WO2007004389A1

WO2007004389A1 - Anti-bacterial film

Info

Publication number: WO2007004389A1
Application number: PCT/JP2006/311749
Authority: WO
Inventors: Shuzo Nakagawa
Original assignee: Techno Trading & Consultant Co., Ltd.; Nakagawa, Yoshihiro
Priority date: 2005-06-13
Filing date: 2006-06-12
Publication date: 2007-01-11
Also published as: JP5150254B2; JPWO2007004389A1

Abstract

[PROBLEMS] To discover a resin which shows a good compatibility with an isothiocyanate ester when kneaded with the ester, produces no air bubble remaining therein when sandwiched between films, and is excellent in biological safety, and to provide a novel anti-bacterial sheet comprising a combination of an isothiocyanate ester and the resin. [MEANS FOR SOLVING PROBLEMS] An anti-bacterial film produced by blending an isothiocyanate ester with a shellac-type adhesive and sandwiching the resulting blend between films.

Description

Specification

Antibacterial film

Technical field

[0001] The present invention relates to an antibacterial film containing a volatile drug.

Background art

[0002] Volatile oily antibacterial substances such as isothiocyanate esters typified by isothiocyanate are known as substances that prevent and inhibit the growth of molds in foods. Here, Patent Document 1 proposes a fungicides using the isothiocyanate esters. This anti-mold sheet has a structure in which isothiocyanate, which is a volatile chemical, and a predetermined resin are kneaded and the kneaded product is sandwiched with a gas permeation restricting layer.

Patent Document 1: JP 2003-171208

Disclosure of the invention

Problems to be solved by the invention

[0003] Here, the kneading resin can be kneaded with isothiocyanate, can be reduced in viscosity, and can be kneaded at a relatively low temperature, resulting in low chemical loss. For reasons such as easy coating, rosin, rosin esters, or modified substances thereof are used. However, when these kneading resins are used, there is a problem that the appearance of the obtained product is deteriorated because air bubbles easily enter the obtained product. In addition, according to the International Chemical Safety Program (IPCS), rosin is known to decompose on heating to produce irritating fumes and to cause asthma by repeated or long-term inhalation of such fumes. Thus, when a sand that is compatible with the isothiocyanate ester is found to be compatible with the foam, no bubbles remain and the biosafety of the fat is found. The purpose is to provide a new antibacterial sheet combined.

Means for solving the problem

[0004] As a result of diligent research, the present inventor has adopted a shellac-based adhesive as a resin. Thus, the inventors have found that the above-mentioned problems can be achieved, and have completed the following inventions (1) and (2).

[0005] The present invention (1) is an antibacterial film obtained by blending isothiocyanates with a shellac-based adhesive and sanding the blend with a film.

[0006] The present invention (2) is an isothiocyanate ester isothiocyanate ester and a cyclodextrin inclusion compound of the isothiocyanate ester, and one of the films is a gas permeable film. The antibacterial film of the invention (1), wherein the other is a water vapor permeable film.

The invention's effect

[0007] According to the present invention (1), no bubbles remain when sanded well when kneaded with isothiocyanates, and even if used continuously for a long period of time (for example, It does not release the causative agent of asthma) and has excellent biological safety!

[0008] According to the present invention (2), since the highly volatile and isothiocyanate esters are one film, the gas permeable film force is gradually released immediately after use, so that a high concentration of isothiocyanate is used from the initial stage of use. Acidic esters can be secured and external moisture is gradually absorbed through the water vapor permeable film, and the cyclodextrin inclusion compound of the isothiocyanate reacts with the moisture to remove the isothiocyanate. As a result of release, long-term sustainability of isothiocyanate ester release can be ensured (two-stage sustained release).

BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, the best mode according to the present invention will be described. First, as shown in FIG. 1, the antibacterial film according to the best mode is a kneaded material layer 1 in which an isothiocyanate ester is blended with a shellac-based adhesive in a gas permeable film 2 and a water vapor permeable film 3. It has a structure with a sound.

