WO2006133672A3 - Verfahren und vorrichtung zur detektion von analyten in fluiden medien - Google Patents

Verfahren und vorrichtung zur detektion von analyten in fluiden medien Download PDF

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Publication number
WO2006133672A3
WO2006133672A3 PCT/DE2006/000979 DE2006000979W WO2006133672A3 WO 2006133672 A3 WO2006133672 A3 WO 2006133672A3 DE 2006000979 W DE2006000979 W DE 2006000979W WO 2006133672 A3 WO2006133672 A3 WO 2006133672A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid media
cantilever probe
pillar
column
detecting analytes
Prior art date
Application number
PCT/DE2006/000979
Other languages
English (en)
French (fr)
Other versions
WO2006133672A2 (de
Inventor
Christiane Ziegler
Egbert Oesterschulze
Original Assignee
Tech Uni Kaiserlautern
Christiane Ziegler
Egbert Oesterschulze
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tech Uni Kaiserlautern, Christiane Ziegler, Egbert Oesterschulze filed Critical Tech Uni Kaiserlautern
Publication of WO2006133672A2 publication Critical patent/WO2006133672A2/de
Publication of WO2006133672A3 publication Critical patent/WO2006133672A3/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N9/00—Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity
    • G01N9/002—Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity using variation of the resonant frequency of an element vibrating in contact with the material submitted to analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/04—Wave modes and trajectories
    • G01N2291/042—Wave modes
    • G01N2291/0427—Flexural waves, plate waves, e.g. Lamb waves, tuning fork, cantilever

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Length Measuring Devices With Unspecified Measuring Means (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Die Erfindung betrifft Verfahren und eine Vorrichtung zur Detektion von Analyten in fluiden Medien mittels einer Cantileversonde. Sie betrifft weiterhin die Verwendung des Verfahrens bzw. der Vorrichtung. Um ein derartiges Verfahren bzw. eine derartige Vorrichtung mit höherer Meßempfindlichkeit zu schaffen, wird im Rahmen der Erfindung vorgeschlagen, daß eine säulen- oder pfeilerartige Cantileversonde verwendet wird, deren Mantelfläche von einem Luftspalt umgeben ist und deren Deckel dem fluiden Medium ausgesetzt ist und die sensitive Fläche darstellt. Durch Verwendung der säulen- oder pfeilerartigen Cantileversonde, also einen einseitig eingespannten mechanischen Schwinger, dessen Eigenschwingung durch Materialablagerung aus einem fluiden Medium auf dem Deckel des säulen- oder pfeilerartigen Cantilevers gedämpft wird und somit seine Resonanzfrequenz, Dämpfung bzw. Amplitude durch die Massenzunahme verändert, wird die Meßempfindlichkeit gegenüber bekannten Verfahren deutlich erhöht.
PCT/DE2006/000979 2005-06-15 2006-06-07 Verfahren und vorrichtung zur detektion von analyten in fluiden medien WO2006133672A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005027788.8 2005-06-15
DE200510027788 DE102005027788B4 (de) 2005-06-15 2005-06-15 Verfahren und Vorrichtung zur Detektion von Analyten in flüssigen Medien

Publications (2)

Publication Number Publication Date
WO2006133672A2 WO2006133672A2 (de) 2006-12-21
WO2006133672A3 true WO2006133672A3 (de) 2007-02-15

Family

ID=36940172

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2006/000979 WO2006133672A2 (de) 2005-06-15 2006-06-07 Verfahren und vorrichtung zur detektion von analyten in fluiden medien

Country Status (2)

Country Link
DE (1) DE102005027788B4 (de)
WO (1) WO2006133672A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102021134179A1 (de) 2021-12-21 2023-06-22 Truedyne Sensors AG Messanordnung mit einem mikromechanischen Oszillator

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19838284C1 (de) * 1998-08-24 2000-05-04 Lorenz Walder Vorrichtung zur Bestimmung der Dichte einer Flüssigkeit
WO2000066266A1 (en) * 1999-05-03 2000-11-09 Cantion A/S Sensor for microfluid handling system
US20050103097A1 (en) * 2002-01-24 2005-05-19 Carsten Faltum Sensor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004510145A (ja) * 2000-09-20 2004-04-02 モレキュラー・リフレクションズ 共鳴センサーとして使用するための微細加工された超音波アレイ
WO2004038354A2 (en) * 2002-08-29 2004-05-06 Bioscale, Inc. Resonant sensor and sensing system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19838284C1 (de) * 1998-08-24 2000-05-04 Lorenz Walder Vorrichtung zur Bestimmung der Dichte einer Flüssigkeit
WO2000066266A1 (en) * 1999-05-03 2000-11-09 Cantion A/S Sensor for microfluid handling system
US20050103097A1 (en) * 2002-01-24 2005-05-19 Carsten Faltum Sensor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
B.ILIC ET AL: "Single cell detection with micromechanical oscillators", JOURNAL OF VACUUM SCIENCE AND TECHNOLOGY B, vol. 19, no. 6, December 2001 (2001-12-01), pages 2825 - 2828, XP002398539 *
CHRISTIANE ZIEGLER: "Cantilever-based biosensors", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 379, no. 7-8, December 2004 (2004-12-01), pages 946 - 959, XP002398538 *

Also Published As

Publication number Publication date
WO2006133672A2 (de) 2006-12-21
DE102005027788B4 (de) 2008-02-14
DE102005027788A1 (de) 2007-01-04

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