WO2006136838A3 - Appareil permettant d'effectuer des essais de solubilite - Google Patents

Appareil permettant d'effectuer des essais de solubilite Download PDF

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Publication number
WO2006136838A3
WO2006136838A3 PCT/GB2006/002298 GB2006002298W WO2006136838A3 WO 2006136838 A3 WO2006136838 A3 WO 2006136838A3 GB 2006002298 W GB2006002298 W GB 2006002298W WO 2006136838 A3 WO2006136838 A3 WO 2006136838A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemical
solvent
samples
hplc
filter
Prior art date
Application number
PCT/GB2006/002298
Other languages
English (en)
Other versions
WO2006136838A2 (fr
Inventor
Richard Hudson
Christian Bernlind
Mark Harding
Original Assignee
Anachem Ltd
Richard Hudson
Christian Bernlind
Mark Harding
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anachem Ltd, Richard Hudson, Christian Bernlind, Mark Harding filed Critical Anachem Ltd
Priority to EP06755598A priority Critical patent/EP1904825A2/fr
Priority to JP2008517595A priority patent/JP2008547014A/ja
Publication of WO2006136838A2 publication Critical patent/WO2006136838A2/fr
Publication of WO2006136838A3 publication Critical patent/WO2006136838A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00603—Reinspection of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00188—Special arrangements of analysers the analyte being in the solid state
    • G01N2035/00198—Dissolution analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00475—Filters
    • G01N2035/00485—Filters combined with sample carriers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1053—General features of the devices using the transfer device for another function for separating part of the liquid, e.g. filters, extraction phase

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Quality & Reliability (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un appareil (100) permettant de soumettre des agents chimiques dissous dans un solvant (211) à un essai de solubilité. Des particules (210) de l'agent chimique non dissous peuvent être agitées dans le solvant (211) pour garantir que le solvant (211) soit saturé avec l'agent dissous. Des échantillons du solvant (211) sont prélevés pour être analysés, par exemple, dans un analyseur par chromatographie liquide à haute performance (CLHP) (150). Les échantillons peuvent être prélevés à différentes températures pour vérifier le profil de solubilité de l'agent chimique dans le solvant (211). L'appareil (100) est équipé d'un filtre (430) permettant d'éviter que des particules (210) de l'agent chimique non dissous apparaissent dans les échantillons. Ce filtre (430) peut comporter un espace (832) destiné à réduire le « volume mort » du filtre. L'appareil peut également comprendre un ordinateur (600) permettant de déterminer si un échantillon contient trop ou s'il ne contient pas assez d'agent chimique pour être analysé par l'analyseur CLHP (150), les échantillons pouvant être dilués dans un flacon d'analyse (141) pour garantir que l'analyseur (CLHP) n'est pas saturé par l'agent chimique.
PCT/GB2006/002298 2005-06-22 2006-06-22 Appareil permettant d'effectuer des essais de solubilite WO2006136838A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP06755598A EP1904825A2 (fr) 2005-06-22 2006-06-22 Appareil permettant d'effectuer des essais de solubilite
JP2008517595A JP2008547014A (ja) 2005-06-22 2006-06-22 化学試験装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0512730A GB2429693A (en) 2005-06-22 2005-06-22 Chemical test apparatus
GB0512730.3 2005-06-22

Publications (2)

Publication Number Publication Date
WO2006136838A2 WO2006136838A2 (fr) 2006-12-28
WO2006136838A3 true WO2006136838A3 (fr) 2007-03-22

Family

ID=34855974

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/002298 WO2006136838A2 (fr) 2005-06-22 2006-06-22 Appareil permettant d'effectuer des essais de solubilite

Country Status (4)

Country Link
EP (1) EP1904825A2 (fr)
JP (1) JP2008547014A (fr)
GB (1) GB2429693A (fr)
WO (1) WO2006136838A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2910950A1 (fr) * 2014-02-20 2015-08-26 CTC Analytics AG Procédé analytique
CN110637218A (zh) * 2017-08-25 2019-12-31 株式会社岛津制作所 自动取样器
CN112858085B (zh) * 2021-01-19 2021-11-02 竹简云(天津)生物科技有限公司 一种食品药物溶解度检测分析装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3620675A (en) * 1969-02-10 1971-11-16 Upjohn Co Apparatus for the measurement of dissolution rates
US5127278A (en) * 1989-12-18 1992-07-07 Sotax Ag Apparatus for dissolution testing of solid medications
EP1174701A1 (fr) * 2000-07-20 2002-01-23 Kimberly R. Gamble Collecte d'un échantillon et dispositif de traitement
US20030086823A1 (en) * 2001-11-07 2003-05-08 Fernando C J Anthony Fiber-optic dissolution systems, devices, and methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3801280A (en) * 1971-11-11 1974-04-02 Upjohn Co Solubility-dissolution test apparatus and method
CA1172061A (fr) * 1982-07-12 1984-08-07 David R. Bell Methode et appareil pour la preparation par lots de fractions d'echantillons, grace a l'extraction au solvant et a la separation des parties solubles de particules non solubles
US5976824A (en) * 1993-11-24 1999-11-02 Abbott Laboratories Method and apparatus for collecting a cell sample from a liquid specimen
US5567309A (en) * 1994-02-14 1996-10-22 Alcott Chromatography, Inc. Self-filtration cap
US5733449A (en) * 1995-12-08 1998-03-31 Orbital Biosciences, Llc Microconcentrator device
US6004822A (en) * 1997-04-04 1999-12-21 Alfred LaGreca Device and method for measuring solubility and for performing titration studies of submilliliter quantities
EP1467208A1 (fr) * 2001-08-10 2004-10-13 Symyx Technologies Sélection de dissolvants
GB2406641B (en) * 2003-08-19 2007-09-12 Wicken Technology Ltd Materials analysis
US20050106745A1 (en) * 2003-09-19 2005-05-19 Agy Therapeutics, Inc. Combination of solubility and membrane permeability measurement methods for profiling of chemical compounds
US20050207941A1 (en) * 2004-03-04 2005-09-22 Luke Lee Dissolution sample transfer device and method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3620675A (en) * 1969-02-10 1971-11-16 Upjohn Co Apparatus for the measurement of dissolution rates
US5127278A (en) * 1989-12-18 1992-07-07 Sotax Ag Apparatus for dissolution testing of solid medications
EP1174701A1 (fr) * 2000-07-20 2002-01-23 Kimberly R. Gamble Collecte d'un échantillon et dispositif de traitement
US20030086823A1 (en) * 2001-11-07 2003-05-08 Fernando C J Anthony Fiber-optic dissolution systems, devices, and methods

Also Published As

Publication number Publication date
GB0512730D0 (en) 2005-07-27
GB2429693A (en) 2007-03-07
JP2008547014A (ja) 2008-12-25
EP1904825A2 (fr) 2008-04-02
WO2006136838A2 (fr) 2006-12-28

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