WO2007017289A3 - Acyltryptophanols for fertility control - Google Patents

Acyltryptophanols for fertility control Download PDF

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Publication number
WO2007017289A3
WO2007017289A3 PCT/EP2006/007949 EP2006007949W WO2007017289A3 WO 2007017289 A3 WO2007017289 A3 WO 2007017289A3 EP 2006007949 W EP2006007949 W EP 2006007949W WO 2007017289 A3 WO2007017289 A3 WO 2007017289A3
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WO
WIPO (PCT)
Prior art keywords
acyltryptophanols
fertility control
osteoporosis
men
women
Prior art date
Application number
PCT/EP2006/007949
Other languages
French (fr)
Other versions
WO2007017289A2 (en
Inventor
Lars Wortmann
Arwed Cleve
Hans-Peter Muhn
Gernot Langer
Anna Schrey
Ronald Kuehne
Bernd Menzenbach
Marcus Koppitz
Dirk Kosemund
Original Assignee
Schering Ag
Lars Wortmann
Arwed Cleve
Hans-Peter Muhn
Gernot Langer
Anna Schrey
Ronald Kuehne
Bernd Menzenbach
Marcus Koppitz
Dirk Kosemund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102005038632A external-priority patent/DE102005038632B4/en
Application filed by Schering Ag, Lars Wortmann, Arwed Cleve, Hans-Peter Muhn, Gernot Langer, Anna Schrey, Ronald Kuehne, Bernd Menzenbach, Marcus Koppitz, Dirk Kosemund filed Critical Schering Ag
Priority to CA002618888A priority Critical patent/CA2618888A1/en
Priority to EP06776768A priority patent/EP1912970A2/en
Priority to JP2008525491A priority patent/JP2009504597A/en
Publication of WO2007017289A2 publication Critical patent/WO2007017289A2/en
Publication of WO2007017289A3 publication Critical patent/WO2007017289A3/en

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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Abstract

The present patent application relates to acyltryptophanols of the general formula I, in which Q, X, Y, W, R1, R2, R3, R4, R5, R8 have the meanings stated in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
PCT/EP2006/007949 2005-08-10 2006-08-08 Acyltryptophanols for fertility control WO2007017289A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002618888A CA2618888A1 (en) 2005-08-10 2006-08-08 Acyltryptophanols for fertility control
EP06776768A EP1912970A2 (en) 2005-08-10 2006-08-08 Acyltryptophanols for fertility control
JP2008525491A JP2009504597A (en) 2005-08-10 2006-08-08 Acyltryptophanol

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70674305P 2005-08-10 2005-08-10
DE102005038632A DE102005038632B4 (en) 2005-08-10 2005-08-10 Acyltryptophanole
US60/706,743 2005-08-10
DE102005038632.6 2005-08-10

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WO2007017289A2 WO2007017289A2 (en) 2007-02-15
WO2007017289A3 true WO2007017289A3 (en) 2007-05-31

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PCT/EP2006/007949 WO2007017289A2 (en) 2005-08-10 2006-08-08 Acyltryptophanols for fertility control

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EP (1) EP1912970A2 (en)
JP (1) JP2009504597A (en)
CA (1) CA2618888A1 (en)
WO (1) WO2007017289A2 (en)

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US8623871B2 (en) 2006-01-25 2014-01-07 Synta Pharmaceuticals Corp. Substituted biaryl compounds for inflammation and immune-related uses
AU2007323540A1 (en) * 2006-11-21 2008-05-29 University Of Virginia Patent Foundation Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity
US20080221195A1 (en) * 2006-12-13 2008-09-11 Lars Wortmann 1,2-diarylacetylene derivatives of acyltryptophanols
EP1956016A1 (en) * 2006-12-15 2008-08-13 Bayer Schering Pharma Aktiengesellschaft Bicyclic acyltryptophanols
WO2008071455A1 (en) * 2006-12-15 2008-06-19 Bayer Schering Pharma Aktiengesellschaft Bicyclic acyltryptophanols
EP1964834A1 (en) * 2007-03-01 2008-09-03 Bayer Schering Pharma Aktiengesellschaft Sulphonyltryptophanols
GB0705656D0 (en) * 2007-03-23 2007-05-02 Addex Pharmaceuticals Sa Novel compounds E1
EP1975159A1 (en) * 2007-03-27 2008-10-01 Bayer Schering Pharma Aktiengesellschaft 2,3,4,9-Tetrahydro-1H-carbazoles
EP1985612A1 (en) * 2007-04-26 2008-10-29 Bayer Schering Pharma Aktiengesellschaft Arymethylen substituted N-Acyl-gamma-aminoalcohols
EP2019102A1 (en) * 2007-07-24 2009-01-28 Bayer Schering Pharma AG Alkylacetylene substituted Acyltryptophanols
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