WO2007020974A1

WO2007020974A1 - Iontophoresis device

Info

Publication number: WO2007020974A1
Application number: PCT/JP2006/316167
Authority: WO
Inventors: Hidero Akiyama; Mizuo Nakayama; Takehiko Matsumura; Akihiko Matsumura
Original assignee: Tti Ellebeau, Inc.
Priority date: 2005-08-17
Filing date: 2006-08-17
Publication date: 2007-02-22
Also published as: JPWO2007020974A1

Abstract

Disclosed is an iontophoresis device (10) wherein an electrolyte solution holding part (24) and a chemical holding part (28) of a working-side electrode structure (12), and second and third electrolyte solution holding parts (34, 38) of a non-working-side electrode structure (14) respectively contain a gel which changes into a liquid when heated or vibrated. By having such a constitution, a chemical in the chemical holding part is prevented from being contaminated with the electrolyte solution during storage, and generation of a gas and changes of the pH are suppressed by the liquid when current is passed through the device.

Description

Iontophoresis device

Technical field

The present invention relates to an iontophoresis device for administering drug ions to a living body.

Background art

[0002] Iontophoresis is one of the methods for allowing a drug to penetrate into a living body through skin or mucous membranes. This iontophoresis comprises an active electrode structure having a chemical solution holding part for holding a chemical solution and a non-working side electrode structure as a counter electrode, with the chemical solution in contact with the skin or mucous membrane. By applying a voltage of the same conductivity type as that of the drug ion in the drug solution holding portion to the working electrode structure, the drug ion is electrically driven and transferred into the living body via the skin and mucous membrane.

[0003] For example, in International Publication WO03Z037425A1, all components of the working electrode structure and the non-working electrode structure are configured in a film state, and the working electrode structure has the same kind as the charged ions of the ionic drug. And dissimilar ion exchange membranes with different ion selectivity, and an ion exchange membrane that selects at least the ion opposite to the charged ion of the ionic drug on the non-working side electrode structure. An iontophoresis device that can administer an ionic drug stably for a long period of time with high transport efficiency is disclosed.

[0004] In contrast to the above, for example, it is conceivable that the chemical solution holding unit for holding the ionic drug and the electrolyte solution holding unit for holding the electrolyte solution are configured as a gel cartridge. When the electrode and the electrolyte holding part come into contact with the working electrode and the non-working electrode and are energized, gas is generated from the contact surface between the electrode and the gel, and the pH of the chemical solution or the electrolyte is reduced. There was a problem that changes could occur. Also, if the chemical solution holding part or the electrolyte solution holding part is a liquid rather than a gel, the chemical solution in the chemical solution holding part and the electrode liquid in the electrolyte solution holding part may cause contamination before use! / There was a problem.

Disclosure of the invention [0005] The present invention has been made in view of the above problems, and the chemical solution holding part and the electrolyte solution holding part are made of gel to suppress contamination and to prevent gas from coming into contact with the electrode. It is an object of the present invention to provide an iontophoresis device capable of suppressing the occurrence of chemical substances and the change in pH of chemicals and electrolytes.

[0006] (1) A working electrode structure and a non-working electrode structure used for administering an ionic drug by iontophoresis, and a working electrode and a working electrode of these working electrode structures A direct-current power supply connected to the non-working side electrode structure of the non-working side electrode with different polarities, wherein the working side electrode structure is disposed adjacent to the working side electrode And the non-working side electrode structure has a non-working side electrolyte solution holding part provided adjacent to the non-working side electrode. The ion solution characterized in that it comprises at least one of the electrolyte solution holding unit, the chemical solution holding unit, and the non-working side electrolyte solution holding unit, and a gel force that changes into a liquid by either heating or vibration. Tophoresis device.

[0007] (2) Working electrode structure and non-working electrode structure used for administering an ionic drug by iontophoresis, working electrode of these working electrode structures, and A direct-current power supply connected to the non-working side electrode structure of the non-working side electrode with different polarities, wherein the working side electrode structure is disposed adjacent to the working side electrode And the non-working side electrode structure has a non-working side electrolyte solution holding part provided adjacent to the non-working side electrode. And at least one of the electrolyte solution holding portion and the chemical solution holding portion and the non-working side electrolyte solution holding portion is swollen with water at a first temperature, and Shrinks at a second temperature higher than the first temperature to release water Iontophoresis device characterized by being configured to include a time-responsive gel.

