WO2006136408A2 - Process for preparing pure amorphous rosuvastatin calcium - Google Patents
Process for preparing pure amorphous rosuvastatin calcium Download PDFInfo
- Publication number
- WO2006136408A2 WO2006136408A2 PCT/EP2006/006008 EP2006006008W WO2006136408A2 WO 2006136408 A2 WO2006136408 A2 WO 2006136408A2 EP 2006006008 W EP2006006008 W EP 2006006008W WO 2006136408 A2 WO2006136408 A2 WO 2006136408A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- rosuvastatin
- calcium
- water
- salt
- process according
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008517414A JP5416403B2 (en) | 2005-06-24 | 2006-06-22 | Process for the preparation of pure amorphous rosuvastatin calcium |
AU2006261088A AU2006261088B2 (en) | 2005-06-24 | 2006-06-22 | Process for preparing pure amorphous rosuvastatin calcium |
CA2611920A CA2611920C (en) | 2005-06-24 | 2006-06-22 | Process for preparing pure amorphous rosuvastatin calcium |
EP06754502.0A EP1915349B2 (en) | 2005-06-24 | 2006-06-22 | Process for preparing pure amorphous rosuvastatin calcium |
PL06754502T PL1915349T5 (en) | 2005-06-24 | 2006-06-22 | Process for preparing pure amorphous rosuvastatin calcium |
ES06754502T ES2564807T5 (en) | 2005-06-24 | 2006-06-22 | Process for the preparation of pure amorphous calcium rosuvastatin |
US11/916,599 US8207333B2 (en) | 2005-06-24 | 2006-06-22 | Process for preparing pure amorphous rosuvastatin calcuim |
SI200632034A SI1915349T1 (en) | 2005-06-24 | 2006-06-22 | Process for preparing pure amorphous rosuvastatin calcium |
CN2006800226730A CN101203496B (en) | 2005-06-24 | 2006-06-22 | Process for preparing pure amorphous rosuvastatin calcium |
IL187578A IL187578A0 (en) | 2005-06-24 | 2007-11-22 | Process for preparing pure amorphous rosuvastatin calcium |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI200500187 | 2005-06-24 | ||
SIP200500187 | 2005-06-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006136408A2 true WO2006136408A2 (en) | 2006-12-28 |
WO2006136408A3 WO2006136408A3 (en) | 2007-04-19 |
Family
ID=37440674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/006008 WO2006136408A2 (en) | 2005-06-24 | 2006-06-22 | Process for preparing pure amorphous rosuvastatin calcium |
Country Status (12)
Country | Link |
---|---|
US (1) | US8207333B2 (en) |
EP (1) | EP1915349B2 (en) |
JP (1) | JP5416403B2 (en) |
CN (1) | CN101203496B (en) |
AU (1) | AU2006261088B2 (en) |
CA (1) | CA2611920C (en) |
ES (1) | ES2564807T5 (en) |
HU (1) | HUE027012T2 (en) |
IL (1) | IL187578A0 (en) |
PL (1) | PL1915349T5 (en) |
SI (1) | SI1915349T1 (en) |
WO (1) | WO2006136408A2 (en) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7244844B2 (en) | 2003-12-02 | 2007-07-17 | Teva Pharmaceutical Industries Ltd. | Reference standard for characterization of rosuvastatin |
WO2008036286A1 (en) * | 2006-09-18 | 2008-03-27 | Teva Pharmaceutical Industries Ltd. | Crystalline rosuvastatin calcium |
US7396927B2 (en) | 2003-08-28 | 2008-07-08 | Teva Pharmaceutical Industries Ltd. | Process for preparation of rosuvastatin calcium |
US7612203B2 (en) | 2005-02-22 | 2009-11-03 | Teva Pharmaceutical Industries Ltd. | Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof |
WO2009143776A1 (en) | 2008-05-27 | 2009-12-03 | 常州制药厂有限公司 | Preparation method of rosuvastatin calcium and its intermediates |
