WO2006123226A3 - An inhibitor of mtor for inhibiting the formation of scar tissue - Google Patents

An inhibitor of mtor for inhibiting the formation of scar tissue Download PDF

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Publication number
WO2006123226A3
WO2006123226A3 PCT/IB2006/001300 IB2006001300W WO2006123226A3 WO 2006123226 A3 WO2006123226 A3 WO 2006123226A3 IB 2006001300 W IB2006001300 W IB 2006001300W WO 2006123226 A3 WO2006123226 A3 WO 2006123226A3
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WO
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Patent type
Prior art keywords
surgery
disease
mtor
impregnated
prevent
Prior art date
Application number
PCT/IB2006/001300
Other languages
French (fr)
Other versions
WO2006123226A2 (en )
Inventor
Hugo Barrie Nel
Original Assignee
Villiers Malan De
Hugo Barrie Nel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine

Abstract

The invention describes the use of an inhibitor of the mammalian Target of Rapamycin (mTOR), such as sirolimus or everolimus, to effect a clinical response on an insult or wound. The compound can be administered in any suitable local or topical delivery form, such as by local injection; local delivery systems, for example impregnated implants and slow release devices; forms of dressings, impregnated suturing material; impregnated mesh, sheets, membranes, prosthetics; gels containing the compound; and so forth. Typical applications where it would be useful to prevent scarring by inhibiting the mTOR according to the invention are: cosmetic surgery; scar revision surgery, including excision of scars and contracture release; tendon repair; nerve repair; and fibrotic or inflammatory conditions, such as de Quervain's disease, Peyronie's disease, plantar fasciitis, Dupuytren's disease, finger triggering, forms of synovitis, such as rheumatoid arthritis, after laparotomy to prevent adhesions, after brain surgery to prevent gliosis, and microsurgery, such as microvascular surgery and fallopian tube surgery.
PCT/IB2006/001300 2005-05-18 2006-05-18 An inhibitor of mtor for inhibiting the formation of scar tissue WO2006123226A3 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US68258105 true 2005-05-18 2005-05-18
ZA2005/04008 2005-05-18
US60/682,581 2005-05-18
ZA200504008 2005-05-18

Publications (2)

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WO2006123226A2 true WO2006123226A2 (en) 2006-11-23
WO2006123226A3 true true WO2006123226A3 (en) 2007-01-11

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ID=36968953

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/001300 WO2006123226A3 (en) 2005-05-18 2006-05-18 An inhibitor of mtor for inhibiting the formation of scar tissue

Country Status (1)

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WO (1) WO2006123226A3 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009030931A1 (en) 2009-06-24 2010-12-30 Eberhard-Karls-Universität Tübingen Universitätsklinikum Surgical wound sealing element for sealing wound in surgical joint in e.g. intestine of human, has body coated with anti-inflammatory composition and designed as thread that comprises fibers, which are interlaced together
US8465413B2 (en) 2010-11-25 2013-06-18 Coloplast A/S Method of treating Peyronie's disease
WO2016130485A1 (en) * 2015-02-09 2016-08-18 The Board Of Regents Of The University Of Texas System Use of mtor inhibitors to prevent and regress adhesions and fibrosis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040087613A1 (en) * 2002-01-29 2004-05-06 Molmenti Ernesto P. Prevention of adhesions with rapamycin
WO2004110347A2 (en) * 2003-05-07 2004-12-23 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
US20050084514A1 (en) * 2000-11-06 2005-04-21 Afmedica, Inc. Combination drug therapy for reducing scar tissue formation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050084514A1 (en) * 2000-11-06 2005-04-21 Afmedica, Inc. Combination drug therapy for reducing scar tissue formation
US20040087613A1 (en) * 2002-01-29 2004-05-06 Molmenti Ernesto P. Prevention of adhesions with rapamycin
WO2004110347A2 (en) * 2003-05-07 2004-12-23 Afmedica, Inc. Compositions and methods for reducing scar tissue formation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KIM A ET AL: "Are keloids really "gli-loids"?: High-level expression of gli-1 oncogene in keloids.", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. NOV 2001, vol. 45, no. 5, November 2001 (2001-11-01), pages 707 - 711, XP002399754, ISSN: 0190-9622 *

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WO2006123226A2 (en) 2006-11-23 application

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