[0008] (3) The iontophoresis according to (2), wherein when the temperature-responsive gel is provided in the chemical solution holding part, the temperature-responsive gel is impregnated with the ionic drug. Sys device.

[0009] (4) When a temperature-responsive gel is provided in the electrolyte solution holding part or the non-working-side electrolyte solution holding part, the temperature-responsive gel is impregnated with an electrolyte solution (2 ) Ontophoresis device.

[0010] (5) The second temperature is set to be equal to or lower than a body temperature of the living body, and the temperature-responsive gel is contracted by the temperature of the skin or mucous membrane at the application site ( 2) The iontophoresis device according to any one of Noto (4).

(6) The iontophoresis according to any one of (2) to (5), wherein a heating device is provided for heating the temperature-responsive gel to the second temperature or higher. Cis equipment.

(7) When a temperature-responsive gel is provided on the working electrode structure, the working electrode and one of the electrolytic solution holding unit and the chemical solution holding unit are accommodated in a container-shaped cell. The iontophoresis device according to (6), wherein the heating device is disposed along the outer periphery of the cell.

[0013] (8) The temperature-responsive gel is set so that the first temperature is 30 ° C and the second temperature is 32 ° C (2) to (7) The iontophoresis device according to any one of the above.

(9) The working side electrode structure is disposed on the front side of the working side electrode, the working side electrode connected to the same kind of polarity as the charged ion of the ionic drug in the DC power source, The electrolyte solution holding unit that holds the electrolyte solution, a second ion exchange membrane that is arranged in front of the electrolyte solution holding unit and that selects ions opposite to the charged ions of the ionic drug, and the second ion exchange membrane A chemical solution holding unit that is disposed in front of the ionic drug, and a first ion exchange membrane that is disposed in front of the chemical solution holding unit and selects ions of the same type as the charged ions of the ionic drug, The iontophoresis device according to any one of (1) to (8), characterized by comprising:

[0015] (10) The non-acting side electrolyte solution holding unit includes a second electrolyte solution holding unit and a third electrolyte solution holding unit, and the non-working side electrode structure is the ion source in the DC power source. The non-working side electrode connected to the opposite polarity to the charged ions of the sexing agent, the second electrolyte holding unit disposed on the front surface of the non-working side electrode and holding the second electrolyte, and the first (2) A third ion exchange membrane that is arranged in front of the electrolyte holding unit and selects ions of the same type as the charged ions of the ionic drug, and is arranged in front of the third ion exchange membrane to hold the third electrolyte. The ionic drug is disposed on the front surface of the third electrolyte solution holding portion and the third electrolyte solution holding portion. A fourth ion exchange membrane that selects ions opposite to the charged ions of the agent, and at least one of the second electrolyte solution holding unit and the third electrolyte solution holding unit is configured to The iontophoresis device according to any one of (1) to (9), wherein the iontophoresis device is one of a gel that changes into a liquid and a temperature-responsive gel.

Brief Description of Drawings

FIG. 1 is a plan view showing an iontophoresis device according to a first example of an embodiment of the present invention. FIG. 2 is an enlarged sectional view taken along line II-II in FIG.

[Figure 3] Enlarged sectional view along line III-III in Figure 1

FIG. 4 is a sectional view showing an iontophoresis device according to a second example of an embodiment of the present invention. FIG. 5 is a sectional view showing an iontophoresis device according to a fourth example of an embodiment of the invention. BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, the best mode for carrying out the present invention will be described in detail with reference to the drawings.

[0018] As shown in FIGS. 1 to 3, the iontophoresis device 10 according to the first example of the embodiment includes a working electrode structure 12 used for administering an ionic drug and a non-acting function. A side electrode structure 14 and a DC power supply 16 connected to the electrode structures 12 and 14 with different polarities are provided.

