WO2007015265A3 - Fabrication de 6,9-imino ether - Google Patents

Fabrication de 6,9-imino ether Download PDF

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Publication number
WO2007015265A3
WO2007015265A3 PCT/IN2006/000180 IN2006000180W WO2007015265A3 WO 2007015265 A3 WO2007015265 A3 WO 2007015265A3 IN 2006000180 W IN2006000180 W IN 2006000180W WO 2007015265 A3 WO2007015265 A3 WO 2007015265A3
Authority
WO
WIPO (PCT)
Prior art keywords
ether
erythromycin
lmino
preparing
imino ether
Prior art date
Application number
PCT/IN2006/000180
Other languages
English (en)
Other versions
WO2007015265A2 (fr
Inventor
Mahajan Kiran Madhaorao
Patil Gokul Laxman
Chawan Mangesh Balwant
Hire Chandrabhan Madhav
Ambre Rajesh Viswanath
Randive Sachin Yashwant
Original Assignee
Kopran Res Lab Ltd
Mahajan Kiran Madhaorao
Patil Gokul Laxman
Chawan Mangesh Balwant
Hire Chandrabhan Madhav
Ambre Rajesh Viswanath
Randive Sachin Yashwant
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kopran Res Lab Ltd, Mahajan Kiran Madhaorao, Patil Gokul Laxman, Chawan Mangesh Balwant, Hire Chandrabhan Madhav, Ambre Rajesh Viswanath, Randive Sachin Yashwant filed Critical Kopran Res Lab Ltd
Publication of WO2007015265A2 publication Critical patent/WO2007015265A2/fr
Publication of WO2007015265A3 publication Critical patent/WO2007015265A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

Procédé de fabrication de 6,9-imino éther à partir de thiocyanate d'érythromycine sans isolement d'une base d'érythromycine et d'un oxime d'érythromicine, dans lequel un réagencement Beckmann d'oxime d'érythromycine a lieu avec un système de solvant biphasique comprenant du chlorure de méthylène et de l'eau en présence de triéthylamine et de bicarbonate de soude, le but étant d'obtenir un 6,9-Imino éther pur à 87-96 %. Le 6,9-imino éther est ensuite hydrogéné en 9-déoxo-9a-aza-9a-homoérythromycine, puis soumis à une méthylation réductive pour obtenir un dihydrate d'azithromicine.
PCT/IN2006/000180 2005-05-24 2006-05-24 Fabrication de 6,9-imino ether WO2007015265A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN627/MUM/2005 2005-05-24
IN627MU2005 2005-05-24

Publications (2)

Publication Number Publication Date
WO2007015265A2 WO2007015265A2 (fr) 2007-02-08
WO2007015265A3 true WO2007015265A3 (fr) 2007-12-06

Family

ID=37709013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2006/000180 WO2007015265A2 (fr) 2005-05-24 2006-05-24 Fabrication de 6,9-imino ether

Country Status (1)

Country Link
WO (1) WO2007015265A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090054634A1 (en) * 2007-08-09 2009-02-26 Vinod Kumar Kansal Process for the preparation of clarithromycin
WO2009156938A2 (fr) * 2008-06-24 2009-12-30 Alembic Limited Procédé économique pour préparer de l'éther 6,9-imino
US8106111B2 (en) 2009-05-15 2012-01-31 Eastman Chemical Company Antimicrobial effect of cycloaliphatic diol antimicrobial agents in coating compositions
CN105481913B (zh) * 2014-09-19 2019-01-08 宁夏启元药业有限公司 一种合成阿奇霉素的方法
CN106083954B (zh) * 2016-06-22 2018-12-11 连云港笃翔化工有限公司 一种红霉素6,9亚胺醚化合物的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026758A1 (fr) * 1993-05-19 1994-11-24 Pfizer Inc. Intermediaire s'appliquant a l'azithromycine
US20010047089A1 (en) * 2000-01-04 2001-11-29 Judith Aronhime Preparation method of azithromycin dihydrate
WO2002044193A1 (fr) * 2000-11-30 2002-06-06 Ercros Industrial, S.A. Procédé permettant d'obtenir de l'azaérythromycine
EP1469008A1 (fr) * 2000-03-15 2004-10-20 Hanmi Pharm. Co., Ltd. Procédé de préparation de crystaux de clarithromycine de qualité non pharmaceutique

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026758A1 (fr) * 1993-05-19 1994-11-24 Pfizer Inc. Intermediaire s'appliquant a l'azithromycine
US20010047089A1 (en) * 2000-01-04 2001-11-29 Judith Aronhime Preparation method of azithromycin dihydrate
EP1469008A1 (fr) * 2000-03-15 2004-10-20 Hanmi Pharm. Co., Ltd. Procédé de préparation de crystaux de clarithromycine de qualité non pharmaceutique
WO2002044193A1 (fr) * 2000-11-30 2002-06-06 Ercros Industrial, S.A. Procédé permettant d'obtenir de l'azaérythromycine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CASREACT STN INTERNATIONAL, KARLSRUHE; 2003, QIN N.: "Study on the processes for preparation roxithromycin" *
GUANGDONG YAOXUE, vol. 13, no. 6, pages 23 - 24 *

Also Published As

Publication number Publication date
WO2007015265A2 (fr) 2007-02-08

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