WO2007005455A3 - Improved process for preparing (disubstitutedpropenyl) phenylalkyl substituted heterocycles - Google Patents

Improved process for preparing (disubstitutedpropenyl) phenylalkyl substituted heterocycles Download PDF

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Publication number
WO2007005455A3
WO2007005455A3 PCT/US2006/025144 US2006025144W WO2007005455A3 WO 2007005455 A3 WO2007005455 A3 WO 2007005455A3 US 2006025144 W US2006025144 W US 2006025144W WO 2007005455 A3 WO2007005455 A3 WO 2007005455A3
Authority
WO
WIPO (PCT)
Prior art keywords
improved process
disubstitutedpropenyl
preparing
substituted heterocycles
phenylalkyl substituted
Prior art date
Application number
PCT/US2006/025144
Other languages
French (fr)
Other versions
WO2007005455A2 (en
Inventor
Jaidev S Goudar
Charles E Hatch Iii
Guozhi Wang
Craig A Polsz
Russell Patera
Original Assignee
Bayer Cropscience Ag
Jaidev S Goudar
Charles E Hatch Iii
Guozhi Wang
Craig A Polsz
Russell Patera
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Cropscience Ag, Jaidev S Goudar, Charles E Hatch Iii, Guozhi Wang, Craig A Polsz, Russell Patera filed Critical Bayer Cropscience Ag
Publication of WO2007005455A2 publication Critical patent/WO2007005455A2/en
Publication of WO2007005455A3 publication Critical patent/WO2007005455A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

An improved process is described for preparing (disubstitutedpropenyl) phenylalkyl substituted heterocycles. This improved process is focused on steps to produce key intermediates, namely compounds of formula (I): where R3, R4, R5 and x are defined herein.
PCT/US2006/025144 2005-06-30 2006-06-28 Improved process for preparing (disubstitutedpropenyl) phenylalkyl substituted heterocycles WO2007005455A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69582105P 2005-06-30 2005-06-30
US60/695,821 2005-06-30

Publications (2)

Publication Number Publication Date
WO2007005455A2 WO2007005455A2 (en) 2007-01-11
WO2007005455A3 true WO2007005455A3 (en) 2007-06-14

Family

ID=37604979

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/025144 WO2007005455A2 (en) 2005-06-30 2006-06-28 Improved process for preparing (disubstitutedpropenyl) phenylalkyl substituted heterocycles

Country Status (2)

Country Link
TW (1) TW200740796A (en)
WO (1) WO2007005455A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020219906A1 (en) * 2019-04-25 2020-10-29 Board Of Regents, The University Of Texas System Heterocyclic inhibitors of tyrosine kinase

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6987194B2 (en) * 2003-04-30 2006-01-17 Fmc Corporation Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives
US20060217433A1 (en) * 2003-02-14 2006-09-28 Eli Lilly And Company Sulfonamide derivatives as ppar modulators

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060217433A1 (en) * 2003-02-14 2006-09-28 Eli Lilly And Company Sulfonamide derivatives as ppar modulators
US6987194B2 (en) * 2003-04-30 2006-01-17 Fmc Corporation Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FUJITA M. ET AL.: "Preference of electron transfer to nucleophillic addition in reactions of ketene allyl acetals with quinones and catalysis magnesium ion", BULL. CHEM. SOC. JAP., vol. 69, no. 4, April 1996 (1996-04-01), pages 1107 - 1116, XP003013790 *

Also Published As

Publication number Publication date
WO2007005455A2 (en) 2007-01-11
TW200740796A (en) 2007-11-01

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