The working side electrode structure 12 is formed on one side of the base sheet 18 (the lower side in FIG. 2) from the base sheet 18 side, from the working side electrode 22, the electrolyte solution holding unit 24, and the second ion The exchange membrane 26, the chemical solution holding unit 28, and the first ion exchange membrane 30 are stacked in this order.

[0020] The working side electrode 22 may be configured to have a conductive coating force applied to the one surface of the base sheet 18, for example, a non-metallic conductive filler such as carbon paste. The working side electrode 22 can be formed of a copper plate or a metal thin film, but the metal eluted from the working side electrode 22 may be transferred to a living body when a drug is administered.

The electrolyte solution holding unit 24 is made of a gel disposed in contact with the working electrode 22. This gel is constituted by gelling an electrolyte. This electrolyte includes water Easier to be oxidized or reduced than the decomposition reaction (acidification at the positive electrode and reduction at the negative electrode). It is particularly preferable to use organic acids such as acid, malic acid, succinic acid, fumaric acid and Z or a salt thereof, which can suppress generation of oxygen gas and hydrogen gas, By blending multiple types of electrolytes that become buffer electrolytes when dissolved in a solvent, fluctuations in pH during energization can be suppressed.

[0022] The second ion exchange membrane 26 is made of an ion exchange resin into which an ion exchange group having a counter ion of a conductivity type opposite to drug ions in the drug solution holding unit 28, which will be described later, is introduced, and the drug solution holding unit An anion exchange resin is added when a drug that dissociates into a positive drug ion is used in 28, while conversely, when a drug that releases a drug ion as a negative drug ion is used. Is mixed with a cation exchange resin.

[0023] The drug solution holding unit 28 is a gelled drug (including a drug precursor) in which the medicinal component dissociates into positive or negative ions (drug ions) by being dissolved in a solvent such as water. Examples of drugs that dissociate medicinal components into positive ions include lidocaine hydrochloride, which is an anesthetic, and morphine hydrochloride, which is an anesthetic. Examples of drugs that dissociate medicinal components into negative ions Ascorbic acid, which is a vitamin agent, can be exemplified.

The first ion exchange membrane 30 is made of an ion exchange resin into which an ion exchange group having the same conductivity type as that of the drug ion of the drug solution holding unit 28 is introduced as a counter ion, and the medicinal component of the drug solution holding unit 28 However, when an agent that dissociates into positive or negative drug ions is used, an anion exchange resin or cation exchange resin is added.

[0025] As the cation exchange resin, a three-dimensional network structure such as a polystyrene resin having a perfluorocarbon skeleton, such as a hydrocarbon resin having a perfluorocarbon skeleton such as an acrylic resin. An ion exchange resin in which a cation exchange group (an exchange group in which the counter ion is a cation) such as a sulfonic acid group, a carboxylic acid group, or a phosphonic acid group is introduced into a polymer having a structure may be used without limitation. I'll do it.

[0026] In addition, as the anion exchange resin, a polymer having a three-dimensional network structure similar to the cation exchange resin, a primary to tertiary amino group, a quaternary ammonia group, Pyridyl group, imidazo An ion exchange resin into which an anion exchange group (an exchange group in which the counter ion is an anion) such as an alkyl group, a quaternary pyridinium group, or a quaternary imidazolium group can be used without limitation.

[0027] The gel that constitutes the electrolyte solution holding unit 24 or the chemical solution holding unit 28 also has a gel that changes to a liquid by heating, for example, a gelatin gel force. The melting temperature of gelatin is 24-30 ° C. By adding glucose, etc., the melting temperature can be changed to about 50 ° C.

[0028] The non-working side electrode structure 14 is provided on one surface side of the non-working side base sheet 19 similar to the base sheet 18, as partially shown in FIG. The non-working side electrode 32, the second electrolyte holding part 34, the ^third ion exchange membrane 36, the third electrolyte holding part 38, and the fourth ion exchange membrane 40 are laminated in this order. Yes.

[0029] The non-working side electrode 32 has the same configuration as the working side electrode 22 in the cell-type working side electrode structure 12, and the second electrolyte holding unit is a non-working side electrolyte holding unit. 34 and the third electrolyte solution holding part 38 are formed of the same gelger as the electrolyte solution holding part 24.

