WO2006136392A3 - Novel genes and proteins of brachyspira pilosicoli and use of same for diagnosis and therapy - Google Patents

Novel genes and proteins of brachyspira pilosicoli and use of same for diagnosis and therapy Download PDF

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Publication number
WO2006136392A3
WO2006136392A3 PCT/EP2006/005961 EP2006005961W WO2006136392A3 WO 2006136392 A3 WO2006136392 A3 WO 2006136392A3 EP 2006005961 W EP2006005961 W EP 2006005961W WO 2006136392 A3 WO2006136392 A3 WO 2006136392A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnosis
pilosicoli
therapy
proteins
same
Prior art date
Application number
PCT/EP2006/005961
Other languages
French (fr)
Other versions
WO2006136392A2 (en
Inventor
Matthew Bellgard
David John Hampson
Tom La
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Univ Murdoch
Matthew Bellgard
David John Hampson
Tom La
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2005903317A external-priority patent/AU2005903317A0/en
Application filed by Novartis Ag, Novartis Pharma Gmbh, Univ Murdoch, Matthew Bellgard, David John Hampson, Tom La filed Critical Novartis Ag
Priority to AU2006261226A priority Critical patent/AU2006261226B8/en
Priority to BRPI0611833-0A priority patent/BRPI0611833A2/en
Priority to EP06762123A priority patent/EP1896589A2/en
Publication of WO2006136392A2 publication Critical patent/WO2006136392A2/en
Publication of WO2006136392A3 publication Critical patent/WO2006136392A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Novel polynucleotide and amino acids of Brachyspira pilosicoli are described. These sequences are useful for diagnosis of B. pilosicoli disease in animals and as a therapeutic treatment or prophylactic treatment of B. pilosicoli disease in animals. These sequences may also be useful for diagnostic and therapeutic and/or prophylactic treatment of diseases in animals caused by other Brachyspira species, including B. intermedia, B. alvinipulli, B. aalborgi, B. innocens, B. murdochii, and B. hyodysenteriae.
PCT/EP2006/005961 2005-06-23 2006-06-21 Novel genes and proteins of brachyspira pilosicoli and use of same for diagnosis and therapy WO2006136392A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2006261226A AU2006261226B8 (en) 2005-06-23 2006-06-21 Novel genes and proteins of brachyspira pilosicoli and use of same for diagnosis and therapy
BRPI0611833-0A BRPI0611833A2 (en) 2005-06-23 2006-06-21 brachyspira pilosicoli genes and proteins and use for diagnosis and therapy.
EP06762123A EP1896589A2 (en) 2005-06-23 2006-06-21 Novel genes and proteins of brachyspira pilosicoli and use of same for diagnosis and therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2005903317 2005-06-23
AU2005903317A AU2005903317A0 (en) 2005-06-23 Novel Genes and Proteins of Brachyspira Pilosicoli and Use of Same for Diagnosis Therapy

Publications (2)

Publication Number Publication Date
WO2006136392A2 WO2006136392A2 (en) 2006-12-28
WO2006136392A3 true WO2006136392A3 (en) 2007-03-01

Family

ID=36952417

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/005961 WO2006136392A2 (en) 2005-06-23 2006-06-21 Novel genes and proteins of brachyspira pilosicoli and use of same for diagnosis and therapy

Country Status (6)

Country Link
EP (1) EP1896589A2 (en)
CN (1) CN101228276A (en)
BR (1) BRPI0611833A2 (en)
PE (1) PE20070096A1 (en)
TW (1) TW200740997A (en)
WO (1) WO2006136392A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2593550A4 (en) * 2010-07-16 2014-01-22 Univ Saskatchewan Diagnostic method for colitis
CN102373276B (en) * 2011-10-27 2013-02-20 中华人民共和国北京出入境检验检疫局 Real-time fluorescence PCR (polymerase chain reaction) kit and oligonucleotide sequence for detecting swine dysentery
CN102373277B (en) * 2011-10-27 2013-01-02 中华人民共和国北京出入境检验检疫局 PCR (Polymerase Chain Reaction) kit and primers for detecting swine dysentery

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1697517A1 (en) * 2003-12-19 2006-09-06 Murdoch University Brachyspira pilosicoli 72kda outer-membrane protein and diagnostic and therapeutic uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1697517A1 (en) * 2003-12-19 2006-09-06 Murdoch University Brachyspira pilosicoli 72kda outer-membrane protein and diagnostic and therapeutic uses thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
GABE JEFFREY D ET AL: "Isolation of extracytoplasmic proteins from Serpulina hyodysenteriae B204 and molecular cloning of the flaB1 gene encoding a 38-kilodalton flagellar protein", INFECTION AND IMMUNITY, vol. 63, no. 1, 1995, pages 142 - 148, XP002399007, ISSN: 0019-9567 *
HAMPSON D J ET AL: "Influences of diet and vaccination on colonisation of pigs by the intestinal spirochaete Brachyspira (Serpulina) pilosicoli", VETERINARY MICROBIOLOGY, vol. 73, no. 1, 4 April 2000 (2000-04-04), pages 75 - 84, XP002399005, ISSN: 0378-1135 *
LA TOM ET AL: "Protection of pigs from swine dysentery by vaccination with recombinant BmpB, a 29.7 kDa outer-membrane lipoprotein of Brachyspira hyodysenteriae", VETERINARY MICROBIOLOGY, AMSTERDAM, NL, vol. 102, no. 1-2, 19 August 2004 (2004-08-19), pages 97 - 109, XP002395514, ISSN: 0378-1135 *
LEE B J ET AL: "A monoclonal antibody reacting with the cell envelope of spirochetes isolated from cases of intestinal spirochaetosis in pigs and humans", FEMS MICROBIOLOGY LETTERS, vol. 131, no. 2, 1995, pages 179 - 184, XP002399006, ISSN: 0378-1097 *
SMITH JAMES L: "Colonic spirochetosis in animals and humans", JOURNAL OF FOOD PROTECTION, vol. 68, no. 7, July 2005 (2005-07-01), pages 1525 - 1534, XP009072439, ISSN: 0362-028X *
TROTT DARREN J ET AL: "Identification and cloning of the gene encoding BmpC: an outer-membrane lipoprotein associated with Brachyspira pilosicoli membrane vesicles", MICROBIOLOGY (READING), vol. 150, no. Part 4, April 2004 (2004-04-01), pages 1041 - 1053, XP002399004, ISSN: 1350-0872 *

Also Published As

Publication number Publication date
CN101228276A (en) 2008-07-23
WO2006136392A2 (en) 2006-12-28
BRPI0611833A2 (en) 2011-12-20
TW200740997A (en) 2007-11-01
EP1896589A2 (en) 2008-03-12
PE20070096A1 (en) 2007-03-12

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