WO2007006922A3 - Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide et leur utilisation comme inducteurs de tyrosine hydroxylase - Google Patents

Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide et leur utilisation comme inducteurs de tyrosine hydroxylase Download PDF

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Publication number
WO2007006922A3
WO2007006922A3 PCT/FR2006/001610 FR2006001610W WO2007006922A3 WO 2007006922 A3 WO2007006922 A3 WO 2007006922A3 FR 2006001610 W FR2006001610 W FR 2006001610W WO 2007006922 A3 WO2007006922 A3 WO 2007006922A3
Authority
WO
WIPO (PCT)
Prior art keywords
indole
inducers
piperidinecarboxamide
novel
hydroxylase
Prior art date
Application number
PCT/FR2006/001610
Other languages
English (en)
Other versions
WO2007006922A8 (fr
WO2007006922A2 (fr
Inventor
Jean-Daniel Brion
Fabrice Bintein
Rodolphe Razet
Patrick Razon
Zafiarisoa Dolor Renko
Eric Levoirier
Jean-Francois Pujol
Dinah Weissman
Ridant Alain Le
Catherine Harpey
Original Assignee
Servier Lab
Centre Nat Rech Scient
Univ Paris Sud
Jean-Daniel Brion
Fabrice Bintein
Rodolphe Razet
Patrick Razon
Zafiarisoa Dolor Renko
Eric Levoirier
Jean-Francois Pujol
Dinah Weissman
Ridant Alain Le
Catherine Harpey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT06778790T priority Critical patent/ATE447406T1/de
Priority to DE602006010221T priority patent/DE602006010221D1/de
Application filed by Servier Lab, Centre Nat Rech Scient, Univ Paris Sud, Jean-Daniel Brion, Fabrice Bintein, Rodolphe Razet, Patrick Razon, Zafiarisoa Dolor Renko, Eric Levoirier, Jean-Francois Pujol, Dinah Weissman, Ridant Alain Le, Catherine Harpey filed Critical Servier Lab
Priority to JP2008519964A priority patent/JP2009500380A/ja
Priority to EA200800208A priority patent/EA014022B1/ru
Priority to BRPI0612684-7A priority patent/BRPI0612684A2/pt
Priority to CA002614000A priority patent/CA2614000A1/fr
Priority to US11/988,424 priority patent/US20090258883A1/en
Priority to EP06778790A priority patent/EP1931341B1/fr
Priority to DK06778790.3T priority patent/DK1931341T3/da
Priority to PL06778790T priority patent/PL1931341T3/pl
Priority to AU2006268527A priority patent/AU2006268527B2/en
Publication of WO2007006922A2 publication Critical patent/WO2007006922A2/fr
Publication of WO2007006922A3 publication Critical patent/WO2007006922A3/fr
Publication of WO2007006922A8 publication Critical patent/WO2007006922A8/fr
Priority to NO20080677A priority patent/NO20080677L/no
Priority to HR20100010T priority patent/HRP20100010T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Composés de formule (I), leurs énantiomères, diastéréoisomères, N-oxydes, ainsi que leurs sels d'addition à un acide ou à une base pharmaceutiquement acceptable. Les composés de la présente invention sont des inducteurs tyrosine hydroxylase.
PCT/FR2006/001610 2005-07-07 2006-07-06 Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide et leur utilisation comme inducteurs de tyrosine hydroxylase WO2007006922A2 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DK06778790.3T DK1931341T3 (da) 2005-07-07 2006-07-06 1H-indolpyridincarboxamid og 1H-indolpiperidincarboxamidderivater og deres anvendelse som induktorere for tyrosinhydroxylase
EP06778790A EP1931341B1 (fr) 2005-07-07 2006-07-06 Derives de 1h-indole-pyridinecarboxamide et de 1h-indole-piperidinecarboxamide et leur utilisation comme inducteurs de tyrosine hydroxylase
JP2008519964A JP2009500380A (ja) 2005-07-07 2006-07-06 新規１ｈ−インドールピリジンカルボキサミド誘導体および１ｈ−インドールピペリジンカルボキサミド、ならびにヒドロキシラーゼチロシン誘導剤としてのその使用
DE602006010221T DE602006010221D1 (de) 2005-07-07 2006-07-06 1h-indol-pyridincarbonsäureamid und 1h-indol-piperidincarbonsäureamid-derivate und ihre verwendung als tyrosin hydroxylase-induktoren
BRPI0612684-7A BRPI0612684A2 (pt) 2005-07-07 2006-07-06 compostos e 1h-indol-piridina-carboxamida e 1h-indol-piperidinacarboxamida, um processo para sua preparação e composições farmacêuticas que contêm os mesmos
CA002614000A CA2614000A1 (fr) 2005-07-07 2006-07-06 Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PL06778790T PL1931341T3 (pl) 2005-07-07 2006-07-06 Pochodne 1H-indolo-pirydynokarboksamidu i 1H-indolo-piperydynokarboksamidu i ich zastosowanie jako induktorów hydroksylazy tyrozynowej
AT06778790T ATE447406T1 (de) 2005-07-07 2006-07-06 1h-indol-pyridincarbonsäureamid und 1h-indol- piperidincarbonsäureamid-derivate und ihre verwendung als tyrosin hydroxylase-induktoren
EA200800208A EA014022B1 (ru) 2005-07-07 2006-07-06 Соединения 1h-индол-пиридинкарбоксамида и 1н-индол-пиперидинкарбоксамида, способ их получения и фармацевтические композиции, которые их содержат
US11/988,424 US20090258883A1 (en) 2005-07-07 2006-07-06 1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds
AU2006268527A AU2006268527B2 (en) 2005-07-07 2006-07-06 Novel 1H-indole-pyridinecarboxamide and 1H-indole-piperidinecarboxamide derivatives and their use as hydroxylase tyrosine inducers
NO20080677A NO20080677L (no) 2005-07-07 2008-02-06 Ny 1H-indol-pyridinkarboksamid og 1H-indol-piperidinkarboksamidforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger som inneholder dem
HR20100010T HRP20100010T1 (hr) 2005-07-07 2010-01-08 Derivati 1h-indol-piridinkarboksamida i 1h-indol-piperidinkarboksamida i njihova uporaba kao izazivača tirozin hidroksilaze

