WO2007029265A3 - A process for preparing clarithromycin and clarithromycin intermediate - Google Patents

A process for preparing clarithromycin and clarithromycin intermediate Download PDF

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Publication number
WO2007029265A3
WO2007029265A3 PCT/IN2006/000149 IN2006000149W WO2007029265A3 WO 2007029265 A3 WO2007029265 A3 WO 2007029265A3 IN 2006000149 W IN2006000149 W IN 2006000149W WO 2007029265 A3 WO2007029265 A3 WO 2007029265A3
Authority
WO
WIPO (PCT)
Prior art keywords
clarithromycin
preparing
methylating
selectiviely
erythromycin
Prior art date
Application number
PCT/IN2006/000149
Other languages
French (fr)
Other versions
WO2007029265A2 (en
Inventor
Rajan Vitthal Gupte
Chandrabhan Madhav Hire
Kishore Balaji Sabade
Original Assignee
Kopran Res Lab Ltd
Rajan Vitthal Gupte
Chandrabhan Madhav Hire
Kishore Balaji Sabade
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kopran Res Lab Ltd, Rajan Vitthal Gupte, Chandrabhan Madhav Hire, Kishore Balaji Sabade filed Critical Kopran Res Lab Ltd
Publication of WO2007029265A2 publication Critical patent/WO2007029265A2/en
Publication of WO2007029265A3 publication Critical patent/WO2007029265A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention discloses a process for preparing Clarithromycin, comprising selectiviely methylating a 2'I4'-O-bis(trimethylsilyl)erythromycin A 9-[O-(1-methoxy-1- methylethyl)oxime] of formula (II) with methylating agent comprising methyl iodide, while stirring in the presence of a base and a ternary solvent system.
PCT/IN2006/000149 2005-04-29 2006-04-28 A process for preparing clarithromycin and clarithromycin intermediate WO2007029265A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN527/MUM/2005 2005-04-29
IN527MU2005 2005-04-29

Publications (2)

Publication Number Publication Date
WO2007029265A2 WO2007029265A2 (en) 2007-03-15
WO2007029265A3 true WO2007029265A3 (en) 2007-12-27

Family

ID=37836269

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2006/000149 WO2007029265A2 (en) 2005-04-29 2006-04-28 A process for preparing clarithromycin and clarithromycin intermediate

Country Status (1)

Country Link
WO (1) WO2007029265A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105801642B (en) * 2016-03-11 2019-03-26 北京理工大学 A method of preparing the bis--O- erythromycin A of 6,11-
CN106905204B (en) * 2017-02-24 2018-07-20 杭州新桂实业有限公司 A kind of recovery method of methylation reaction solvent in clarithromycin building-up process

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272110A2 (en) * 1986-12-17 1988-06-22 Taisho Pharmaceutical Co. Ltd Erythromycin a derivatives and method for the preparation of the same
CN1318548A (en) * 2000-04-14 2001-10-24 山东新华制药股份有限公司 Preparation of clarithromycin
WO2001087807A2 (en) * 2000-05-15 2001-11-22 Ranbaxy Laboratories Limited A cost effective method for selective methylation of erythromycin a derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272110A2 (en) * 1986-12-17 1988-06-22 Taisho Pharmaceutical Co. Ltd Erythromycin a derivatives and method for the preparation of the same
CN1318548A (en) * 2000-04-14 2001-10-24 山东新华制药股份有限公司 Preparation of clarithromycin
WO2001087807A2 (en) * 2000-05-15 2001-11-22 Ranbaxy Laboratories Limited A cost effective method for selective methylation of erythromycin a derivatives

Also Published As

Publication number Publication date
WO2007029265A2 (en) 2007-03-15

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