Here, the kneaded material layer 1 contains “isothiocyanate esters” as an immediate active ingredient. Here, “isothiocyanate” refers to isothiocyanate and its derivatives. For example, methyl isothiocyanate, ethyl isothiocyanate, n-propyl isothiocyanate, isopropyl isothiocyanate, n-isothiocyanate. Examples include chill, isobutyl isothiocyanate, isoamyl isothiocyanate, aryl isothiocyanate, isothiocyanate phenol, and benzyl isothiocyanate. The esters may be chemically synthesized or derived from natural products, but are preferably derived from natural products from the viewpoint of biological safety. As a natural product-derived material, it is preferable to use the above-mentioned substance derived from a natural shark rust or a power pear extract. Here, “extraction” refers to a steam distillation method or the like.

Furthermore, the kneaded material layer 1 contains “cyclodextrin inclusion compound of isothiocyanate” as a sustained-release active ingredient. Here, “cyclodextrin” is a cyclic oligosaccharide obtained by allowing an enzyme (cyclodextrin glucanotransferase) to act on starch. For example, α-cyclodextrin, β-cyclodextrin, γ-cycle Rhodextrin can be mentioned, and β-cyclodextrin is preferred. The “cyclodextrin inclusion compound of isothiocyanate esters” refers to those in which isothiocyanate esters are encapsulated inside the inside of the donut-shaped ring of cyclodextrins (in the cavity). This inclusion compound is available from Shisui Minato Seika Co., Ltd. under the trade name Dexy Pearl®-100. In addition to the isothiocyanate esters, other substances such as isothiocyanate esters generally have odors as required, and foods and their odors! In order to change or extinguish the above-mentioned odor by substances having a fragrance if they are not compatible, fragrance or deodorant such as cinnamate, vanillin, gel acetate, pepper oil, ethyl acetate, etc. May be contained.

Next, the kneaded material layer 1 uses a shellac-based adhesive as a base resin. Here, “Sierrac” is a natural product obtained by refining the scab-like material secreted by the scale scale insect, called Laccifer lacca Kerr. For example, seed rack, refined shellac, and decolorized shellac that are raw materials for shellac. There is white shellac. Note that the shellac-based adhesive is available under the trade name “Unique Paper Varnish FZA-5714-1”, for example.

[0013] Furthermore, in addition to the above components, the kneaded material layer 1 may contain various additives as necessary. For example, release accelerators for improving the release control performance of isothiocyanate esters (for example, oil such as coconut oil and corn oil, cellulose fiber, cellulose powder) Cellulose, etc., inorganic substances such as titanium oxide, calcium silicate, etc.), anti-oxidation agents (for example, BHT, vitamin C, etc.) to improve the stability of isothiocyanate esters, to improve adhesive strength And known adhesion aids (for example, rubber adhesives, acrylic adhesives, etc.).

[0014] Isothiocyanate esters and cyclodextrin of isothiocyanate ester The kneading ratio of isothiocyanate esters in the kneaded mixture of the clathrate compound and the shellac base adhesive is from 0.1 to 100 parts by weight with respect to 100 parts by weight of the kneaded product. 30.0 parts by weight is preferred, and 1.0-20. 0 parts by weight is more preferred.

[0015] Next, the gas permeable film 2 is not particularly limited as long as it is permeable to volatilized isothiocyanate esters. For example, stretched or unstretched polypropylene, polyethylene (for example, linear) Low-density polyethylene, low-density polyethylene, etc.), polyethylene terephthalate, polymethylpentene, biodegradable films {for example, polylactic acid films (plant-based (for example, corn starch) and petroleum-based)} and the like. These films may be used alone or in combination of two or more, and the thickness of the gas permeable film 2 is preferably 10 to: ίΟΟ / ζ. πι, more preferably 30 to 70 μm.