Further, the third ion exchange membrane 36 is made of the same ion exchange resin as that forming the first ion exchange membrane 30 and functions as an ion exchange membrane similar to the first ion exchange membrane 30. To do.

The fourth ion exchange membrane 40 constitutes the second ion exchange membrane 26 and is formed of the same ion exchange resin as the ion exchange resin. The fourth ion exchange membrane 40 is

2Ion exchange membrane Functions as an ion exchange membrane similar to 26.

[0032] A working electrode terminal 42 is provided on the other surface of the base sheet 18. The working electrode terminal 42 is a base sheet with respect to the working electrode 22 of the working electrode structure 12.

Conducted through a through hole provided in 18.

Similarly, a non-working side electrode terminal 44 is provided on the other surface of the base sheet 19, and the non-working side electrode terminal 44 is a non-working side electrode structure 14. 32 is conducted through a through hole formed in the base sheet 19.

[0034] The DC power supply 1 is provided between the working side electrode terminal 42 and the non-working side electrode terminal 44.

6 is arranged. The DC power source 16 is a cell type battery, and the base sheet 18 The first active electrode layer 46, the separator layer 47, and the second active electrode layer 48 are sequentially laminated on one surface by a coating method such as printing. The first active electrode layer 46 and the working electrode terminal 42 of the DC power source 16 are directly connected, and the second active electrode layer 4

8 and the non-working side electrode terminal 44 are connected to each other by a coating film (non-working conductive layer) 45 of a conductive paint formed through an insulating paste layer 49.

Reference numeral 13 in FIG. 1 denotes a binding belt that connects the working electrode structure 12 and the non-working electrode structure 14. The coating film 45 is also applied to the coupling belt 13 and continues to the non-working side electrode terminal 44.

A thin battery constituting the DC power supply 16 is disclosed in, for example, Japanese Patent Laid-Open No. 11 067236.

Those disclosed in US Patent Publication No. 2004Z0185667A1, US Pat. No. 6,855,441 and the like can be used, and are not limited to the structure of the embodiment.

[0037] In this iontophoresis device 10, during use, the working electrode structure 12 and the non-working electrode structure 14 are heated by coming into contact with the skin or mucous membrane of a living body. It is easily heated up to near.

By this heating, the gel constituting the chemical solution holding unit 28, the electrolytic solution holding unit 24, the second electrolytic solution holding unit 34, and the third electrolytic solution holding unit 38 is changed into a chemical solution and an electrolytic solution. This one

In addition, the liquid is interposed on the contact surface between the gel and the working electrode and the contact surface between the gel and the non-working electrode 32, so that gas generation and pH change can be suppressed.

Furthermore, in the example of this embodiment, since the chemical solution and the electrolytic solution are in the gel state in the storage state, the electrolytic solution does not become a liquid and contaminates the chemical component of the chemical solution holding unit 28.

Next, an iontophoresis device according to the second example of the embodiment of the present invention shown in FIG.

50 will be described.

[0041] The iontophoresis device 50 includes a liquid crystal device 52 for making the chemical solution holding unit 28, the electrolyte solution holding unit 24, the second electrolyte solution holding unit 34, and the third electrolyte solution holding unit 38 into a liquid state. In addition, the working electrode structure 12 and the non-working electrode structure 14 are accommodated in container-shaped cells 54 and 56, respectively, with the ion exchange membrane at the tip exposed. Yes. Since other configurations are the same as those of the iontophoresis device 10 described above, the same portions are denoted by the same reference numerals as those in the iontophoresis device 10 and description thereof is omitted. It shall be omitted.

[0042] In the liquefaction device 52, a heating device is used when the gel is changed to a liquid by heating, and a vibration means such as an ultrasonic generator is used when the gel is changed to a liquid by vibration. . In the case of a warming device, the liquefaction device 52 is composed of an iron oxidation heat generating material 52A and a seal 52B that seals the material so that it does not come into contact with air. The iron oxide heating material 52A is disposed outside the cells 54, 56, and is further covered by the outer force of the seal 52B.