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0507225A FR2888238B1 (fr) 2005-07-07 2005-07-07 Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent.
FR0507225 2005-07-07

Publications (3)

Publication Number Publication Date
WO2007006922A2 WO2007006922A2 (fr) 2007-01-18
WO2007006922A3 true WO2007006922A3 (fr) 2007-04-05
WO2007006922A8 WO2007006922A8 (fr) 2008-01-10

Family

ID=35954102

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2006/001610 WO2007006922A2 (fr) 2005-07-07 2006-07-06 Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide et leur utilisation comme inducteurs de tyrosine hydroxylase

Country Status (25)

Country Link
US (1) US20090258883A1 (fr)
EP (1) EP1931341B1 (fr)
JP (1) JP2009500380A (fr)
KR (1) KR20080027925A (fr)
CN (1) CN101257905A (fr)
AR (1) AR054862A1 (fr)
AT (1) ATE447406T1 (fr)
AU (1) AU2006268527B2 (fr)
BR (1) BRPI0612684A2 (fr)
CA (1) CA2614000A1 (fr)
DE (1) DE602006010221D1 (fr)
DK (1) DK1931341T3 (fr)
EA (1) EA014022B1 (fr)
ES (1) ES2336250T3 (fr)
FR (1) FR2888238B1 (fr)
GE (1) GEP20104963B (fr)
HR (1) HRP20100010T1 (fr)
MA (1) MA29616B1 (fr)
NO (1) NO20080677L (fr)
PL (1) PL1931341T3 (fr)
PT (1) PT1931341E (fr)
SI (1) SI1931341T1 (fr)
UA (1) UA89544C2 (fr)
WO (1) WO2007006922A2 (fr)
ZA (1) ZA200800833B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2926077A1 (fr) * 2008-01-04 2009-07-10 Servier Lab Nouveaux derives d'1h-indol-1-yl uree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
EP3202758A1 (fr) * 2016-02-03 2017-08-09 Evonik Degussa GmbH Alkylation reductrice d'amines a l'aide d'esters d'acide orthocarboxylique

