WO2006125001A3 - Compositions and methods related to the intracellular effects of intracellular domains of delta1 and jagged1 - Google Patents

Compositions and methods related to the intracellular effects of intracellular domains of delta1 and jagged1 Download PDF

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Publication number
WO2006125001A3
WO2006125001A3 PCT/US2006/019087 US2006019087W WO2006125001A3 WO 2006125001 A3 WO2006125001 A3 WO 2006125001A3 US 2006019087 W US2006019087 W US 2006019087W WO 2006125001 A3 WO2006125001 A3 WO 2006125001A3
Authority
WO
WIPO (PCT)
Prior art keywords
intracellular
compositions
jagged1
delta1
methods related
Prior art date
Application number
PCT/US2006/019087
Other languages
French (fr)
Other versions
WO2006125001A2 (en
Inventor
Igor Prudovsky
Thomas Maciag
Vihren Kolev
Doreen Kacer
Maria Duarte
Original Assignee
Maine Medical Ct Res Inst
Igor Prudovsky
Thomas Maciag
Vihren Kolev
Doreen Kacer
Maria Duarte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maine Medical Ct Res Inst, Igor Prudovsky, Thomas Maciag, Vihren Kolev, Doreen Kacer, Maria Duarte filed Critical Maine Medical Ct Res Inst
Publication of WO2006125001A2 publication Critical patent/WO2006125001A2/en
Publication of WO2006125001A3 publication Critical patent/WO2006125001A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Abstract

The present invention pertains to compositions and methods related to the intracellular domains of Jagged and Delta. More specifically, the invention relates to the cellular roles and effects of the intracellular domains of Jagged and Delta.
PCT/US2006/019087 2005-05-17 2006-05-17 Compositions and methods related to the intracellular effects of intracellular domains of delta1 and jagged1 WO2006125001A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68161205P 2005-05-17 2005-05-17
US60/681,612 2005-05-17

Publications (2)

Publication Number Publication Date
WO2006125001A2 WO2006125001A2 (en) 2006-11-23
WO2006125001A3 true WO2006125001A3 (en) 2007-05-24

Family

ID=37432098

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/019087 WO2006125001A2 (en) 2005-05-17 2006-05-17 Compositions and methods related to the intracellular effects of intracellular domains of delta1 and jagged1

Country Status (1)

Country Link
WO (1) WO2006125001A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004924A (en) * 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US6136952A (en) * 1997-06-25 2000-10-24 University Of Washington Human jagged polypeptide, encoding nucleic acids and methods of use
US20030083465A1 (en) * 1996-05-31 2003-05-01 Maine Medical Center Research Institute Therapeutic and diagnostic methods and compositions based on Jagged/Notch proteins and nucleic acids
US6716974B1 (en) * 1996-05-31 2004-04-06 Maine Medical Center Research Institute Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004924A (en) * 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US20030083465A1 (en) * 1996-05-31 2003-05-01 Maine Medical Center Research Institute Therapeutic and diagnostic methods and compositions based on Jagged/Notch proteins and nucleic acids
US6716974B1 (en) * 1996-05-31 2004-04-06 Maine Medical Center Research Institute Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids
US6136952A (en) * 1997-06-25 2000-10-24 University Of Washington Human jagged polypeptide, encoding nucleic acids and methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
POPOVIC ET AL.: "Gene synthesis, expression, purification, and characterization of human Jagged-1 intracellular region", PROTEIN EXPRESSION & PURIFICATION, vol. 47, 2006, pages 398 - 404, XP005439614 *

Also Published As

Publication number Publication date
WO2006125001A2 (en) 2006-11-23

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