WO2007003344A3 - Device for quantitative analysis of a metabolite profile - Google Patents

Device for quantitative analysis of a metabolite profile Download PDF

Info

Publication number
WO2007003344A3
WO2007003344A3 PCT/EP2006/006328 EP2006006328W WO2007003344A3 WO 2007003344 A3 WO2007003344 A3 WO 2007003344A3 EP 2006006328 W EP2006006328 W EP 2006006328W WO 2007003344 A3 WO2007003344 A3 WO 2007003344A3
Authority
WO
WIPO (PCT)
Prior art keywords
quantitative analysis
metabolite profile
relates
present
drug
Prior art date
Application number
PCT/EP2006/006328
Other languages
French (fr)
Other versions
WO2007003344A2 (en
Inventor
Steven Lewis Ramsay
Wolfgang Guggenbichler
Klaus Michael Weinberger
Armin Graber
Wolfgang Markus Stoeggl
Original Assignee
Biocrates Life Sciences Gmbh
Steven Lewis Ramsay
Wolfgang Guggenbichler
Klaus Michael Weinberger
Armin Graber
Wolfgang Markus Stoeggl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK06754632.5T priority Critical patent/DK1875401T3/en
Application filed by Biocrates Life Sciences Gmbh, Steven Lewis Ramsay, Wolfgang Guggenbichler, Klaus Michael Weinberger, Armin Graber, Wolfgang Markus Stoeggl filed Critical Biocrates Life Sciences Gmbh
Priority to CN200680022942A priority patent/CN100594501C/en
Priority to AU2006265381A priority patent/AU2006265381B2/en
Priority to IN2241DEN2014 priority patent/IN2014DN02241A/en
Priority to JP2008518727A priority patent/JP5155160B2/en
Priority to BRPI0613478A priority patent/BRPI0613478B8/en
Priority to EP06754632.5A priority patent/EP1875401B1/en
Priority to NZ563431A priority patent/NZ563431A/en
Priority to CA2608965A priority patent/CA2608965C/en
Publication of WO2007003344A2 publication Critical patent/WO2007003344A2/en
Publication of WO2007003344A3 publication Critical patent/WO2007003344A3/en
Priority to IL187470A priority patent/IL187470A/en
Priority to NO20080559A priority patent/NO339319B1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/30—Data warehousing; Computing architectures
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics

Abstract

The present invention relates to a device, in particular to a sample preparation device for the quantitative analysis of a drug and/ or metabolite profile in a biological sample. Moreover, the present invention relates to an insert for such a device being impregnated with at least one internal standard, to the internal standard itself, and to a kit comprising the device. Further, the present invention also relates to an apparatus containing the device, and to a method for the quantitative analysis of a drug and/or metabolite profile in a biological sample employing the device.
PCT/EP2006/006328 2005-06-30 2006-06-29 Device for quantitative analysis of a metabolite profile WO2007003344A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
BRPI0613478A BRPI0613478B8 (en) 2005-06-30 2006-06-29 device for quantitative analysis of a metabolite profile
CN200680022942A CN100594501C (en) 2005-06-30 2006-06-29 Device for quantitative analysis of a metabolite profile
AU2006265381A AU2006265381B2 (en) 2005-06-30 2006-06-29 Device for quantitative analysis of a metabolite profile
IN2241DEN2014 IN2014DN02241A (en) 2005-06-30 2006-06-29
JP2008518727A JP5155160B2 (en) 2005-06-30 2006-06-29 Equipment for quantitative analysis of metabolite characteristics
DK06754632.5T DK1875401T3 (en) 2005-06-30 2006-06-29 Device for quantitative analysis of a metabolite profile
EP06754632.5A EP1875401B1 (en) 2005-06-30 2006-06-29 Device for quantitative analysis of a metabolite profile
NZ563431A NZ563431A (en) 2005-06-30 2006-06-29 Device for quantitative analysis of a metabolite profile
CA2608965A CA2608965C (en) 2005-06-30 2006-06-29 Device for quantitative analysis of a metabolite profile
IL187470A IL187470A (en) 2005-06-30 2007-11-19 Device for quantitative analysis of a metabolite profile
NO20080559A NO339319B1 (en) 2005-06-30 2008-01-30 Device for quantitative analysis of a metabolite profile

