WO2007013965A3 - Synthesis of scabronines and analogues thereof - Google Patents
Synthesis of scabronines and analogues thereof Download PDFInfo
- Publication number
- WO2007013965A3 WO2007013965A3 PCT/US2006/028155 US2006028155W WO2007013965A3 WO 2007013965 A3 WO2007013965 A3 WO 2007013965A3 US 2006028155 W US2006028155 W US 2006028155W WO 2007013965 A3 WO2007013965 A3 WO 2007013965A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- scabronines
- synthesis
- analogs
- disease
- analogues
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/36—Unsaturated compounds containing —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/38—Unsaturated compounds containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002616028A CA2616028A1 (en) | 2005-07-22 | 2006-07-21 | Synthesis of scabronines and analogues thereof |
US12/017,951 US7910623B2 (en) | 2005-07-22 | 2008-01-22 | Synthesis of scabronines and analogues thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70169805P | 2005-07-22 | 2005-07-22 | |
US60/701,698 | 2005-07-22 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/017,951 Continuation US7910623B2 (en) | 2005-07-22 | 2008-01-22 | Synthesis of scabronines and analogues thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007013965A2 WO2007013965A2 (en) | 2007-02-01 |
WO2007013965A3 true WO2007013965A3 (en) | 2009-05-14 |
Family
ID=37683798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/028155 WO2007013965A2 (en) | 2005-07-22 | 2006-07-21 | Synthesis of scabronines and analogues thereof |
Country Status (2)
Country | Link |
---|---|
CA (1) | CA2616028A1 (en) |
WO (1) | WO2007013965A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011133651A1 (en) * | 2010-04-20 | 2011-10-27 | Chiral Quest , Inc. | An enantioselective process for cycloalkenyl b-substituted alanines |
CN109824686B (en) * | 2019-02-22 | 2021-07-06 | 西北农林科技大学 | Bird nest alkane type diterpenoid compound, preparation method and application thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4629700A (en) * | 1983-11-30 | 1986-12-16 | Standard Oil Company (Indiana) | Selective conversion of cyano compounds to amides and carboxylic acids |
JPH0769961A (en) * | 1993-08-31 | 1995-03-14 | Kagome Co Ltd | Cyathane derivative, and neuro growth factor production inducing agent and antimicrobial agent using the same as active component |
JPH11269125A (en) * | 1998-03-19 | 1999-10-05 | Kagome Co Ltd | Cyathane derivative and nerve growth factor production inducer containing the same as active ingredient |
JP2002234896A (en) * | 2001-02-09 | 2002-08-23 | Kinokkusu:Kk | Cyathane derivative |
JP2003089670A (en) * | 2001-09-18 | 2003-03-28 | Nippon Tenganyaku Kenkyusho:Kk | Cyathane derivative and composition including the same |
US6683087B2 (en) * | 2000-04-18 | 2004-01-27 | Axon Biochemicals B.V. | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use |
US20050032802A1 (en) * | 2002-12-05 | 2005-02-10 | Gemin X Biotechnologies Inc. | Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents |
-
2006
- 2006-07-21 CA CA002616028A patent/CA2616028A1/en not_active Abandoned
- 2006-07-21 WO PCT/US2006/028155 patent/WO2007013965A2/en active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4629700A (en) * | 1983-11-30 | 1986-12-16 | Standard Oil Company (Indiana) | Selective conversion of cyano compounds to amides and carboxylic acids |
JPH0769961A (en) * | 1993-08-31 | 1995-03-14 | Kagome Co Ltd | Cyathane derivative, and neuro growth factor production inducing agent and antimicrobial agent using the same as active component |
JPH11269125A (en) * | 1998-03-19 | 1999-10-05 | Kagome Co Ltd | Cyathane derivative and nerve growth factor production inducer containing the same as active ingredient |
US6683087B2 (en) * | 2000-04-18 | 2004-01-27 | Axon Biochemicals B.V. | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use |
JP2002234896A (en) * | 2001-02-09 | 2002-08-23 | Kinokkusu:Kk | Cyathane derivative |
JP2003089670A (en) * | 2001-09-18 | 2003-03-28 | Nippon Tenganyaku Kenkyusho:Kk | Cyathane derivative and composition including the same |
US20050032802A1 (en) * | 2002-12-05 | 2005-02-10 | Gemin X Biotechnologies Inc. | Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents |
Non-Patent Citations (2)
Title |
---|
OBARA, Y. ET AL.: "Scabronine G-Methylester Enhances Secretion of Neurotrophic Factors Mediated by an Activation of Protein Kinase C-.", MOLECULAR PHARMACOLOGY., vol. 59, no. 5, 2001, pages 1289, - 1296 * |
WARD, D. ET AL.: "Synthetic Studies on Cyathin Diterpenes Total Synthesis of +/- -allocyathin B3.", CAN J CHEM. 2004., vol. 82, pages 254 - 258 * |
Also Published As
Publication number | Publication date |
---|---|
CA2616028A1 (en) | 2007-02-01 |
WO2007013965A2 (en) | 2007-02-01 |
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