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0563916A1 (fr) * 1992-04-03 1993-10-06 Hoechst-Roussel Pharmaceuticals Incorporated (1H-indol-1-yl)-2-(amino)acétamides et composés apparentés de (1H-indol-1-yl)-(aminoalkyl)amides, leur intermédiaires, leur préparation et leur utilisation comme médicaments
US5622957A (en) * 1993-12-14 1997-04-22 Adir Et Compagnie Benzopyrrolizinoquinolizinones

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4204998A (en) * 1974-03-28 1980-05-27 Siegfried Aktiengesellschaft N-Amino indole derivatives having pharmacological activity
DE3852335T2 (de) * 1987-04-24 1995-05-11 Hoechst Roussel Pharma N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel.
CA2017621A1 (fr) * 1989-06-23 1990-12-23 Masayuki Kato Derives de l'indole et procede de preparation
US5102891A (en) * 1990-07-23 1992-04-07 Hoechst-Roussel Pharmaceuticals Inc. 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates
GB9710523D0 (en) * 1997-05-23 1997-07-16 Smithkline Beecham Plc Novel compounds
US6084098A (en) * 1999-02-26 2000-07-04 Neurogen Corporation Benzylpiperazinyl and piperidinyl ethanone derivatives: dopamine receptor subtype specific ligands

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0563916A1 (fr) * 1992-04-03 1993-10-06 Hoechst-Roussel Pharmaceuticals Incorporated (1H-indol-1-yl)-2-(amino)acétamides et composés apparentés de (1H-indol-1-yl)-(aminoalkyl)amides, leur intermédiaires, leur préparation et leur utilisation comme médicaments
US5622957A (en) * 1993-12-14 1997-04-22 Adir Et Compagnie Benzopyrrolizinoquinolizinones

Also Published As

Publication number Publication date
CA2614000A1 (fr) 2007-01-18
HRP20100010T1 (hr) 2010-03-31
PL1931341T3 (pl) 2010-06-30
WO2007006922A8 (fr) 2008-01-10
DK1931341T3 (da) 2010-03-15
UA89544C2 (uk) 2010-02-10
WO2007006922A2 (fr) 2007-01-18
ATE447406T1 (de) 2009-11-15
US20090258883A1 (en) 2009-10-15
AU2006268527A1 (en) 2007-01-18
CN101257905A (zh) 2008-09-03
MA29616B1 (fr) 2008-07-01
FR2888238A1 (fr) 2007-01-12
ES2336250T3 (es) 2010-04-09
BRPI0612684A2 (pt) 2010-11-30
KR20080027925A (ko) 2008-03-28
NO20080677L (no) 2008-02-06
SI1931341T1 (sl) 2010-03-31
GEP20104963B (en) 2010-04-26
AU2006268527B2 (en) 2009-12-24
JP2009500380A (ja) 2009-01-08
ZA200800833B (en) 2009-04-29
FR2888238B1 (fr) 2007-09-07
EP1931341A2 (fr) 2008-06-18
EA200800208A1 (ru) 2008-08-29
EA014022B1 (ru) 2010-08-30
AR054862A1 (es) 2007-07-25
PT1931341E (pt) 2009-11-30
EP1931341B1 (fr) 2009-11-04
DE602006010221D1 (de) 2009-12-17

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