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69498305P 2005-06-30 2005-06-30
US69498405P 2005-06-30 2005-06-30
US60/694,983 2005-06-30
US60/694,984 2005-06-30

Publications (2)

Publication Number Publication Date
WO2007003344A2 WO2007003344A2 (en) 2007-01-11
WO2007003344A3 true WO2007003344A3 (en) 2007-04-26

Family

ID=36783737

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2006/006328 WO2007003344A2 (en) 2005-06-30 2006-06-29 Device for quantitative analysis of a metabolite profile
PCT/EP2006/006327 WO2007003343A1 (en) 2005-06-30 2006-06-29 Apparatus and method for analyzing a metabolite profile

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/006327 WO2007003343A1 (en) 2005-06-30 2006-06-29 Apparatus and method for analyzing a metabolite profile

Country Status (16)

Country Link
US (2) US8265877B2 (en)
EP (2) EP1897014B1 (en)
JP (2) JP4829297B2 (en)
KR (1) KR100967573B1 (en)
CN (1) CN100594501C (en)
AU (1) AU2006265381B2 (en)
BR (1) BRPI0613478B8 (en)
CA (2) CA2608963C (en)
DK (2) DK1897014T3 (en)
ES (1) ES2452025T3 (en)
IL (1) IL187470A (en)
IN (1) IN2014DN02241A (en)
NO (1) NO339319B1 (en)
NZ (1) NZ563431A (en)
RU (1) RU2391672C2 (en)
WO (2) WO2007003344A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7169278B2 (en) 2017-01-18 2022-11-10 バイオクラテス ライフ サイエンシズ アクチェンゲゼルシャフト A novel biomarker for evaluating ovarian cancer

