WO2007000531A3 - Method for preparing solid lipidic particles using a membrane reactor - Google Patents

Method for preparing solid lipidic particles using a membrane reactor Download PDF

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Publication number
WO2007000531A3
WO2007000531A3 PCT/FR2006/050447 FR2006050447W WO2007000531A3 WO 2007000531 A3 WO2007000531 A3 WO 2007000531A3 FR 2006050447 W FR2006050447 W FR 2006050447W WO 2007000531 A3 WO2007000531 A3 WO 2007000531A3
Authority
WO
WIPO (PCT)
Prior art keywords
phase
membrane
lipid
mixture
lipids
Prior art date
Application number
PCT/FR2006/050447
Other languages
French (fr)
Other versions
WO2007000531A2 (en
Inventor
Catherine Charcosset
Hatem Fessi
Original Assignee
Univ Claude Bernard Lyon
Centre Nat Rech Scient
Catherine Charcosset
Hatem Fessi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Claude Bernard Lyon, Centre Nat Rech Scient, Catherine Charcosset, Hatem Fessi filed Critical Univ Claude Bernard Lyon
Publication of WO2007000531A2 publication Critical patent/WO2007000531A2/en
Publication of WO2007000531A3 publication Critical patent/WO2007000531A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2475—Membrane reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0021—Preparation of sols containing a solid organic phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0026—Preparation of sols containing a liquid organic phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium

Abstract

The invention relates to a method for preparing particles and, in particular, solid lipidic nanoparticles from a first liquid lipidic phase A comprising a lipid or a mixture of lipids, and from a second liquid phase B in which the lipid or the mixture of lipids of the first phase A is insoluble or slightly soluble. Said method uses a membrane reactor comprising a porous membrane, in which the second phase B circulates tangential to the membrane, and the first phase A held, before passing though the membrane, at a temperature greater than the melting point of the lipid of or the mixture of lipids, passes through the pores of the membrane in order to form droplets that have just met with the second phase B. The inventive method is characterized in that the second phase B is held at a temperature less than the melting temperature of the lipid or mixture of lipids constituting the first lipidic phase A so that the droplets of lipidic phase A that are formed solidify when coming into contact with the second phase B.
PCT/FR2006/050447 2005-05-16 2006-05-16 Method for preparing solid lipidic particles using a membrane reactor WO2007000531A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0504883A FR2885538B1 (en) 2005-05-16 2005-05-16 NOVEL PROCESS FOR PREPARING SOLID LIPID PARTICLES USING A MEMBRANE REACTOR
FR0504883 2005-05-16

Publications (2)

Publication Number Publication Date
WO2007000531A2 WO2007000531A2 (en) 2007-01-04
WO2007000531A3 true WO2007000531A3 (en) 2007-03-08

Family

ID=35708837

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2006/050447 WO2007000531A2 (en) 2005-05-16 2006-05-16 Method for preparing solid lipidic particles using a membrane reactor

Country Status (2)

Country Link
FR (1) FR2885538B1 (en)
WO (1) WO2007000531A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1967173A1 (en) 2007-03-06 2008-09-10 Peter Greven Hautschutz GmbH & Co. KG Skin cleaning agent with particles comprising hardened castor oil
WO2013105101A1 (en) * 2012-01-13 2013-07-18 Department Of Biotechnology Solid lipid nanoparticles entrapping hydrophilic/ amphiphilic drug and a process for preparing the same

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4251195A (en) * 1975-12-26 1981-02-17 Morishita Jinta Company, Limited Apparatus for making miniature capsules
US5662932A (en) * 1993-05-18 1997-09-02 Pharmos Corporation Solid fat nanoemulsions
WO2001045830A1 (en) * 1999-12-22 2001-06-28 University Of Leeds Rotating membrane
WO2003014196A1 (en) * 2001-08-03 2003-02-20 Akzo Nobel N.V. Process to make dispersions
WO2003078043A2 (en) * 2002-03-13 2003-09-25 Appleton Papers Inc. Uniform microcapsules
WO2006067307A1 (en) * 2004-12-21 2006-06-29 Universite Claude Bernard Lyon I Novel method for preparing particles whereof at least the peripheral surface is polymeric, using a membrane reactor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU658608B2 (en) * 1991-03-25 1995-04-27 Astellas Pharma Europe B.V. Topical preparation containing a suspension of solid lipid particles

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4251195A (en) * 1975-12-26 1981-02-17 Morishita Jinta Company, Limited Apparatus for making miniature capsules
US5662932A (en) * 1993-05-18 1997-09-02 Pharmos Corporation Solid fat nanoemulsions
WO2001045830A1 (en) * 1999-12-22 2001-06-28 University Of Leeds Rotating membrane
WO2003014196A1 (en) * 2001-08-03 2003-02-20 Akzo Nobel N.V. Process to make dispersions
WO2003078043A2 (en) * 2002-03-13 2003-09-25 Appleton Papers Inc. Uniform microcapsules
WO2006067307A1 (en) * 2004-12-21 2006-06-29 Universite Claude Bernard Lyon I Novel method for preparing particles whereof at least the peripheral surface is polymeric, using a membrane reactor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHARCOSSET C ET AL: "The membrane emulsification process: A review", JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, WILEY & SONS, CHICHESTER, GB, vol. 79, no. 3, 23 January 2004 (2004-01-23), pages 209 - 218, XP002300936, ISSN: 0268-2575 *
CHARCOSSET ET AL: "Preparation of nanoparticles with a membrane contactor", JOURNAL OF MEMBRANE SCIENCE, ELSEVIER SCIENTIFIC PUBL.COMPANY. AMSTERDAM, NL, vol. 266, no. 1-2, 1 December 2005 (2005-12-01), pages 115 - 120, XP005118392, ISSN: 0376-7388 *
CHARCOSSET ET AL: "Preparation of solid lipid nanoparticles using a membrane contactor", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 108, no. 1, 2 November 2005 (2005-11-02), pages 112 - 120, XP005123757, ISSN: 0168-3659 *
JOSCELYNE S M ET AL: "Membrane emulsification - a literature review", JOURNAL OF MEMBRANE SCIENCE, ELSEVIER SCIENCE, AMSTERDAM, NL, vol. 169, no. 1, April 2000 (2000-04-01), pages 107 - 117, XP004191135, ISSN: 0376-7388 *
S. SUGIURA, M. NAKAJIMA, J. TONG, H. NABETANI, M. SEKI: "Preparation of monodispersed solid lipid microspheres using a microchannel emulsification technique", JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 227, 2000, pages 95 - 103, XP002366586 *
VLADISAVLJEVIC G T ET AL: "Recent developments in manufacturing emulsions and particulate products using membranes", ADVANCES IN COLLOID AND INTERFACE SCIENCE, ELSEVIER, vol. 113, no. 1, 17 March 2005 (2005-03-17), pages 1 - 20, XP004781055, ISSN: 0001-8686 *

Also Published As

Publication number Publication date
FR2885538A1 (en) 2006-11-17
WO2007000531A2 (en) 2007-01-04
FR2885538B1 (en) 2007-08-10

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