WO2010035284A2 (en) * | 2008-09-26 | 2010-04-01 | Matrix Laboratories Ltd | An improved process for the preparation of rosuvastatin calcium |
WO2010081861A1 (en) * | 2009-01-14 | 2010-07-22 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of rosuvastatin |
WO2010082072A1 (en) * | 2009-01-15 | 2010-07-22 | Egis Gyógyszergyár | Process for the preparation of rosuvastatin salts |
US7777034B2 (en) | 2003-11-24 | 2010-08-17 | Teva Pharmaceutical Industries Ltd. | Crystalline ammonium salts of rosuvastatin |
US7868169B2 (en) | 2005-08-16 | 2011-01-11 | Teva Pharmaceutical Industries, Ltd. | Crystalline rosuvastatin intermediate |
US7884226B2 (en) | 2007-07-12 | 2011-02-08 | Teva Pharmaceutical Industries, Ltd. | Purification of rosuvatatin intermediate by thin film evaporation and chemical method |
WO2012073055A1 (en) | 2010-11-29 | 2012-06-07 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Method for the preparation of high-purity pharmaceutical intermediates |
WO2012093227A1 (en) | 2011-01-07 | 2012-07-12 | Jacquot Epouse Guilmin Liliane | Prodrugs for dispensing a statin to the liver |
WO2013046222A2 (en) * | 2011-08-10 | 2013-04-04 | Glenmark Generics Limited | A process for the preparation of amorphous rosuvastatin calcium |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9150518B2 (en) * | 2005-06-24 | 2015-10-06 | Lek Pharmaceuticals, D.D. | Process for preparing amorphous rosuvastatin calcium of impurities |
WO2008053334A2 (en) * | 2006-10-31 | 2008-05-08 | Aurobindo Pharma Limited | An improved process for preparing rosuvastatin calcium |
ES2385623T3 (en) * | 2007-02-08 | 2012-07-27 | Aurobindo Pharma Limited | An improved procedure for the preparation of calcium rosuvastatin |
EP2467363A1 (en) | 2009-08-17 | 2012-06-27 | Aurobindo Pharma Limited | Process for the manufacture of rosuvastatin calcium using crystalline rosuvastatin ethyl ester |
CN102070537B (en) * | 2011-01-28 | 2012-01-11 | 海南美大制药有限公司 | Rosuvastatin calcium compound and novel refining method thereof |
CN103709107B (en) * | 2012-09-29 | 2016-04-20 | 安徽省庆云医药化工有限公司 | New crystal of Rosuvastatin methyl esters and preparation method thereof |
CN104370827B (en) * | 2013-08-13 | 2016-09-07 | 天津汉瑞药业有限公司 | Rosuvastatin calcium compound |
JP2017512183A (en) | 2014-02-13 | 2017-05-18 | リガンド・ファーマシューティカルズ・インコーポレイテッド | Prodrug compounds and their use |
US11970482B2 (en) * | 2018-01-09 | 2024-04-30 | Ligand Pharmaceuticals Inc. | Acetal compounds and therapeutic uses thereof |
CN108398501A (en) * | 2018-03-02 | 2018-08-14 | 海南通用三洋药业有限公司 | A method of the related substance of detection rosuvastain calcium |
CN108675931A (en) * | 2018-05-18 | 2018-10-19 | 合肥合源药业有限公司 | A kind of low barium statin calcium and preparation method thereof |
CN111170950A (en) * | 2020-01-16 | 2020-05-19 | 河南豫辰药业股份有限公司 | Method for preparing rosuvastatin calcium salt |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2648897B2 (en) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | Pyrimidine derivatives |
GB9903472D0 (en) * | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Chemical process |
GB0003305D0 (en) | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
GB0218781D0 (en) | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