Next, the water vapor permeable film 3 is not particularly limited as long as it is water vapor permeable, but is preferably one having a water vapor permeability (JIS Z 0208) force of 40 gZm ² ′ 24h, for example, (1) PET film with a thickness of 9-16 πι, (2) Polyurethane film with a thickness of 1-20 πι, (3) Chlorinated polypropylene film with a thickness of 1-10 μm, (4) Thickness of 1-10 μm Examples thereof include a butyl chloride film, (5) a butyl chloride copolymer film having a thickness of 1 to 10 πι, and (6) an ethylene acetate acetate copolymer film having a thickness of 1 to πι.

Next, the use of the antibacterial film according to the best mode will be described. Here, “antibacterial” is a concept that includes not only antibacterial in a narrow sense but also antifungal. The film can be used, for example, on a food or in a form for coating or packaging food. Thereby, it is possible to achieve antibacterial, antifungal, insectproof and freshness maintenance of the food. The amount of the isothiocyanate used above is not particularly limited, but is preferably 30 to 6000 mg with respect to the volatile drug-containing adhesive sheet lm ² . Example

Hereinafter, the present invention will be specifically described with reference to examples. The technical scope of the present invention is not limited in any way by the following examples.

[0019] Example 1

10 parts by weight of isothiocyanate allyl and 90 parts by weight of shellac base adhesive (unique paper base FZA-5714-1 (trademark), manufactured by Arakawa Paint Industry Co., Ltd.) are mixed with the gas-permeable film ( OTP35M (trademark) manufactured by Otsuka Techno Co., Ltd .: Oxygen permeation amount 9000cc / m ² '24h, 50 m) sand (coating amount 5 g / m ² ), then 80-120 The film according to this example was obtained by heating at C for 30 seconds.

[0020] Ironmaking example 2

10 parts by weight of isothiocyanate allyl, 10 parts by weight of cyclodextrin clathrated with isothiocyanate allyl (Shimizu Minato Sugar Co., Ltd., Dixie Pearl K 100) and shellac base adhesive (unique paper varnish FZA-5714-1 (trademark), Arakawa Paint Industry Co., Ltd.) 80 parts by weight, and kneaded the gas-permeable film (OTP35M (trademark) Otsuka Techno Co., Ltd .: oxygen transmission rate 9000cc / m ² '24h, 35 m) and water vapor transmission 80 to 120 after sanding with a temporary film (OTP35H (trademark) manufactured by Otsuka Techno Co., Ltd .: oxygen transmission rate 13000cc / m ² · 24h, water vapor transmission rate 32g / m ² '24h, 35m). The film according to this example was obtained by heating at C for 30 seconds.

[0021] Test Example 1

The antibacterial sheets (7 × 20 cm) of Production Examples 1 and 2 were coated on two commercially available cuttings and allowed to stand, and the occurrence of mold over time was observed. As a comparative example, a sample coated with the same size PP film was also tested. As a result, in the comparative example, force cracks occurred on the cutting bar 4 days after the start of the test. In contrast, the sheet produced in Production Example 1 showed no mold even after 30 days, and the sheet produced in Production Example 2 was strong, with no mold observed for more than 60 days.

[0022] Test Example 2

In order to evaluate the antibacterial effect of the antibacterial sheets of Production Examples 1 and 2, according to the method described in JP-A-11 332 534, Escherichia coli IFO 3972 and Staphylococcus aureus subsp. Aureus IFP 12732); ¾r SA ', narrow? still, In the test, the entire petri dish was covered with the antibacterial sheet. The results are shown in Table 1.

[0023] [Table 1]

[0024] From the above results, the sheets of Production Example 1 and Production Example 2 have a fungicidal effect of 30 days or more, and also have high antibacterial activity in both culture tests of Escherichia coli and Staphylococcus aureus. And was found to be bactericidal.

Brief Description of Drawings

FIG. 1 is a sectional view of a sheet according to the best mode.

Claims

The scope of the claims

[1] An antibacterial film obtained by blending isothiocyanates with a shellac-based adhesive and sanding the blend with a film.

[2] Strength of isothiocyanate ester A cyclodextrin inclusion compound of isothiocyanate ester and the isothiocyanate ester, and one of the films is a gas permeable film and the other is a water vapor permeable film. The antibacterial film according to claim 1, wherein