The Board Of Trustees Of The Leland Stanford Junior University Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity
US5583101A (en) * 1994-07-15 1996-12-10 Harvard College Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction
US5930700A (en) * 1995-11-29 1999-07-27 Bell Communications Research, Inc. System and method for automatically screening and directing incoming calls
US7378105B2 (en) * 1997-09-26 2008-05-27 Abbott Laboratories Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens
US6580784B2 (en) * 2000-12-04 2003-06-17 International Business Machines Corporation System and method for urgent phone message delivery
US20030041048A1 (en) * 2001-08-15 2003-02-27 Senaka Balasuriya System and method for providing dymanic selection of communication actions using stored rule set
US20050171596A1 (en) * 2004-02-03 2005-08-04 Furst Joseph G. Stents with amphiphilic copolymer coatings

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5155137A (en) * 1990-09-20 1992-10-13 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Complexes of nitric oxide with polyamines
WO2005039664A2 (fr) * 2003-10-14 2005-05-06 Cube Medical A/S Dispositif medical
WO2005081752A2 (fr) * 2004-02-09 2005-09-09 Amulet Pharmaceuticals, Inc. Polymeres liberant du monoxyde d'azote
WO2006037105A2 (fr) * 2004-09-27 2006-04-06 Government Of The United States Of America, Represented By The Secretary Department Of Health And Human Services Polymeres diazeniumdiolates a base d'acrylonitrile liberant du monoxyde d'azote et compositions, dispositifs medicaux et utilisations correspondantes
WO2007024501A2 (fr) * 2005-08-25 2007-03-01 Medtronic Vascular, Inc. Polymeres biodegradables liberant de l'oxyde nitrique utiles comme dispositifs medicaux et revetements associes

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8282967B2 (en) 2005-05-27 2012-10-09 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8956658B2 (en) 2005-05-27 2015-02-17 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8962029B2 (en) 2005-05-27 2015-02-24 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US9403852B2 (en) 2005-05-27 2016-08-02 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US9403851B2 (en) 2005-05-27 2016-08-02 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US9526738B2 (en) 2009-08-21 2016-12-27 Novan, Inc. Topical gels and methods of using the same
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
US8981139B2 (en) 2011-02-28 2015-03-17 The University Of North Carolina At Chapel Hill Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same

Also Published As

Publication number Publication date
EP1928515A2 (fr) 2008-06-11
WO2007030266A2 (fr) 2007-03-15
US20070053952A1 (en) 2007-03-08
JP2009506869A (ja) 2009-02-19

Similar Documents

Publication Publication Date Title
WO2007030266A3 (fr) Polymeres a liberation d'acide nitrique derives de polyimines modifiees
WO2007024501A3 (fr) Polymeres biodegradables liberant de l'oxyde nitrique utiles comme dispositifs medicaux et revetements associes
WO2007024481A3 (fr) Compositions polymeres a base de 4-aza-caprolactone utiles pour la fabrication de dispositifs medicaux biodegradables et en tant que revetements pour dispositifs medicaux
WO2006002399A3 (fr) Dispositifs medicaux biodegradables implantables, procedes et systemes associes
WO2009005909A3 (fr) Copolymères triséquencés biodégradables pour dispositifs implantables
TNSN08079A1 (en) Pharmaceutical compositions for the treatment of inner ear disorders
WO2004000379A8 (fr) Enrobages d'endoprothese vasculaire a liberation medicamenteuse prolongee
WO2007146426A3 (fr) Nanobilles pour délivrance de médicament
WO2007056134A3 (fr) Polymeres phenoliques resorbables
WO2008021368A3 (fr) Compositions et méthodes de neuroprotection
WO2006049907A3 (fr) Dispositifs implantables comprenant des polymeres en etoile biologiquement absorbables, procedes de fabrication de ces derniers
WO2005110508A3 (fr) Procedes de modulation des proprietes thermiques et mecaniques de revetements sur des dispositifs implantables
WO2008042748A3 (fr) Milieux polyélectrolytiques destinés à la distribution d'agents bioactifs
WO2008034013A3 (fr) Dispositifs médicaux et procédés de réalisation desdits dispositifs
WO2008002434A3 (fr) Dispositifs médicaux pour libération d'agents thérapeutiques de faible solubilité
WO2006074391A3 (fr) Compositions de revetement biodegradables comportant des melanges
WO2008036144A3 (fr) Nano-enveloppes sur polymères
WO2005113031A3 (fr) Articles médicaux ayant des zones contenant l’agent thérapeutique formes a partir de particules polymeres combinees
WO2009141823A3 (fr) Conjugués d'un polymère, d'un bisphosphonate et d'un agent anti-angiogenèse et leurs utilisations dans le traitement et la surveillance de maladies concernant les os
WO2006060235A3 (fr) Polymeres bioabsorbables et biobenefiques a base de tyrosine, destines a des revetements d'endoprotheses a elution de medicaments
WO2005099621A3 (fr) Revetements topographiques et procede de revetement de dispositifs medicaux
MXPA04006731A (es) Sistema de administracion de farmacos que comprenden rapamicina y derivados de la misma para la prevencion y tratamiento de enfermedades vasculares.
WO2006023130A3 (fr) Dispositif biodegradable de diffusion d'un agent bioactif a liberation lente
WO2009132070A3 (fr) Systèmes de thiol-vinyl et de thiol-yne pour polymères à mémoire de forme
WO2006104894A3 (fr) Enrobage pour dispositifs implantables et leur methode de formation

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 2008530056

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006801283

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 06801283

Country of ref document: EP

Kind code of ref document: A2