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2585395A (en) 1994-05-09 1995-11-29 Chiron Corporation Retroviral vectors having a reduced recombination rate
US8969089B2 (en) 2004-10-12 2015-03-03 Quest Diagnostics Investments, Inc. Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry
WO2007003344A2 (en) * 2005-06-30 2007-01-11 Biocrates Life Sciences Ag Device for quantitative analysis of a metabolite profile
AU2007248476B2 (en) * 2006-05-05 2012-09-06 Perkinelmer Las, Inc Quantitative analysis of surface-derived samples using mass spectrometry
EP1923806A1 (en) * 2006-11-14 2008-05-21 Metanomics GmbH Fast metabolomic analysis and system therefor
US7999084B2 (en) * 2007-05-16 2011-08-16 Agilent Technologies, Inc. Devices and methods for reducing matrix effects
WO2008145385A1 (en) * 2007-05-31 2008-12-04 Biocrates Life Sciences Ag Biomarker and method for determining an oxidative stress level
JP2010528302A (en) * 2007-05-31 2010-08-19 バイオクレイツ ライフ サイエンス エージー Inflammation and oxidative stress level assay
CN101796408B (en) * 2007-06-29 2014-05-07 奎斯特诊断投资公司 Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry
JP5306345B2 (en) * 2007-07-26 2013-10-02 フェノメノーム ディスカバリーズ インク Methods for diagnosing, assessing risk and monitoring autism spectrum disorders
DE102007043614B3 (en) * 2007-09-13 2008-11-20 Biocrates Life Sciences Gmbh Retainer for wells of multi-corrugated plate, has support arranged in opening below retaining bar, where retainer rests with lateral outer surfaces of support bars, retaining bar and/or connecting rods against inner side of opening
WO2009043149A1 (en) * 2007-10-01 2009-04-09 Mds Analytical Technologies, A Business Unit Of Mds Inc., Doing Business Through Its Sciex Division Analysis of conjugated metabolites of alcohol consumption
WO2009070233A1 (en) * 2007-11-26 2009-06-04 Waters Technologies Corporation Internal standards and methods for use in quantitatively measuring analytes in a sample
US9983099B2 (en) * 2008-06-13 2018-05-29 Smiths Detection Montreal Inc. Analytical instrument with temporal control of ion mobility spectrometer control parameters
CA2743211A1 (en) 2008-11-12 2010-05-20 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods and systems of using exosomes for determining phenotypes
EP2192196A1 (en) 2008-11-27 2010-06-02 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Prediction of lipid-metabotype-related physiological susceptibilities
CN102326073B (en) 2009-03-05 2013-11-13 株式会社日立高新技术 Analysis apparatus
CN102414778B (en) * 2009-04-30 2016-03-16 普度研究基金会 Moist porous material is used to produce ion
US9500572B2 (en) 2009-04-30 2016-11-22 Purdue Research Foundation Sample dispenser including an internal standard and methods of use thereof
EP2249161B1 (en) 2009-05-05 2020-05-13 InfanDx AG Method of diagnosing asphyxia
US20120129265A1 (en) * 2009-06-02 2012-05-24 Biocrates Life Sciences Ag New biomarkers for assessing kidney diseases
WO2011066589A1 (en) 2009-11-30 2011-06-03 Caris Life Sciences Luxembourg Holdings Methods and systems for isolating, storing, and analyzing vesicles
CA2787027A1 (en) 2010-01-13 2011-07-21 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Detection of gastrointestinal disorders
US9128101B2 (en) 2010-03-01 2015-09-08 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
JP2013526852A (en) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス Circulating biomarkers for disease
JP5894078B2 (en) 2010-10-29 2016-03-23 アトナープ株式会社 Sampling device
SG190070A1 (en) 2010-10-29 2013-06-28 Thermo Fisher Scientific Oy System layout for an automated system for sample preparation and analysis
EP2492690A1 (en) * 2011-02-22 2012-08-29 BIOCRATES Life Sciences AG Method and use of metabolites for the diagnosis of inflammatory brain injury in preterm born infants
EP2587264A1 (en) 2011-10-25 2013-05-01 InfanDx AG Method and use of metabolites for the diagnosis and differentiation of neonatal encephalopathy
JP6444736B2 (en) 2011-11-23 2018-12-26 クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド Detection of kisspeptin-54 by tandem mass spectrometry
JP6198408B2 (en) * 2012-04-02 2017-09-20 株式会社日立ハイテクノロジーズ Method for analyzing volatile substances in sample liquid
US8870028B2 (en) 2012-05-25 2014-10-28 Restek Corporation Dispensing device
CN104769434B (en) * 2012-08-13 2018-01-02 亥姆霍兹慕尼黑中心德国研究健康与环境有限责任公司 Biomarker for diabetes B