EP1562912A2 (en) | 2003-08-28 | 2005-08-17 | Teva Pharmaceutical Industries Limited | Process for preparation of rosuvastatin calcium |
US20070191318A1 (en) * | 2003-10-22 | 2007-08-16 | Yatendra Kumar | Process for the preparation of amorphous rosuvastatin calcium |
WO2005054207A1 (en) | 2003-12-04 | 2005-06-16 | Glenmark Pharmaceuticals Limited | Process for the preparation of pyrimidine derivatives |
WO2005077917A1 (en) | 2004-01-19 | 2005-08-25 | Ranbaxy Laboratories Limited | Amorphous salts of rosuvastatin |
WO2006035277A2 (en) * | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Novel processes for preparing amorphous rosuvastatin calcium and a novel polymorphic form of rosuvastatin sodium |
-
2006
- 2006-06-22 ES ES06754502T patent/ES2564807T5/en active Active
- 2006-06-22 PL PL06754502T patent/PL1915349T5/en unknown
- 2006-06-22 EP EP06754502.0A patent/EP1915349B2/en not_active Not-in-force
- 2006-06-22 AU AU2006261088A patent/AU2006261088B2/en not_active Ceased
- 2006-06-22 HU HUE06754502A patent/HUE027012T2/en unknown
- 2006-06-22 CA CA2611920A patent/CA2611920C/en not_active Expired - Fee Related
- 2006-06-22 JP JP2008517414A patent/JP5416403B2/en not_active Expired - Fee Related
- 2006-06-22 CN CN2006800226730A patent/CN101203496B/en not_active Expired - Fee Related
- 2006-06-22 WO PCT/EP2006/006008 patent/WO2006136408A2/en active Application Filing
- 2006-06-22 US US11/916,599 patent/US8207333B2/en active Active
- 2006-06-22 SI SI200632034A patent/SI1915349T1/en unknown
-
2007
- 2007-11-22 IL IL187578A patent/IL187578A0/en active IP Right Grant
Non-Patent Citations (1)
Title |
---|
None |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7396927B2 (en) | 2003-08-28 | 2008-07-08 | Teva Pharmaceutical Industries Ltd. | Process for preparation of rosuvastatin calcium |
US7777034B2 (en) | 2003-11-24 | 2010-08-17 | Teva Pharmaceutical Industries Ltd. | Crystalline ammonium salts of rosuvastatin |
US7741482B2 (en) | 2003-12-02 | 2010-06-22 | Teva Pharmaceutical Industries Ltd. | Reference standard for characterization of rosuvastatin |
US8487097B2 (en) | 2003-12-02 | 2013-07-16 | Teva Pharmacedutical Industries Ltd. | Reference standard for characterization of rosuvastatin |
US7692009B2 (en) | 2003-12-02 | 2010-04-06 | Teva Pharmaceutical Industries Ltd. | Reference standard for characterization of rosuvastatin |
US7692008B2 (en) | 2003-12-02 | 2010-04-06 | Teva Pharmaceutical Industries Ltd. | Reference standard for characterization of rosuvastatin |
US7692010B2 (en) | 2003-12-02 | 2010-04-06 | Teva Pharmaceutical Industries Ltd. | Reference standard for characterization of rosuvastatin |
US7244844B2 (en) | 2003-12-02 | 2007-07-17 | Teva Pharmaceutical Industries Ltd. | Reference standard for characterization of rosuvastatin |
US7612203B2 (en) | 2005-02-22 | 2009-11-03 | Teva Pharmaceutical Industries Ltd. | Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof |
US8063211B2 (en) | 2005-02-22 | 2011-11-22 | Teva Pharmaceutical Industries, Ltd. | Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof |
US7868169B2 (en) | 2005-08-16 | 2011-01-11 | Teva Pharmaceutical Industries, Ltd. | Crystalline rosuvastatin intermediate |
US7994178B2 (en) | 2006-09-18 | 2011-08-09 | Teva Pharmaceutical Industries, Ltd. | Crystalline rosuvastatin calcium and compositions thereof for treatment of hyperlipidaemia |
