WO2007020505A3 - Medicinal forms of phospholipid preparations and methods for their preparation - Google Patents

Medicinal forms of phospholipid preparations and methods for their preparation Download PDF

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Publication number
WO2007020505A3
WO2007020505A3 PCT/IB2006/002195 IB2006002195W WO2007020505A3 WO 2007020505 A3 WO2007020505 A3 WO 2007020505A3 IB 2006002195 W IB2006002195 W IB 2006002195W WO 2007020505 A3 WO2007020505 A3 WO 2007020505A3
Authority
WO
WIPO (PCT)
Prior art keywords
phospholipid
preparation
methods
composition
homogenization
Prior art date
Application number
PCT/IB2006/002195
Other languages
French (fr)
Other versions
WO2007020505A2 (en
Inventor
Alexandr Ivanovich Archakov
Mariya Kirillovna Guseva
Vasiliy Fedorovich Uchaikin
Elena Georgievna Tikhonova
Olga Mikhailovna Ipatova
Original Assignee
Alexandr Ivanovich Archakov
Mariya Kirillovna Guseva
Vasiliy Fedorovich Uchaikin
Elena Georgievna Tikhonova
Olga Mikhailovna Ipatova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexandr Ivanovich Archakov, Mariya Kirillovna Guseva, Vasiliy Fedorovich Uchaikin, Elena Georgievna Tikhonova, Olga Mikhailovna Ipatova filed Critical Alexandr Ivanovich Archakov
Priority to US12/063,581 priority Critical patent/US8680061B2/en
Priority to EP06795234A priority patent/EP1919455A2/en
Publication of WO2007020505A2 publication Critical patent/WO2007020505A2/en
Publication of WO2007020505A3 publication Critical patent/WO2007020505A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

A method for producing a pharmaceutical composition comprising a combination of phospholipid and glycyrrhizic acid or a pharmaceutically acceptable salt thereof, which composition is hydratable to produce an injectable medicinal form, said method comprising subjecting a mixture of phospholipid and an aqueous solution of glycyrrhizic acid or a pharmaceutically acceptable salt thereof and a carbohydrate to homogenization, for example at 800-1200 bar pressure at a temperature of less than 90°C, and subjecting the product of the homogenization to a sublimation drying step to produce said composition. Compositions obtainable using this method, and hydrated forms of these ready for administration by injection form further aspects of the invention.
PCT/IB2006/002195 2005-08-12 2006-08-11 Medicinal forms of phospholipid preparations and methods for their preparation WO2007020505A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/063,581 US8680061B2 (en) 2005-08-12 2006-08-11 Medicinal forms of phospholipid preparations and methods for their preparation
EP06795234A EP1919455A2 (en) 2005-08-12 2006-08-11 Medicinal forms of phospholipid preparations and methods for their preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2005125634/15A RU2304431C2 (en) 2005-08-12 2005-08-12 Method for preparing capsulated medicinal formulation of phospholipid preparation "fosfogliv" for treatment and prophylaxis of acute and chronic hepatic diseases
RU2005125634 2005-08-12

Publications (2)

Publication Number Publication Date
WO2007020505A2 WO2007020505A2 (en) 2007-02-22
WO2007020505A3 true WO2007020505A3 (en) 2007-07-12

Family

ID=37757942

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/002195 WO2007020505A2 (en) 2005-08-12 2006-08-11 Medicinal forms of phospholipid preparations and methods for their preparation

Country Status (4)

Country Link
EP (1) EP1919455A2 (en)
CN (1) CN101370482A (en)
RU (1) RU2304431C2 (en)
WO (1) WO2007020505A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2411942C2 (en) * 2009-05-05 2011-02-20 Общество с ограниченной ответственностью "ЭкоБиоФарм" Pharmaceutic composition including arbidol in composition of phospholipid nanoparticles
DE102010028365A1 (en) * 2010-04-29 2011-11-03 Lichtblick Gmbh Use of a phospholipid-containing composition for the removal of subcutaneous fat accumulations
RU2449276C1 (en) * 2010-12-03 2012-04-27 Федеральное бюджетное учреждение науки "Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения" (ФБУН "ФНЦ медико-профилактических технологий управления рисками здоровью населения") Method of differential clinical-laboratory diagnostics of degree of expression of inflammatory changes of stomach and duodenum mucosa in case of chronic gastroduodenitis in children with contamination of organism with chemical substances of industrial origin
CN102716463A (en) * 2012-06-19 2012-10-10 北京中海康医药科技发展有限公司 Glycyrrhizic acid organic salt phospholipid ligand and preparation thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4002166A1 (en) * 1990-01-25 1991-08-01 Nii Fiz Khim Mediciny Suspensions for reconstructing cell membranes - are prepd. from phosphatidyl-choline and glycyrrhizate salt
EP0556394A1 (en) * 1990-11-06 1993-08-25 Nippon Shinyaku Company, Limited Lyophilized preparation and production thereof
RU2133122C1 (en) * 1998-10-14 1999-07-20 Научно-исследовательский институт биомедицинской химии РАМН Composition exhibiting property for biological membrane repairing

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4002166A1 (en) * 1990-01-25 1991-08-01 Nii Fiz Khim Mediciny Suspensions for reconstructing cell membranes - are prepd. from phosphatidyl-choline and glycyrrhizate salt
EP0556394A1 (en) * 1990-11-06 1993-08-25 Nippon Shinyaku Company, Limited Lyophilized preparation and production thereof
RU2133122C1 (en) * 1998-10-14 1999-07-20 Научно-исследовательский институт биомедицинской химии РАМН Composition exhibiting property for biological membrane repairing

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; March 2002 (2002-03-01), ARCHAKOV A I ET AL: "Phosphogliv: Mechanism of therapeutic action and clinical efficiency", XP002427450, Database accession no. PREV200200545266 *
HIDEKI TSUJI,SAYOKO OSAKA, HIROSHI KIWADA: "Targeting of Liposomes Surface-Modified with Glycyrrhizin to the Liver. I. Preparation and Biological Disposition", CHEM. PHARM. BULL., vol. 39, no. 4, 1991, pages 1004 - 1008, XP001245628 *
VOPROSY MEDITSINSKOI KHIMII, vol. 48, no. 2, March 2002 (2002-03-01), pages 139 - 153, ISSN: 0042-8809 *

Also Published As

Publication number Publication date
RU2005125634A (en) 2007-03-10
RU2304431C2 (en) 2007-08-20
WO2007020505A2 (en) 2007-02-22
CN101370482A (en) 2009-02-18
EP1919455A2 (en) 2008-05-14

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