WO2006131570A3 - Procede de fabrication d'un materiau composite comprenant une substance active - Google Patents

Procede de fabrication d'un materiau composite comprenant une substance active Download PDF

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Publication number
WO2006131570A3
WO2006131570A3 PCT/EP2006/063110 EP2006063110W WO2006131570A3 WO 2006131570 A3 WO2006131570 A3 WO 2006131570A3 EP 2006063110 W EP2006063110 W EP 2006063110W WO 2006131570 A3 WO2006131570 A3 WO 2006131570A3
Authority
WO
WIPO (PCT)
Prior art keywords
active substance
extruder
polymer matrix
producing
composite material
Prior art date
Application number
PCT/EP2006/063110
Other languages
English (en)
Other versions
WO2006131570A2 (fr
Inventor
Jacques Fages
Martial Sauceau
Jean-Jacques Letourneau
Original Assignee
Armines
Jacques Fages
Martial Sauceau
Jean-Jacques Letourneau
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Armines, Jacques Fages, Martial Sauceau, Jean-Jacques Letourneau filed Critical Armines
Priority to EP06763648A priority Critical patent/EP1888676A2/fr
Publication of WO2006131570A2 publication Critical patent/WO2006131570A2/fr
Publication of WO2006131570A3 publication Critical patent/WO2006131570A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
    • C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
    • C08J9/122—Hydrogen, oxygen, CO2, nitrogen or noble gases
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2201/00—Foams characterised by the foaming process
    • C08J2201/02—Foams characterised by the foaming process characterised by mechanical pre- or post-treatments
    • C08J2201/03—Extrusion of the foamable blend
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2203/00—Foams characterized by the expanding agent
    • C08J2203/08—Supercritical fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Abstract

L'invention concerne un procédé de fabrication d'un matériau composite comprenant des dispersions solides d' une substance active dans une matrice polymère, le procédé étant caractérisé en ce qu' il comprend les étapes suivantes : - l'étape d'introduire la matrice polymère dans une extrudeuse (1) , - l'étape d'actionner l' extrudeuse (1) de manière à modifier des propriétés rhéologiques de la matrice polymère, - l'étape de placer un fluide dans des conditions supercritiques et de l'injecter, pur ou mélangé avec un autre constituant dans l' extrudeuse (1), notamment via une buse d'injection (11), l'étape d'introduire une substance active dans l ' extrudeuse ( 1 ) , - l'étape de mélanger le fluide supercritique, la substance active et la matrice polymère, - l'étape de détendre le mélange ainsi obtenu afin de lui conférer une structure microporeuse.
PCT/EP2006/063110 2005-06-10 2006-06-12 Procede de fabrication d'un materiau composite comprenant une substance active WO2006131570A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06763648A EP1888676A2 (fr) 2005-06-10 2006-06-12 Procede de fabrication d'un matériau composite comprenant une substance active

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0551577 2005-06-10
FR0551577A FR2886938B1 (fr) 2005-06-10 2005-06-10 Procede d'extrusion permettant de fabriquer des dispersions solides de principes actifs pharmaceutiques dans une matrice polymere

Publications (2)

Publication Number Publication Date
WO2006131570A2 WO2006131570A2 (fr) 2006-12-14
WO2006131570A3 true WO2006131570A3 (fr) 2007-06-07

Family

ID=36008403

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/063110 WO2006131570A2 (fr) 2005-06-10 2006-06-12 Procede de fabrication d'un materiau composite comprenant une substance active

Country Status (3)

Country Link
EP (1) EP1888676A2 (fr)
FR (1) FR2886938B1 (fr)
WO (1) WO2006131570A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1968553A2 (fr) * 2005-11-09 2008-09-17 Novartis AG Procede de fabrication de compositions pharmaceutiques utilisant un plastifiant transitoire
CN102443970A (zh) * 2011-10-28 2012-05-09 中原工学院 一种制备聚砜类微孔纤维非织造布的方法
FR2989916B1 (fr) * 2012-04-27 2014-04-11 Arkema France Procede de fabrication de particules de polymere thermoplastique a base de polyamide en presence de co2 supercritique
EP2815879A3 (fr) 2014-09-02 2015-04-29 Mondi Consumer Packaging Technologies GmbH Feuille de coextrusion en polyéthylène
HUE030040T2 (en) 2014-09-02 2017-04-28 Mondi Consumer Packaging Tech Gmbh Multilayer plastic film
GB2565831A (en) * 2017-04-25 2019-02-27 Windsor Hamilton Stephen Apparatus for depolymerisation of waste plastics

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5082608A (en) * 1990-06-14 1992-01-21 Owens-Illinois Plastic Products Inc. Polystyrene foam sheet manufacture
WO1998009616A1 (fr) * 1996-09-03 1998-03-12 Basf Aktiengesellschaft Preparations solides expansees de principes actifs
US5866053A (en) * 1993-11-04 1999-02-02 Massachusetts Institute Of Technology Method for providing continuous processing of microcellular and supermicrocellular foamed materials
US6403663B1 (en) * 1999-09-20 2002-06-11 North Carolina State University Method of making foamed materials using surfactants and carbon dioxide
US20030064156A1 (en) * 2001-08-03 2003-04-03 Industrial Technology Research Institute Method of making porous biodegradable polymers
WO2005023215A2 (fr) * 2003-09-10 2005-03-17 Janssen Pharmaceutica N.V. Particules en forme de lamelles

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5082608A (en) * 1990-06-14 1992-01-21 Owens-Illinois Plastic Products Inc. Polystyrene foam sheet manufacture
US5866053A (en) * 1993-11-04 1999-02-02 Massachusetts Institute Of Technology Method for providing continuous processing of microcellular and supermicrocellular foamed materials
US6051174A (en) * 1993-11-04 2000-04-18 Massachusetts Institute Of Technology Method for providing continuous processing of microcellular and supermicrocellular foamed materials
WO1998009616A1 (fr) * 1996-09-03 1998-03-12 Basf Aktiengesellschaft Preparations solides expansees de principes actifs
US6403663B1 (en) * 1999-09-20 2002-06-11 North Carolina State University Method of making foamed materials using surfactants and carbon dioxide
US20030064156A1 (en) * 2001-08-03 2003-04-03 Industrial Technology Research Institute Method of making porous biodegradable polymers
WO2005023215A2 (fr) * 2003-09-10 2005-03-17 Janssen Pharmaceutica N.V. Particules en forme de lamelles

Also Published As

Publication number Publication date
FR2886938A1 (fr) 2006-12-15
EP1888676A2 (fr) 2008-02-20
FR2886938B1 (fr) 2008-04-18
WO2006131570A2 (fr) 2006-12-14

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