[0043] Therefore, when the iontophoresis device 50 is used, if the seal 52B is removed, the iron oxidation heat generating material 52A comes into contact with oxygen in the air and oxidizes. The second electrolyte solution holding part 34 is heated to the liquefaction temperature. As a result, as described above, the gel causes the generation of gas and the pH change because the liquid is interposed on the contact surface between the chemical solution and the electrolyte solution, and the working side electrode 22 and the non-working side electrode 32. You can be depressed.

[0044] Further, in the second example of this embodiment, the liquid skin device 52 also warms the skin and mucous membrane of the living body, and the penetration of the chemical solution is further accelerated to increase the absorption rate. You can.

[0045] In the iontophoresis device 50, the liquefaction device 52 is a force that uses the iron oxidation heating material 52A. The present invention is not limited to this, for example, a surface that generates heat when energized. A heating element may be wound around the cells 54 and 56, and a part of the power from the DC power source 16 may be supplied to the gel 54 to heat the gel. Further, a heating device may be arranged on the upper side in FIG. 4 of the base sheets 18 and 19 so as to heat through the electrode terminals 42 and 52.

[0046] Furthermore, in the example of each of the above embodiments, the gel changes to a liquid by heating. However, as a gel in the case of vibration, a thixotropic modifier 'viscosity modifier' is added. There is. This is a highly viscous gel when there is no vibration, but it can be reduced by applying vibration (adding shearing force) when applied. An ultrasonic transmitter or a pager (small vibrator) is used as the vibration means. Since the reaction is reversible, it must be vibrated during the application period. In the case of ultrasound, the penetration of ions is promoted by applying A secondary effect can also be expected. Examples of the thixotropic modifier include bentonite, aluminum hydroxide, light caustic anhydride, cross-linked polyacrylic acid, and cross-linked sodium polyacrylate.

Next, an iontophoresis device according to a third example of the embodiment of the present invention will be described.

[0048] In this iontophoresis device, the electrolytic solution holder in the working electrode structure 12 of the iontophoresis device 10 is brought into contact with the working electrode 22 as shown by reference numeral 62 in FIG. The temperature responsive gelger is arranged as described above.

[0049] The other configuration is the same as the configuration of the iontophoresis device 10 according to the first example of the embodiment, and therefore the description thereof will be omitted by using FIG.

[0050] This temperature-responsive gel 62 is swollen by an electrolyte and water. This electrolyte is the same as that used for the electrolyte solution holding unit 24.

[0051] The temperature-responsive gel 62 constituting the electrolytic solution holding part swells and contains water and an electrolytic solution at a first temperature (for example, 30 ° C) or lower, but a second temperature (for example, It is composed of a gel that shrinks by 1Z10 or more and releases water and electrolyte, for example, N-isopropylatyramide (IPAAm) gel.

[0052] “Poly-N-isopropylacrylamide (PIPAAm) is a special polymer that changes its properties depending on the temperature. It is between“ dissolved ”and“ aggregated ”at 32 ° C in water. It has a characteristic that its form changes. More specifically, PIPAAm hydrates at 32 ° C or less because the amide and isopropyl groups are attached to the polymer straight chain as side chains. Above C, the bond with isopropyl group becomes stronger and dehydrates.

[0053] The first temperature and the second temperature are forces determined by the blending ratio of the components constituting the temperature-responsive gel. In this example, the temperatures are set to 30 ° C and 32 ° C.

[0054] The second electrolyte solution holding part in the non-working side electrode 32 is constituted by a temperature-responsive gelger similar to the electrolyte solution holding part, as indicated by reference numeral 64 in FIG. Since the other configuration is the same as that of the iontophoresis device 10 according to the first example of the embodiment, the description thereof will be omitted by using FIG. The third electrolyte holding part is also It may be composed of a temperature-responsive gel.

In this iontophoresis device, in use, the working electrode structure 12 and the non-working electrode structure 14 are heated by contact with the skin or mucous membrane of the living body, for example, more than the human body temperature. About 4 ° C low and easily heated up to 32 ° C.

By this heating, water and the electrolytic solution are released from the temperature-responsive gels 62 and 64 that constitute all or part of the electrolytic solution holding unit and the second electrolytic solution holding unit. As a result, liquid is interposed on the contact surface between the temperature-responsive gel 62 and the working electrode and the contact surface between the temperature-responsive gel 64 and the non-working electrode 32, thereby suppressing gas generation and pH change. it can.