WO2014072537A1 (en) 2012-11-12 2014-05-15 Biocrates Life Sciences Ag Use of quality indicators for checking thawing processes in frozen sample tissues
WO2014110196A1 (en) * 2013-01-10 2014-07-17 Restek Corporation Dispensing device and method
BR112015018484A2 (en) 2013-01-31 2017-07-18 Purdue Research Foundation methods of analyzing crude oil
US10008375B2 (en) 2013-01-31 2018-06-26 Purdue Research Foundation Systems and methods for analyzing an extracted sample
WO2014209474A1 (en) 2013-06-25 2014-12-31 Purdue Research Foundation Mass spectrometry analysis of microorganisms in samples
CN103558354B (en) 2013-11-15 2015-07-15 南京大学 Water toxicity analysis method based on biologic omics integrated technology
JP2017101924A (en) * 2014-03-31 2017-06-08 積水メディカル株式会社 Internal standard substance reagent
CN104200087B (en) * 2014-06-05 2018-10-02 清华大学 For the parameter optimization of machine learning and the method and system of feature tuning
US9786478B2 (en) 2014-12-05 2017-10-10 Purdue Research Foundation Zero voltage mass spectrometry probes and systems
CN107960130A (en) 2015-02-06 2018-04-24 普度研究基金会 Probe, system, box and its application method
EP3171173A1 (en) 2015-11-19 2017-05-24 Medizinische Universität Innsbruck Method of diagnosis of a thoracic aortic aneurysm
US10001501B2 (en) 2015-12-31 2018-06-19 Universal Diagnostics, S. L. Systems and methods for automated, customizable sample preparation for detection of metabolites and lipids
DE102017112612A1 (en) * 2016-06-10 2017-12-14 Hitachi High-Tech Science Corporation A liquid chromatograph and method for correcting variations in a detector output of the liquid chromatograph
US10607723B2 (en) 2016-07-05 2020-03-31 University Of Kentucky Research Foundation Method and system for identification of metabolites using mass spectra
EP3535418B1 (en) * 2016-11-07 2021-12-15 Battelle Memorial Institute Nanoscale biochemical sample preparation and analysis
US11719702B2 (en) * 2016-11-07 2023-08-08 Battelle Memorial Institute Methods and systems of proteome analysis and imaging
EP3376230A1 (en) 2017-03-13 2018-09-19 Biocross, S.L. Identification of signatures for neurodegeneration diseases diagnoses
WO2018174876A1 (en) * 2017-03-22 2018-09-27 Mprobe Inc. Methods and compositions for providing a preeclampsia assessment with metabolites
CN107727850B (en) * 2017-10-10 2021-08-27 常州博闻迪医药股份有限公司 Lateral flow chromatography detection reaction start control method
EP3624691A1 (en) * 2017-05-17 2020-03-25 Radiometer Medical ApS Porous optical fiber for the detection of an analyte in a fluid
CN107561150A (en) * 2017-07-03 2018-01-09 宁波华仪宁创智能科技有限公司 The detection method of drug abuse
CN107798981A (en) * 2017-10-31 2018-03-13 楚雄医药高等专科学校 A kind of permanent teaching micro-capsule sample slice and preparation method thereof
CN109030673A (en) * 2018-07-04 2018-12-18 易达精准（杭州）科技有限公司 The detection method and detection kit of immunosuppressor in dried blood spot
CN109298115B (en) * 2018-10-19 2020-07-28 深圳市绘云生物科技有限公司 Quantitative detection method for multiple metabolites in biological sample and metabolic chip
WO2020099683A1 (en) 2018-11-16 2020-05-22 Biocrates Life Sciences Ag Metabolites for use in ovarian cancer detection and diagnosis
FR3091351B1 (en) 2018-12-27 2021-05-21 Univ Rouen Centre Hospitalier FABRY'S DISEASE BIOMARKER
KR102035162B1 (en) * 2019-03-12 2019-11-08 한국과학기술원 Method for predicting drug candidate for diseases by using human metabolite specific for the disease target metabolizing enzyme
CN111579665B (en) 2020-05-20 2021-11-05 苏州帕诺米克生物医药科技有限公司 UPLC/HRMS-based metabonomics relative quantitative analysis method
WO2021237035A1 (en) * 2020-05-21 2021-11-25 Mayo Foundation For Medical Education And Research Calibration methods for mass spectrometry measurements
CN111704654B (en) * 2020-06-18 2021-12-03 上海交通大学医学院附属仁济医院 Peptide compound and preparation method and application thereof
US11754536B2 (en) 2021-11-01 2023-09-12 Matterworks Inc Methods and compositions for analyte quantification
JP7206365B1 (en) 2021-12-22 2023-01-17 浜松ホトニクス株式会社 sample support
KR102547430B1 (en) * 2022-11-16 2023-06-23 (주)애터미오롯 Method for qualitative analysis of noni-containing composition
CN117538530A (en) * 2023-11-07 2024-02-09 中国医学科学院肿瘤医院 Biomarker composition and kit for detecting metastatic breast cancer and application of biomarker composition and kit

