WO2007029265A3 - A process for preparing clarithromycin and clarithromycin intermediate - Google Patents
A process for preparing clarithromycin and clarithromycin intermediate Download PDFInfo
- Publication number
- WO2007029265A3 WO2007029265A3 PCT/IN2006/000149 IN2006000149W WO2007029265A3 WO 2007029265 A3 WO2007029265 A3 WO 2007029265A3 IN 2006000149 W IN2006000149 W IN 2006000149W WO 2007029265 A3 WO2007029265 A3 WO 2007029265A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- clarithromycin
- preparing
- methylating
- selectiviely
- erythromycin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Abstract
The present invention discloses a process for preparing Clarithromycin, comprising selectiviely methylating a 2'I4'-O-bis(trimethylsilyl)erythromycin A 9-[O-(1-methoxy-1- methylethyl)oxime] of formula (II) with methylating agent comprising methyl iodide, while stirring in the presence of a base and a ternary solvent system.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN527/MUM/2005 | 2005-04-29 | ||
IN527MU2005 | 2005-04-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007029265A2 WO2007029265A2 (en) | 2007-03-15 |
WO2007029265A3 true WO2007029265A3 (en) | 2007-12-27 |
Family
ID=37836269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2006/000149 WO2007029265A2 (en) | 2005-04-29 | 2006-04-28 | A process for preparing clarithromycin and clarithromycin intermediate |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007029265A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105801642B (en) * | 2016-03-11 | 2019-03-26 | 北京理工大学 | A method of preparing the bis--O- erythromycin A of 6,11- |
CN106905204B (en) * | 2017-02-24 | 2018-07-20 | 杭州新桂实业有限公司 | A kind of recovery method of methylation reaction solvent in clarithromycin building-up process |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0272110A2 (en) * | 1986-12-17 | 1988-06-22 | Taisho Pharmaceutical Co. Ltd | Erythromycin a derivatives and method for the preparation of the same |
CN1318548A (en) * | 2000-04-14 | 2001-10-24 | 山东新华制药股份有限公司 | Preparation of clarithromycin |
WO2001087807A2 (en) * | 2000-05-15 | 2001-11-22 | Ranbaxy Laboratories Limited | A cost effective method for selective methylation of erythromycin a derivatives |
-
2006
- 2006-04-28 WO PCT/IN2006/000149 patent/WO2007029265A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0272110A2 (en) * | 1986-12-17 | 1988-06-22 | Taisho Pharmaceutical Co. Ltd | Erythromycin a derivatives and method for the preparation of the same |
CN1318548A (en) * | 2000-04-14 | 2001-10-24 | 山东新华制药股份有限公司 | Preparation of clarithromycin |
WO2001087807A2 (en) * | 2000-05-15 | 2001-11-22 | Ranbaxy Laboratories Limited | A cost effective method for selective methylation of erythromycin a derivatives |
Also Published As
Publication number | Publication date |
---|---|
WO2007029265A2 (en) | 2007-03-15 |
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