[0057] Furthermore, the storage temperature of ordinary chemicals is not more than the upper limit of room temperature of 30 ° C specified by the Japanese Pharmacopoeia. In the example of this embodiment, the electrolyte is absorbed by the temperature-responsive gel. Therefore, the stability of the chemical solution during storage that does not contaminate the chemical component of the chemical solution holding unit 28 can be improved.

[0058] Although the first temperature and the second temperature are set to 30 ° C and 32 ° C, respectively, the first temperature is set higher than the maximum temperature in the storage state. The second temperature should be set slightly lower than the body temperature of the living body. Therefore, for humans, it varies slightly depending on race and age, and for animals, it becomes hot.

[0059] As another temperature-responsive gel, a mixed polymer gel showing a swelling transition near 37 ° C using a triblock copolymer of polyethylene oxide-polypropylene oxide-polyethylene oxide and polybulal alcohol. Is mentioned. Since this gel forms a gel based on intramolecular or intermolecular interactions based on hydrogen bonds, transition occurs due to temperature sensitivity of hydrogen bonds depending on temperature. Using this gel, drug release due to swelling transition of the polymer between 35 ° C force and 40 ° C is shown.

[0060] Still another temperature-responsive gel is a copolymer of methyl acrylate and stearyl acrylate. When this copolymer is cross-linked, it becomes soft when the force exceeds 50 ° C, which is hard at 25 ° C or less. This is due to a reversible transition due to the interaction between the alkyl chains of stearyl acrylate. At 50 ° C or below, long-chain alkyl groups strengthen the crystal aggregation structure, and at 50 ° C and above, the side chain This is because the packaging becomes amorphous and the material is soft and flexible. Using this principle, shape memory polymer gels are shown. Is done.

[0061] In the third example of the above embodiment, the temperature-responsive gels 62 and 64 are heated by the body temperature of the living body, but the present invention is not limited to this. For example, FIG. The liquid crystal device 52 used in the iontophoresis device 50 according to the second example of the embodiment shown may be a heating device.

[0062] In this case, since the heating device can make the temperature higher than in the case of heating by heat from the living body, both the first temperature and the second temperature are the first example of the embodiment. It can be set higher than in the case of. In addition, the warming device warms the skin and mucous membrane of the living body, so that the penetration of the chemical solution is further accelerated and the absorption rate can be increased.

[0063] It should be noted that the heating device is a force using ferrous oxide heating material 52A. The present invention is not limited to this, for example, the ion of the fourth example of the embodiment shown in FIG. As in the tophoresis device 70, the heating device 72 is composed of a heater such as a surface heating element that generates heat when energized, and is wound around the cells 54 and 56, where the power from the DC power source 16 is supplied. A portion may be supplied to warm the temperature-responsive gels 62, 64. Further, the heating device 72 is arranged on the upper side in FIG. 4 of the base sheets 18 and 19 so as to heat the force provided on the outer periphery of the cells 54 and 56, for example, via the electrode terminals 42 and 52. May

[0064] Further, in the example of each of the above embodiments, the working electrode structure 12 has an electrolyte solution holding unit in addition to the chemical solution holding unit, and further includes a two-layer ion exchange membrane, and also has a non-working side. The electrode structure 14 includes a two-layer electrolyte solution holding portion and an ion exchange membrane, but the present invention is not limited to this, and the chemical solution holding portion is in direct contact with the working electrode. May be.

[0065] In the third and fourth examples of the embodiment, the electrolyte solution holding part constituting the working electrode structure may be formed of a temperature-responsive gel. However, the electrolyte solution holding part and Z or The chemical holding part may be composed of a temperature-responsive gel.

Industrial applicability

[0066] In the iontophoresis device of the present invention, when the chemical solution holding unit and the electrolyte solution holding unit are made of gel or a temperature-responsive gel, contamination of the chemical solution and the electrolyte solution is prevented in the storage state. The shelf life is improved. It is possible to improve the usability by changing from a liquid to a liquid, or by releasing water with a temperature-responsive gel force to suppress the generation of gas from the contact surface with the electrode and the change in pH.