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996024062A1 (en) * 1995-02-01 1996-08-08 Cornell Research Foundation, Inc. Liposome-enhanced immunoaggregation assay and test device
WO2000072019A2 (en) * 1999-05-20 2000-11-30 Cornell Research Foundation, Inc. Liposome-enhanced test device and method
WO2003016861A2 (en) * 2001-08-14 2003-02-27 President And Fellows Of Harvard College Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry
US20030044799A1 (en) * 2001-08-31 2003-03-06 Matson Robert S. Analysis using a distributed sample
GB2385918A (en) * 2001-12-08 2003-09-03 Micromass Ltd Method of mass spectrometry
WO2005031304A2 (en) * 2003-09-22 2005-04-07 Becton, Dickinson And Company Quantification of analytes using internal standards

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9718129D0 (en) * 1997-08-27 1997-10-29 Isis Innovation Branched structures
US6258605B1 (en) * 1999-03-26 2001-07-10 Neo Gen Screening, Inc. Clinical method for the genetic screening of newborns using tandem mass spectrometry
US6455321B1 (en) * 1999-01-30 2002-09-24 Neo Gen Screening, Inc. Method for interpreting tandem mass spectrometry data for clinical diagnosis
US20020009394A1 (en) * 1999-04-02 2002-01-24 Hubert Koster Automated process line
EP1113269B1 (en) * 1999-12-29 2006-10-18 PerkinElmer Life Sciences, Inc. Test tray, kit and methods for screening body fluids of newborns by tandem mass spectrometry
AU2001262943A1 (en) * 2000-04-14 2001-10-30 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US6680203B2 (en) 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
CA2416744A1 (en) * 2000-07-18 2002-01-24 Invitrogen Corporation Device and methods for subdividing and filtering gel material and extracting molecules therefrom
US6627444B1 (en) * 2000-08-07 2003-09-30 Smiths Detection - Toronto Ltd. Method and solid phase calibration sample for calibration of analytical instructions
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
AU2002320316A1 (en) 2001-07-06 2003-01-21 Lipomics Technologies, Inc. Generating, viewing, interpreting, and utilizing a quantitative database of metabolites
US6939716B2 (en) 2001-09-19 2005-09-06 Washington University Method for detecting conditions indicative of sepsis
US20030129760A1 (en) * 2001-11-13 2003-07-10 Aguilera Frank Reinaldo Morales Mass intensity profiling system and uses thereof
US20040023295A1 (en) * 2001-11-21 2004-02-05 Carol Hamilton Methods and systems for analyzing complex biological systems
GB0128498D0 (en) 2001-11-28 2002-01-23 Inst Of Child Health International standards for sphingolipids
AUPS177202A0 (en) * 2002-04-16 2002-05-23 Diakyne Pty Ltd Multi-element screening of trace elements
WO2004038602A1 (en) 2002-10-24 2004-05-06 Warner-Lambert Company, Llc Integrated spectral data processing, data mining, and modeling system for use in diverse screening and biomarker discovery applications
AU2003286726A1 (en) 2002-10-25 2004-05-13 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
EP1556684A4 (en) * 2002-11-01 2008-01-23 Univ Colorado Regents Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry
US20040121305A1 (en) 2002-12-18 2004-06-24 Wiegand Roger Charles Generation of efficacy, toxicity and disease signatures and methods of use thereof
US6909981B2 (en) * 2003-01-27 2005-06-21 Ciphergen Biosystems, Inc. Data management system and method for processing signals from sample spots
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
KR20050050714A (en) * 2003-11-26 2005-06-01 매그나칩 반도체 유한회사 Method for fabricating transistor of semiconductor device
US7745226B2 (en) * 2005-04-06 2010-06-29 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites
WO2007003344A2 (en) * 2005-06-30 2007-01-11 Biocrates Life Sciences Ag Device for quantitative analysis of a metabolite profile

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996024062A1 (en) * 1995-02-01 1996-08-08 Cornell Research Foundation, Inc. Liposome-enhanced immunoaggregation assay and test device
WO2000072019A2 (en) * 1999-05-20 2000-11-30 Cornell Research Foundation, Inc. Liposome-enhanced test device and method
WO2003016861A2 (en) * 2001-08-14 2003-02-27 President And Fellows Of Harvard College Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry
US20030044799A1 (en) * 2001-08-31 2003-03-06 Matson Robert S. Analysis using a distributed sample
GB2385918A (en) * 2001-12-08 2003-09-03 Micromass Ltd Method of mass spectrometry
WO2005031304A2 (en) * 2003-09-22 2005-04-07 Becton, Dickinson And Company Quantification of analytes using internal standards
US20050112635A1 (en) * 2003-09-22 2005-05-26 Becton, Dickinson And Company Quantification of analytes using internal standards

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7169278B2 (en) 2017-01-18 2022-11-10 バイオクラテス ライフ サイエンシズ アクチェンゲゼルシャフト A novel biomarker for evaluating ovarian cancer

