WO2007025304A3 - Process for preparing saccharinic acids and lactones - Google Patents

Process for preparing saccharinic acids and lactones Download PDF

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Publication number
WO2007025304A3
WO2007025304A3 PCT/US2006/033736 US2006033736W WO2007025304A3 WO 2007025304 A3 WO2007025304 A3 WO 2007025304A3 US 2006033736 W US2006033736 W US 2006033736W WO 2007025304 A3 WO2007025304 A3 WO 2007025304A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparing
lactones
utilizes
saccharinic acids
saccharinic
Prior art date
Application number
PCT/US2006/033736
Other languages
French (fr)
Other versions
WO2007025304A2 (en
Inventor
David Hotchkiss
George Fleet
Thomas Heinz
Richard Storer
Original Assignee
Chancellors Masters And Schola
Idenix Pharmaceuticals Inc
Novartis Ag
David Hotchkiss
George Fleet
Thomas Heinz
Richard Storer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chancellors Masters And Schola, Idenix Pharmaceuticals Inc, Novartis Ag, David Hotchkiss, George Fleet, Thomas Heinz, Richard Storer filed Critical Chancellors Masters And Schola
Publication of WO2007025304A2 publication Critical patent/WO2007025304A2/en
Publication of WO2007025304A3 publication Critical patent/WO2007025304A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

An improved process for preparing a saccharinic acid or lactone is disclosed that utilizes the well-known Amadori rearrangement reaction. The synthesis utilizes protected or unprotected sugars or their analogues as starting materials, and reagents not previously utilized to afford increased product yields in decreased reaction time.
PCT/US2006/033736 2005-08-26 2006-08-28 Process for preparing saccharinic acids and lactones WO2007025304A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71193405P 2005-08-26 2005-08-26
US60/711,934 2005-08-26

Publications (2)

Publication Number Publication Date
WO2007025304A2 WO2007025304A2 (en) 2007-03-01
WO2007025304A3 true WO2007025304A3 (en) 2007-05-31

Family

ID=37772543

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/033736 WO2007025304A2 (en) 2005-08-26 2006-08-28 Process for preparing saccharinic acids and lactones

Country Status (3)

Country Link
AR (1) AR057096A1 (en)
UY (1) UY29769A1 (en)
WO (1) WO2007025304A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8299038B2 (en) 2000-05-23 2012-10-30 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ547204A (en) 2000-05-26 2008-01-31 Idenix Cayman Ltd Methods and compositions for treating flaviviruses and pestiviruses
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and flaviviridae mutation
JP5342887B2 (en) * 2009-01-29 2013-11-13 花王株式会社 Method for producing α-aminoketone compound
US20150126752A1 (en) 2012-06-13 2015-05-07 Bristol-Myers Squibb Company Process for the preparation of 2-c-methyl-d-ribonic-gamma-lactone
CN104693157A (en) * 2015-02-15 2015-06-10 上海应用技术学院 Preparation method of 2-C-methyl-D-ribotide-1,4-lactone
CN104693158B (en) * 2015-02-15 2017-03-29 上海应用技术学院 A kind of method for preparing 2 C methyl D ribonic acids, 1,4 lactone

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6891036B2 (en) * 2003-02-10 2005-05-10 Inalco S.P.A. Process for the preparation of ribofuranose derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6891036B2 (en) * 2003-02-10 2005-05-10 Inalco S.P.A. Process for the preparation of ribofuranose derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KUHN R. ET AL: "Uber eine molekulare Umlagerung von N-glucosiden", BERICHTE, vol. 69B, 1936, pages 1745 - 1754, XP008081654 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8299038B2 (en) 2000-05-23 2012-10-30 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus

Also Published As

Publication number Publication date
WO2007025304A2 (en) 2007-03-01
AR057096A1 (en) 2007-11-14
UY29769A1 (en) 2007-02-28

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