WO2008036286A1 (en) * | 2006-09-18 | 2008-03-27 | Teva Pharmaceutical Industries Ltd. | Crystalline rosuvastatin calcium |
US7884226B2 (en) | 2007-07-12 | 2011-02-08 | Teva Pharmaceutical Industries, Ltd. | Purification of rosuvatatin intermediate by thin film evaporation and chemical method |
WO2009143776A1 (en) | 2008-05-27 | 2009-12-03 | 常州制药厂有限公司 | Preparation method of rosuvastatin calcium and its intermediates |
US8765947B2 (en) | 2008-05-27 | 2014-07-01 | Changzhou Pharmaceutical Factory | Preparation method of Rosuvastatin calcium and its intermediates |
US8653265B2 (en) | 2008-05-27 | 2014-02-18 | Changzhou Pharmaceutical Factory | Preparation method of rosuvastatin calcium and its intermediates |
WO2010035284A2 (en) * | 2008-09-26 | 2010-04-01 | Matrix Laboratories Ltd | An improved process for the preparation of rosuvastatin calcium |
WO2010035284A3 (en) * | 2008-09-26 | 2011-03-10 | Matrix Laboratories Ltd | An improved process for the preparation of rosuvastatin calcium |
WO2010081861A1 (en) * | 2009-01-14 | 2010-07-22 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of rosuvastatin |
EP2752407A1 (en) * | 2009-01-14 | 2014-07-09 | Krka Tovarna Zdravil, D.D., Novo Mesto | Crystalline rosuvastatin calcium trihydrate |
EA019995B1 (en) * | 2009-01-14 | 2014-07-30 | Крка, Товарна Здравил, Д.Д., Ново Место | Rosuvastatin salt, process for the preparation thereof and process for the preparation of pharmaceutically acceptable rosuvastatin salt |
WO2010082072A1 (en) * | 2009-01-15 | 2010-07-22 | Egis Gyógyszergyár | Process for the preparation of rosuvastatin salts |
EA021942B1 (en) * | 2009-01-15 | 2015-10-30 | Эгиш Дьёдьсердьяр Зрт. | Process for the preparation of rosuvastatin salts |
WO2012073055A1 (en) | 2010-11-29 | 2012-06-07 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Method for the preparation of high-purity pharmaceutical intermediates |
WO2012093227A1 (en) | 2011-01-07 | 2012-07-12 | Jacquot Epouse Guilmin Liliane | Prodrugs for dispensing a statin to the liver |
FR2970178A1 (en) * | 2011-01-07 | 2012-07-13 | Liliane Therese Jacquot | PROMOTERS FOR SPECIFIC LIVER LEVEL DELIVERY AND BETTER TOLERANCE |
WO2013046222A2 (en) * | 2011-08-10 | 2013-04-04 | Glenmark Generics Limited | A process for the preparation of amorphous rosuvastatin calcium |
WO2013046222A3 (en) * | 2011-08-10 | 2013-06-20 | Glenmark Generics Limited | A process for the preparation of amorphous rosuvastatin calcium |
Also Published As
Publication number | Publication date |
---|---|
JP5416403B2 (en) | 2014-02-12 |
AU2006261088B2 (en) | 2012-11-08 |
ES2564807T3 (en) | 2016-03-29 |
EP1915349B2 (en) | 2018-09-12 |
US20080188504A1 (en) | 2008-08-07 |
IL187578A0 (en) | 2008-03-20 |
HUE027012T2 (en) | 2016-10-28 |
CN101203496B (en) | 2011-04-20 |
EP1915349B1 (en) | 2015-12-09 |
CA2611920A1 (en) | 2006-12-28 |
JP2008543899A (en) | 2008-12-04 |
PL1915349T5 (en) | 2019-02-28 |
EP1915349A2 (en) | 2008-04-30 |
AU2006261088A1 (en) | 2006-12-28 |
CA2611920C (en) | 2015-05-05 |
CN101203496A (en) | 2008-06-18 |
PL1915349T3 (en) | 2016-05-31 |
ES2564807T5 (en) | 2019-02-26 |
US8207333B2 (en) | 2012-06-26 |
SI1915349T1 (en) | 2016-05-31 |
WO2006136408A3 (en) | 2007-04-19 |
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