Also Published As

Publication number Publication date
IN2014DN02241A (en) 2015-07-10
JP4829297B2 (en) 2011-12-07
RU2008102835A (en) 2009-08-10
US20070004044A1 (en) 2007-01-04
US8265877B2 (en) 2012-09-11
US20070003965A1 (en) 2007-01-04
NO339319B1 (en) 2016-11-28
BRPI0613478B8 (en) 2021-07-27
CA2608965C (en) 2014-08-19
BRPI0613478A2 (en) 2012-01-17
BRPI0613478B1 (en) 2019-07-09
IL187470A (en) 2015-02-26
ES2452025T3 (en) 2014-03-31
DK1897014T3 (en) 2014-03-10
CN100594501C (en) 2010-03-17
EP1875401A2 (en) 2008-01-09
KR20080025092A (en) 2008-03-19
IL187470A0 (en) 2008-03-20
JP2008547031A (en) 2008-12-25
NO20080559L (en) 2008-01-30
WO2007003344A2 (en) 2007-01-11
CA2608963C (en) 2014-08-26
KR100967573B1 (en) 2010-07-05
US8116983B2 (en) 2012-02-14
CA2608963A1 (en) 2007-01-11
JP5155160B2 (en) 2013-02-27
CN101208697A (en) 2008-06-25
CA2608965A1 (en) 2007-01-11
JP2008547030A (en) 2008-12-25
RU2391672C2 (en) 2010-06-10
EP1875401B1 (en) 2014-03-05
AU2006265381A1 (en) 2007-01-11
NZ563431A (en) 2012-05-25
EP1897014A1 (en) 2008-03-12
DK1875401T3 (en) 2014-04-07
AU2006265381B2 (en) 2010-06-10
EP1897014B1 (en) 2014-01-15
WO2007003343A1 (en) 2007-01-11

Similar Documents

Publication Publication Date Title
WO2007003344A3 (en) Device for quantitative analysis of a metabolite profile
WO2008039946A3 (en) Integrated meter for analyzing biological samples
EP1966731A4 (en) Method for ascertaining interferants in small liquid samples in an automated clinical analyzer
EP1867978A4 (en) Method of analyte analysis and analyte analyzer
EP1819283A4 (en) System and method for analyte sampling and analysis with hydrogel
EP1882950A4 (en) Testing chip for analyzing target substance contained in analyte, and microscopic comprehensive analytical system
EP1849001A4 (en) Lateral flow test kit and method for detecting an analyte
AU2013207599A1 (en) Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof
EP1820021B8 (en) Improved method of electrochemical analysis of an analyte
WO2005067582A3 (en) Methods and apparatus for enhanced sample identification based on combined analytical techniques
WO2009134944A3 (en) Methods of determining the health status of an individual
WO2008045526A3 (en) Method and device for preparing an analyte for analysis by mass spectrometry
WO2009051821A3 (en) Sample preparation devices and analyzers
EP1739402A4 (en) Methods of separating, identifying and dispensing specimen and device therefor, and analyzing device method
GB2439032B (en) Method and system for sample testing
EP1960112A4 (en) Enrichment unit for biological components and an enrichment method
EP1672984A4 (en) Methods for reducing the range in concentrations of analyte species in a sample
GB0507457D0 (en) Improvements in or relating to methods and apparatus for analyzing biological samples by mass spectrometry
WO2010141075A8 (en) Specific analysis of ketone and aldehyde analytes using reagent compounds, labeling strategies, and mass spectrometry workflow
EP1904653A4 (en) Microfluidic methods and apparatuses for sample preparation and analysis
EP1939611A4 (en) Method for detecting sample supply condition, and analyzer
EP1873522A4 (en) Method for determination of hemoglobin derivative, and reagent composition, assay kit, analysis device and analysis system for use in the method
WO2009142835A3 (en) Method and apparatus for analyzing skin and hair
WO2006132797A3 (en) Preparation of small liquid samples for automated analysis
EP1930726A4 (en) Method of assaying substance with affinity in sample including step of destroying blood-cell ingredient

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 563431

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2608965

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2006754632

Country of ref document: EP

Ref document number: 187470

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: MX/a/2007/016553

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 9888/DELNP/2007

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 200680022942.3

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 2008518727

Country of ref document: JP

Ref document number: 1020077030772

Country of ref document: KR

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Ref document number: DE

WWE Wipo information: entry into national phase

Ref document number: 2006265381

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2006754632

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2008102835

Country of ref document: RU

WWE Wipo information: entry into national phase

Ref document number: 2006265381

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2006265381

Country of ref document: AU

ENP Entry into the national phase

Ref document number: PI0613478

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20071228