WO2006123226A3 - An inhibitor of mtor for inhibiting the formation of scar tissue - Google Patents
An inhibitor of mtor for inhibiting the formation of scar tissue Download PDFInfo
- Publication number
- WO2006123226A3 WO2006123226A3 PCT/IB2006/001300 IB2006001300W WO2006123226A3 WO 2006123226 A3 WO2006123226 A3 WO 2006123226A3 IB 2006001300 W IB2006001300 W IB 2006001300W WO 2006123226 A3 WO2006123226 A3 WO 2006123226A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- surgery
- disease
- mtor
- impregnated
- prevent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Abstract
The invention describes the use of an inhibitor of the mammalian Target of Rapamycin (mTOR), such as sirolimus or everolimus, to effect a clinical response on an insult or wound. The compound can be administered in any suitable local or topical delivery form, such as by local injection; local delivery systems, for example impregnated implants and slow release devices; forms of dressings, impregnated suturing material; impregnated mesh, sheets, membranes, prosthetics; gels containing the compound; and so forth. Typical applications where it would be useful to prevent scarring by inhibiting the mTOR according to the invention are: cosmetic surgery; scar revision surgery, including excision of scars and contracture release; tendon repair; nerve repair; and fibrotic or inflammatory conditions, such as de Quervain's disease, Peyronie's disease, plantar fasciitis, Dupuytren's disease, finger triggering, forms of synovitis, such as rheumatoid arthritis, after laparotomy to prevent adhesions, after brain surgery to prevent gliosis, and microsurgery, such as microvascular surgery and fallopian tube surgery.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68258105P | 2005-05-18 | 2005-05-18 | |
US60/682,581 | 2005-05-18 | ||
ZA200504008 | 2005-05-18 | ||
ZA2005/04008 | 2005-05-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006123226A2 WO2006123226A2 (en) | 2006-11-23 |
WO2006123226A3 true WO2006123226A3 (en) | 2007-01-11 |
Family
ID=36968953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2006/001300 WO2006123226A2 (en) | 2005-05-18 | 2006-05-18 | An inhibitor of mtor for inhibiting the formation of scar tissue |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2006123226A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102009030931A1 (en) | 2009-06-24 | 2010-12-30 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Surgical wound sealing element for sealing wound in surgical joint in e.g. intestine of human, has body coated with anti-inflammatory composition and designed as thread that comprises fibers, which are interlaced together |
US8465413B2 (en) | 2010-11-25 | 2013-06-18 | Coloplast A/S | Method of treating Peyronie's disease |
DK2948134T3 (en) | 2013-01-24 | 2020-06-02 | Palvella Therapeutics Inc | COMPOSITIONS FOR TRANSDERMAL ADMINISTRATION OF MTOR INHIBITORS |
PL3030232T3 (en) * | 2013-04-29 | 2022-11-07 | Medregen, Llc | Wound healing via autologous stem cell mobilization |
HUP1400075A2 (en) | 2014-02-14 | 2015-08-28 | Druggability Technologies Ip Holdco Jersey Ltd | Complexes of sirolimus and its derivatives, process for the preparation thereof and pharmaceutical composition containing them |
WO2016130485A1 (en) * | 2015-02-09 | 2016-08-18 | The Board Of Regents Of The University Of Texas System | Use of mtor inhibitors to prevent and regress adhesions and fibrosis |
CA3049402A1 (en) | 2017-01-06 | 2018-07-12 | Palvella Therapeutics Llc | Anhydrous compositions of mtor inhibitors and methods of use |
EP3817743A4 (en) | 2018-07-02 | 2022-07-06 | Palvella Therapeutics, Inc. | Anhydrous compositions of mtor inhibitors and methods of use |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040087613A1 (en) * | 2002-01-29 | 2004-05-06 | Molmenti Ernesto P. | Prevention of adhesions with rapamycin |
WO2004110347A2 (en) * | 2003-05-07 | 2004-12-23 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
US20050084514A1 (en) * | 2000-11-06 | 2005-04-21 | Afmedica, Inc. | Combination drug therapy for reducing scar tissue formation |
-
2006
- 2006-05-18 WO PCT/IB2006/001300 patent/WO2006123226A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050084514A1 (en) * | 2000-11-06 | 2005-04-21 | Afmedica, Inc. | Combination drug therapy for reducing scar tissue formation |
US20040087613A1 (en) * | 2002-01-29 | 2004-05-06 | Molmenti Ernesto P. | Prevention of adhesions with rapamycin |
WO2004110347A2 (en) * | 2003-05-07 | 2004-12-23 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
Non-Patent Citations (1)
Title |
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KIM A ET AL: "Are keloids really "gli-loids"?: High-level expression of gli-1 oncogene in keloids.", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. NOV 2001, vol. 45, no. 5, November 2001 (2001-11-01), pages 707 - 711, XP002399754, ISSN: 0190-9622 * |
Also Published As
Publication number | Publication date |
---|---|
WO2006123226A2 (en) | 2006-11-23 |
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