Claims

The scope of the claims

[1] Working electrode structure and non-working electrode structure used for administering an ionic drug by iontophoresis, and working electrode and non-working electrode structure of these working electrode structures An iontophoresis device having a DC power source connected to the non-working side electrode of the body with different polarities,

The working electrode structure has one of an electrolyte solution holding part and a chemical solution holding part arranged adjacent to the working electrode,

The non-working side electrode structure has a non-working side electrolyte solution holding portion provided adjacent to the non-working side electrode,

The iontophoresis is characterized in that at least one of the electrolyte solution holding unit, the chemical solution holding unit, and the non-working-side electrolyte solution holding unit is configured to have a gel force that changes from liquid to liquid by force heating and vibration. Lesis device.

[2] Working electrode structure and non-working electrode structure used for administering an ionic drug by iontophoresis, and working electrode and non-working electrode structure of these working electrode structures An iontophoresis device having a DC power source connected to the non-working side electrode of the body with different polarities,

At least one of the electrolyte solution holding unit and the chemical solution holding unit and at least one of the non-acting side electrolyte solution holding unit is swollen with water at a first temperature, and An iontophoresis device comprising a temperature-responsive gel that shrinks at a second temperature higher than 1 to release water.

[3] In claim 2,

When a temperature-responsive gel is provided in the chemical solution holding unit, the iontophoresis device is characterized in that the temperature-responsive gel is impregnated with the ionic drug.

[4] In claim 2, When a temperature-responsive gel is provided in the electrolyte solution holding part or the non-working-side electrolyte solution holding part, the iontophoresis device is characterized in that the temperature-responsive gel is impregnated with an electrolyte solution.

[5] In any one of claims 2 to 4,

An iontophoresis device characterized in that the second temperature is set to be equal to or lower than a body temperature of a living body, and the temperature-responsive gel contracts from a temperature of a skin or a mucous membrane at an application site.

[6] In any one of claims 2 to 5,

An iontophoresis device comprising a heating device for heating the temperature-responsive gel to the second temperature or higher.

[7] In claim 6,

When a temperature-responsive gel is provided on the working electrode structure, the working electrode and one of the electrolytic solution holding unit and the chemical solution holding unit are accommodated in a container-shaped cell, and the heating device Is an iontophoresis device, which is arranged along the outer periphery of the cell.

[8] In any one of claims 2 to 7,

An iontophoresis device, wherein the temperature-responsive gel is set so that the first temperature is 30 ° C and the second temperature is 32 ° C.

[9] In any one of claims 1 to 8

The working-side electrode structure includes the working-side electrode connected to the same polarity as the ionic drug charging ion in the DC power source;

The electrolyte solution holding part that is arranged on the front surface of the working side electrode and holds the electrolyte solution, and a second ion that is arranged on the front surface of the electrolyte solution holding part and that is opposite to the charged ions of the ionic drug is selected. An ion exchange membrane;

A chemical solution holding part arranged on the front surface of the second ion exchange membrane and holding the ionic drug;

A first ion exchange membrane that is disposed in front of the chemical solution holding unit and selects ions of the same type as the charged ions of the ionic drug; An iontophoresis device comprising:

In a hurry

The non-working-side electrolyte holding part is composed of a second electrolyte-holding part and a third electrolyte-holding part.

The non-working side electrode connected to the polarity opposite to the charged ion of the ionic drug in the DC power source;

The second electrolyte solution holding unit disposed on the front surface of the non-working side electrode and holding the second electrolyte solution;

A third ion exchange membrane that is disposed in front of the second electrolyte solution holding unit and selects ions of the same type as the charged ions of the ionic agent;

The third electrolyte solution holding unit disposed on the front surface of the third ion exchange membrane and holding the third electrolyte solution;

A fourth ion exchange membrane disposed on the front surface of the third electrolyte solution holding unit and selecting ions opposite to the charged ions of the ionic drug;

Having

At least one of the second electrolyte solution holding unit and the third electrolyte solution holding unit is one of a gel and a temperature-responsive gel that change into a liquid by either the heating or the vibration. Lesis device.